Patents
Patents for C07C 405 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins (3,702)
01/1990
01/16/1990US4894336 Cultures, microorganisms, hydrolytic enzymes
01/10/1990EP0349658A1 New prostanoids and their use for increasing the birth rate in animal females
01/09/1990CA1264320A1 Prostaglandin analogues, process for their preparation and pharmaceutical compositions containing them
12/1989
12/19/1989US4888358 13,14-dihydroprostaglandin C-type derivatives
12/13/1989EP0345951A1 Tracheobronchodilator
12/12/1989US4886903 Process for production of prostaglandins D2
12/12/1989US4886788 Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents
12/06/1989EP0344235A1 Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension.
11/1989
11/28/1989CA1263382A1 Carbacyclins, processes for their production and their use as medicinal agents
11/08/1989EP0340247A1 New process for the antipodal separation of bicyclo 3.3.0]octane-3,7-dion-2-carboxylic acid esters and their 7-monocetals.
10/1989
10/25/1989EP0338796A2 2-Substituted-2-cyclopentenones
10/18/1989EP0173753B1 6-substituted prostaglandin e1's and process for their preparation
10/11/1989EP0336522A2 Thromboxane antagonists for use in the treatment of hormone-dependent neoplasias
10/04/1989EP0335827A1 Process for the preparation of bicyclo(3.3.0)octan-3-one derivatives
10/03/1989US4871869 Intermediate for prostacyclin
10/03/1989US4871772 Process for making a stable pharmaceutical preparation of prostagladin E compounds, and/or 15R forms thereof
09/1989
09/26/1989US4870104 Antiulcer, luteolytic
09/26/1989CA1261827A1 Tetraenyl prostaglandins
09/26/1989CA1261826A1 13-aza-14-oxo-txa.sub.2 analogues
09/13/1989EP0332178A1 2-cyclopentenone derivatives
09/13/1989EP0215860B1 9-halogenprostaglandines, process for their manufacture
09/12/1989US4866205 5-hydroxy-2-(3-hydroxy-4,4-dimethyl-1-octenyl)-3 -methylcyclopentane acetic acid and derrivatives; cardiovascular agents, oxytocics
09/05/1989US4863961 Tetraenyl prostaglandins
08/1989
08/23/1989EP0134246B1 Prostacyclines and process for their preparation
08/02/1989EP0325869A1 Novel processes and intermediates
07/1989
07/26/1989EP0324815A1 New 9-substituted carbocycline derivatives, process for manufacturing them and their use as drugs
07/25/1989US4851523 Cyclopentyl ethers and their preparation and pharmaceutical formulation
07/18/1989US4849535 Production of cyclopentenylheptanoic acid derivatives
07/12/1989EP0323913A2 Processes for the preparation of optically active bicyclo [3.3.0]octane
07/11/1989US4847370 Cyclopentyl ethers and their preparation and pharmaceutical formulation
07/11/1989US4847369 Antiulcer agents; antisecretory agents
07/11/1989US4847293 Tetraenyl prostaglandins
07/04/1989US4845282 Process for prostaglandin E1 production, and novel delta 7-prostaglandins E and 7-hydroxyprostaglandins E
06/1989
06/20/1989US4841091 Process for producing 16-substituted prostaglandin es.
06/20/1989US4840968 Reacting prostaglandin hydophobic ester with ethyldiisopropylamine
06/20/1989CA1256029A1 Process for making a stable pharmaceutical preparation of prostaglandin e compounds, and/or 15r thereof
06/13/1989US4839388 Prostacyclins and pharmaceuticals containing the same
06/06/1989US4837363 Gastric acid secretion inhibitors, antiulcer agents
06/06/1989US4837342 Stability
06/06/1989US4837234 Prostaglandins
06/06/1989CA1255298A1 Prostaglandin analogues
05/1989
05/23/1989US4833271 Structurally defined oligomers and preparation thereof for the protection of oxidative phosphorylation and which exhibit ionophoretic activity
05/23/1989US4833157 Antiulcer agents
05/02/1989US4827017 Novel carbacyclins, processes for their production and their use as medicinal agents
05/02/1989CA1253494A1 12,16 - DIFLUOROPROSTAGLANDIN F.SUB.2.alpha. COMPOUNDS
05/02/1989CA1253493A1 Bicycloheptane substituted ethers
04/1989
04/26/1989EP0312906A2 Novel sulfonamide derivatives
04/26/1989EP0173754B1 7-thiaprostaglandin e 1?'s and process for their preparation
04/25/1989US4824993 Cyclopentyl ethers and their preparation and pharmaceutical formulation
04/20/1989WO1989003384A1 Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
