Patents
Patents for C07H 21 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids (89,892)
01/1999
01/26/1999US5864015 Hodgkin's disease associated molecules
01/26/1999US5864013 Materials for the production of nanometer structures and use thereof
01/26/1999US5863905 2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof
01/26/1999US5863893 Anticoagulants
01/26/1999US5863891 Protein fragments joined by peptide bonds
01/26/1999US5863796 Immunizing a mammal with specific polypeptide and collecting the antibody
01/26/1999US5863784 Obtained by site-directed mutagenesis with recombinant beta-amylase gene coding 531 amino acids; substitutions were met181 with leu, ser291 with ala, ile293 with val, ser346 with pro, ser347 with pro, gln348, with asp, ala372 with ser
01/26/1999US5863772 Discriminating animal and plant individuals on the basis of a difference in dna sequence, using dna oligonucleotide primer having a symmetrical base sequence, producing amplified dna fragments, separating by electrophoresis, silver staining
01/26/1999US5863767 Keratinocyte growth factor fragment lacks the first 23 amino acid residues of the n-terminus of mature, full-length kgf; treatment of hyperproliferative disease of epidermis
01/26/1999US5863757 An expression vector comprising polynucleotide having an open reading frame operably linked to a promoter and encoding a specific polypeptide
01/26/1999US5863756 Utilize recombinant pace 4 and 4.1, mammalian endopeptidases that are specific for dibasic amino acid sites; therapeutic compositions and methods employing pace 4 or 4.1 or their inhibitors are also provided
01/26/1999US5863755 Nucleic acid encoding novel receptor-type phosphotyrosine phosphatase-κ
01/26/1999US5863727 An acceptor fluorophore efficiently absorbs energy emission of a linked donor xanthene fluorophore labelling a oligonucleotide primer; reagent for sequencing nucleic acids
01/26/1999US5863724 Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
01/26/1999US5863722 Method of sorting polynucleotides
01/26/1999US5863528 Porcine cytokines
01/26/1999CA1340343C Protected biotin derivatives
01/26/1999CA1340329C Superoxide dismutasee
01/26/1999CA1340328C Method for protein binding enzyme complementation assays
01/21/1999WO1999002544A1 Compounds having energy transfer function and method for dna base sequencing by using the same
01/21/1999WO1999002167A1 ANTISENSE OLIGONUCLEOTIDE MODULATION OF raf GENE EXPRESSION
01/21/1999CA2265551A1 Compounds having energy transfer function and method for dna base sequencing by using the same
01/20/1999EP0891393A1 Asymmetric benzoxanthene dyes
01/20/1999EP0891374A1 Unique associated kaposi's sarcoma virus sequences and uses thereof
01/20/1999EP0891373A1 Method and compounds for inhibition of ribonucleases
01/20/1999EP0891372A1 Growth factor htter36
01/20/1999EP0891369A1 Process and device for isolating nucleic acids
01/20/1999EP0891184A1 Method for solubilising hydrophylic materials (e.g. proteins) in a hydrophobic solvent
01/20/1999EP0767657A4 Novel method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
01/20/1999EP0675965A4 Polynucleotide immobilized support.
01/19/1999US5861501 Capped synthetic RNA, analogs, and aptamers
01/19/1999US5861493 Process for the synthesis of 2'-O-substituted pyrimidines
01/19/1999US5861480 Capable of isolation from seeds of aralia or impatiens exhibit antifungal and antibacterial activity
01/19/1999US5861378 Polypeptides having specified amino acid sequences; antiseptics, effective against grampositive and gramnegative bacteria
01/19/1999US5861377 Antistasin type serine protease inhibitors
01/19/1999US5861314 Genetic manipulation which comprises a liposome comprised of lipid material, and adeno-associated viral (aav) material for genomes
01/19/1999US5861309 Amino acid sequences encoding it, vectors for its expression in yeast, bacterial, and mammalian cells; research into the characterization of the pharmacology of individual human alpha 1 receptor subtypes
01/19/1999US5861307 Liposomes embedded with dna; antitumor agents; apotosis
01/19/1999US5861287 Distinguishing polynucleotides with 3'-terminal dideoxynucleotides with dna sequencing requiring electrophoresis
01/19/1999US5861276 CDNAS encoding murine antibody against human plasma apolipoprotein B-100
01/19/1999US5861259 Immunoassays for human cyclin E
01/19/1999US5861252 Method of analysis or assay for polynucleotides and analyzer or instrument for polynucleotides
01/19/1999US5861250 Protecting nucleic acids and methods of analysis
01/19/1999US5861242 Array of oligonucleotide probes immobilized on a solid support for analysis of a target sequence from a human immunodeficiency virus
01/19/1999US5861171 Adeno-associated viral (AAV) liposomes and methods related thereto
01/19/1999US5861157 An immunogenic fragment obtained from a bacterial protein capable of eliciting antibody response
01/19/1999US5861156 Methods of delivering agents to target cells
01/19/1999CA1340323C Rna catalyst for cleaving specific rna sequences
01/19/1999CA1340322C Human papillomavirus type 41, its dna and the proteins encoded therefrom
01/14/1999WO1999001579A1 Compositions and methods for the delivery of oligonucleotides via the alimentary canal
01/14/1999WO1999001571A2 Compositions and methods for detecting vancomycin resistant enterococci by cycling probe reactions
01/14/1999CA2294988A1 Compositions and methods for the delivery of oligonucleotides via the alimentary canal
01/14/1999CA2294565A1 Compositions and methods for detecting vancomycin resistant enterococci by cycling probe reactions
01/13/1999EP0890363A2 A device for nucleic acid sterilization
01/13/1999EP0889959A1 Partial intron sequence of von hippel-lindau (vhl) disease gene and its use in diagnosis of disease
01/13/1999EP0889899A1 Mycoplasma arthritidis superantigen
01/13/1999EP0889728A2 Method of treating ciliary dyskinesia with uridine triphosphates and related compounds
01/13/1999CN1205079A Transistor-based apparatus and method for molecular detection and field enhancement
01/12/1999US5859346 Crucifer AFT proteins and uses thereof
01/12/1999US5859336 Synthetic DNA sequence having enhanced activity in maize
01/12/1999US5859259 Activated esters of 1-phenylpyrazolin-5-one for labeling amine-functionalized molecules
01/12/1999US5859234 3'-diisopropylmethylphosphonamidityl-5'-dimethoxytrityl-n4 -isobutyryl-2'-o-methylcytidine monomer do not undergo transamination for efficient oligonucleotide and methylphosphonate oligomer synthesis
01/12/1999US5859233 Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
01/12/1999US5859232 Process for the synthesis of oligomeric phosphite, phosphodiester, phosphorothioate and phosphorodithioate compounds
01/12/1999US5859231 Synthesizing an oligonucleotide comprsing an internucleotide h-phosphate diester linkage, reacting diester with bis/trimethylsilyl/acetamide or halogenating agent to form triester, boronating with amine borane; reacting with ammonia
01/12/1999US5859229 For inhibition of gene expression of human cyclooxygenase 2 by binding to specific untranslated regions of messenger rna; treatment of premature labor, preeclampsia, endometriosis, rheumatoid arthritis
01/12/1999US5859228 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
01/12/1999US5859224 Base sequence of the coat protein gene of papaya leaf-distortion mosaic virus
01/12/1999US5859223 Dna molecules coding for no more than three short consensus repeats including scr3 of long homologous repeat a of complement receptor 1; antiinflammatory agents; multiple sclerosis; parkinson's/alzheimer's disease
01/12/1999US5859221 Hybrid dna, rna; nuclease resistant
01/12/1999US5859219 Isolated nucleotide sequences used for detection of infection as primers for amplification and probes for hybridization; antiulcer agents; anticancer agents
01/12/1999US5859208 Human basic fibroblast growth factor analog
01/12/1999US5858988 Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
01/12/1999US5858976 Inhibiting tumor cell growth by administering dna for gene expression of a polypeptide fragment of p53, which regulates cell growth, capable of binding to novel human mdm2, a cancer-causing gene product that normally sequesters p53
01/12/1999US5858963 Inducing xenograft tolerance and porcine cytokines therefor
01/12/1999US5858780 Cisplatin resistant cell line
01/12/1999US5858744 Gene transfer into stem cells
01/12/1999US5858740 Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
01/12/1999US5858731 Nucleotide sequences including nondegenerate and degenerate nucleotide bases which can be ligated together for longer molecules; for rapid and efficient synthesis of preselected sequences for dna sequencing, polymerase chain reaction
01/12/1999US5858729 Preparation of glycosylated open reading frames 3 and 4 of protein associated with mystery swine disease, by co-infecting, culturing, harvesting eukaryotic cells with subgenomic dna fragments in viral vectors
01/12/1999US5858727 Secretion of outer membrane proteins of gram-negative bacteria by means of gram-positive host organisms
01/12/1999US5858674 Screening assays to identify agents that modulate cisplatin resistance
01/12/1999US5858670 Screening randomly synthesized oligopeptide- or oligonucleotide-solid phase libraries with acceptor molecules (e.g. antibodies), isolating solid phase support/oligomer bound to molecule, sequencing oligomer
01/12/1999US5858668 Homogeneous gene probe test using a receptor directed against the label
01/12/1999US5858660 Parallel selex
01/12/1999US5858658 Amplification of repetive sequences in both sample and added standard nucleic acids using complemtary primers, determining total amount of heterogenous, contaminant dna, for quality control of recombinant products
01/12/1999US5858656 Indexing linkers
01/12/1999US5858376 Introducing into cell isolated protein derived from herpes simplex virus
01/12/1999CA2117903C Targeted cleavage of rna using eukaryotic ribonuclease and external guide sequence
01/07/1999WO1999000521A1 Lyophilization of cultured human cells to preserve rna and dna
01/07/1999WO1999000402A1 Purification of oligomers
01/07/1999WO1999000401A1 3'-monophosphorylating oligonucleotides
01/07/1999EP0889122A2 Inhibition of DNA Methyltransferase
01/07/1999EP0889120A1 A micro-organism having reduced adaption to a particular environment
01/07/1999EP0888456A2 Prostate specific antigen oligo-epitope peptide
01/07/1999EP0888374A1 High affinity nucleic acid ligands of complement system proteins
01/07/1999EP0888372A1 Oligonucleotide-anthracycline and oligonucleotide-anthracyclinone conjugates
01/07/1999EP0888367A1 Isolated rna molecules which bind to arginine and uses thereof
01/07/1999EP0888110A1 Composite gel microparticles as active principle carriers
01/07/1999EP0525076B1 Recombinant bile salt activated lipases