| Patents for C07D 489 - Heterocyclic compounds containing 4ah-8, 9 c- iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: (2,334) |
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| 09/11/2013 | EP2635586A1 Method for the manufacturing of naltrexone |
| 09/11/2013 | EP2635107A1 Papaver bracteatum with modified alkaloid content |
| 09/11/2013 | CN103298819A Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same |
| 09/10/2013 | US8530495 Nalmefene hydrochloride dihydrate |
| 09/10/2013 | US8530494 Buprenophine analogs |
| 09/05/2013 | US20130231485 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same |
| 09/03/2013 | US8524904 Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates |
| 08/28/2013 | EP2630150A2 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| 08/27/2013 | US8519133 Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer |
| 08/21/2013 | CN103261203A 6-amido derivatives of 4,5a-poxymorphinans for treatment of pain |
| 08/21/2013 | CN103257189A (s)-n-methylnaltrexone, process for its synthesis and its pharmaceutical use |
| 08/20/2013 | CA2579378C Treatment of diseases using nalmefene and its analogs |
| 08/15/2013 | WO2013119886A1 One pot process for producing 6-hydroxyl nal-opiate |
| 08/15/2013 | US20130210854 Compositions Comprising Enzyme-Cleavable Prodrugs of Active Agents and Inhibitors Thereof |
| 08/13/2013 | CA2393141C Novel methods for the treatment and prevention of ileus |
| 08/08/2013 | WO2013113120A1 Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans |
| 08/08/2013 | WO2013093931A3 Novel prodrugs of phenolic drugs |
| 08/08/2013 | US20130205452 Papaver somniferum with high concentration of codeine |
| 08/08/2013 | US20130203999 One Pot Process for Producing 6-Hydroxyl Nal-Opiate |
| 08/08/2013 | US20130203797 Therapeutic or prophylactic agent for biliary diseases |
| 08/07/2013 | EP2621496A1 Crystalline naloxol-peg conjugate |
| 08/07/2013 | CN103237804A Method for the manufacturing of naltrexone |
| 07/31/2013 | EP2619212A1 Buprenorphine analogs |
| 07/23/2013 | US8492547 Method for the enrichment of buprenorphine using chromatographic techniques |
| 07/18/2013 | WO2013106528A1 Bivalent ligands for the treatment of neurological disorders |
| 07/17/2013 | CN103204859A Nalmefene hydrochloride compound and preparation method thereof |
| 07/09/2013 | US8481501 Synthesis of metabolically stable analgesics, pain medications and other agents |
| 06/27/2013 | WO2013095321A1 Heroin haptens, immunoconjugates and related uses |
| 06/26/2013 | CN103172640A Preparation method of (R)-N-bromine-methyl naltrexone and naltrexone derivatives |
| 06/25/2013 | US8471022 Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone |
| 06/20/2013 | US20130158061 Controlled release hydrocodone |
| 06/13/2013 | WO2013084060A1 Quaternized buprenorphine analogs |
| 06/13/2013 | WO2013083685A1 Process for recovery of nalmefene hydrochloride |
| 06/13/2013 | US20130150395 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
| 06/13/2013 | CA2857096A1 Process for recovery of nalmefene hydrochloride |
| 06/12/2013 | EP2601196A1 N-demethylation of 6-keto morphinans |
| 06/12/2013 | EP2601195A1 Tandem process for preparing n-alkyl morphinans |
| 06/12/2013 | CN103154000A Buprenorphine analogs |
| 06/12/2013 | CN101827819B Quaternary opioid carboxamides |
| 06/11/2013 | US8461122 Derivatives of morphine-6-glucuronide, preparation method thereof and use of same in therapeutics |
| 06/04/2013 | US8455644 Peripheral opioid receptor antagonists and uses thereof |
| 06/04/2013 | US8455509 Method for the preparation of morphine compounds |
| 05/22/2013 | EP2593095A1 (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| 05/22/2013 | CN103113378A Synthesis method of oxymorphone hydrochloride |
| 05/21/2013 | CA2555215C Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates |
| 05/15/2013 | EP2590649A1 Process for the synthesis of substituted morphinans |
| 05/14/2013 | US8440687 Oligomer-opioid agonist conjugates |
| 05/14/2013 | US8440686 Nalmefene prodrugs |
| 05/14/2013 | US8440634 Bicyclic derivatives of morphine-6-glucuronide, preparation method thereof and use of same in therapeutics |
| 05/08/2013 | EP2588481A1 Process for the synthesis and purification of oxycodone |
| 05/07/2013 | US8436175 Carboxamide bioisosteres of opiates |
| 05/07/2013 | CA2744932C Nalmefene hydrochloride dihydrate |
| 05/02/2013 | WO2013063204A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
| 05/02/2013 | CA2856608A1 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
| 04/30/2013 | US8431701 Process for the reductive alkylation of normorphinans |
| 04/25/2013 | US20130102784 Process for n-dealkylation of tertiary amines |
| 04/25/2013 | US20130102780 Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| 04/24/2013 | CN1653050B Opioid and opioid-like compounds and uses thereof |
| 04/17/2013 | EP2580218A1 Process for n-dealkylation of tertiary amines |
| 04/17/2013 | CN102166432B Method for extracting morphine from opium |
| 04/16/2013 | CA2486157C Opioid and opioid-like compounds and uses thereof |
| 04/11/2013 | WO2013050748A2 An improved method of preparing buprenorphine |
| 04/11/2013 | US20130089504 Compositions Comprising Enzyme-Cleavable Hydromorphone Prodrug |
| 04/11/2013 | CA2849988A1 Process for preparing buprenorphine |
| 04/03/2013 | CN103012416A Method for preparing high-purity nalmefene hydrochloride |
| 04/03/2013 | CN101607963B Morphinan derivatives and preparation method thereof |
| 04/03/2013 | CN101228172B 6,7-unsaturated-7-carbamoyl substituted morphinan derivative |
| 04/02/2013 | CA2702032C Skin property-improving therapeutic agent comprising a morphinan derivative or any of its pharmacologically permissible acid addition salts as an active ingredient |
| 03/28/2013 | US20130079364 Peripheral Opioid Agonists and Peripheral Opioid Antagonists |
| 03/26/2013 | US8404706 Opioid and opioid-like compounds and uses thereof |
| 03/26/2013 | CA2539659C Process for the synthesis of morphinane compounds and intermediates thereof |
| 03/19/2013 | US8399671 Methods for producing hydrocodone, hydromorphone or a derivative thereof |
| 03/19/2013 | US8399475 Crystalline and amorphous forms of naltrexone hydrochloride |
| 03/14/2013 | WO2013036729A1 Production of alkaloids without the isolation of intermediates |
| 03/14/2013 | US20130066080 Production of Alkaloids without the Isolation of Intermediates |
| 03/14/2013 | CA2845187A1 Production of alkaloids without the isolation of intermediates |
| 03/12/2013 | US8394813 Active agent delivery systems and methods for protecting and administering active agents |
| 03/06/2013 | EP2563793A1 Preparation of saturated ketone morphinan compounds having low metal content |
| 03/05/2013 | US8389540 Polymorphic solvates of naltrexone with ethanol, benzyl alcohol, dimethylformamide, methanol, dichloromethane, acetone and hexane; sustained release formulations |
| 02/27/2013 | EP2562177A2 Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof |
| 02/27/2013 | CN102942572A Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof |
| 02/26/2013 | US8383815 Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof |
| 02/26/2013 | CA2638195C Process for the preparation of quaternary n-alkyl morphin or morphinan alkaloid derivatives |
| 02/21/2013 | US20130045960 Abuse-Deterrent Pharmaceutical Compositions of Opiods and Other Drugs |
| 02/21/2013 | US20130045165 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators |
| 02/19/2013 | US8377851 Method of altering the alkaloid composition in poppy plants |
| 02/19/2013 | CA2644881C Demethylation of 14-hydroxy substituted alkaloid derivatives |
| 02/07/2013 | WO2013019825A1 Stepwise process for the production of alkaloid salts |
| 02/07/2013 | US20130035489 Preparation of low impurity opiates in a continuous flow reactor |
| 02/07/2013 | US20130035488 Stepwise Process for the Production of Alkaloid Salts |
| 02/07/2013 | CA2842370A1 Stepwise process for the production of alkaloid salts |
| 02/06/2013 | EP2552924A1 Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs |
| 02/05/2013 | US8367827 Process for preparing hydrocodone using a super acid |
| 02/05/2013 | US8367693 Opioid salts and formulations exhibiting anti-abuse anti-dose dumping properties |
| 01/29/2013 | US8361499 Controlled release hydrocodone formulations |
| 01/29/2013 | CA2448665C Sustained-release analgesic compounds |
| 01/24/2013 | US20130023553 Pegylated opioids with low potential for abuse and side effects |
| 01/23/2013 | CN102887903A Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone |
| 01/22/2013 | US8357802 Process for preparing oxymorphone |
| 01/17/2013 | WO2013007986A1 Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse |