| Patents for C12P 41 - Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture (4,784) |
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| 08/08/2012 | CN102628076A Preparation technology of chiral amino acid |
| 08/08/2012 | CN102628075A Method for producing chiral amino acid by penicillin acylase resolution and product thereof |
| 08/07/2012 | CA2264651C Microorganism, lactamase enzyme obtained therefrom, and their use |
| 08/01/2012 | EP2480664A1 Amidase and use thereof for producing 3-amino carboxylic acid esters |
| 08/01/2012 | CN102618618A Method for producing D-phenylalanine by using L-phenylalanine as raw material |
| 08/01/2012 | CN102617384A Preparation method and application of N-acyl-DL-leucine |
| 07/25/2012 | EP2479272A1 Method for producing monatin |
| 07/25/2012 | CN102605034A Biological enzyme resolution method for preparing optically pure (S)-5-(4-fluorophenyl)-5-hydroxypentanoate |
| 07/25/2012 | CN101831483B Preparation method of L-methionine |
| 07/25/2012 | CN101547893B Method for collection of L-biphenylalanine compound salt, and method for collection of biphenylalanine ester compound using the same |
| 07/24/2012 | US8227607 Processes for 4-((1R,35)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine or a salt thereof |
| 07/18/2012 | CN102586384A Biological catalysis method for preparing D-amino acid through deracemizing DL-amino acid |
| 07/18/2012 | CN101671664B Preparation method of immobilized aminoacylase and product and application thereof |
| 07/11/2012 | CN102559834A Method for preparing D-serine and L-serine with DL-serine as raw material |
| 07/11/2012 | CN102559833A Method for preparing (S)-(+)-2,2-dimethyl cyclopropane methanoic acid by biological resolution in ionic liquid cosolvent |
| 07/11/2012 | CN102559570A Engineering bacteria for expressing L-lactate dehydrogenase subjected to orthogenetic evolution and application thereof |
| 07/04/2012 | CN102549151A Amidase and use thereof for producing 3-amino carboxylic acid esters |
| 07/04/2012 | CN102533923A Method using organic solvent cosolvent biological resolution to prepare (S)-(+)-2, 2-dimethyl cyclopropane methanoic acid |
| 07/04/2012 | CN102533922A Method for catalyzing dynamic kinetic resolution of arylamine via racemization catalyst |
| 07/04/2012 | CN102533921A Method and bacterial strains for preparing (S)-epichlorohydrin through microbial transformation |
| 06/27/2012 | EP1553170B1 Novel carbonyl reductase, gene thereof and method of using the same |
| 06/27/2012 | CN101709323B Method for producing R-mandelic acid with biocatalysis and separating and coupling method |
| 06/26/2012 | US8206914 Evolving new molecular function |
| 06/21/2012 | US20120156721 Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity |
| 06/20/2012 | EP2465929A1 R-HNL random variants and their use for preparing optically pure, sterically hindered cyanohydrins |
| 06/13/2012 | EP2004838B1 Process for the preparation of steroid derivatives by reduction of oxosteroid compounds or by oxidation of hydroxysteroid compounds using a hydroxysteroid dehydrogenase |
| 06/13/2012 | CN101985609B Pseudomonas and method for performing microbial transformation on pregabalin intermediate by using same |
| 06/13/2012 | CN101870984B RSP_2728 esterase mutant genes obtained by directed evolution and application of esterase in methyl mandelate resolution reaction |
| 06/13/2012 | CN101250546B Lipase gene as well as engineering bacterium and lipase strain |
| 06/12/2012 | US8198069 Method of producing an optically enriched tertiary alcohol from an epoxide using halohydrin dehalogenase |
| 06/07/2012 | US20120142939 Process for the preparation of fosinopril and intermediates thereof |
| 06/06/2012 | EP2460885A1 Method for producing optically active 3-substituted glutaric acid monoamide |
| 06/06/2012 | CN1993472B Method for enantioselectively opening 3-substituted oxetan-2-ones under the action of lipases of candida antarctica or burkholderia plantarrii |
