| Patents for C07D 489 - Heterocyclic compounds containing 4ah-8, 9 c- iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: (2,334) |
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| 11/27/2008 | WO2008143240A1 Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation |
| 11/27/2008 | WO2008143239A1 Crystalline micropowder particles |
| 11/27/2008 | WO2008064353A3 7,8-saturated-4,5-epoxy-morphinanium analogs |
| 11/27/2008 | CA2687955A1 Crystalline micropowder particles |
| 11/27/2008 | CA2687558A1 Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation |
| 11/27/2008 | CA2686851A1 Fused-ring heterocycle opioids |
| 11/26/2008 | EP1994034A2 Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
| 11/20/2008 | WO2008138605A2 Method for producing n-methylnaltrexone bromide |
| 11/20/2008 | WO2008138383A1 Method for the production of n-methyl naltrexone bromide |
| 11/20/2008 | WO2008109156A3 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| 11/20/2008 | WO2008064351A3 (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs |
| 11/19/2008 | EP1736157B1 Morphinan derivatives as anti-itching agent |
| 11/13/2008 | WO2008137672A1 Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
| 11/13/2008 | WO2008136865A2 (s)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs |
| 11/12/2008 | EP1989208A1 New morphine compounds for pharmaceutical compositions |
| 11/06/2008 | WO2008133297A1 Therapeutic or prophylactic agent for dyskinesia |
| 11/06/2008 | WO2008131567A1 Solvent-free crystalline form of naltrexone |
| 11/06/2008 | US20080275074 Anti-Itching Agent |
| 11/06/2008 | CA2685126A1 Therapeutic or prophylactic agent for dyskinesia |
| 11/05/2008 | CN100430399C Methods and compositions comprising nitric oxide donors and opioid analgesics |
| 11/04/2008 | CA2637610A1 Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
| 10/30/2008 | WO2008130553A1 Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
| 10/30/2008 | CA2684458A1 Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
| 10/23/2008 | WO2008127618A1 Crystalline and amorphous forms of naltrexone hydrochloride |
| 10/22/2008 | EP1981891A1 The use of oripavine as a starting material for buprenorphine |
| 10/16/2008 | WO2008070462A3 N-oxides of 4,5-epoxy-morphinanium analogs |
| 10/14/2008 | US7435817 C-14 oxidation of morphine derivatives |
| 10/09/2008 | WO2008121352A2 Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof |
| 10/09/2008 | WO2008121348A2 Peripheral opioid receptor antagonists and uses thereof |
| 10/09/2008 | WO2008120562A1 Therapeutic tablet for postherpetic neuralgia and method of treating postherpetic neuralgia |
| 10/09/2008 | US20080249112 Antiproliferavtive agents; small molecule inhibitors of KSP(kinesin-related proteins); N-(3-aminopropyl)-N-[1-(3-benzyl-4-oxo-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide |
| 10/09/2008 | CA2682129A1 Crystal forms and uses thereof |
| 10/09/2008 | CA2682125A1 Peripheral opioid receptor antagonists and uses thereof |
| 10/02/2008 | WO2008118654A1 Improved preparation of oxymorphone from oripavine |
| 10/02/2008 | CA2681740A1 Improved preparation of oxymorphone from oripavine |
| 09/25/2008 | WO2008115820A1 Combination of a narcotic and a non-narcotic analgesic |
| 09/25/2008 | US20080234307 Novel 6-Amino-Morphinan Derivatives, Method of Manufacturing Them and Their Application as Analgesics |
| 09/25/2008 | US20080234306 (S)-17-Cyclopropylmethyl-4,5 alpha -epoxy-3,14-dihydroxymorphinan N-oxide and an opioid agonist; significant mu-opioid receptor antagonistic activity; reducing opioid side-effects, dysphoria, pruritis, urinary retention, nausea, emesis |
| 09/24/2008 | EP1971607A2 Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions |
| 09/12/2008 | CA2707757A1 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| 09/12/2008 | CA2680205A1 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| 09/10/2008 | CN101260111A Method for preparing buprenorphine hydrochloride intermediate |
| 09/03/2008 | EP1487838B1 Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography |
| 08/28/2008 | US20080207906 Halogenation in presence of catalyst, heating in presence of acid, oxidation, reduction |
| 08/28/2008 | US20080207669 (S)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs |
| 08/28/2008 | US20080207668 Pharmaceutical compositions of hydromorphone for prevention of overdose or abuse |
| 08/27/2008 | EP1711502B1 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates |
| 08/21/2008 | WO2008101202A1 N-17-alkylated prodrugs of opioids |
| 08/14/2008 | WO2008096046A1 Noroxymorphone for use as a medicament |
| 08/14/2008 | US20080196123 Modulation of Alkaloid Siosynthesis in Plants and Plants Having Altered Alkaloid Biosynthesis |
| 08/14/2008 | US20080194568 Pyridomorphinans, Pyridazinomorphinans and Use Thereof |
| 08/07/2008 | US20080188661 Transforming morphine to hydromorphone or codeine to hydrocodone in the presence of Irridium or Rhodium-Aminophosphine Complexes |
