Patents
Patents for C07H 21 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids (89,892)
10/1990
10/31/1990EP0394261A1 Novel thrombolytic proteins
10/30/1990US4966964 Inhibitors of angiogenin
10/27/1990CA2013800A1 Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
10/24/1990EP0393744A1 Methods of extracting, amplifying and detecting a nucleic acid from PBMC blood fraction
10/24/1990EP0393502A1 Soluble interferon-gamma receptors and methods for their production
10/24/1990EP0393431A1 Homologues of Alzheimer protease inhibitor prepared genetechnologically, host-strains and expression vectors for their preparation and use as a medicament
10/23/1990US4965350 Fluorescent detectors
10/23/1990US4965349 Hydrolysis of linking group with mixture of alcohol, water, and hindered amine
10/23/1990US4965190 Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes
10/21/1990CA2014990A1 Method of inhibiting induction of latent or chronic viral infection
10/19/1990WO1990012802A1 Novel oligodeoxynucleotides with 5'-linked chemical groups, method of production thereof and use thereof
10/19/1990CA2049361A1 Oligodeoxynucleotides with 5'-linked chemical groups, method of product thereof and use thereof
10/19/1990CA2014752A1 Soluble interferon-gamma receptors and methods for their production
10/18/1990WO1990012096A1 Method for enhancing transmembrane transport of exogenous molecules
10/18/1990WO1990012024A1 Method of synthesizing oligonucleotides adaptable to large scale syntheses
10/18/1990WO1990012022A1 Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
10/18/1990WO1990012020A1 Coumarin derivatives for use as nucleotide crosslinking reagents
10/18/1990WO1990008828A3 Molecular methods of hybrid seed production
10/18/1990DE3905448C1 Process for the synthesis of macromolecules of specific chain length, structure and sequence
10/18/1990CA2051692A1 Method of synthesizing oligonucleotides adaptable for large scale syntheses
10/18/1990CA2014855A1 Amplified nucleic acid hybridization assays for hbv
10/17/1990EP0392546A2 Process for determination of a complete or a partial contents of very short sequences in the samples of nucleic acids connected to the discrete particles of microscopic size by hybridization with oligonucleotide probes
10/17/1990EP0391957A1 A METHOD OF SIMULTANEOUSLY PRODUCING A LARGE NUMBER OF Leu?17 -VIP-ANALOGS AND NEW Leu?17 -VIP-ANALOGS
10/17/1990CA2013316A1 Methods of extracting, amplifying and detecting a nucleic acid from whole blood or pbmc fraction
10/16/1990US4963532 dsRNA-based prevention of viral escape
10/16/1990US4963477 Probe containing a modified nucleic acid, recognizable by specific antibodies and use of this probe and theses specific antibodies to detect and characterize a homologous DNA sequence
10/10/1990EP0391039A1 A DNA probe for Lactobacillus delbrueckii
10/10/1990EP0391022A2 Signal peptide for the secretion of peptides in Escherichia coli, method for obtaining it and its use
10/10/1990EP0390910A1 Hapten derivatized captured membran and diagnostic assays using such membrane.
10/09/1990US4962029 Covalent oligonucleotide-horseradish peroxidase conjugate
10/04/1990WO1990011322A2 Method and reagent for sulfurization of organophosphorous compounds
10/04/1990WO1990011092A1 Expression of exogenous polynucleotide sequences in a vertebrate
10/04/1990WO1990011089A1 Nanbv diagnostics and vaccines
10/04/1990DE3910151A1 5'-Bromo-2'-deoxyuridine-labelled DNA or RNA probes
10/04/1990CA2489769A1 Expression of exogenous polynucleotide sequences in a vertebrate
10/04/1990CA2357538A1 Expression of exogenous polynucleotide sequences in a vertebrate
10/03/1990EP0390518A2 Novel compositions and protocols applicable to genetic analysis
10/03/1990EP0389521A1 2',5'-phosphorothioate oligoadenylates and antiviral uses thereof
10/03/1990CA2013580A1 Method for enhancing transmembrane transport of exogenous molecules
10/02/1990US4960700 Compositions and methods for the synthesis and assay of a mammalian enkephalinase
09/1990
09/26/1990EP0389066A1 Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase and plant materials containing it
09/26/1990EP0389063A2 Process for isolating nucleic acid
09/26/1990EP0389034A1 Hog cholera virus vaccine and diagnostic
09/25/1990US4959463 Coupling ribonucleotides or deoxyribonucleotides though phosphonate groups
09/25/1990US4959353 Promotion of corneal stroma wound healing with human epidermal growth factor prepared from recombinant DNA
09/25/1990US4959309 Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
09/23/1990CA2271603A1 Process for isolating nucleic acid
09/20/1990WO1990010699A1 MOLECULAR CLONING OF GENOMIC AND cDNA SEQUENCES ENCODING CELLULAR RECEPTORS FOR POLIOVIRUS
09/20/1990WO1990010637A1 Method for purifying nucleic acids
09/19/1990EP0388232A1 NANBV diagnostics and vaccines
09/19/1990EP0388171A2 Methods for purification, amplification and detection of a nucleic acid
09/19/1990EP0387915A1 F antigens of the human immunodeficiency virus, and their applications
09/19/1990EP0387914A1 Envelope antigens of the human immuno-deficiency virus, and their applications
09/19/1990EP0387775A1 Genetic construct for inhibiting RNA function
09/19/1990EP0387668A1 Intercellular adhesion molecule - 2 and its binding ligands
09/19/1990EP0387452A2 Method of preparing nucleotide probes using a hybridizable complementary element
09/18/1990WO1990011367A1 IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA
09/18/1990US4958013 Cholesteryl modified oligonucleotides
09/18/1990US4957858 Replicative RNA reporter systems
09/18/1990CA2049984A1 Immunoglobulin al proteases (iga1 proteases), method of gene-technologically producing this type of enzyme and vaccines containing the enzymes and fragments thereof for immunizingagainst bacterial meningitis and other diseases caused by iga1 protease-producing bacteria
09/17/1990CA2483289A1 Hepatitis c diagnostics and vaccines
09/17/1990CA2011818A1 Methods for purification, amplification and detection of a nucleic acid
09/15/1990WO1990010713A1 Method for stabilizing the hybridization of complementary polynucleotide sequences
09/15/1990CA2050913A1 Complementary base sequence hybridization stabilization process
09/12/1990EP0386987A1 Method and reagent for sulfurization of organophosphorous compounds
09/12/1990EP0386563A1 Antisense-oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (Tat) of HIV-I, and their use
09/12/1990EP0386229A1 Support-bound oligonucleotides.