| 06/05/2012 | CA2505552C Stereoselective process for the production of dioxolane nucleoside analogues |
| 05/31/2012 | US20120135441 Enzymes and methods for resolving amino vinyl cyclopropane carboxylic acid derivatives |
| 05/30/2012 | CN102482649A 立体专一性羰基还原酶 Stereospecific carbonyl reductase |
| 05/30/2012 | CN101967489B Epoxide hydrolase gene, vector and engineering bacteria and application thereof |
| 05/30/2012 | CN101701243B Method for producing R-mandelic acid and derivates thereof by biocatalysis |
| 05/29/2012 | CA2346702C Non-homogeneous systems for the resolution of enantiomeric mixtures |
| 05/23/2012 | EP1119635B1 Non-homogeneous systems for the resolution of enantiomeric mixtures |
| 05/15/2012 | US8178324 Deracemisation of amines |
| 04/26/2012 | US20120100581 Phospholipases, nucleic acids encoding them and methods for making and using them |
| 04/18/2012 | EP2203562B1 Process for the preparation of an enantiomerically and/or diastereomerically enriched ester, thioester, alcohol or thiol |
| 04/18/2012 | EP2087127B1 Process for the enantioselective enzymatic reduction of secodione derivatives via continuous cofactor regeneration |
| 04/18/2012 | CN102417900A 一种atc消旋酶和编码基因及其重组表达蛋白质的应用 One kind atc racemase and recombinant expression of protein coding genes and their applications |
| 04/18/2012 | CN102417889A 红串红球菌及其在微生物催化制备手性芳香醇中的应用 Rhodococcus its applications in microbial catalysis chiral aromatic alcohol |
| 04/18/2012 | CN101886063B 一种具有拆分消旋体苯基缩水甘油酯活性的酯酶及其编码基因与应用 A resolution of racemic glycidyl phenyl esterase activity and its coding gene and application has |
| 04/17/2012 | US8158406 reduction of keto compounds, in particular of 4-halo-3-oxobutyric acid esters, to the corresponding R-alcohols or S-4-halo-3-hydroxybutyric acid esters, respectively, using an R-specific oxidoreductase in the presence of a cofactor such as NAD(P)H |
| 04/11/2012 | CN102409074A 一种光学纯2-氨基-2'-羟基-1,1'-联萘的酶拆分方法 An optically pure 2-amino-2'-hydroxy-1,1'-binaphthyl enzymatic resolution methods |
| 04/11/2012 | CN102408289A 一种应用蛋白质功能化磁性纳米颗粒拆分手性药物的方法 A protein function chiral drug particle method applied magnetic nanoparticles |
| 04/11/2012 | CN102408288A 应用蛋白质功能化磁性纳米颗粒拆分手性药物的方法 Chiral drug particles Application protein functional magnetic nanoparticles |
| 04/10/2012 | US8153416 Process for manufacture of optically active 2-(acyloxymethyl)-1,3-oxathiolanes using enzymatic resolution |
| 04/05/2012 | WO2012043653A1 Novel transaminase showing high activity for glutamic acid, gene encoding same, and method for utilization thereof |
| 04/05/2012 | WO2012043622A1 Novel aminotransferase and gene encoding same, and use of the aminotransferase and the gene |
| 04/05/2012 | WO2012001305A3 Novel method for continuous enzymatic regeneration of nadh and for detection of nad+ and system for implementing same |
| 04/04/2012 | EP1658277B1 Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament |
| 04/03/2012 | US8148128 Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity |
| 03/28/2012 | CN102395671A Mutant blocked in glycerol oxidaion pathway for producing 1,3-propanediol |
| 03/28/2012 | CN102392066A Method for effectively separating raceme and preparing homochiral substance |
| 03/28/2012 | CN102392065A Dynamic kinetic resolution method of 1-(1-naphthyl) ethylamine |
| 03/27/2012 | US8143052 Process for preparing optically active (S or R)-α amino acid and (R or S)-α amino acid ester in one phase organic reaction medium |
| 03/21/2012 | CN102382847A Epoxy hydrolase gene, coded protein and application thereof |
| 03/21/2012 | CN102382780A Microbacterium oxydans and method for preparing chiral bis(trifluoromethyl) phenyl ethanol by using same |
| 03/20/2012 | CA2453510C Treatment of fatigue and cognitive side effects associated with cancer, cancer treatments and menopause with d-threo-methyphenidate |
| 03/15/2012 | US20120064611 Process For The Preparation of (3R)-Hydroxybutyl (3R) -Hydroxybutyrate By Enzymatic Enantioselective Reduction Employing Lactobacillus Brevis Alcohol Dehydrogenase |
| 03/15/2012 | US20120064601 Chromatography Membranes for the Purification of Chiral Compounds |
| 03/14/2012 | EP2428576A1 Oxidoreductases for stereo-selective reduction of keto compounds |
| 03/14/2012 | EP2428575A1 Oxidoreductases for stereo-selective reduction of keto compounds |
| 03/14/2012 | EP2428574A1 Oxidoreductases for stereo-selective reduction of keto compounds |
| 03/14/2012 | EP1966373B1 Polypeptide having esterase activity and recombinant esterase and use thereof |
| 03/14/2012 | CN101693914B Process for preparing (R)-2-methylbutanoic acid and (R)-2-methylbutanoic acid ethyl ester via lipase resolution |
| 03/13/2012 | US8133717 deracemizing D or L amino acid by using a biocatalyzed oxidation (using D or L amino acid oxidase) while preventing decarboxylation of keto acid, and a chemocatalyzed reduction reaction (using supported metal catalyst), take place separately and sequentially; aminobutyric acid/2-/, ketobutyric acid/2-/ |
| 03/08/2012 | WO2012029819A1 Novel hydrolase protein |
| 03/07/2012 | EP2426209A1 Oxidoreductases for stereo-selective reduction of keto compounds |
| 03/07/2012 | CN102367430A Pseudoalteromonas sp.B3 and application thereof to biological oxidation of L-amino acid |
| 03/06/2012 | US8129173 Mixing (1a,3b,5E,7E,20R)-1,3-bis(tert-butyldimethylsiloxy)-20-(3'-cyclopropyl -3'(R,S)-hydroxy-1'-propenyl)-9,10-secopregna-5,7,10(19)-triene with lipase |
| 03/06/2012 | US8129152 Method of producing enantioselective immobilized candida rugosa lipase |
| 03/06/2012 | CA2518714C Enzymatic process for stereo-selective preparation of chemical compounds in hydrofluorocarbon solvents |
| 03/06/2012 | CA2259954C Process for the preparation of (s)- or (r)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid |
| 02/29/2012 | EP2203557B1 Ketoreductase polypeptides and uses thereof |
| 02/29/2012 | CN102102087B Leifsonia xyli and use thereof in preparation of (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol |
| 02/22/2012 | EP2257635B1 Process for the enzymatic deracemization of secondary alcohols |
| 02/21/2012 | CA2682254C 1,3-oxathiolane nucleoside analogues |
| 02/15/2012 | CN101370943B 旋光联苯基丙氨酸化合物或其盐或酯的制备方法 Optically active biphenylalanine compound or preparation of a salt or ester |
| 02/08/2012 | CN102344947A Biological enzyme resolution method for preparing (R)-2-chloro-1-(3-chlorphenyl) ethanol with high optical purity |
| 02/02/2012 | WO2012014953A1 Process for production of optically active succinimide derivative |
| 02/02/2012 | US20120028340 Kinetic resolution of (4s) -- 4- phenyl -- 3- [(5rs)-5-(4-flurophenyl)-5- hydroxypentanoyl] --1,3-oxazolidin-2-one to the (5s) isomer via lipase catalyzed enantioselective esterification of the (5r) isomer |
| 02/01/2012 | CN102341501A Method for stereoselectively and enzymatically reducing keto compounds |
| 02/01/2012 | CN102341494A Transaminase polypeptides |
| 01/31/2012 | US8105806 Process for preparing optically active amino acids using a whole-cell catalyst |
| 01/19/2012 | WO2012007445A1 Mutarotase in crystallization |
| 01/17/2012 | CA2644268C Process for dynamic kinetic resolution (dkr) of racemic compounds in (hydro) fluorocarbon solvents |
| 01/12/2012 | US20120010104 Growth selection method |
| 01/12/2012 | US20120009642 Biomass hydrothermal decomposition system and saccharide-solution production method using biomass material |
| 01/12/2012 | US20120009637 Nitrilases, Nucleic Acids Encoding Them and Methods For Making and Using Them |
| 01/12/2012 | US20120009633 Nitrilases and methods for making and using them |
| 01/11/2012 | EP2403953A1 Method for stereoselectively and enzymatically reducing keto compounds |
| 01/05/2012 | WO2012002450A1 D-succinylase, and method for producing d-amino acid using same |
| 01/05/2012 | WO2012001305A2 Novel method for continuous enzymatic regeneration of nadh and for detection of nad+ and system for implementing same |
| 01/04/2012 | CN101993828B Method for improving transformation efficiency of (S)-phenyl glycol by coupling glucose-6-phosphate dehydrogenase and (S)-carbonyl reductase |