| Patents for C07D 453 - Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids (5,704) |
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| 05/21/2009 | US20090131470 Pyrazole-substituted benzimidazole derivatives for use in the treatment of cancer and autoimmune disorders |
| 05/21/2009 | US20090126125 Styryl tetrahydroquinolinium thiol/disulfide dye compound and method for lightening keratin materials using the same |
| 05/20/2009 | CN101437803A Dibenzyl amine derivatives as CETP inhibitors |
| 05/14/2009 | US20090124807 2-(2,2-Dimethoxy-ethyl)-4,4-dimethoxy-butyric acid methyl ester; for making 1H-indole-3-carboxylic acid 10-oxo-8-aza-tricyclo[5.3.1.03,8]undec-5-yl ester; antiemetic and antinausea |
| 05/14/2009 | US20090124653 Muscarinic Acetylcholine Receptor Antagonists |
| 05/12/2009 | US7531662 Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them |
| 05/12/2009 | CA2264005C Piperazino derivatives as neurokinin antagonists |
| 05/07/2009 | US20090118502 organic or inorganic salt of N-{3-[4'-(4-Aminomethyl-[1,2,3]triazol-1-ylmethyl)-2-fluoro-biphenyl- 4-yl]-2-oxo-oxazolidin-5-(S)-ylmethyl}-acetamide; anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents |
| 05/07/2009 | US20090118326 Nicotinic Acetylcholine Receptor Modulators |
| 05/06/2009 | CN100484937C Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| 05/06/2009 | CN100484934C Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase |
| 04/30/2009 | WO2009055437A2 (1,4-diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone ligands for nicotinic acetylcholine receptors, useful for the treatment of disease |
| 04/30/2009 | CA2703163A1 (1,4-diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone ligands for nicotinic acetylcholine receptors, useful for the treatment of disease |
| 04/29/2009 | EP1651592B1 Novel dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof |
| 04/29/2009 | CN100482661C Method of synthesizing 3-quininone hydrochlorate |
| 04/28/2009 | USRE40703 N-(2-aminophenyl)-4-(N-benzoylaminomethyl)benzamide hydrochloride; differentiation-inducing activity, for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism, hematologic malignancy, a solid carcinoma |
| 04/28/2009 | US7524959 Biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenyl-carbamoyl)ethyl]piperidin-4-yl ester; beta 2 adrenergic receptor agonist and muscarinic receptor antagonist; bronchodilator agent; pulmonary disorders, asthma |
| 04/28/2009 | US7524839 Such as 1-phenylsulfonyl-4-piperazinylindole hydrochloride for treatment or prophylaxis of disease mediated by serotonin related receptor, obesity, and/or central nervous system disorder |
| 04/28/2009 | US7524838 Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them |
| 04/23/2009 | US20090105298 Pharmaceutical composition for therapy of interstitial cystitis |
| 04/22/2009 | EP2050752A1 Isoquinuclidine derivative and method for producing 1-cyclohexene-1-carboxylic acid derivative by using the same |
| 04/22/2009 | EP2049533A2 Quinuclidine derivatives as m3 antagonists |
| 04/22/2009 | CN101411996A Macromolecule supported Cinchona bases compound, production method and application |
| 04/21/2009 | US7521561 Biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenyl-carbamoyl)ethyl]piperidin-4-yl ester; beta 2 adrenergic receptor agonist and muscarinic receptor antagonist; bronchodilator agent; pulmonary disorders, asthma |
| 04/21/2009 | US7521559 side effects reduction; for asthma, COPD, cold, rhinitis, peptic ulcer, diarrhea, arrhythmia; 3-quinuclidinyl-(2'-phenyl-2'-cyclopentyl-2'-hydroxyl)ethyl ether; reacting phenylalkylethylene oxide and 2-quinuclidinol, product then reacted with halogenated alkane to give quarternery ammonium compounds |
| 04/21/2009 | US7521558 Crystalline form of a biphenyl compound |
| 04/16/2009 | WO2009046624A1 Preparation methods of (4s,5r)-semi-esters |
| 04/16/2009 | US20090099365 Processes for solifenacin preparation |
| 04/16/2009 | US20090099364 Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5- tert-butyl-2-methoxybenzyl)quinuclidin-3-amine |
| 04/16/2009 | US20090099143 Tetrahydro-indazole cannabinoid modulators |
| 04/15/2009 | EP2046753A2 Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| 04/15/2009 | EP2046751A2 Process for preparing solifenacin and its salts |
| 04/15/2009 | EP1689720B1 Pyrazolyl derivatives in the form of drugs for treating acute or chronic neuronal regressions |
| 04/14/2009 | US7517517 Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands |
| 04/09/2009 | WO2009046025A1 Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
| 04/09/2009 | CA2701126A1 Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
| 04/08/2009 | EP2044067A1 Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3- phenoxypropyl)-1 -azoniabicyclo[2.2.2]octane bromide |
| 04/08/2009 | CN101402634A Separation and purification process for alkaloid in cinchona bark |
| 04/08/2009 | CN101402633A Benzamide derivatives, preparation method and medical uses thereof |
| 04/07/2009 | US7514558 e.g. 3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethyl}amino)-hexyl]oxy}butyl)benzenesulfonamide; beta 2 adrenergic receptor agonist and muscarinic receptor antagonist activity; bronchodilator agent; pulmonary disorders: chronic obstructive pulmonary disease; asthma |
| 04/07/2009 | US7514450 Azabicyclic aryl derivatives |
| 04/02/2009 | WO2009010299A8 Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators |
| 04/02/2009 | US20090088418 4-substituted quinuclidine derivatives, methods of production, and pharmaceutical uses thereof |
| 04/01/2009 | EP1594869B9 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| 04/01/2009 | CN101400668A 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors |
| 03/26/2009 | US20090082384 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| 03/24/2009 | US7507751 Biphenyl derivatives |
| 03/17/2009 | CA2412594C Pyrazino[1',2':1,6]pyrido[3-4-5] indole derivatives |
| 03/12/2009 | WO2009031526A1 Process for production of optically active 3-quinuclidinol derivative |
| 03/12/2009 | US20090069282 Alkyne compounds with mch antagonistic activity and medicaments comprising these compounds |
| 03/11/2009 | EP2033953A1 Vanilloid receptor modulators |
| 03/11/2009 | EP1781651B1 Process for preparing quinuclidinium carbamate derivatives |
| 03/11/2009 | EP0976722B1 Benzamidine derivatives |
| 03/11/2009 | CN101384555A Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| 03/05/2009 | WO2009011844A8 Processes for solifenacin preparation |
| 03/05/2009 | US20090062268 Novel inhibitors of poly(adp-ribose)polymerase (parp) |
| 03/05/2009 | CA2696609A1 Therapeutic isoxazole compounds |
| 03/04/2009 | EP2029587A2 Process for the preparation of solifenacin |
| 03/04/2009 | EP1452527B1 Azabicyclo compound, matrix metalloprotease inhibitor, and skin preparation |
| 03/04/2009 | EP1230243B1 Poycyloalkylpurines as adenosine receptor antagonists |
| 03/03/2009 | US7498440 1-(2-{[(3-fluorophenyl)methyl]oxy}ethyl)-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide; muscle relaxants, respiratory system disorders; asthma, bronchitis, chronic obstructive lung disease, chronic bronchitis, chronic respiratory obstruction, pulmonary fibrosis, pulmonary fibrosis |
| 02/26/2009 | US20090054480 Novel quinuclidine carbamate derivatives and medicinal compositions containing the same |
| 02/26/2009 | US20090054446 Aza-bicycloalkyl ethers and their use as alpha7-nachr agonists |
| 02/26/2009 | US20090054396 Substituted thiophenes and uses thereof |
| 02/25/2009 | CN101374836A Muscarinic agonists and methods of use thereof |