09/12/1990EP0386228A1 Replicative rna-based amplification/detection systems.
09/11/1990US4956281 DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3
09/11/1990CA2048993A1 Molecular cloning of genomic and cdna sequences encoding cellular receptors for poliovirus
09/11/1990CA1273862A1 Reagents and kits for quantitation of a viral nucleic acid in a biological medium and quantitation process of such viral nucleic acid
09/08/1990WO1990010448A2 Covalent conjugates of lipid and oligonucleotide
09/08/1990CA2049028A1 Covalent conjugates of lipid and oligonucleotide
09/07/1990WO1990010649A1 Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression
09/07/1990WO1990010067A1 Dna sequences coding for pth variants, pth variants, expression vector, bacterial host, use and therapeutic composition
09/07/1990WO1990010013A1 TYPE oc PLATELET-DERIVED GROWTH FACTOR RECEPTOR GENE
09/07/1990WO1990010011A1 Use of 2-tert.-alkylimino-2-di-c1-4-alkylamino-1,3-di-c1-3-alkylperhydro-1,3,2-diazaphosphorine for o-substitution reactions of ribonucleosides
09/07/1990WO1990009802A1 Human intra-acrosomal sperm antigen for use in a contraceptive vaccine
09/07/1990WO1990009737A1 Human elastase inhibitor
09/06/1990DE3915462A1 Verwendung von 2-tert.-alkylimino-2-di-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)-(pfeil abwaerts)(pfeil abwaerts)4(pfeil abwaerts)-alkylamino- 1,3-di-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)-(pfeil abwaerts)(pfeil abwaerts)3(pfeil abwaerts)-alkyl-perhydro-1,3,2-diazaphosphorin fuer 0-substituierungsreaktionen von ribonukleosiden Use of 2-tert-alkylimino-2-di-c (down arrow) 1 (arrow down) (Down Arrow) - (arrow down) (Down Arrow) 4 (down arrow) alkylamino 1,3-di- c (Down Arrow) 1 (arrow down) (Down Arrow) - (arrow down) (Down Arrow) 3 (down arrow) alkyl-perhydro-1,3,2-diazaphosphorine for 0-substituierungsreaktionen of ribonucleosides
09/05/1990EP0385558A2 Materials and methods for genome walking
09/04/1990WO1990010075A1 Yeast processing system comprising a negatively charged amino acid adjacent to the processing site
09/04/1990CA1273590A1 Messenger rna, production and use thereof
09/04/1990CA1273589A1 Carriers, process for their preparation and the intermediates obtained, use in the synthesis of oligonucleotides linked to such carriers
09/02/1990WO1990010228A1 Matrix metalloproteinase peptides: role in diagnosis and therapy
08/1990
08/29/1990EP0384122A2 Mutants of human antithrombin III
08/29/1990EP0383803A1 Oligonucleotide-polyamide conjugates
08/28/1990US4952674 Dna segment endcoding the immunogenic glycoprotein
08/28/1990US4952512 Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators
08/25/1990WO1990009786A1 Heterologous block oligomers
08/25/1990CA2028153A1 Heterologous block oligomers
08/23/1990WO1990009393A1 Method of separating oligonucleotides from a mixture
08/23/1990WO1990009180A1 Methods and compositions for treatment of cancer using oligonucleotides
08/22/1990EP0383620A2 Process for making genes encoding random polymers of amino acids
08/21/1990US4950745 Used in genetic engineering
08/21/1990US4950652 Aids and aids-related complex
08/21/1990US4950602 Analogs of nicotinamide-adenine-dinucleotide
08/17/1990CA2009996A1 Process for making genes encoding random polymers of amino acids
08/16/1990EP0224578B1 Compositions and methods for functionalizing nucleic acids
08/14/1990US4948882 Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis