| Patents for C12P 35 - Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin (1,082) |
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| 02/01/2000 | US6020151 Process for the production of 7-ADCA via expandase activity on penicillin G |
| 01/25/2000 | US6017726 Efficient process for producing 7-aminodeacetyl-cephalosoporanic acid by culturing penicillium chrysogenum with adipic acid, salt or ester to produce adipoyl-6-aminopenicillanic acid, then enzymatically altering molecule |
| 01/12/2000 | EP0970236A2 Fermentative production of valuable compounds on an industrial scale using chemically defined media |
| 01/05/2000 | EP0969088A1 ENZYMATIC PROCESS FOR THE PREPARATION OF CEPHALOSPORANIC 7$b(g)-(4-CARBOXYBUTANAMIDE) ACID BY MEANS OF THE MODIFIED ENZYME D-AMINOACID OXIDASE OF $i(TRIGONOPSIS VARIABILIS) PRODUCED IN $i(ESCHERICHIA COLI) |
| 01/05/2000 | CN1240485A Process for the production of pencillin G or V, cepholsporin G or V, and derivatives thereof |
| 12/16/1999 | DE19823332A1 Verfahren zur enzymatischen Herstellung von Betalactam-Antibiotika A process for the enzymatic preparation of beta-lactam antibiotics |
| 12/14/1999 | CA2058216C Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives |
| 12/08/1999 | EP0961825A1 Mutant penicillin g acylases |
| 12/08/1999 | CN1047202C Process for preparing protein encoded by cephalosporin acetylhydrolase gene |
| 12/01/1999 | EP0960945A2 Enzymatic process for producing beta-lactam antibiotics involving product recovery at pH 1 in the presence of immobilized penicillin amidase |
| 11/25/1999 | WO1999060102A2 Improved in vivo production of cephalosporins |
| 11/04/1999 | WO1999055881A1 Cephalosporin deacetylase, gene coding for it, and preparation method of deacetylated cephalosporin compounds using it |
| 10/28/1999 | WO1999054476A1 Penicillin conversion |
| 10/20/1999 | EP0771357B1 PROCESS FOR PREPARATION OF $g(b)-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS |
| 10/07/1999 | WO1999050271A1 Novel process for the fermentative production of cephalosporin |
| 09/29/1999 | EP0944729A1 Process for the production of penicillin g or v, cephalosporin g or v, and derivatives thereof |
| 09/29/1999 | CN1045297C Method for acylation of 7-amino group of cephalosporanic ring |
| 09/08/1999 | CN1227872A Process for preparing enzyme encoded by cephalosporin acetylthydrolase gene |
| 09/08/1999 | CN1045008C Process for production of cephalosporin C using Acremonium chrysogenum |
| 09/07/1999 | CA2026041C Deacetoxycephalosporin c hydroxylase |
| 08/31/1999 | US5945414 Process for the preparation of new intermediates useful in the synthesis of cephalosporins |
| 08/24/1999 | US5942411 Process of producing B-lactam antibiotics applying microorganisms with increased ligase activity |
| 08/17/1999 | US5939299 Enzymatic production of cefaclor from cephalexin |
| 08/17/1999 | CA2021299C Enzymatic oxidation of ceph c to glutaryl-7-amino cephalosporanic acid |
| 08/05/1999 | WO1999038982A1 Nucleic acid molecule encoding a cephalosporin acetylesterase |
| 08/04/1999 | EP0932685A2 Isopenicillin n synthetase and deacetoxycephalosporin c synthetase enzymes and method |
| 07/28/1999 | CN1224471A Method for preparing beta-lactam antibiotic |
| 07/28/1999 | CN1224470A Improved process for fermentative production of cephalosporin |
| 07/28/1999 | CN1224469A Process for fermentative production of deacylated cephaloporins |
| 07/28/1999 | CN1224468A Process for fermentative production of deacylated cephalosporins |
| 07/15/1999 | WO1999034774A1 Topical application of enzymes using a peelable film |
| 07/13/1999 | US5922907 A chemical intermediate phenylglycyl hydroxyethyl ester or 4-phenylglycyl hydroxyethyl ester |
| 07/08/1999 | WO1999033994A1 Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure |
| 07/08/1999 | CA2316401A1 Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure |
| 07/06/1999 | US5919680 Process for the production of SSC's via expandase activity on penicillin G |
| 07/06/1999 | US5919648 One step conversion of cephalosporin c or derivative into 7-aminocephalosporanic acid or derivative using aminohydrolase from psuedomonas vesicularis b965; for cephalothin, cephaloridine, and cefuroxime synthesis |
| 07/01/1999 | WO1999032113A1 Application of enzyme prodrugs as anti-infective agents |
| 07/01/1999 | CA2315201A1 Application of enzyme prodrugs as anti-infective agents |
| 06/24/1999 | WO1999031109A1 COMPLEXES OF ss-LACTAM ANTIBIOTICS AND 1-NAPHTHOL |
| 06/15/1999 | CA2100987C A transformant capable of producing d-amino acid oxidase |
| 06/10/1999 | WO1999013058A3 Esterase free enzymes |
| 06/09/1999 | EP0920527A1 SYNTHESIS OF beta-LACTAM ANTIBACTERIALS USING SOLUBLE SIDE CHAIN ESTERS AND ENZYME ACYLASE |
| 06/09/1999 | CN1219200A Promoters of genes glutamate deshydrogenase, beta-N-acetylhexosaminidase and gamma actine, and their use in systems of expression, secretion and anti-sens in filamentary fungi |
| 06/02/1999 | EP0918879A1 A METHOD FOR PREPARING A $g(b)-LACTAM ANTIBIOTIC |
| 06/02/1999 | EP0918878A1 Improved process for the fermentative production of cephalosporin |
| 05/19/1999 | EP0915988A1 Process for the fermentative production of deacylated cephalosporins |
| 05/12/1999 | EP0914463A2 NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM) |
| 05/06/1999 | EP0912754A1 Process for the fermentative production of deacylated cephalosporins |
| 04/29/1999 | WO1999020786A1 PROCESS FOR THE PREPARATION OF A β-LACTAM ANTIBIOTIC |
| 04/20/1999 | CA1340504C Y-glutamyltranspeptidase, its preparation and its use |
| 04/06/1999 | US5891703 Mutated penicillin G acylase genes |
| 04/01/1999 | WO1999015632A1 ENZYMATIC PROCESS FOR THE PREPARATION OF CEPHALOSPORANIC 7$b(g)-(4-CARBOXYBUTANAMIDE) ACID BY MEANS OF THE MODIFIED ENZYME D-AMINOACID OXIDASE OF TRIGONOPSIS VARIABILIS PRODUCED IN $i(ESCHERICHIA COLI) |
| 04/01/1999 | WO1999015532A1 PROCESS FOR RECOVERY OF A β-LACTAM ANTIBIOTIC |
| 04/01/1999 | WO1999015531A1 PROCEDE FOR RECOVERY OF A β-LACTAM ANTIBIOTIC |
| 04/01/1999 | CA2272354A1 Enzymatic process for the preparation of cephalosporanic 7.beta.-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of trigonopsis variabilis produced in escherichia coli |
| 03/18/1999 | WO1999013098A1 Improvements in or relating to the preparation of lactam compounds |
| 03/18/1999 | WO1999013058A2 Esterase free enzymes |
| 03/18/1999 | CA2302443A1 Improvements in or relating to the preparation of lactam compounds |
| 03/17/1999 | CN1042535C Improved process for isolation of cefaclor after enzymatic acylation |
| 03/16/1999 | US5882879 Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase |
| 03/11/1999 | WO1998047594A3 Use of aerogels as adsorption agents |
| 02/23/1999 | US5874572 Process for preparing cyclosporin A |
| 02/23/1999 | US5874571 Acidification of a homogeneous basic mixture of cephalexin and 7-aminodesacetoxy cephalosporanic acid to a ph of lower than 7.8; crystallization and isolation; purification; simplification |
| 02/10/1999 | CN1207742A Process for preparation of antibiotic |
| 01/19/1999 | US5861141 Pharmaceutical formulations of cefaclor |