| 02/24/2009 | US7495104 Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors |
| 02/24/2009 | US7495102 N-{4-[4-(2-{3-[(dimethylamino)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]phenyl}-N'-phenylurea; antitumor and anticarcinogenic agent; G2 and mitotic phases in cycling cells; solid tumor and hematological cancers |
| 02/19/2009 | WO2008153937A3 Novel 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| 02/19/2009 | US20090048291 Novel Piperidine-4-Acetic Acid Derivatives and Their Use |
| 02/19/2009 | US20090048290 2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl-benzyofuran-2-carboxamide, novel salt forms, and methods of use thereof |
| 02/19/2009 | US20090048281 Organic Compounds |
| 02/17/2009 | US7491734 psychotic and intellectual impairment disorders; Alzheimer's disease, cognitive or attention disorders, antidepressant, anxiolytic agent; ,smoking cessation, neuroprotection, schizophrenia, analgesia, Tourette's syndrome, and Parkinson's disease |
| 02/17/2009 | CA2400217C Pteridine compounds for the treatment of psoriasis |
| 02/10/2009 | US7488827 Muscle relaxants; respiratory system disorders; asthma;COPD; emphysema; bronchitis |
| 02/10/2009 | US7488735 antagonists of M3 muscarinic receptors; N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-hydroxy-2,2-dithien-2-ylacetamide; respiratory disorders, urological disorders, gastrointestinal disorders, cardiovascular disorders; alkylation |
| 02/05/2009 | WO2008129054A3 Heterocyclic compounds with affinity to muscarinic receptors |
| 01/29/2009 | WO2009013535A1 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor |
| 01/27/2009 | US7482455 Chemical compounds |
| 01/27/2009 | US7482370 Compounds for the treatment of inflammatory disorders |
| 01/27/2009 | US7482352 Such as N6-[6-(2-dimethylaminoethylamino)-4-methylsulfanyl-[1,3,5]triazin-2-yl]-2-methylquinoline-4,6-diamine, which stabilizes DNA in G-quadruplex structures (guanine tetrads); anticancer agents |
| 01/22/2009 | WO2009011844A1 Processes for solifenacin preparation |
| 01/22/2009 | WO2009010987A1 An improved process for the preparation of pure palonosetron hydrochloride |
| 01/22/2009 | WO2009010299A1 Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators |
| 01/22/2009 | WO2008009397A8 Process for manufacturing 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide |
| 01/15/2009 | US20090018160 Heterocyclic Compounds with Affinity to Muscarinic Receptors |
| 01/14/2009 | CN100451018C Novel quinuclidine derivatives and medicinal compositions containing the same |
| 01/08/2009 | US20090012116 Muscarinic Receptor Antagonists |
| 01/08/2009 | US20090012101 Mucarinic Agonists and Methods of Use Thereof |
| 01/07/2009 | EP2010527A1 1,5 and 3,6- substituted indole compounds having nos inhibitory activity |
| 01/07/2009 | CN100448868C Tri-substituted heteroaryls and methods of making and using the same |
| 01/01/2009 | US20090005412 Novel quinuclidine derivatives and medicinal compositions containing the same |
| 01/01/2009 | US20090005390 Novel quinuclidine derivatives and their use |
| 12/31/2008 | EP1737863B1 2-cyanopyrrolidinecarboxamides as dipeptidyl peptidase-iv inhibitors |
| 12/30/2008 | US7470709 Benzimidazole quinolinones and uses thereof |
| 12/30/2008 | CA2245587C Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists |
| 12/24/2008 | WO2008013851A3 Processes for preparing polymorphic forms of solifenacin succinate |
| 12/24/2008 | CN100445281C Quinuclidine derivatives binding to mucarinic M3 receptors |
| 12/17/2008 | EP2001877A1 Method for extracting target alkaloid using an ionic liquid as extracting solvent |
| 12/17/2008 | EP2001863A1 2-(cyclic amino)-pyrimidone derivatives as tpk1 inhibitors |
| 12/17/2008 | EP2001474A2 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |