| Patents for C07D 489 - Heterocyclic compounds containing 4ah-8, 9 c- iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: (2,334) |
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| 06/07/2012 | US20120142720 Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof |
| 06/07/2012 | US20120142719 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
| 06/07/2012 | US20120142718 N-17-Alkylated Prodrugs of Opioids |
| 05/31/2012 | US20120136019 (s)-n-methylnaltrexone |
| 05/31/2012 | US20120135978 6,7-unsaturated-7-carbamoyl substituted morphinan derivative |
| 05/24/2012 | US20120129879 Compounds and Compositions for Use in Phototherapy and in Treatment of Ocular Neovascular Disease and Cancers |
| 05/23/2012 | EP2453895A1 (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| 05/22/2012 | US8183376 Stereoselective reduction of a morphinone |
| 05/18/2012 | WO2012063933A1 Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same |
| 05/18/2012 | CA2814195A1 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same |
| 05/17/2012 | US20120123123 Preparation of nalmefene hydrochloride from naltrexone |
| 05/16/2012 | CN102459276A 从纳曲酮制备盐酸纳美芬 Naltrexone hydrochloride was prepared from nalmefene |
| 05/16/2012 | CN102459275A Processes for preparation of morphinane and morphinone compounds |
| 05/16/2012 | CN102459274A 6-酮基去甲吗啡喃通过催化氢转移的还原胺化 6- keto norepinephrine morphinans by catalytic hydrogen transfer reductive amination |
| 05/10/2012 | WO2012059103A1 Method for the manufacturing of naltrexone |
| 05/10/2012 | WO2012058714A1 Papaver bracteatum with modified alkaloid content |
| 05/10/2012 | US20120116086 Sinomenine Derivatives and Processes for their Synthesis |
| 05/10/2012 | US20120116085 Method for the manufacturing of naltrexone |
| 05/10/2012 | US20120114599 Opioid and opioid-like compounds and uses thereof |
| 05/10/2012 | CA2815093A1 Method for the manufacturing of naltrexone |
| 05/09/2012 | EP2450360A2 (S)-N-Methylnaltrexone |
| 05/09/2012 | EP2450359A2 (R)-N-Methylnaltrexone |
| 05/08/2012 | US8173666 Oligomer-opioid agonist conjugates |
| 05/01/2012 | US8168790 Process for the preparation of 6-beta hydroxy morphinan compounds |
| 04/26/2012 | WO2012054566A2 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| 04/26/2012 | CA2814795A1 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| 04/18/2012 | EP2441766A1 Nalmefene hydrochloride dihydrate |
| 04/18/2012 | EP2440562A1 Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
| 04/18/2012 | EP2440561A2 Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
| 04/17/2012 | US8158793 Demethylation of 14-hydroxy substituted alkaloid derivatives |
| 04/12/2012 | US20120088745 Chemically modified small molecules |
| 04/11/2012 | CN101848713B 含有特定的有机酸的口服制剂以及口服制剂的溶出性和化学稳定性的改善方法 Method for improving dissolution property and chemical stability of an organic acid containing a specific oral formulations, and oral preparations |
| 04/05/2012 | WO2011137331A3 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators |
| 04/04/2012 | EP2435439A1 Preparation of nalmefene hydrochloride from naltrexone |
| 04/03/2012 | US8148528 Processes and compounds for the preparation of normorphinans |
| 03/29/2012 | WO2012038813A1 Buprenorphine analogs |
| 03/29/2012 | CA2810356A1 Buprenorphine analogs |
| 03/28/2012 | CN102391271A Improved method for making analgesics |
| 03/28/2012 | CN101812065B Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone |
| 03/27/2012 | US8142811 Controlled release hydrocodone formulations |
| 03/22/2012 | US20120070495 Oral formulations and lipophilic salts of methylnaltrexone |
| 03/21/2012 | CN102382118A Preparation method of 7alpha-acetyl-6,14-ethyl bridge tetrahydrothebaine |
| 03/13/2012 | US8134002 Process for preparing oxymorphone |
| 03/08/2012 | US20120059167 Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds |
| 03/08/2012 | US20120059066 Pharmaceutical salts |
| 03/07/2012 | EP2426132A1 Process for preparing 14-hydroxycodeinone from thebaine |
| 02/29/2012 | EP2421868A1 Processes for the preparation of morphinane and morphinone compounds |
| 02/29/2012 | CN101778632B Remedy or preventive for integration dysfunction syndrome |
| 02/23/2012 | US20120046466 Preparation of opiate analgesics by reductive alkylation |
| 02/23/2012 | US20120046465 Processes for the Preparation of Morphinane and Morphinone Compounds |
| 02/23/2012 | US20120046272 Novel Therapeutic Compounds |
| 02/22/2012 | EP2420503A1 Process for the synthesis of 14-oxygenated morphinan-6-ones |
| 02/22/2012 | EP2300479B1 Nalmefene hydrochloride dihydrate |
| 02/21/2012 | US8119803 Preparation of opiate analgesics by reductive alkylation |
| 02/15/2012 | EP2417139A1 Preparation of saturated ketone morphinan compounds by catalytic isomerization |
| 02/15/2012 | CN102351869A Preparation method of high-purity methylnaltrexone bromide |
| 02/15/2012 | CN102351868A Extraction method of morphine from opium |
| 02/14/2012 | CA2549730C Chemically modified small molecules |
| 02/09/2012 | WO2012018872A1 N-demethylation of 6-keto morphinans |
| 02/09/2012 | WO2012018871A1 Tandem process for preparing n-alkyl morphinans |
| 02/09/2012 | US20120035367 Tandem Process for Preparing N-Alkyl Morphinans |
| 02/09/2012 | US20120035366 N-Demethylation of 6-Keto Morphinans |
| 02/09/2012 | CA2806620A1 Tandem process for preparing n-alkyl morphinans |
| 02/09/2012 | CA2806596A1 N-demethylation of 6-keto morphinans |
| 02/08/2012 | EP2413937A1 Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof |
| 02/08/2012 | EP1989208B1 New morphine compounds for pharmaceutical compositions |
| 02/02/2012 | WO2012013671A1 Processes for the production of 14 - oxygenated morphinan - 6 - ones |
| 02/02/2012 | US20120029008 Crystalline and amorphous forms of nalbuphine hydrochloride |
| 02/01/2012 | EP2121698B1 Process for reducing impurities in oxycodone base |
| 02/01/2012 | CN102336760A Method for preparing bromized morphinan quaternary ammonium salt |
| 01/31/2012 | US8106065 Antitussive agent |
| 01/26/2012 | WO2012010106A1 Preparation method for morphinan bromide quaternary ammonium salt |
| 01/26/2012 | US20120022259 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates |
| 01/26/2012 | US20120022093 Crystalline forms of oxymorphone hydrochloride |
| 01/24/2012 | US8101757 Processes for the preparation of normorphinan salts |
| 01/24/2012 | US8101756 Process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives |
| 01/19/2012 | WO2012008984A1 (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| 01/19/2012 | CA2768199A1 (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| 01/18/2012 | CN102325778A Nalmefene hydrochloride dihydrate |
| 01/18/2012 | CN102325777A (+)-morphinananium n-oxides and processes for their production |
| 01/18/2012 | CN102325776A (+)-morphinanium quaternary salts and processes for their production |
| 01/18/2012 | CN102325775A (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| 01/12/2012 | US20120010412 Process for the Synthesis of Substituted Morphinans |
| 01/12/2012 | US20120010231 Dihydroetorphines and Their Preparation |
| 01/11/2012 | CN101570539B Morphinone quaternary ammonium salt derivatives and preparation method thereof |
| 01/10/2012 | CA2504262C Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| 01/05/2012 | WO2012003468A1 Process for the synthesis and purification of oxycodone |
| 01/05/2012 | CA2804101A1 Process for the synthesis and purification of oxycodone |
| 01/04/2012 | EP2402346A1 Processes for reducing contaminating Michael acceptor levels in oxycodone and other compositions |
| 01/04/2012 | CN102307877A Dihydroetorphines and their preparation |
| 01/04/2012 | CN102307876A Synthesis of morphine-6-glucuronide or one of the derivatives thereof |
| 01/04/2012 | CN102307874A Peripheral opioid receptor antagonists and uses thereof |
| 12/29/2011 | US20110318345 Nasal delivery |
| 12/28/2011 | EP2398808A1 Process for the reductive alkylation of normorphinans |
| 12/28/2011 | EP2398807A1 (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| 12/28/2011 | EP2398806A1 (+)-morphinanium n-oxides and processes for their production |
| 12/28/2011 | EP2398805A1 (+)-morphinanium quaternary salts and processes for their production |
| 12/28/2011 | CN102300848A 使用超酸制备氢可酮的方法 Use super acid preparation method hydrocodone |
| 12/27/2011 | US8084460 6,7-unsaturated-7-carbamoyl substituted morphinan derivative |
| 12/22/2011 | US20110313163 Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids |