| Patents for C07D 489 - Heterocyclic compounds containing 4ah-8, 9 c- iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: (2,334) |
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| 12/28/1999 | US6008355 Oxidizing codeine to form codeinone, converting codeinone to oxycodone in a two step one pot reaction: reacting codeinone with hydrogen peroxide in water in presence of an acid to form 14-hydroxycodeinone then hydrogenating the intermediate |
| 12/28/1999 | US6008354 Protecting hydroxy group of morphine in 3 and 6 position, demethylating n-methyl on 17 position and hydrolizing the acyl group, forming 17-benzyl-3(o)protected group, oxidizing to form intermediate, hydrogenation of intermediate |
| 12/16/1999 | WO1999064430A2 Morphine-6-glucuronide synthesis |
| 12/01/1999 | EP0960111A1 Morphine derivatives with analgesic activity |
| 11/30/1999 | US5994327 Opioid antagonist |
| 11/09/1999 | US5981750 Loading morphine onto methylation resin comprising methyl(dialkyl or diaryl)anilinium salts covalently bonded to the resin; contacting the loaded resin with hydrocarbon or ether solvent to cover the loaded resin, heating |
| 11/09/1999 | US5981540 Selective delta opioid agonists and antagonists; useful as analgesics and in treating general neurologic disorders |
| 11/09/1999 | US5981467 Containing quatenary nitrogen unit |
| 10/26/1999 | US5972953 Morphinan derivative; usefal as preventive and therapuetic agents of ischemic brain disorders, brain nerve cell disorders and dementia |
| 10/26/1999 | US5972932 Olanzapine or a salt or solvate thereof, and an opoid in a specific weight ratio; administering to provide mild pre-surgical anesthesia to provide amnesia while maintaining cooperation in mammals such as humans |
| 10/13/1999 | CN1231667A Preparation of narcotic analgesics |
| 10/06/1999 | EP0946564A1 New process for the preparation of morphinans |
| 09/22/1999 | EP0943617A1 Process for the preparation of opiates |
| 09/14/1999 | US5952499 Therapeutic compound-fatty acid conjugates |
| 09/14/1999 | US5952495 Preparation of 14-hydroxynormorphinones from normorphinones |
| 09/07/1999 | US5948788 Normorphine and normorphinone derivatives |
| 08/05/1999 | WO1999038869A1 Therapeutic compounds |
| 08/05/1999 | CA2319627A1 Therapeutic compounds |
| 07/13/1999 | US5922876 Preparation of oxymorphone from morphine |
| 06/23/1999 | CN1220668A Indolomorphinane derivatives and remedies/preventives for cerebral disorders |
| 06/23/1999 | CN1220667A Morphinane derivatives and medicinal use thereof |
| 06/23/1999 | CN1043766C Indole derivative and preparation and pharmaceutical using of same |
| 06/15/1999 | US5912347 Process for preparing a morphinan derivative |
| 06/01/1999 | US5908927 Synthesis of deuterated opiate glucuronides |
| 06/01/1999 | US5908846 Topical compositions for transdermal delivery of prodrug derivatives of morphine |
| 05/26/1999 | EP0804459A4 Therapeutic compound - fatty acid conjugates |
| 05/26/1999 | EP0635019B1 Opiate derivatives and protein and polypeptide opiate derivative conjugates and labels |
| 05/19/1999 | EP0915884A1 Preparation of narcotic analgesics |
| 05/12/1999 | EP0915094A1 Morphinane derivatives and medicinal use thereof |
| 05/12/1999 | EP0914038A1 Improved production of thebaine and oripavine |
| 05/06/1999 | EP0912577A2 Novel methods of o-demethylation and n-deprotection |
| 05/04/1999 | US5900420 Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| 04/28/1999 | EP0911334A1 Quinolinomorphinane derivatives and medicinal use thereof |
| 04/21/1999 | CN1214634A Antipruritic agent |
| 04/07/1999 | CN1213372A Heterocycle-condensed morphinoid derivatives (II) |
| 04/01/1999 | WO1999015528A1 Acidic addition salts of morphine alkaloids and the application thereof |
| 04/01/1999 | DE19834005A1 Säureadditionssalze von Morphin-Alkaloiden und deren Verwendung Acid addition salts of morphine alkaloid and their use |
| 03/31/1999 | EP0904083A1 Anesthetic method |
| 03/31/1999 | EP0496830B1 Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates |
| 03/31/1999 | CN1212698A Morphine and diamorphine salts of anionic non-narcotic analgesics of substituted carboxylic acid type |
| 03/23/1999 | US5886001 Agonist compounds |
| 03/11/1999 | WO1999011289A1 Remedies for drug addiction |
| 02/24/1999 | EP0897726A1 Antipruritic agent |
| 02/09/1999 | US5869669 Reacting with an oxidizing agent in the presence of a weak acid |
| 02/09/1999 | CA2084519C Method for treating alcoholism with nalmefene |
| 02/04/1999 | WO1999005146A1 Hyponatremia remedies |
| 02/03/1999 | EP0894799A1 Indolomorphinane derivatives and remedies/preventives for cerebral disorders |
| 02/03/1999 | EP0763038B1 The preparation of nalbuphine having low levels of beta-epimer |
| 02/03/1999 | CN1207098A Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
| 01/21/1999 | WO1999002529A1 Preparation of oxymorphone, oxycodone and derivatives |
| 01/13/1999 | CN1205009A Pyrazolopyrimidines type compound |
| 01/13/1999 | CN1204649A Naloxonate and naltrexonate and series product and preparation method |
| 01/07/1999 | EP0889045A1 Process for the production of thebaine and analogues thereof, as well as intermediate products therefor |
| 12/30/1998 | CA2241772A1 Preparation of opiates, intermediates and uses of salts |
| 12/23/1998 | WO1998057637A1 Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| 12/23/1998 | CA2294281A1 Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine |
| 12/16/1998 | EP0883619A1 Morphine and diamorphine salts of anionic non-narcotic analgesics of the substituted carboxylic acid type |
| 12/15/1998 | US5849917 Process for the preparation of isoquinoline compounds |
| 12/15/1998 | US5849915 Buprenorphine analgesic analogues |
| 12/08/1998 | US5847142 Preparation of narcotic analgesics |
| 12/02/1998 | EP0880526A1 Heterocycle-condensed morphinoid derivatives (ii) |
| 12/02/1998 | EP0880523A1 Pyrazolopyrimidines as crf receptor antagonists |
| 11/11/1998 | EP0877022A1 Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
| 11/11/1998 | EP0597915B1 A process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| 11/10/1998 | US5834478 Morphinan hydroxamic acid compounds |
| 11/09/1998 | CA2237267A1 Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
| 10/21/1998 | EP0661283B1 Brain cell protective |
| 10/14/1998 | EP0577847B1 Morphinan derivative and medicinal use |
| 10/08/1998 | WO1998043978A1 Morphinane derivatives and medicinal use thereof |
| 10/08/1998 | WO1998043977A1 Quinolinomorphinane derivatives and medicinal use thereof |
| 09/02/1998 | EP0861250A1 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
| 08/13/1998 | DE3790166C2 Pure stereoisomers of N-cyclopropyl-methyl-nor-morphine cpds. |
| 07/28/1998 | CA2105072C Morphinan derivative and its pharmaceutical applications |
| 07/23/1998 | WO1998031684A1 Indolomorphinane derivatives and remedies/preventives for cerebral disorders |
| 07/22/1998 | EP0557385B1 Topical compositions for transdermal delivery of produg derivatives of morphine |
| 06/30/1998 | CA2067200C Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates |
| 06/10/1998 | EP0846694A1 Morphinan derivative and its pharmaceutical applications |
| 06/04/1998 | WO1998023290A1 Antipruritic agent |
| 05/28/1998 | WO1998022467A1 New process for the preparation of morphinans |
| 05/28/1998 | CA2269910A1 New process for the preparation of morphinans |
| 05/26/1998 | US5756745 Preparation of nalbuphine having low levels of β-epimer |
| 05/20/1998 | EP0636371B1 Antitussive |
| 04/08/1998 | CN1178535A Therapeutic compound-fatty acid conjugates |
| 04/08/1998 | CN1178218A Process for production of (Z)-1-£1-(4-methoxybenzylidene)-1,2,3,4,5,6,7,8-octahydro-isoquinolin-2-yl| alkanones of general formula |
| 03/18/1998 | EP0829481A1 Morphinan hydroxamic acid compounds |
| 02/12/1998 | WO1998005667A1 Preparation of narcotic analgesics |
| 02/03/1998 | US5714483 Antitussive |
| 01/28/1998 | EP0820288A1 Use of dextromethorphan or dextrorphan for the treatment of urinary incontinence |
| 01/22/1998 | WO1998002033A1 Improved production of thebaine and oripavine |
| 01/15/1998 | WO1997044317A3 Novel methods of o-demethylation and n-deprotection |
| 01/06/1998 | US5705585 Aminimide-containing molecules and materials as molecular recognition agents |
| 12/30/1997 | US5703231 Process for making antimicrobial compounds |
| 12/24/1997 | CN1168377A Novel buprenophine analgesic analogues |
| 11/27/1997 | WO1997044317A2 Novel methods of o-demethylation and n-deprotection |
| 11/05/1997 | EP0804459A1 Therapeutic compound - fatty acid conjugates |
| 10/02/1997 | WO1997035585A1 Anesthetic method |
| 10/02/1997 | CA2250155A1 Anesthetic method |
| 10/01/1997 | CN1161041A Heterocycle-condensed morphinoid derivatives |
| 09/16/1997 | US5668285 Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
| 09/10/1997 | EP0793664A1 Morphine and codeine derivatives for use in therapy |