| Patents for C07D 451 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof (5,273) |
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| 06/02/2010 | EP1831211B1 Indazole-carboxamide compounds |
| 06/02/2010 | CN101230063B Method for preparing tiotropium bromide |
| 06/01/2010 | US7728010 Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
| 06/01/2010 | US7728006 Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| 06/01/2010 | US7728004 crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or solvate thereof; treating disease associated with 5-HT4 receptor activity; gastrointestinal tract disorder |
| 06/01/2010 | CA2440699C Compounds for treating inflammatory diseases |
| 05/27/2010 | WO2009153178A3 Aryl ketone as mri |
| 05/26/2010 | EP1315709B1 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same |
| 05/26/2010 | CN101712679A Acylamide class compound, medicine composition, preparation method and application thereof |
| 05/20/2010 | WO2010056855A1 Preparation of retapamulin via its pleuromutilin-thiol precursor |
| 05/19/2010 | EP2185553A1 Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| 05/12/2010 | EP2183249A1 8-azabicycloý3.2.1¨octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists |
| 05/12/2010 | EP1644397B1 Specific glucocorticosteroid compound having anti- inflammatory activity |
| 05/12/2010 | CN1910180B Process for the preparation of 2-(ethoxymethyl)-tropane derivatives |
| 05/11/2010 | US7714170 Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs; Alzheimer's disease; diabetes; A beta amyloidosis |
| 05/06/2010 | WO2010049635A1 Tropane urea derivatives, preparation thereof and therapeutic application thereof as modulators of the activity of 11betahsd1 |
| 05/06/2010 | WO2007012626A3 Novel method for producing tiotropium salts |
| 05/05/2010 | EP2181995A2 Salts and crystalline form of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-sufanyl)-acetate |
| 05/05/2010 | EP0888345B1 Sigma-2 receptors as biomarkers of tumor cell proliferation |
| 05/05/2010 | CN1764661B Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain. |
| 05/04/2010 | US7709642 Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
| 05/04/2010 | US7709480 2-(3,4-dichlorophenylamino)-4-thiocyanato-5-nitro-pyrimidine; 2-chloro-4-(2-acetylamino-ethylamino)-5-trifluoromethyl-pyrimidine; lung cancer |
| 05/04/2010 | CA2453609C Bridged piperidine derivatives as melanocortin receptor agonists |
| 04/29/2010 | WO2010048131A1 C-met protein kinase inhibitors |
| 04/29/2010 | WO2010046445A2 Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| 04/29/2010 | US20100105915 Chemokine receptor binding heterocyclic compounds |
| 04/29/2010 | US20100105693 Modulators of Muscarinic Receptors |
| 04/29/2010 | US20100105675 11 beta-hsd1 modulators |
| 04/29/2010 | CA2741718A1 Modulators of cystic fibrosis transmembrane conductance regulator |
| 04/29/2010 | CA2740583A1 C-met protein kinase inhibitors |
| 04/29/2010 | CA2738453A1 Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| 04/28/2010 | CN1875020B Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same |
| 04/21/2010 | CN101696207A Tropine purification method and atropine production process |
| 04/20/2010 | US7700619 Monohydrates; monoamine neurotransmitter re-uptake inhibitors; central nervous system; nervous system disorders; stability; hydrophobic;bioavailability; handling; melting points; reproduction; crystal structure |
| 04/15/2010 | WO2010040272A1 Amide compounds, their pharmaceutical compositions, their preparation and their use |
| 04/14/2010 | EP2173746A2 Process for preparing an intermediate to mu opioid receptor antagonists |
| 04/14/2010 | EP1704146B1 Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| 04/13/2010 | US7696222 Indole derivatives as CRTH2 receptor antagonists |
| 04/13/2010 | US7695917 Rescue of gonadotropin releasing hormone receptor mutants |
| 04/08/2010 | US20100087364 Tropine modulators of 5-ht3 receptor |
| 04/07/2010 | EP2170897A1 Methods for one-pot n-demethylation/n-acylation of morphine and tropane alkaloids |
| 04/07/2010 | EP1551829B1 Novel compounds with antibacterial activity |
| 04/06/2010 | CA2453383C Piperidine derivatives as nmda receptor antagonists |
| 03/31/2010 | EP2167503A1 Tropane derivatives useful as pesticides |
| 03/31/2010 | CN101687801A Ethers of naphtalene carboxylic acid amides as cancer cure |
| 03/31/2010 | CN101684117A Novel method for preparing nor-tropine |
| 03/30/2010 | CA2450961C Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| 03/25/2010 | WO2010031517A1 Radioactively marked cyclopropane derivatives of dat affine tropanes |
| 03/24/2010 | EP2164848A1 Polymorphic form of granisetron base, methods for obtaining it and formulation containing it |
| 03/24/2010 | EP2164843A1 Pyridazinone derivates |
| 03/24/2010 | EP1789404B1 Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors |
| 03/24/2010 | CN101679407A Novel chromen-2-one derivatives |
| 03/23/2010 | US7683070 insecticides for soil-borne insects, such as termites and white grubs; less costly and safer to use on crops; N-{4-[(4-{bis[4-(trifluoromethyl)phenyl]methylene}piperidyl)methyl]phenyl}ethoxycarboxamide, N-oxide |
| 03/17/2010 | CN101675047A hydrochloride salt of an azabicyclo[3.2.1]octane derivative |
| 03/11/2010 | WO2010028213A2 N-sulfonamido polycyclic pyrazolyl compounds |
| 03/11/2010 | US20100063289 Method for producing ammonium hexafluorophosphates |
| 03/11/2010 | CA2736767A1 N-sulfonamido polycyclic pyrazolyl compounds |
| 03/10/2010 | EP1682541B1 Method for producing tiotropium salts |
| 03/09/2010 | US7674908 1-isopropyl-1H-indazole-3-carboxylic acid {(1S,3R,5R)-8-[2-(4-acetylpiperazin-1-yl)-ethyl]8-azabicyclo[3.2.1]oct-3-yl}amide; improved pharmacokinetic, bioavailability; gastrointestinal disorders: irritable bowel syndrome (IBS), chronic constipation, dyspepsia; CNS behavioral, mood disorder |
| 03/09/2010 | CA2493313C Novel benzodioxoles |
| 03/09/2010 | CA2431952C Muscarinic antagonists |
| 03/04/2010 | WO2010023161A1 Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| 03/04/2010 | US20100056561 Hydrochloride salt of an azabicyclo[3.2.1]octane derivative |
| 03/04/2010 | CA2735204A1 Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| 03/03/2010 | EP2158200A1 Novel chromen-2-one derivatives |
| 03/03/2010 | EP1937261B1 Novel azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 03/03/2010 | EP1773796B1 Oxopiperidine derivatives, preparation and therapeutic use thereof |
| 02/25/2010 | US20100048903 Method For Producing Azoniaspironortropine Esters And Nortropan-3-One Compounds |
| 02/23/2010 | US7667040 Azacyclic ethynyl derivatives |
| 02/17/2010 | EP2152703A2 Method for producing scopine esters |
| 02/17/2010 | CN101648950A Tiotropium salts, pharmaceutical composition and uses thereof |
| 02/16/2010 | US7662963 Process for the preparation of tiotropium bromide |
| 02/10/2010 | CN101643473A Synthesis method of homatropine hydrobromide |
| 02/10/2010 | CN101643472A Method for preparing 2-hydroxyl-2,2-diphenyl acetic acid-3alpha-(8-azabicyclo[3,2,1]-3-octyl ester |
| 02/09/2010 | US7659400 Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging |
| 02/04/2010 | US20100029711 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 02/03/2010 | EP2149571A1 Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position |
| 02/03/2010 | CN100586948C Crystalline anticholinergic, method for its preparation, and use thereof in medicament preparation |
| 02/02/2010 | US7655663 (2S)-4,4-difluoro-1-(2-{[1-(2-pyrazinyl)piperidin-4-yl]amino}acetyl)-2-pyrrolidine carbonitrile; enzyme inhibitors; diabetes |
| 02/02/2010 | CA2407520C Sigma-2 receptors as biomarkers of tumor cell proliferation |
| 02/02/2010 | CA2345838C Method for the synthesis of radiolabeled compounds |
| 01/26/2010 | US7652138 Anticholinergics, processes for preparing them and pharmaceutical composition containing them |
| 01/26/2010 | US7652021 (2S)-4,4-difluoro-1-{N-[3-(pyrimidin-2-ylamino)-1-adamantyl]glycyl}pyrrolidine-2-carbonitrile; dipeptidyl peptidase IV enzyme inhibitors; non-insulin dependent diabetes mellitus |
| 01/21/2010 | WO2010009195A1 Bicyclic heterocycle derivatives and use thereof as gpr119 modulators |
| 01/21/2010 | WO2009007115A8 Tropane derivatives useful as pesticides |
| 01/21/2010 | CA2768183A1 Targeted nitroxide agents |
| 01/21/2010 | CA2730593A1 Bicyclic heterocycle derivatives and use thereof as gpr119 modulators |
| 01/13/2010 | EP2141990A1 11beta-hsd1 active compounds |
| 01/12/2010 | US7645771 HIV, acquired immune deficiency syndrome (AIDS); 1-(8-{2-[1-(2,2-Dimethylpropanoyl)-4-phenylpiperidin-4-yl]ethyl}-8-azabicyclo[3.2.1]oct-3-yl)-2-methyl-1H-benzimidazole |
| 01/06/2010 | EP2141163A1 Substituted thiazolidinones, their production and utilisation as medicine |
| 01/06/2010 | CN100577662C Setron-like compounds, preparation method and medicament use thereof |
| 01/06/2010 | CN100577661C Process for preparing substituted 8-azabicyclo[3.2.1] octan-3-ols |
| 12/30/2009 | EP1682542B1 Novel crystalline anhydride with anticholinergic effect |
| 12/30/2009 | CN101616916A Crystalline forms of an 8-azabicyclo[3.2.1]octane compound |
| 12/29/2009 | US7638629 4-Isopropylphenyl)-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetic acid; modulators of gamma secretase isoforms, 1-42; antifibrillatory agents; neurodegenerative diseases; modulating activity of gamma -secretase as opposed to suppressing it to reduced risk of side effects; beta secretase inhibitors |
| 12/29/2009 | US7638532 exo-3-(3 ,4-Dichloro-phcnoxy)-8-aza-bicyclo[3.2.1]oct-6-ene; antidepressants, psychological disorders |
| 12/29/2009 | US7638508 Glucocorticosteroid compound having anti-inflammatory activity |
| 12/29/2009 | CA2524043C 1-(2h-pyrazol-3-yl)-3-{4-'1-(benzoyl)-piperidin-4-ylmethyl!-phenyl}-urea derivatives and related compounds as inhibitors of p38 kinase and/or tnf inhibitors for the treatment of inflammations |
| 12/24/2009 | US20090318493 Aryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof |
| 12/24/2009 | US20090318373 Receptor-type kinase modulators and methods of use |