04/19/1989EP0312055A2 6-Fluoroprostaglandins
04/18/1989US4822909 Using aminosulfur trifluoride florinating agent
04/18/1989US4822804 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them
04/18/1989CA1252781A1 Allenic prostacyclins
04/18/1989CA1252780A1 Carbacyclin derivatives, process for their preparation and compositions containing them
04/11/1989US4820728 Tetraenyl prostaglandins
04/11/1989CA1252461A1 Bicyclooctane derivatives and their production and use
04/05/1989EP0310409A2 Prostaglandin derivatives
03/1989
03/28/1989US4816472 Antisecretory agents
03/28/1989CA1251788A1 Sulfur-containing 6-ketoprostaglandins
03/22/1989EP0308135A2 Ocular hypotensive agents
03/21/1989US4814490 Bicyclic olefin with alkyl acetoxymercurio carboxylate
03/14/1989US4812475 New method of treatment using prostaglandin analogues
03/14/1989US4812457 Prostaglandin derivatives
03/14/1989CA1251202A1 Carbacylin derivatives
03/14/1989CA1251201A1 9-halogen prostaglandins
03/14/1989CA1251200A1 Carbacyclins, processes for their manufacture and their use as medicaments
03/07/1989US4810805 Intermediates for prostac6yclins
03/07/1989CA1250835A1 .alpha. CHAIN DIENIC PROSTANOIC ACID DERIVATIVES
03/07/1989CA1250834A1 5-fluoro-carbacyclins, process for their manufacture and their use as medicaments
02/1989
02/23/1989WO1989001470A1 Process for producing e/z mixtures of 2-(bicyclo[3.3.0]octane-3-ylidene) acetic acid derivatives with predominant e or z moieties
02/21/1989US4806668 Producing 5-chloro-3-hydroxycyclopentyl aldehydes
02/21/1989CA1250285A1 Intermediates for the preparation of prostaglandin analogues
02/15/1989EP0303562A1 Process for the preparation of E/Z mixtures of 2-(bicyclo[3.3.0]octan-3-ylidene) acetic-acid derivatives with a major proportion of E or Z isomer
02/14/1989US4804787 Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
02/09/1989WO1989000990A1 New 9-substituted carbocycline derivatives, process for manufacturing them and their use as drugs
02/08/1989EP0181409B1 15(r+s)-fluorine-11,15-didesoxyprostaglandin e 1? derivatives
02/07/1989CA1249842A1 Method for preparing ( )s-2-hydroxy-2-methyl-hexanoic acid
01/1989
01/26/1989WO1989000559A1 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs
01/26/1989DE3724190A1 9-Halo-3-oxa-(Z)- DELTA <5>-prostaglandin derivatives, process for their preparation, and their use as medicaments
01/26/1989DE3724189A1 9-Halo-(Z)- DELTA <4>-prostaglandin derivatives, process for their preparation and their use as medicaments
01/18/1989EP0299914A1 9-Halogen (Z) prostaglandin derivatives, process for their production and their use as medicines
01/11/1989EP0157883B1 Process for preparing prostaglandin d 2?'s
01/10/1989US4797506 Antiulcer agents
01/10/1989CA1248527A1 Cyclopentyl ethers and their preparation and pharmaceutical formulation
01/10/1989CA1248526A1 [3.2.0]bicycloheptanone oxime ethers with valuable therapeutic properties
01/10/1989CA1248525A1 Carbacyclins, process for their manufacture and their use as medicaments
12/1988
12/29/1988WO1988010252A1 Prostaglandin derivates, their process and pharmaceutical compositions
12/21/1988EP0295284A1 Compositions containing sulphur prostaglandines
12/20/1988US4792617 Lower intraocular pressure
12/20/1988US4792550 Thromboxane antagonist-hypotensive agent; cardiovascular, nervous system disorders; antiallergens
12/14/1988EP0294757A2 Process of preparing higher order cuprate complexes
12/13/1988CA1246594A1 Prostaglandins
12/13/1988CA1246561A1 Prostaglandin derivatives
12/13/1988CA1246560A1 Intermediates for making 16-phenoxy and 16- substituted phenoxy-prostatrienoic acid derivatives
12/13/1988CA1246558A1 Carbacyclin amides, process for their manufacture and their use as medicaments
12/13/1988CA1246557A1 Carbacyclin esters, process for their manufacture and their use as medicaments
12/06/1988US4789685 9-fluoroprostaglandin derivatives, their preparation and use as medicinal agents
11/1988
11/29/1988US4788319 Prostaglandin intermediates
11/29/1988CA1245646A1 Carbacyclins, process for their manufacture and their use as medicaments
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