Patents
Patents for C07H 21 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids (89,892)
09/1999
09/01/1999CN1227227A Antisense nucleoside for inhibiting the growth of human malignant tumor
08/1999
08/31/1999US5945526 Energy transfer dyes with enhanced fluorescence
08/31/1999US5945525 Mixing composite particle of superparamagnetic oxide and fine silica with polynucleotide solution and chaotropic agent, separating particle from solution using magnetic field, eluting polynucleotide from carrier
08/31/1999US5945524 Nucleoside with dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group; for efficient synthesis
08/31/1999US5945521 Preparation of phosphorothioate oligomers
08/31/1999US5945334 Apparatus for packaging a chip
08/31/1999US5945282 Nucleic acid probes from prokaryotic microoganism not including the transfer rna gene for diagnosis of neisseria, haemophilus, branhamella, bordetella, streptococcus, camphylobactter infections
08/31/1999CA2149765C Sequence-specific binding polymers for duplex nucleic acids
08/31/1999CA2110988C Sequence-specific binding polymers for duplex nucleic acids
08/31/1999CA2012777C Process for isolating nucleic acid
08/26/1999WO1999042813A1 Method and apparatus for synthesis of arrays of dna probes
08/26/1999WO1999042593A1 Compositions and methods for sensitizing and inhibiting growth of human tumor cells
08/26/1999WO1999042118A2 Compounds and methods for diagnosis of tuberculosis
08/26/1999WO1999029703A3 Isolation of nucleic acids
08/26/1999WO1999020774A3 NOVEL MODIFIED MSP-1 NUCLEIC ACID SEQUENCES AND METHODS FOR INCREASING mRNA LEVELS AND PROTEIN EXPRESSION IN CELL SYSTEMS
08/26/1999CA2322617A1 Compounds and methods for diagnosis of tuberculosis
08/26/1999CA2320808A1 Compositions and methods for sensitizing and inhibiting growth of human tumor cells
08/25/1999EP0937155A2 Resistance against nematodes and/or aphids
08/25/1999EP0937139A1 Amidase
08/25/1999EP0937097A1 Compositions and methods for immobilizing nucleic acids to solid supports
08/25/1999EP0937096A2 High density immobilization of nucleic acids
08/25/1999EP0937090A1 Methods for labeling nucleotides, labeled nucleotides and useful intermediates
08/25/1999EP0936951A1 Methods for producing low binding surfaces
08/25/1999EP0237545B2 Production of pluripotent granulocyte colony-stimulating factor
08/25/1999CN1226928A Probe foranalysis of nucleic acids
08/24/1999US5942610 Incorporating into oligonucleotides a reagent with stable hydroxyl protecting group, reporter molecule, and phosphorus linkage or coupled to solid support; natural internucleotide distance between phosphate groups is conserved
08/24/1999US5942608 Reacting alkanediol with 4,48-dimethoxy trityl chloride; then alkanoic acid halide; immobilization
08/24/1999US5942496 Methods and compositions for multiple gene transfer into bone cells
08/24/1999US5942434 Regulatory sequence from phophoglycerate kinase operably linked to coding sequence of exogenous gene; for gene therapy; in situ expression of enzymes which convert prodrugs to active anticarcinogenic/antitumor drugs or cytokines
08/24/1999US5942425 Subjecting a sample of disrupted cells to sufficient agitation in the presence of particles to separate nucleic acids from other cellular components; heat lysis without other lysogenic agents or conditions is the preferred method
08/24/1999US5942414 Polynucleotides encoding human G-protein coupled receptor HIBEF51
08/24/1999US5942411 Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity
08/24/1999US5942397 Biopolymer containing monolayer of thiol-derivatized oligonucleotides and organic thiols bound to metal substrate; for efficient hybridizations
08/24/1999US5942393 Method for the detection of the presence or absence of methylthioadenosine phosphorylase (MTASE) in a cell sample by detection of the presence or absence of MTASE encoding nucleic acid in the cell sample
08/24/1999US5942235 Exogenous dna encoding an antigenic determinant of a pathogen; recombinant viruses and gene products are useful for cancer therapy
08/24/1999CA2082650C Method and apparatus for biopolymer synthesis
08/24/1999CA2082044C Modulation of gene expression through interference with rna secondary structure
08/19/1999WO1999041367A1 Heteroaromatic oligoamides as affinity ligands
08/19/1999WO1999041273A2 Pna and dna conjugates and methods for preparation thereof
08/19/1999WO1999041271A1 High affinity nucleic acid ligands of complement system proteins
08/19/1999WO1999041269A1 Oligodeoxyribonucleotides comprising o6-benzylguanine and their use
08/19/1999WO1999041007A2 Method and apparatus for chemical and biochemical reactions using photo-generated reagents
08/19/1999WO1999040789A1 Methods and compounds for the genetic treatment of hyperlipidemia
08/19/1999WO1999023108A9 Inducible phosphofructokinase and the warburg effect
08/19/1999CA2521289A1 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
08/19/1999CA2320965A1 Methods and compounds for the genetic treatment of hyperlipidemia
08/18/1999EP0935415A1 Methods for delivering compounds into a cell
08/18/1999EP0789715A4 Complementarily bonded two- and three-dimensional supramolecular structures
08/17/1999US5939555 Polymorphs B and C of 1- 2,4-dichloro-β- (7-chlorobenzo b!thien-3-yl)methoxy!phenethyl!imidazole mononitrate
08/17/1999US5939402 Treating plasmodium, viral infections or parasites in mammals
08/17/1999US5939301 Cloned DNA polymerases from Thermotoga neapolitana and mutants thereof
08/17/1999US5939277 Detection and treatment of breast and gynecological cancer
08/17/1999US5939268 Diels-alder reaction product of a diene and a dienophile; chemical intermediates for drugs, solid phase synthesis
08/17/1999CA2152446C Covalent cyanine dye oligonucleotide conjugates
08/12/1999WO1999040225A1 Immediate early genes and methods of use therefor
08/12/1999WO1999040223A1 Dideoxy dye terminators
08/12/1999WO1999040186A1 Optimized antisense oligonucleotides complementary to dna methyltransferase sequences
08/12/1999WO1999040173A1 Substrates for immobilizing and amplifying dna, dna-immobilized chips having dna immobilized on the substrates, and method for amplifying dna
08/12/1999WO1999040110A1 Breast cancer resistance protein (bcrp) and the dna which encodes it
08/12/1999WO1999040105A2 Array fabrication methods
08/12/1999WO1999040104A1 Neokine protein and nucleic acid molecules and uses therefor
08/12/1999WO1999040101A1 Synthetic process for the preparation of oligonucleotides, nucleoside synthons used therein, and oligonucleotides prepared thereby
08/12/1999WO1999040098A1 Method for isolating and purifying nucleic acids
08/12/1999WO1999040038A1 Substrate for array printing
08/12/1999WO1999039735A1 Live vaccine for human immunodeficiency virus
08/12/1999WO1999024452A9 Pyrimidine derivatives for labeled binding partners
08/12/1999DE19805431A1 Heteroaromatische Oligoamide als Affinitätsliganden Heteroaromatic oligoamides as affinity ligands
08/12/1999CA2320947A1 Array fabrication methods
08/12/1999CA2320489A1 Live vaccine for human immunodeficiency virus
08/12/1999CA2320462A1 Substrates for immobilizing and amplifying dna, dna-immobilized chips having dna immobilized on the substrates, and method for amplifying dna
08/12/1999CA2320144A1 Neokine protein and nucleic acid molecules and uses therefor
08/12/1999CA2319086A1 Optimized antisense oligonucleotides complementary to dna methyltransferase sequences
08/11/1999EP0934331A2 Mirror-symmetrical selection and evolution of nucleic acids
08/11/1999EP0934330A1 Base-protected nucleotide analogs with protected thiol groups
08/11/1999EP0934327A1 Saccharide library
08/11/1999EP0789706A4 Sugar modified nucleosides and their use for synthesis of oligonucleotides
08/11/1999EP0722508A4 Self-sustained sequence replication electrochemiluminescent nucleic acid assay
08/11/1999EP0699240B1 Gibbon ape leukemia virus-based retroviral vectors
08/11/1999CN1225640A Hodgkin disease associated molecules and uses thereof
08/10/1999US5936092 Fatty acid conjugate containing a disulfide linkage; increased absorption of compounds
08/10/1999US5936087 Dibenzorhodamine dyes
08/10/1999US5936080 Compositions and methods for the synthesis of organophosphorus derivatives
08/10/1999US5936079 Oligonucleotide which binds to a chromosomal binding site for p53 protein
08/10/1999US5936077 Solid phase synthesis of oligonucleotides
08/10/1999US5936066 Recombinant human interleukin-1α
08/10/1999US5936064 Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex
08/10/1999US5935934 Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
08/10/1999US5935865 Semaphorin gene family
08/10/1999US5935832 Farnesyl diphosphate synthase
08/10/1999US5935830 Site-directed mutagenesis by forming triple helix with double-stranded dna and oligonucleotide with electrophilic group, electrophilic group causes modification of dna nucleotide, then replication causes mutation
08/10/1999US5935820 Polynucleotides encoding vascular endothelial growth factor 2
08/10/1999US5935819 Process for producing a pharmaceutical preparation of PDGF-AB
08/10/1999US5935791 Detection of nucleic acids by fluorescence quenching
08/10/1999US5935784 Prolactin receptor gene as a genetic marker for increased litter size in pigs
08/10/1999US5935779 Forming a compositon comprising sample, assay-performance substance containing electrochemiluminescent label, analyte, binding partner, reacticve component; incubating and collecting complex; inducing electrochemiluminescence;
08/10/1999US5935578 Contraceptive vaccine
08/10/1999US5935555 Pharmaceutical formulations for treating cystic fibrosis
08/10/1999US5935527 Using phosphoramidite or hydrogen phosphonate chemistry on a nonswellable porous polystyrene support
08/10/1999CA2142156C Nucleic acid sequences specific for mycobacterium kansasii
08/10/1999CA1340703C Production of insulin-like growth factor binding protein