| Patents for C07D 489 - Heterocyclic compounds containing 4ah-8, 9 c- iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: (2,334) |
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| 03/03/2015 | US8969368 Crystalline, anhydrous forms of oxymorphone hydrochloride |
| 03/03/2015 | US8969358 Buprenorphine analogs |
| 02/24/2015 | US8962841 Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| 02/24/2015 | US8962647 Conjugate of polyethylene gylcol and naloxone and pharmaceutical composition and use thereof |
| 02/24/2015 | US8962646 Peripherally acting opioid compounds |
| 02/24/2015 | US8962547 Compositions comprising enzyme-cleavable oxycodone prodrug |
| 02/24/2015 | CA2692433C Methods for n-demethylation of morphine and tropane alkaloids |
| 02/17/2015 | US8957085 Carboxamide bioisosteres of opiates |
| 02/17/2015 | US8957072 Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents |
| 02/17/2015 | US8956651 Oral formulations and lipophilic salts of methylnal trexone |
| 02/17/2015 | CA2609393C (s)-n-methylnaltrexone, process for its synthesis and its pharmaceutical use |
| 02/10/2015 | US8952032 Oligomer-opioid agonist conjugates |
| 02/10/2015 | US8951555 Controlled release hydrocodone formulations |
| 02/10/2015 | CA2671551C Process for reducing impurities in oxycodone base |
| 02/05/2015 | WO2015015147A1 Process for the preparation of morphinan-6-one compounds |
| 02/05/2015 | WO2015015146A1 Process for the preparation of oxymorphone |
| 02/05/2015 | US20150038715 Process |
| 02/05/2015 | US20150038524 Crystalline naloxol-peg conjugate |
| 02/05/2015 | US20150037409 Controlled release hydrocodone formulations |
| 02/03/2015 | US8946439 Amide compounds, compositions and uses thereof |
| 02/03/2015 | US8946419 (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| 02/03/2015 | US8946285 Oligomer-opioid agonist conjugates |
| 02/03/2015 | US8946254 Bivalent ligands for the treatment of neurological disorders |
| 02/03/2015 | US8946214 Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer |
| 01/29/2015 | WO2015011474A1 Preparation of saturated ketone morphinan compounds by catalytic isomerisation |
| 01/29/2015 | WO2015011131A1 Novel synthesis of noroxymorphone from morphine |
| 01/28/2015 | EP2829541A1 Novel synthesis of noroxymorphone from morphine |
| 01/27/2015 | US8940729 Abuse deterrent and anti-dose dumping pharmaceutical salts useful for the treatment of attention deficit/hyperactivity disorder |
| 01/15/2015 | WO2015004240A1 Nalmefene salts as medicaments for reducing alcohol consumption or for preventing excessive alcohol consumption |
| 01/07/2015 | CN102227433B 烷基化吗啡喃衍生物的仲胺基团的方法 Alkylated morphinan derivatives of secondary amine groups |
| 01/06/2015 | US8927716 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
| 12/30/2014 | US8921557 Preparation of low impurity opiates in a continuous flow reactor |
| 12/30/2014 | US8921556 Process for N-dealkylation of tertiary amines |
| 12/30/2014 | US8921386 Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties |
| 12/25/2014 | US20140377348 Controlled release hydrocodone formulations |
| 12/24/2014 | CN104230945A 盐酸纳洛酮的合成方法 Synthesis of naloxone hydrochloride |
| 12/23/2014 | US8916707 Process |
| 12/23/2014 | US8916706 Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone |
| 12/23/2014 | US8916581 (S)-N-methylnaltrexone |
| 12/18/2014 | US20140371255 Non-peptidyl, potent, and selective mu opioid receptor antagonists and their use in treating opioid addiction and opioid induced constipation |
| 12/18/2014 | US20140370006 Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| 12/18/2014 | US20140370005 Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| 12/17/2014 | CN104211707A 盐酸纳美芬二水合物的制备方法 Preparation of nalmefene hydrochloride dihydrate |
| 12/17/2014 | CN101801977B 吗啡生物碱和托烷生物碱的n-脱甲基化的方法 Morphine alkaloids tropane alkaloids and n- demethylation method |
| 12/11/2014 | US20140364612 Industrial process for the preparation of buprenorphine and its intermediates |
| 12/11/2014 | US20140364448 Quarternized buprenorphine analogs |
| 12/10/2014 | CN102307876B 吗啡-6-葡萄糖苷酸或其一种衍生物的合成 Morphine-6-glucoside, or a derivative of the acid synthesis |
| 12/10/2014 | CN101896464B 青藤碱衍生物和它们的合成方法 Sinomenine derivatives and their synthesis |
| 12/04/2014 | US20140357656 Bivalent Ligands for the Treatment of Neurological Disorders |
| 12/02/2014 | US8901175 Use of opioids or opioid mimetics for the treatment of resistant cancer patients |
| 12/02/2014 | US8901148 Large substituent, non-phenolic opioids and methods of use thereof |
| 11/18/2014 | US8889635 Dendrimer conjugates |
| 10/30/2014 | US20140323416 5-methyldihydromorphone compounds for treatment of pain |
| 10/28/2014 | US8871779 Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds |
| 10/14/2014 | US8859777 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators |
| 10/09/2014 | US20140303371 Process for the Synthesis of Substituted Morphinans |
| 10/09/2014 | US20140303200 Polymorphic Forms of Naltrexone |
| 10/08/2014 | EP2786997A1 Peripheral opioid receptor antagonists and uses thereof |
| 10/07/2014 | US8853402 Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation |
| 10/07/2014 | US8853401 Processes for the preparation of morphinane and morphinone compounds |
| 10/07/2014 | US8853232 Peripheral opioid receptor antagonists and uses thereof |
| 10/02/2014 | US20140296525 Process for recovery of nalmefene hydrochloride |
| 09/30/2014 | US8846923 Preparation of 14-hydroxycodeinone sulfate |
| 09/25/2014 | WO2014152657A1 6-acetylmorphine analogs, and methods for their synthesis and use |
| 09/23/2014 | US8841452 Process for recovery of nalmefene hydrochloride |
| 09/23/2014 | CA2602968C Crystals of morphinan derivative and process for producing the same |
| 09/18/2014 | WO2014140899A2 Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
| 09/18/2014 | WO2014140784A2 Buprenorphine analogs |
| 09/18/2014 | US20140275545 8-carboxamido-2,6-methano-3-benzazocines |
| 09/18/2014 | US20140275146 Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
| 09/18/2014 | US20140275117 Buprenorphine analogs |
| 09/11/2014 | US20140255308 6-AMIDO DERIVATIVES OF 4, 5-a EPOXYMORPHINANS FOR THE TREATMENT OF PAIN |
| 09/03/2014 | EP2771002A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
| 09/02/2014 | US8822687 8a,14-dihydroxy-7,8-dihydrocodeinone |
| 09/02/2014 | US8822490 Peripheral opioid receptor antagonists and uses thereof |
| 08/26/2014 | US8816084 Crystals of morphinan derivative, manufacturing method thereof, and pharmaceutical composition using the same |
| 08/26/2014 | US8816083 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
| 08/21/2014 | US20140235860 Method of preparing buprenorphine |
| 08/13/2014 | EP2763996A2 Process for preparing buprenorphine |
| 08/13/2014 | CN102325778B 盐酸纳美芬二水合物 Nalmefene hydrochloride dihydrate |
| 08/05/2014 | US8796301 Therapeutic or prophylactic agent for dyskinesia |
| 07/24/2014 | US20140206871 Low abuk oxycodone, its salts and methods of making same |
| 07/23/2014 | CN102558188B 一种溴甲纳曲酮的制备方法 A methyl naltrexone preparation bromine |
| 07/17/2014 | US20140200235 Oligomer-opioid agonist conjugates |
| 07/17/2014 | US20140199394 Controlled release hydrocodone |
| 07/16/2014 | EP2753622A1 Production of alkaloids without the isolation of intermediates |
| 07/15/2014 | US8778958 Synthesis of metabolically stable agents for alcohol and drug abuse |
| 07/10/2014 | US20140194457 Carboxamide bioisosteres of opiates |
| 07/09/2014 | CN103917543A 在不分离中间体的情况下制备生物碱 Alkaloids prepared without isolation of the intermediate of |
| 07/08/2014 | US8772308 Non-peptidyl, potent, and selective mu opioid receptor antagonists |
| 07/03/2014 | WO2014102591A1 PROCESS FOR PREPARING 7β-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7β-SUBSTITUTED 6α,14α-ETHANOMORPHINANS |
| 07/02/2014 | CN102300848B 使用超酸制备氢可酮的方法 Use super acid preparation method hydrocodone |
| 06/25/2014 | CN102036993B 纳美芬二酯前药 Nalmefene two ester prodrugs |
| 06/19/2014 | US20140171643 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates |
| 06/17/2014 | US8754217 Nalmefene hydrochloride dihydrate |
| 06/12/2014 | WO2014087226A1 Buprenorphine analogs as opiod receptor modulators |
| 06/12/2014 | US20140163058 Buprenorphine analogs |
| 06/10/2014 | US8748611 Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds |
| 06/05/2014 | US20140155608 Method for the manufacturing of naltrexone |
| 06/03/2014 | CA2426942C 8-carboxamido-2,6-methano-3-benzazocines |