| Patents for C07D 453 - Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids (5,704) |
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| 04/02/2008 | EP1905771A2 Quinuclidine derivatives and their use |
| 04/02/2008 | CN100378092C Biphenyl derivatives |
| 04/02/2008 | CN100378074C 2-,3-4- or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
| 03/27/2008 | US20080076927 safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous sytem |
| 03/26/2008 | CN100376569C Inhibitors of farnesyl protein transferase |
| 03/25/2008 | US7348330 1-azabicyclo [2,2,2] octan-3-one derivatives |
| 03/20/2008 | WO2008005910A3 Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| 03/20/2008 | US20080070906 Quinolinone derivatives |
| 03/19/2008 | EP1900737A1 Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide |
| 03/19/2008 | CN101146806A Pyrazole derivatives for the inhibition of CDK and GSK |
| 03/18/2008 | US7345175 Biphenyl derivatives |
| 03/13/2008 | WO2008012290A3 Quinuclidine derivatives as m3 antagonists |
| 03/13/2008 | WO2007136570A3 5,6-fused pyrrolidine compounds useful as tachykinin receptor antagonists |
| 03/13/2008 | US20080064726 Dipeptidyl peptidase-IV (DPP-IV) inhibitor; diabetes mellitus, insulin-resistant diseases, obesity, hypoglycemia ; 2-[4-({2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl}amino)-4-methylpiperdin-1-yl]-2-oxoethyl acetate monofumarate |
| 03/12/2008 | EP1896469A2 Fused bicycloheterocycle substituted quinuclidine derivatives |
| 03/12/2008 | CN100374425C Aryl and heteroaryl urea CHK1 inhibitors for use as radiosensitizers and chamosensitizers |
| 03/11/2008 | US7342028 Medical use for tachykinin antagonists |
| 03/06/2008 | WO2008025541A1 Polymorph of (r) -3- (2-hydroxy-2, 2-diphenyl-acetoxy) -1- (isoxazol-s-ylcarbamoyl-methyl) -1-azoni a-bicyclo- [2.2.2] octane bromide |
| 03/06/2008 | CA2660983A1 Polymorph of (r) -3- (2-hydroxy-2, 2-diphenyl-acetoxy) -1- (isoxazol-3-ylcarbamoyl-methyl) -1-azoni a-bicyclo- [2.2.2] octane bromide |
| 03/05/2008 | CN101137654A Novel salt of quinuclidine derivative |
| 02/27/2008 | EP1891048A1 Pyrazole-substituted benzimidazole derivatives for use in the treatment of cancer and autoimmune disorders |
| 02/27/2008 | EP1558610B1 Substituted aminoquinuclidine compounds and their use as delta-opioid receptor ligands |
| 02/27/2008 | EP1268470B1 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof |
| 02/26/2008 | US7335774 Quinolinone derivatives |
| 02/26/2008 | US7335668 Gastrointestinal disorders; urogenital disorders |
| 02/26/2008 | US7335656 Medical devices employing triazine compounds and compositions thereof |
| 02/20/2008 | EP1889845A1 Novel pleuromutilin derivatives |
| 02/20/2008 | EP1404704B9 Bridged bicyclic serine protease inhibitors |
| 02/19/2008 | US7332610 Chemical intermediates for production of sibutramine |
| 02/19/2008 | US7332507 Cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters; treating pain, neurodegeneration, inflammation, and drug or alcohol withdrawal symptoms; 3-benzimidazole, indole or triazole substituted |
| 02/19/2008 | US7332490 inhibit smooth muscle cell proliferation by modulating Heparan Sulfate Proteoglycans (HSPGs); inhibit or block glycated protein and Advanced Glycation Endproducts (AGE) produced induction of the signaling-associated inflammatory response in endothelial cells; antiproliferative and antiinflammatory agent |
| 02/19/2008 | US7332489 Methods and compositions of novel triazine compounds |
| 02/19/2008 | US7332488 Methods and compositions of novel triazine compounds |
| 02/14/2008 | US20080039516 Composition of Solifenacin or Salt Thereof for Use in Solid Formulation |
| 02/14/2008 | US20080039493 Quinuclidine derivatives as M3 antagonists |
| 02/14/2008 | CA2660349A1 2-aminobenzoxazole carboxamides as 5ht3 modulators |
| 02/13/2008 | CN101124224A Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| 02/06/2008 | EP1339712B1 3-substituted quinuclidines and their use as nicotinic agonists |
| 02/06/2008 | CN101119994A Nicotinic acetycholine receptor ligands |
| 02/05/2008 | US7326787 Preparing (R)-quinuclidin-3-yl 6-((3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl)hexanoate; ethyl 4-amino-3-methoxypiperidine-1-carboxylate; benzylation; chiral salt; basification; ethyl 6-bromohexanoate; R)-quinuclidin-3-ol; deprotect; 4-amino-5-chloro-2-methoxybenzoic acid |
| 01/31/2008 | WO2008013269A1 Isoquinuclidine derivative and method for producing 1-cyclohexene-1-carboxylic acid derivative by using the same |
| 01/31/2008 | WO2008012290A2 Quinuclidine derivatives as m3 antagonists |
| 01/31/2008 | CA2658649A1 Quinuclidine derivatives as m3 antagonists |
| 01/30/2008 | EP1882691A1 Quinuclidine derivatives as M3 antagonists |
| 01/24/2008 | WO2008009397A1 Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide |
| 01/24/2008 | US20080021060 Quinuclidine carbamate derivatives and their use as M3 antagonists |
| 01/24/2008 | CA2657679A1 Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide |
| 01/23/2008 | EP1879887A2 Npy antagonists, preparation and use |
| 01/23/2008 | EP1879867A2 Intermediates for preparing solifenacin |
| 01/23/2008 | EP1532144B1 quinuclidine derivatives and their use |
| 01/23/2008 | CN101108825A Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists |
| 01/23/2008 | CN100363363C Novel quinuclidine derivatives and medicinal compositions containing the same |
| 01/17/2008 | WO2007075297A3 Muscarinic agonists and methods of use thereof |
| 01/17/2008 | US20080015220 Biphenyl-2-ylcarbamic acid 1-{7-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]heptyl}piperidin-4-yl ester; beta 2 adrenergic receptor agonist and muscarinic receptor antagonist; bronchodilator agent; pulmonary disorders, chronic obstructive pulmonary disease and asthma |
| 01/16/2008 | EP1877367A1 Acetylene derivatives |
| 01/10/2008 | WO2008005910A2 Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| 01/10/2008 | US20080009624 Heteroaryl carboxamides |
| 01/09/2008 | EP1874761A2 4h-1,2,4-triazin-5-one derivatives, their preparation and their use as alpha 7 nicotinic acetylcholine receptors |
| 01/09/2008 | EP1711473B1 Substituted n-cyclohexylimidazolinones having an mch-modulatory effect |
| 01/09/2008 | EP1601635B1 Process for producing optically active alcohol in the presence of rhodium, a chiral ferrocenyldiphosphine and an optically active diamine |
| 01/08/2008 | US7317028 Antitumor agents; autoimmune disease; skin disorders; anticancer agents |
| 01/08/2008 | CA2172513C Aminocyclohexylesters and uses thereof |
| 01/02/2008 | EP1871772A1 Quinolinone compounds as 5-ht4 receptor agonists |
| 01/01/2008 | US7314870 Compounds, their preparation and use |
| 12/27/2007 | WO2007149929A1 Piperidine derivatives for the treatment of gastrointestinal and cns disorders |
| 12/27/2007 | WO2007147374A2 Process for the preparation of solifenacin |
| 12/27/2007 | US20070299082 (+-)-3-(6-Phenylethynyl-pyridazin-3-yloxy)-1-aza-bicyclo[2.2.2]octane; (+-)-N-{4-[6-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-pyridazin-3-ylethynyl]-phenyl}-acetamide; nicotinic and monoamine receptor modulators |
| 12/27/2007 | US20070299039 Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
| 12/26/2007 | CN100357276C Quinoline and quinoxaline compounds as PDGF-R and/or LCD tyrosine kinase inhibitors |
| 12/25/2007 | US7312335 Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts |
| 12/25/2007 | US7312231 Quaternization of compound for treatment of urogenital disorders, respiratory system disorders or gastrointestinal disorders |
| 12/25/2007 | US7312208 Quaternary ammonium compounds |
| 12/21/2007 | WO2007063418A3 Substituted indole compounds having nos inhibitory activity |
| 12/20/2007 | US20070293498 used for the treatment of cachexia and other weight loss disorders, such as those resulting from cancer, HIV, old age and anorexia nervosa |
| 12/19/2007 | EP1867654A1 Process for production of optically active quinuclidinol |
| 12/19/2007 | EP1594869B1 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| 12/19/2007 | CN101088999A Process of synthesizing 3-amino quinine dihydrochloride |
| 12/19/2007 | CN100355419C Therapeutic agent for overactive bladder |
| 12/18/2007 | US7309699 Such as 4'-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1'-biphenyl-3-amine; nicotinic acetylcholine receptor modulators; for treatment of attention deficit disorder, Alzheimer*s disease, or AIDS |
| 12/13/2007 | WO2007141504A1 Fused thiophene derivatives as kinase inhibitors |
| 12/13/2007 | US20070287743 Adamantyl Pyrrolidin-2-One Derivatives as 11-Beta Hydroxtsteroid Dehydrogenase Inhibitors |
| 12/13/2007 | US20070287728 Novel Naphthyl Substituted Azabicyclo Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors |
| 12/12/2007 | EP1713801B1 Process for preparation of 1-(2s,3s)-2-benzhydr yl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine |
| 11/29/2007 | US20070276003 Biphenyl-2-ylcarbamic acid 1-{7-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]heptyl}piperidin-4-yl ester; beta 2 adrenergic receptor agonist and muscarinic receptor antagonist; bronchodilator agent; pulmonary disorders, chronic obstructive pulmonary disease and asthma |
| 11/29/2007 | US20070275975 3-quinuclidinyl amino-substituted biaryl derivatives |
| 11/28/2007 | CN101080385A Amine salts of (-)-2-((2-(4-hydroxyphenyl)ethyl)thio)-3-(4-(2-(4-((methylsulfonyl)oxy)phenoxy)ethyl)phenyl)propanoic acid |
| 11/28/2007 | CN100351249C Quinolinone derivatives as tyrosine kinase inhibitors |
| 11/22/2007 | WO2007076116A3 Intermediates for preparing solifenacin |
| 11/22/2007 | WO2005046589A3 Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties |
| 11/22/2007 | US20070270458 Nicotinic Acetylcholine Receptor Ligands |
| 11/22/2007 | US20070270453 TRICYCLIC MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF |
| 11/20/2007 | US7297682 liquid crystal diphosphate polymorph; antibacterial and antiprotozoal agents |
| 11/14/2007 | EP1853600A1 Pyrazole derivatives for the inhibition of cdk's and gsk's |
| 11/14/2007 | EP1853597A1 Benzoxazole carboxamides for treating cinv and ibs-d |
| 11/06/2007 | US7291731 7-(3-Pyridyl)-1,7-diazaspiro-[4,4]nonane and its salts and proline amides; capable of affecting nicotinic cholinergic receptors, e.g., as modulators of specific nicotinic receptor subtypes; neuroprotective agents |
| 10/31/2007 | EP1849782A1 Quinolinone derivatives as tyrosine kinase inhibitors |
| 10/31/2007 | CN100345847C Novel biarylcarboxamides |
| 10/30/2007 | US7288656 Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics |
| 10/25/2007 | WO2007119463A1 2-(cyclic amino)-pyrimidone derivatives as tpk1 inhibitors |
| 10/25/2007 | US20070249664 Muscle relaxants; respiratory system disorders; asthma;COPD; emphysema; bronchitis |