| 01/14/1999 | WO1999001566A1 PREPARATION OF ENZYME WITH REDUCED β-LACTAMASE ACTIVITY |
| 01/14/1999 | WO1999001561A1 IMPROVED PROCESS FOR THE PRODUCTION OF β-LACTAMS |
| 01/14/1999 | WO1998037179A3 Fermentative production of valuable compounds on an industrial scale using chemically defined media |
| 12/29/1998 | US5854054 Rathayibacter biopuresis produces cephalosporin haloperoxidase |
| 12/17/1998 | WO1998056945A1 PROCESS FOR ENZYMATICALLY PREPARING A β-LACTAM ANTIBIOTIC AND THIS ANTIBIOTIC |
| 12/17/1998 | WO1998056944A1 APPLICATION OF REDUCING SULPHUR COMPOUNDS DURING ENZYMATIC PREPARATION OF β-LACTAM COMPOUNDS |
| 11/24/1998 | CA2077921C Bioprocess for preparing 7-adca |
| 11/12/1998 | DE19719395A1 Adsorption from gas or liquid phase using aerogel adsorbents |
| 10/29/1998 | WO1998048038A1 A METHOD FOR PREPARING A β-LACTAM ANTIBIOTIC |
| 10/29/1998 | WO1998048037A1 A METHOD FOR CONTROLLING THE SOLUBILITY OF A β-LACTAM NUCLEUS |
| 10/29/1998 | WO1998048036A1 Improved process for the fermentative production of cephalosporin |
| 10/29/1998 | WO1998048035A1 Process for the fermentative production of deacylated cephalosporins |
| 10/29/1998 | WO1998048034A1 Process for the fermentative production of deacylated cephalosporins |
| 10/29/1998 | WO1998047594A2 Use of aerogels as adsorption agents |
| 10/29/1998 | CA2289280A1 Use of aerogels as adsorption agents |
| 10/14/1998 | EP0869962A1 Process for the recovery of a beta-lactam antibiotic |
| 10/14/1998 | EP0869961A1 Process for the recovery of cephalexin |
| 09/23/1998 | EP0865443A1 Process for the preparation of an antibiotic |
| 09/16/1998 | EP0863989A2 Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g |
| 09/11/1998 | WO1998039459A1 PROMOTERS OF THE GENES GLUTAMATE DESHYDROGENASE, β-N-ACETYLHEXOSAMINIDASE AND $b(g)-ACTINE, AND THEIR USE IN SYSTEMS OF EXPRESSION, SECRETION AND ANTI-SENS IN FILAMENTARY FUNGI |
| 09/11/1998 | CA2253250A1 Promoters of the genes glutamate deshydrogenase, .beta.-n-acetylhexosaminidase and $b(g)-actine, and their use in systems of expression, secretion and anti-sens in filamentary fungi |
| 09/08/1998 | US5804429 Mutants; expression vector; transformed cell; culture product |
| 09/01/1998 | US5801048 Process for producing 7B-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme |
| 09/01/1998 | US5801011 Process for preparing cephalosporins with penicillin acylase without pH control |
| 08/27/1998 | WO1998037179A2 Fermentative production of valuable compounds on an industrial scale using chemically defined media |
| 08/18/1998 | US5795733 Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA |
| 08/13/1998 | WO1998016648A3 Isopenicillin n synthetase and deacetoxycephalosporin c synthetase enzymes and methods |
| 08/12/1998 | CN1190440A Process for production of 7-ADCA via expandase activity on penicillin G |
| 08/05/1998 | EP0856516A1 Novel bioprocess for preparing 7-aca and 7-adac |
| 07/08/1998 | EP0458932B1 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase |
| 06/30/1998 | US5773272 D-amino acid oxidase of F. solani and methods for its recombinant production |
| 06/25/1998 | WO1998027221A1 Process for the production of penicillin g or v, cephalosporin g or v, and derivatives thereof |
| 06/10/1998 | EP0846695A1 Process for the preparation of new intermediates useful in the synthesis of cephalosporins |
| 06/10/1998 | CN1184479A Substrates for beta-lactamase and uses thereof |
| 05/20/1998 | EP0843015A1 PROCESS FOR PRODUCING THE ENZYME D-AMINOACIDO OXYDASE OF $i(RHODOTORULA GRACILIS) IN HOST CELLS |