| 08/06/2008 | EP1953164A1 Therapeutic or prophylactic agent for functional bowel disorder |
| 07/30/2008 | EP1233966B1 Hydromorphinone and hydrocodeinone compositions and methods for their synthesis |
| 07/29/2008 | US7405301 N-demethylating an N-methyl morphinane by oxidizing an N-methyl morphinane to form the N-oxide, then treating with a reducing agent; a Delta 6,Delta 8-morphinane compound |
| 07/24/2008 | WO2008070656A3 Process for reducing impurities in oxycodone base |
| 07/24/2008 | US20080176885 Improved Pharmacokinetics; side effects reduction; codrugs are covalently bound by a linker that is capable of cleavage in the body; analgesics |
| 07/24/2008 | US20080176884 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs |
| 07/23/2008 | EP1946759A1 Therapeutic agent for nausea and/or vomiting |
| 07/23/2008 | CN101228172A 6,7-unsaturated-7-carbamoyl substituted morphinan derivative |
| 07/17/2008 | WO2007120648A3 Mono and di-substituted oxycodone compounds and compositions |
| 07/16/2008 | EP1944292A1 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| 07/15/2008 | US7399859 Transforming morphine to hydromorphone or codeine to hydrocodone in the presence of Irridium or Rhodium-Aminophosphine Complexes |
| 07/15/2008 | US7399858 Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| 07/09/2008 | EP1219624B1 Remedies for neuropathic pain and model animals of neuropathic pain |
| 07/09/2008 | CN100400539C Method for the catalytic production of hydrocodone and hydromorphone |
| 07/03/2008 | WO2008036980B1 Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof |
| 07/03/2008 | US20080161570 Processes for Synthesizing Quaternary 4,5-Epoxy-Morphinan Analogs and Isolating their N-Stereoisomers |
| 07/02/2008 | EP1282404B1 Method for preparing microparticles having a selected polymer molecular weight |
| 07/02/2008 | CN100398154C Remedies for psychoneurosis |
| 06/25/2008 | CN101208345A (S)-N-methylnaltrexone, processes for its synthesis and its pharmaceutical use |
| 06/25/2008 | CN101208344A (R)-N-methylnaltrexone, processes for its synthesis and its pharmaceutical use |
| 06/25/2008 | CN101208343A Hydromorphone polymorphs |
| 06/25/2008 | CN100396685C New method for synthesizing codeine from morphine |
| 06/19/2008 | WO2008072018A1 Improved method for making analgesics |
| 06/19/2008 | US20080146804 making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base |
| 06/19/2008 | CA2672644A1 Improved method for making analgesics |
| 06/18/2008 | EP1931678A1 Novel 6-amino-morphinan derivatives, method of manufacturing them and their application as analgesics |
| 06/12/2008 | WO2008070658A1 Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
| 06/12/2008 | WO2008070656A2 Process for reducing impurities in oxycodone base |
| 06/12/2008 | US20080139814 Heating an oxycodone base starting material having more than 100 ppm of 14-hydroxycodeinone and sodium hydrosulfite, sodium bisulfite, or sodium metabisulfite in an alcohol/water; isolating oxycodone base having less than 10 ppm of 14-hydroxycodeinone |
| 06/12/2008 | CA2671551A1 Process for reducing impurities in oxycodone base |
| 06/12/2008 | CA2671518A1 Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
| 06/12/2008 | CA2670342A1 N-oxides of 4,5-epoxy-morphinanium analogs |
| 06/11/2008 | EP1928882A2 (s)-n-methylnaltrexone, process for its synthesis and its pharmaceutical use |
| 06/11/2008 | EP1928881A2 Prodrugs of active agents |
| 06/11/2008 | CN101198612A A new synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
| 06/05/2008 | US20080132751 by the administration of analgesics that are encapsulated in diacylglycerol-polyethyleneglycol liposomes and delivered sublingually as aerosols |
| 06/05/2008 | US20080132703 Process for Reducing Impurities in Oxycodone Base |
| 06/04/2008 | CN101193894A Method for separation and purification of naltrexone by preparative chromatography |
| 05/29/2008 | WO2008064150A1 Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers |
| 05/29/2008 | US20080125592 Process for preparing oxymorphone, naltrexone, and buprenorphine |
| 05/29/2008 | CA2670386A1 Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers |
| 05/29/2008 | CA2670382A1 (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs |
| 05/29/2008 | CA2670136A1 7,8-saturated-4,5-epoxy-morphinanium analogs |
| 05/28/2008 | EP1925297A1 Method for preparing microparticles having a selected polymer molecular weight |
| 05/28/2008 | EP1924559A2 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents |
| 05/28/2008 | EP1554282B1 Morphinan derivatives substituted in position 14 and quaternary ammonium salts thereof, method for production and use thereof |
| 05/21/2008 | EP0911334B1 Quinolinomorphinane derivatives and medicinal use thereof |
| 05/20/2008 | CA2205664C Indole derivatives and medicinal use thereof |