| Patents for C07D 489 - Heterocyclic compounds containing 4ah-8, 9 c- iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: (2,334) |
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| 07/06/1988 | EP0144341B1 NOVEL 4,5$g(a)EPOXYMORPHINAN-6-SPIRO-2'-(4'-CARBOXY,1',3'-THIAZOLIDINE) DERIVATIVES |
| 06/14/1988 | US4751307 Wittig-reaction processes |
| 06/08/1988 | EP0270290A2 Method and compositions for reducing neurotoxic injury |
| 06/07/1988 | US4749706 Orally active nonaddicting analgesics |
| 06/01/1988 | EP0268710A1 Improved process for the preparation of codeine from morphine |
| 04/12/1988 | CA1235121A1 Process for the preparation of vinyl carbamates and novel vinyl carbamates |
| 03/08/1988 | US4730048 Gut-selective opiates |
| 02/23/1988 | US4727146 By catalytic reaction |
| 02/02/1988 | US4722928 N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes |
| 01/27/1988 | EP0254120A2 Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| 01/07/1988 | EP0250796A2 Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| 11/19/1987 | EP0245366A1 Method and composition for blocking antigen-induced allergic responses |
| 11/05/1987 | WO1987005903A3 Orally active nonaddicting analgesics |
| 11/03/1987 | CA1228814A1 Growth regulation and related applications of opioid antagonists |
| 10/28/1987 | EP0242417A1 Morphinane-skeletoned hydrazone derivatives, process for preparing them, pharmaceutical composition and use |
| 10/08/1987 | WO1987005903A2 Orally active nonaddicting analgesics |
| 09/30/1987 | EP0238507A1 Potent, selective opioid receptor agonists and antagonists |
| 08/25/1987 | US4689332 Growth regulation and related applications of opioid antagonists |
| 06/16/1987 | US4673679 Esters, carbonates, carbamates, or sulfonates |
| 05/26/1987 | US4668685 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| 05/19/1987 | US4667037 Dealkylation of opioid ethers |
| 05/07/1987 | WO1987002586A2 Method and composition for blocking antigen-induced allergic responses |
| 03/26/1987 | WO1987001703A1 Potent, selective opioid receptor agonists and antagonists |
| 03/10/1987 | CA1218990A1 4,5.alpha.EPOXYMORPHINAN-6-SPIRO-2'-(4'-CARBOXY,1',3'- THIAZOLIDINE) DERIVATIVES |
| 01/27/1987 | US4639520 Peroxy acid |
| 10/28/1986 | US4619936 Orally administering nalorphine or a salt thereof |
| 10/07/1986 | CA1212323A1 Method for improving gastrointestinal motility |
| 09/30/1986 | CA1212108A1 Process for the preparation of oripavine derivative |
| 09/23/1986 | US4613668 Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
| 08/26/1986 | US4608376 Opiate agonists and antagonists |
| 07/29/1986 | CA1208626A1 Process for the preparation of hydrochlorides |
| 02/05/1986 | EP0170090A1 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes |
| 01/22/1986 | EP0168686A1 Process for N-demethylating morphinane alkaloids |
| 12/24/1985 | CA1198423A1 Synthesis of derivatives of codeine and other 3-0- alkylmorphines |
| 12/11/1985 | EP0164290A1 Process for the dealkylation of alcaloids and intermediates |
| 11/12/1985 | CA1196633A1 N-(2-methoxyethyl)noroxymorphone, the acid addition salts thereof, pharmaceutical compositions containing them and processes for the preparation thereof |
| 10/30/1985 | EP0159823A1 Preparation of 14-Hydroxy-N-Ethoxy-Carbonyl-Norcodeinone |
| 10/16/1985 | EP0158476A1 Preparation of noroxymorphone from morphine |
| 09/25/1985 | EP0155424A1 A total synthesis of morphinan compounds by cyclization of cycloalkylcarbonyl compounds |
| 09/24/1985 | US4543256 (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers |
| 08/13/1985 | US4535157 Reacting naloxone and naltrexone with potassium e-butoxide |
| 05/08/1985 | EP0140367A2 Improved process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| 04/17/1985 | EP0137600A1 Pharmaceutically active salts of morphine |
| 04/02/1985 | US4508715 Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs |
| 03/14/1985 | WO1985000970A1 Pharmaceutical compositions having appetite reducing activity and a process for their preparation |
| 02/26/1985 | CA1183134A1 Preparation of chiral 1-benzyl-1,2,3,4- tetrahydroisoquinolines by optical resolution |
| 01/29/1985 | US4496570 Narcotic, antagonist, antidepressant |
| 11/21/1984 | EP0125542A1 Process for preparing hydrochlorides |
| 10/23/1984 | US4478840 Appetite suppressing compositions and methods |
| 10/16/1984 | US4477457 Method for inducing anorexia using nalmetrene |
| 09/27/1984 | WO1984003627A1 NOVEL 4,5alphaEPOXYMORPHINAN-6-SPIRO-2'-(4'-CARBOXY,1',3'-THIAZOLIDINE) DERIVATIVES |
| 09/25/1984 | US4473573 N-(2-methoxyethyl)-noroxymorphone and pharmaceutical compositions for relieving pain containing same |
| 09/18/1984 | US4472253 Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
| 08/29/1984 | EP0116538A1 Method of treating pruritis and composition therefor |
| 08/07/1984 | CA1172251A1 17-CYCLOPROPYLMETHYL-3-HYDROXY-14-METHOXY-7.alpha.- METHYLMORPHINAN-6-ONE |
| 06/12/1984 | CA1169058A1 Short total synthesis of dihydrothebainone, dihydrocodeinone and nordihydrocodeinone |
| 05/29/1984 | US4451470 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans |
| 05/09/1984 | EP0107855A1 Method for inducing anorexia |
| 04/18/1984 | EP0105361A1 Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs |
| 04/17/1984 | US4443605 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans |
| 04/04/1984 | EP0104984A2 Vinylcarbamic acid esters and their preparation |
| 04/03/1984 | US4440932 Narcotic analgesics |
| 04/03/1984 | US4440931 7β-Arylalkyl-3-methoxy or 3-hydroxy-4,5α-epoxy-6β-hydroxy-7α-hydroxymethyl-17-methyl or 17-cycloalkylmethylmorphinans |
| 03/15/1984 | WO1984000889A1 Method of treating pruritis and composition therefor |
| 01/18/1984 | EP0098583A2 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans |
| 01/12/1984 | EP0079383A4 Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution. |
| 12/21/1983 | EP0096279A1 N-(2-methoxyethyl)-noroxymorphone, its acid addition salts, medicines containing it and process for its preparation |
| 10/27/1983 | WO1983003541A1 Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs |
| 10/18/1983 | US4410700 Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution |
| 09/29/1983 | WO1983003197A1 Method for controlling gastrointestinal dysmotility |
| 07/19/1983 | CA1150251A1 17-SUBSTITUTED-6-DESOXY-7,8-DIHYDRO-6.alpha.- METHYLNOROXYMORPHONE NARCOTIC ANTAGONISTS |
| 06/28/1983 | US4390699 6-Keto-morphinans belonging to the 14-hydroxy-series |
| 05/25/1983 | EP0079383A1 Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution |
| 04/27/1983 | EP0077521A1 Opiate agonists and antagonists |
| 03/22/1983 | CA1143376A1 Fluorination process and fluoro analogs of hydrocodone and oxycodone |
| 01/25/1983 | US4370333 Nonhabit-forming |
| 01/11/1983 | US4368326 Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone |
| 01/05/1983 | EP0068384A1 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one |
| 12/21/1982 | CA1137974A1 Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled conjugates |
| 12/07/1982 | US4362870 Selective opioid receptor alkylating agents |
| 11/25/1982 | WO1982004049A1 Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution |
| 11/16/1982 | CA1135691A1 7 AND 7-8 SUBSTITUTED 4,5.alpha. EPOXYMORPHINAN- 6-ONE COMPOUNDS |
| 11/02/1982 | CA1134764A1 Producing codeine from papaver cell cultures |
| 08/31/1982 | US4347361 Analgesics, narcotic antagonists |
| 06/16/1982 | EP0053788A1 4,5-Alpha-epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds |
| 06/08/1982 | US4334071 17-Cyclobutylmethyl-3-hydroxy-8β-methyl-6-methylene-morphinane methanesulfonate |
| 03/30/1982 | US4322426 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
| 01/21/1982 | WO1982000144A1 A short total synthesis of dihydrothebainone,dihydrocodeinone,and nordihydrocodeinone |
| 01/13/1982 | EP0043706A2 A short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydrocodeinone |
| 11/11/1981 | EP0039444A1 7,7-Ditosyloxymethyl-4,5 alpha-epoxy-morphinan-6-ols and their use as intermediates in the production of epoxymorphinan derivatives |
| 11/04/1981 | EP0039066A2 17-Substituted 6-desoxy-7,8-dihydro-6-alpha-methylnoroxymorphone narcotic antagonists |
| 09/01/1981 | CA1108132A1 Process for producing oxymorphone |
| 08/04/1981 | CA1106369A1 8.beta.-ETHYL-AND 8.beta.-METHYL-4,5.alpha.-EPOXYMORPHINAN-6- ONE COMPOUNDS |
| 07/07/1981 | US4277604 Codeinone and neopinone |
| 06/23/1981 | US4275205 Analgesics, narcotic antagonists |
| 06/09/1981 | US4272541 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them |
| 06/09/1981 | CA1102789A1 Immunological determination |
| 05/26/1981 | US4269843 Nonhabit-forming; antagonist, antagonism |
| 02/19/1981 | WO1981000409A1 Intermediate compounds for preparation of morphine derivatives |
| 02/11/1981 | EP0023576A1 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them |