| Patents for C07D 451 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof (5,273) |
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| 01/25/2011 | US7875630 reacting exo-8-methyl-8-azabicyclo[3.2.1]octan-3-thiol with mutilin 14-methanesulfonyloxyacetate in the presence of a tetra-n-butylammonium hydrogensulfate phase transfer catalyst, 4-methyl-2-pentanone, and aqueous NaOH to form mutilin 14-(exo-8-methyl-8-azabicyclo[3.2. 1]oct-3-ylsulfanyl)-acetate |
| 01/20/2011 | US20110015180 Chemokine receptor antagonists |
| 01/20/2011 | CA2767470A1 Non-polar and polar leaving groups |
| 01/19/2011 | EP1957493B1 8-azabicyclo[3.2.1]octane derivatives useful as monoamine reuptake inhibitors |
| 01/19/2011 | CN101395154B 8-azabicyclo[3.2.1]octane compounds as [mu] opioid receptor antagonists |
| 01/18/2011 | US7872017 such as 5-{5-[(endo)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy]-pyridin-2-yl}-1H-indole, having nicotinic receptors modualtory activity, used for the treatment of attention deficit disorder, senile dementia, Down's syndrome, amyotrophic lateral sclerosis, Huntington's, Pick's and Alzheimer's disease |
| 01/18/2011 | CA2481876C Inhalation kit comprising inhalable powder of tiotropium |
| 01/12/2011 | EP2272847A1 Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors |
| 01/12/2011 | EP1987006B1 Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| 01/12/2011 | EP1902053B1 Benzoimidazolone-carboxamide compounds as 5-ht4 receptor agonists |
| 01/12/2011 | EP1517907B1 Azabicyclo-octane and nonane derivatives with ddp-iv inhibiting activity |
| 01/11/2011 | US7868178 4-Phenoxy-, 4-phenylthio-, 4-phenylsulfonyl- or 5-phenylsulfinyl-1-(2-pyridinyl)pyrrolidene derivatives; e.g. 3-[4-(trifluoromethyl)phenoxy]-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidine insecticides, miticides and nematocides |
| 01/11/2011 | CA2472149C New fluorenecarboxylic acid esters, process for the manufacture thereof and use thereof as medicaments |
| 01/06/2011 | US20110003849 Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment |
| 01/05/2011 | EP2268631A1 Aminopiperidinyl derivatives and uses thereof |
| 01/05/2011 | EP1797088B1 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 01/05/2011 | EP1677795B1 Muscarinic acetycholine receptor antagonists |
| 01/05/2011 | EP1118674B1 Process for producing optically active tropinone monocarboxylic acid derivative |
| 01/04/2011 | US7863293 Aminoalkylpyridines; treating HIV infections; antiinflammatory agents; rheumatic diseases; elevating progesator and stem cell count |
| 01/04/2011 | US7863281 4-[(3-chloro-4-fluoro-phenyl)amino]-6-{[4-((1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-1-oxo-2-buten-1-yl]amino}-7-cyclopropylmethoxy-quinazoline; inhibitor of signal transduction mediated by tyrosine kinases; antitumor agent; benign prostatic hyperplasia, lungs and respiratory tract disease; bile duct |
| 12/30/2010 | US20100331544 Method for producing (1r,5s) anhydroecgonine ester salts |
| 12/30/2010 | US20100331360 3-substituted sulfonyl piperidine derivative |
| 12/30/2010 | US20100331348 Tropane derivatives useful as pesticides |
| 12/30/2010 | US20100331310 Bicycloamine derivatives |
| 12/29/2010 | EP2265607A1 Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases |
| 12/29/2010 | CN101928284A Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
| 12/28/2010 | US7858781 inflammatory conditions, allergies, autoimmune diseases, chronic pain, graft rejection, cancers which involve leukocyte filtration, stenosis or restenosis, atherosclerosis, rheumatoid arthritis, osteoarthritis; e.g. 4-Isobutoxy-1H-indole-2-carboxylic acid [4-(2-azepan-1-yl-ethyl)-phenyl]-amide |
| 12/23/2010 | WO2010146597A1 2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors |
| 12/22/2010 | EP2264026A1 Alkylaminopyridine derivative |
| 12/22/2010 | EP2262789A1 2-aminoquinolines |
| 12/22/2010 | CN101925599A Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators |
| 12/21/2010 | US7855296 Reacting an aqueous solution of 2-carbomethoxytropinone bitartrate, sodium amalgam and an acid that forms a highly soluble sodium salt; carbomethoxytropinone bitartrate converted to methylecgonine which is then converted into cocaine. cost efficiency; industrial scale; nasal sprays |
| 12/21/2010 | US7855294 (6R,8S)-6-(spiro[isobenzofuran-1-(3H), 4'-piperidin]-1'-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-ol), exhibiting an antagonism to binding of nociceptin to opioid receptor-like-1 receptors, useful as medicines for diseases associated with pain and appetite control or memory and learning |
| 12/21/2010 | CA2448425C Inhalation capsules |
| 12/21/2010 | CA2397981C Azacyclic compounds for use in the treatment of serotonin related diseases |
| 12/16/2010 | US20100317690 Treatment of protein folding disorders |
| 12/15/2010 | CN101918401A Novel process for the preparation of scopine esters |
| 12/09/2010 | US20100311979 Quinolinone-carboxamide compounds as 5-ht4 receptor agonists |
| 12/09/2010 | US20100311977 Method for producing 2-azaadamantane |
| 12/08/2010 | EP2258682A2 Amino-substituted tricyclic derivatives and methods of use |
| 12/08/2010 | EP1996584B1 Tropane prodrugs with central nervous system activity |
| 12/08/2010 | EP1781290B1 Anti-inflammatory agents |
| 12/08/2010 | CN101910169A Bicycloamine derivative |
| 12/08/2010 | CN101910168A Tropane compounds |
| 12/08/2010 | CN101910152A 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
| 12/08/2010 | CN101910151A Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 |
| 12/08/2010 | CN100999521B Crystal anti-choline medicine thiatropic bromoammonium |
| 12/07/2010 | US7847092 Reacting fluorine salt containing radioactive fluorine-18 with alkyl halide or alkyl sulfonate in presence of alcohol; decreased reaction time; high yield; reduces the formation of side products |
| 12/07/2010 | CA2285516C Dopamine transporter imaging agents |
| 12/02/2010 | WO2010138720A2 Compounds and methods for chelating metals in aqueous solutions |
| 12/02/2010 | WO2010138487A1 BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE |
| 12/02/2010 | US20100305146 Method for the Production of 1,3-Dioxolane-2-Ones and Carboxylic Acid Esters by Means of Transacylation in Basic Reaction Conditions |
| 12/02/2010 | CA2763008A1 Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
| 12/01/2010 | EP1951721B1 3 -monosubstituted tropane derivative as nociceptin receptor ligand |
| 12/01/2010 | EP1896467B1 Tricyclic opioid modulators |
| 11/30/2010 | US7842705 Curcumin analogs with anti-tumor and anti-angiogenic properties |
| 11/25/2010 | WO2010133457A1 Salts of tiotropium with 10-camphorsulfonic acid |
| 11/23/2010 | US7838518 1-(4-methoxynaphthalene-1-sulfonyl)-2,3-dihydro-1H-indole-3-carboxylic acid [2-(1-methyl-pyrrolidin-2-yl)-ethyl]amide; selective affinity for 5-HT6 receptor; psychosis, schizophrenia, depression, neurological disorders, cognitive enhancement, Parkinson's disease, ALS, Alzheimer's, Huntington's disease |
| 11/18/2010 | WO2010130620A1 Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 11/18/2010 | US20100292478 Process of preparing a radioactive compound containing a fluorine-18 isotope |
| 11/18/2010 | US20100292215 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
| 11/18/2010 | CA2760981A1 Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 11/17/2010 | CN101885721A Pyrrole derivatives serving as CCR5 antagonists, method for preparing same and application thereof |
| 11/16/2010 | US7834043 Prevent reproduct of aids virus |
| 11/11/2010 | US20100286193 Novel Azabicyclo[3.2.1]Oct-2-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors |
| 11/11/2010 | US20100286134 Novel phenoxazin-3-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 11/10/2010 | EP1742944B1 Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| 11/10/2010 | EP1590007B1 Improved radiometal complex compositions |
| 11/04/2010 | WO2010126163A1 Heteroarylthiomethyl pyridine derivative |
| 11/04/2010 | CA2759471A1 Heteroarylthiomethyl pyridine derivative |
| 11/03/2010 | EP2121678B1 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 11/03/2010 | EP2121677B1 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 11/03/2010 | CN101878208A Substituted-quinoxaline-type-piperidine compounds and the uses thereof |
| 11/03/2010 | CN101874899A Medicine for developing dopamine transporter and preparation method thereof |
| 10/28/2010 | WO2010122968A1 Diacylethylenediamine compound |
| 10/28/2010 | US20100273794 Benzimidazolone Compounds Having 5-HT4 Receptor Agonistic Activity |
| 10/28/2010 | CA2759264A1 Diacylethylenediamine compound |
| 10/27/2010 | EP2242754A1 Novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| 10/26/2010 | US7820838 Ecteinascidin 743; 5-(1,2-diaminoethyl-), 3,4-methylenedioxyphenol intermediate, of which the amine group cyclizes |
| 10/26/2010 | US7820817 substituted piperazine compounds that are useful modulators of muscarinic receptors; 1-(5-bicyclo[2.2.1]hept-2-enylmethyl)-4-(3-nitro-2-pyridyl)-piperazine; treatment of COPD, asthma, urinary incontinence, glaucoma, Alzheimer's (AchE inhibitors), and pain |
| 10/21/2010 | US20100267765 Pharmaceutical Compositions and Methods for CCR5 Antagonists |
| 10/21/2010 | US20100267764 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors |
| 10/21/2010 | US20100267739 Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| 10/20/2010 | EP2241567A1 Bicycloamine derivative |
| 10/20/2010 | EP2240477A1 Novel process for the preparation of scopine esters |
| 10/20/2010 | EP2240476A1 Novel phenylethynyl derivatives of 8-aza-bicyclo[3.2.1]octane and their use as monoamine neurotransmitter re-uptake inhibitors |
| 10/20/2010 | CN101863885A Method for preparing tiotropium bromide |
| 10/14/2010 | US20100261716 Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| 10/13/2010 | EP2239260A1 Novel compounds with antibacterial activity |
| 10/13/2010 | CN101861315A Method for producing 2-azaadamantane |
| 10/12/2010 | CA2470578C Tetrahydroquinoline analogues as muscarinic agonists |
| 10/07/2010 | WO2010114958A1 Bridged bicyclic heterocycle derivatives and methods of use thereof |
| 10/07/2010 | WO2010113834A1 Pyrimidine compound |
| 10/07/2010 | US20100256356 Heterobicyclic pyrazole compounds and methods of use |
| 10/07/2010 | US20100256114 Amido Compounds And Their Use As Pharmaceuticals |
| 10/07/2010 | CA2757188A1 Pyrimidine compound |
| 10/05/2010 | US7807833 Chemical intermediates for sulfiding under mild conditions forming ring compounds for use as marine alkaloids; connecting reaction of 4 components, transforming c22-tert-butyltriphenylsilyl to acety group, cyclization, hydroxy group to methanesulonyl group, reduction of amide, dehydration,Heck reaction |
| 09/30/2010 | US20100249181 HIV Protease Inhibiting Compounds |
| 09/29/2010 | EP2231657A1 Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators |
| 09/29/2010 | EP1534695B1 Tyrosine kinase inhibitors |