| Patents for C12P 35 - Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin (1,082) |
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| 03/20/2002 | EP1188838A1 Method for producing 7-aminodesacetoxycephalosporanic acid (7-adca) |
| 03/14/2002 | WO2002020819A2 AN ENZYMATIC PROCESS FOR PREPARING β-LACTAM COMPOUNDS |
| 03/13/2002 | EP1186668A1 An enzymatic process for preparing Beta-lactam compounds |
| 03/13/2002 | EP1185683A1 Method for delaying the deactivation of glutaryl amidase during an enzyme catalysis |
| 03/07/2002 | WO2002018618A2 PROCESS FOR THE PREPARATION OF A β-LACTAM NUCLEUS AND THE APPLICATION THEREOF |
| 03/06/2002 | EP0726958B1 A new cephalosporin c acylase |
| 02/19/2002 | CA2032963C Process for producing 7-aminocephem compound or salts thereof |
| 02/13/2002 | EP1178991A1 A process for the preparation of beta-lactam derivatives |
| 01/23/2002 | CN1332247A Expression vector containing coding expansion enzyme DNA and host cell for its transformation |
| 01/17/2002 | US20020006642 Method for preparing a beta-lactam antibiotic |
| 01/16/2002 | CN1331751A Improved i(in vivo) prodn. of cephalosporins |
| 01/10/2002 | DE10029671A1 Biotransformation von biologisch aktiven Verindungen aus verschiedenen chemischen Stoffklassen mittels der Enzyme Laccase und Manganperoxidase Biotransformation of biologically active Verindungen from different classes of chemical substances by means of enzymes laccase and manganese peroxidase |
| 01/09/2002 | EP1170369A1 Extracellular protease from acremonium chrysogenum with cpc-acetyl hydrolase activity and its utilization in the synthesis of deacetylated derivatives of cephalosporin c and inactivation of the gene for increasing production of cephalosporin |
| 01/08/2002 | US6337190 Culture of bacillus and mutant amino acid aminotransferase |
| 01/03/2002 | WO2001066767A3 Direct production of desacetylcephalosporin c |
| 12/27/2001 | WO2001098518A2 Biotransformation of biologically active compounds made of various classes of chemical substances by means of laccase and manganese peroxidase enzymes |
| 12/27/2001 | CA2413554A1 Biotransformation of biologically active compounds made of various classes of chemical substances by means of laccase and manganese peroxidase enzymes |
| 11/21/2001 | EP0828850B1 Process for the production of 7-adca via expandase activity on penicillin g |
| 11/20/2001 | US6319684 Libraries and primers, annealing, target sequences and amplification |
| 11/15/2001 | WO2001085951A1 A modified expandase and uses thereof |
| 11/08/2001 | WO2001032904A3 Method for enhancing secretion of beta-lactam compounds |
| 10/24/2001 | EP0801686B1 Process for preparing cyclosporin a |
| 10/10/2001 | EP1141372A2 Improved in vivo production of cephalosporins |
| 10/09/2001 | US6300095 A dna fragment used for blocking genetic expression through antisense constructs and for increased antibiotic production |
| 10/02/2001 | US6297032 Expressing enzyme associated with the degradation of preferential antibiotic; transform and culture cells, recover preferential protein |
| 09/18/2001 | US6291162 Determining amount of lactamase activity; transfecting cells with a nucleic acid having an expression control sequence linked to a secretion defective sequence; mixing cells with lactamase substrate; determine amount of cleaved substrate |
| 09/13/2001 | WO2001066767A2 Direct production of desacetylcephalosporin c |
| 09/13/2001 | CA2402223A1 Direct production of desacetylcephalosporin c |
