Patents
Patents for C07H 21 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids (89,892)
12/1999
12/22/1999EP0964932A2 Methods for identifying herbicidal agents that inhibit d1 protease
12/22/1999EP0964930A1 Catalytic rna molecules
12/21/1999US6005096 For oligonucleotides that are modified to enhance the binding affinity and to bear detectable labels; for diagnostic use
12/21/1999US6005094 Mixture of an acid resistant, antisense oligonucleotide and a carrier; for oral administration
12/21/1999US6005093 Conmpounds used as replacements for one or more complementary nucleoside bases in probes; enable photoactive crosslinking of nucleic acid strands in hybridization assays and therapeutic applications
12/21/1999US6005091 Nucleic acids encoding immunoglobulin domains
12/21/1999US6005087 Nuclease resistant oligonucleotides which are useful as therapeutics, diagnostics, and research reagents for various viral diseases
12/21/1999US6004826 Repair-mediated process for amplifying and detecting nucleic acid sequences
12/21/1999US6004804 Non-chimeric mutational vectors
12/21/1999US6004796 Amino acid sequence of enzyme effective in removal of arginine, phenylalanine or methionine from the n-terminal end of peptides in peptide or peptidomimetic synthesis
12/21/1999US6004752 Solid support with attached molecules
12/21/1999US6004747 Nucleic acid molecule for the detection and identification of salmonella serotypes comprising a single stranded dna fragment
12/21/1999US6004513 Automatic device for nucleic acid sequence detection employing amplification probes
12/21/1999CA2197075C Method of gene therapy using dna vectors without selection marker gene
12/21/1999CA2022942C Method of assessing sensitivity of hiv to zidovudine
12/19/1999CA2242316A1 Dna encoding a plasminogen activating protein
12/16/1999WO1999064631A1 Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
12/16/1999WO1999064629A1 Acrp30r2, a homolog of acrp30 (30 kd adipocyte complement-related protein)
12/16/1999WO1999064623A1 Support for the parallel identification and establishment of transcription profiles of polynucleic acids
12/16/1999WO1999064589A1 Human receptor tyrosine kinase
12/16/1999WO1999064519A1 Energy transfer assay method and reagent
12/16/1999WO1999064437A1 Nucleotide analogues with 3'-pro-fluorescent fluorophores in nucleic acid sequence analysis
12/16/1999WO1999064434A1 Synthetic methods and intermediates for triester oligonucleotides
12/16/1999WO1999064432A2 Multi-fluorescent hairpin energy transfer oligonucleotides
12/16/1999WO1999064431A2 Purines and pyrimidines linked to a quencher
12/16/1999WO1999055718A3 Solution phase biopolymer synthesis
12/16/1999DE19825899A1 Immobilized oligo- or polynucleotide product useful for identifying and quantifying polynucleotides
12/16/1999CA2335026A1 Multi-fluorescent hairpin energy transfer oligonucleotides
12/16/1999CA2334610A1 Purines and pyrimidines linked to a quencher
12/16/1999CA2330478A1 Support for the parallel identification and establishment of transcription profiles of polynucleic acids
12/15/1999EP0963997A1 Novel nucleotide analogues
12/15/1999EP0963443A1 Releasable nonvolatile mass-label molecules
12/15/1999EP0963246A1 Automated chemical synthesis device
12/15/1999EP0963208A1 INHIBITION OF Ii SYNTHESIS
12/15/1999EP0788366B1 Use of 2'-substituted oligonucleotides to down-regulating gene expression
12/15/1999EP0786014B1 Massively parallel sequencing of sorted polynucleotides
12/15/1999EP0750612B1 Acridone-derived bisintercalators as chemotherapeutic agents
12/15/1999EP0743949B1 Process for producing endotoxin-free or endotoxin-poor nucleic acids and/or oligonucleotides for gene therapy
12/15/1999EP0529008B1 Modulation of gene expression through interference with rna secondary structure
12/14/1999US6002071 Transcriptional silencing elements and their binding factors
12/14/1999US6001993 Testing the phoshorous bearing monomers for chemical suitability, reacting selected monomers with solid support or growing chain, mixing all supports together, dividing mixture, repeating coupling steps
12/14/1999US6001991 Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression
12/14/1999US6001990 Antisense inhibition of hepatitis C virus
12/14/1999US6001988 High affinity nucleic acid ligands to lectins
12/14/1999US6001983 Oligonucleotides with non-standard bases and methods for preparing same
12/14/1999US6001982 Synthesis of oligonucleotides
12/14/1999US6001966 Reacting n-terminal protected amino acid with peptide starting material forming a peptide product, partitioning from unreacted material and reagents based on presence of n-terminal blocking/anchoring group
12/14/1999US6001841 Cyclobutyl oligonucleotide surrogates
12/14/1999US6001651 Antisense modulation of LFA-3
12/14/1999US6001611 Modified nucleic acid amplification primers
12/14/1999US6001598 Two new human DnaJ-like proteins
12/14/1999US6001577 Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
12/14/1999US6001566 DNA polymerase having 3'-intrinsic editing activity
12/14/1999US6000772 Tubulin promoter regulates gene expression in neurons
12/14/1999CA2186526C Method and product for regulating cell responsiveness to external signals
12/14/1999CA2155024C Genetic modification of neural stem cells
12/14/1999CA1340852C Process for purifying primate gm-csf protein
12/14/1999CA1340847C Adhesin antigens
12/09/1999WO1999063111A2 Method of labelling nucleic acid
12/09/1999WO1999063100A1 Process for obtaining transgenic plants which have an improved capacity for the uptake of nutrients and tolerance to toxic compounds which are present in the soil
12/09/1999WO1999062924A1 D-labeled 5'-ribonucleotide and process for producing the same
12/09/1999WO1999062923A2 Immunostimulatory oligonucleotides with modified bases and methods of use thereof
12/09/1999WO1999062922A1 Activators for oligonucleotide synthesis
12/09/1999WO1999062847A2 Construction and use of catalogued nucleic acid libraries that contain advantageously adjusted representations of defined components
12/09/1999WO1999054340A8 Endotoxin reduction in nucleic acid purification
12/09/1999WO1999027081A3 Alpha/beta hydrolase-fold enzymes
12/09/1999WO1998005673A8 Methods for purifying nucleic acids
12/09/1999CA2330827A1 Construction and use of catalogued nucleic acid libraries that contain advantageously adjusted representations of defined components
12/09/1999CA2330225A1 Immunostimulatory oligonucleotides with modified bases and methods of use thereof
12/09/1999CA2330192A1 Activators for oligonucleotide synthesis
12/08/1999EP0962537A2 Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
12/08/1999EP0962463A1 Uncharged morpholino-based polymers having phosphorus-containing chiral intersubunit linkages
12/08/1999EP0961837A1 Three component chimeric antisense oligonucleotides
12/08/1999EP0961831A1 Human endokine alpha
12/08/1999EP0961652A1 Laminated assembly for active bioelectronic devices
12/08/1999EP0850320B1 Methods for detecting binding of ligand pair with enhanced sensitivity
12/08/1999EP0601117B1 SYNTHETIC tRNAs
12/08/1999EP0594837B2 Radiolabelled compound formulations
12/08/1999CN1238012A Stabilized aqueous nucleoside triphosphate solution
12/08/1999CN1237582A Cancer suppressor action of antisense nucteic acid of para-insulin growth factor receptor gene
12/07/1999US5998604 3'- or 5'-polynucleotide cis-diol phosphate diester, reverse phase hplc
12/07/1999US5998603 4'-desmethyl nucleoside analogs, and oligomers thereof
12/07/1999US5998602 RNase L activators and antisense oligonucleotides effective to treat RSV infections
12/07/1999US5998601 VR-2332 viral nucleotide sequence and methods of use
12/07/1999US5998596 Inhibition of protein kinase activity by aptameric action of oligonucleotides
12/07/1999US5998594 Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use
12/07/1999US5998203 Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
12/07/1999US5998145 Method to determine predisposition to hypertension
12/07/1999US5998142 Nucleic acid ligand which binds to protein
12/07/1999US5998135 Energy transfer hybridization assay using intercalators and lanthanide metals
12/07/1999US5998133 Use of genetic markers to diagnose familial dysautonomia
12/07/1999US5997870 Isolated peptides which bind to HLA-B44 Molecules
12/07/1999CA1340846E Expression of biologically active platelet derived growth factor analogs in eucaryotic cells
12/07/1999CA1340843C Selective amplification of target polynucleotide sequences
12/02/1999WO1999061653A2 Light-mediated regional analysis of biologic material
12/02/1999WO1999061652A1 Carotenoid ketolase genes and gene products, production of ketocarotenoids and methods of modifying carotenoids using the genes
12/02/1999WO1999061607A2 Antisense oligonucleotides for treating proliferating cells
12/02/1999WO1999061603A1 Rapid and simple process for isolation of circular nucleic acids
12/02/1999WO1999061462A1 Antisense modulation of cellular adhesion molecule expression and treatment of cellular adhesion molecule-associated diseases
12/02/1999WO1999061461A1 Sandwich arrays and methods of making and using the same