| 09/11/2001 | US6287799 Preparation of antibiotic by enzymatic acylation of beta-lactam nucleus with acylation agent at molar ratio less than 2.5; at least one of the reactants is present at superaturated concentration at one part of reaction |
| 08/22/2001 | EP0869961B1 Process for the recovery of cephalexin |
| 07/05/2001 | US20010006795 Penicillin conversion |
| 07/05/2001 | US20010006675 Forming a formulation comprising protease enzyme and polyvinyl alcohol film forming agent, topically applying the formulation, incubating to form a film incorporating enzyme, removing the film incorporating the enzyme from the site |
| 06/27/2001 | CN1301303A Improved i(in vivo) production of cephalosporins |
| 06/06/2001 | CN1066731C Substrates for beta-lactamase and uses thereof |
| 05/30/2001 | CN1066488C Bioprocess for preparing 7-ADCA |
| 05/29/2001 | CA2086250C Process for preparation of beta-lactams |
| 05/23/2001 | CN1296078A Recombination nucleic acid molecule and application thereof |
| 05/16/2001 | CN1295575A Novel process for fermentative production of cephalosporin |
| 05/10/2001 | WO2001032904A2 Method for enhancing secretion of beta-lactam compounds |
| 05/02/2001 | CN1065278C Method for preparation of 7-amino cephaloalkyl acid by one step and two enzyme method |
| 04/26/2001 | WO2001029073A1 Methods for improving secondary metabolite production in fungi |
| 04/26/2001 | CA2388427A1 Methods for improving secondary metabolite production in fungi |
| 04/17/2001 | US6218138 Reacting amino-beta-lactam component and corresponding amino-group containing acylating side chain component in presence of biocatalystto form antibiotic, solubilizing by adding acid which deactivates enzyme; enzyme is reusedenzyme |
| 04/04/2001 | EP0817785B1 Substrates for beta-lactamase and uses thereof |
| 04/04/2001 | CN1064079C Transforment capable of producing D-amino acid oxidase |
| 03/28/2001 | EP1086690A2 Pharmaceutical formulations of cefaclor |
| 03/28/2001 | EP1086689A2 Pharmaceutical formulations of cefaclor |
| 03/21/2001 | CN1063491C Improved process for preparing cephalosporins |
| 03/07/2001 | CN1062903C New cephalosporin C acylase |
| 02/28/2001 | EP1078069A2 Improved in vivo production of cephalosporins |
| 02/28/2001 | CN1285745A Application of enzyme products as anti-infective agents |
| 02/21/2001 | CN1284997A Modified deacetoxycephalosporin C synthase (DAOCS) and x-ray structure |
| 02/13/2001 | US6187574 Process for producing the enzyme D-amino acid oxidase of Rhodotorula gracilis in host cells |
| 01/31/2001 | CN1282377A Process for preparation of beta-lactam antibiotic |
| 01/30/2001 | US6180361 Recombinant DNA expression vectors and DNA compounds that encode deacetoxycephalosporin C synthetase and deacetylcephalosporin C synthetase |
| 01/30/2001 | US6180360 Process of producing β-lactam antibiotics applying micro-organisms with increased ligase activity |
| 01/10/2001 | EP1066294A1 Novel process for the fermentative production of cephalosporin |
| 01/10/2001 | CN1279685A Process for recovery of beta-lactam antibiotic |
| 01/10/2001 | CN1279684A Process for recovery of beta-lactam antibiotic |
| 12/28/2000 | WO2000078989A1 Method for producing 7-aminodesacetoxycephalosporanic acid (7-adca) |
| 12/12/2000 | US6159706 Application of enzyme prodrugs as anti-infective agents |
| 12/07/2000 | WO2000073490A1 Method for delaying the deactivation of glutaryl amidase during an enzyme catalysis |
| 12/05/2000 | US6156534 Producing antibiotic cefprozil, cefadroxil or amoxicillin by reacting penicillin or cephalosporin derivitive with 4-hydroxy-d-phenylglycyl ester in presence of penicillin g amidase |
| 11/30/2000 | WO2000071547A1 A PROCESS FOR THE PREPARATION OF β-LACTAM DERIVATIVES |
| 11/30/2000 | DE19924632A1 Verfahren zur Verzögerung der Desaktivierung von Glutarylamidase während einer Enzymkatalyse Method of delaying the deactivation of glutaryl amidase during enzyme catalysis |
| 11/30/2000 | CA2374686A1 A process for the preparation of .beta.-lactam derivatives |
| 11/21/2000 | CA2051090C Cephalosporin c acylase |
| 11/15/2000 | EP1051501A1 Nucleic acid molecule encoding a cephalosporin acetylesterase |
| 11/09/2000 | WO2000066751A1 Expression cassette for efficient production of a protein |
| 11/02/2000 | EP1047785A1 Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure |
| 10/19/2000 | WO2000061767A1 Extracellular protease from $i(acremonium chrysogenum) with cpc-acetyl hydrolase activity and its utilization in the synthesis of deacetylated derivatives of cephalosporin c and inactivation of the gene for increasing production of cephalosporin |
| 10/11/2000 | EP1041983A1 Application of enzyme prodrugs as anti-infective agents |
| 10/11/2000 | CN1269838A Improvement in or relating to preparation of lactam compounds |
| 10/11/2000 | CN1269830A Esterase free enzymes |
| 09/26/2000 | CA2268710C Improved enzymatic oxidation of ceph c to glutaryl-7-amino cephalosporanic acid |
| 09/14/2000 | WO2000037671A3 Improved in vivo production of cephalosporins |
| 08/08/2000 | US6100393 Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes |
| 08/08/2000 | US6100363 Polyurethane based energy absorbing elastomers useful for coating large objects filling a void between two substrates, and where moisture resistance is an important consideration |
| 08/02/2000 | EP1023454A1 Process for the preparation of a (beta)-lactam antibiotic |
| 07/12/2000 | EP1017699A1 PROCESS FOR RECOVERY OF A $g(b)-LACTAM ANTIBIOTIC |
| 07/12/2000 | EP1017698A1 PROCESS FOR RECOVERY OF A (beta)-LACTAM ANTIBIOTIC |
| 06/29/2000 | WO2000037671A2 Improved in vivo production of cephalosporins |
| 06/21/2000 | EP1009849A1 Improvements in or relating to the preparation of lactam compounds |
| 06/14/2000 | CN1256645A Use of aerogels as adsorption agents |
| 06/14/2000 | CN1256625A Topical application of enzymes using peelable film |
| 06/14/2000 | CN1053447C Enzymatic acylation of 3-hydroxymethyl cephalosporins |
| 06/06/2000 | US6071713 Bioprocesses for preparing 7-ACA and 7-ADAC |
| 06/06/2000 | US6071712 Hydrolyzing the 7-position acyl ester of certain cephalosporin compounds to the corresponding alcohol using esterase or lipase in ph range of 3.5 to 8.0 |
| 05/23/2000 | US6066468 Isolated dna segment or restriction fragment having a nucleotide sequence endogenous to streptomyces clavuligerus atcc 27064; for synthesis of penicillin and cephalosporin antibiotics |
| 05/03/2000 | EP0997199A1 Method for separation of solid compounds in suspension |
| 04/12/2000 | EP0991752A2 Esterase free enzymes |
| 04/11/2000 | US6048708 Process for preparation of β-lactams at constantly high concentration of reactants |
| 03/22/2000 | CN1248294A Fermentative production of valuable compounds on industrial scale using chemically defined media |
| 03/07/2000 | US6033823 Mutated penicillin G acylase genes |
| 03/01/2000 | EP0982398A1 Substrates for beta-lactamase and uses thereof |
| 03/01/2000 | CN1246147A Enzymatic process for preparation of cephalosporanic 7 beta-(4-carboxybutanamide) acid by means of modified enzyme D-aminoacid oxidase of trigonopsis variabilis produced in escherichia coli |
| 02/03/2000 | WO1999060102A3 Improved in vivo production of cephalosporins |
| 02/02/2000 | EP0975405A2 Use of aerogels as adsorption agents |
| 02/02/2000 | EP0975326A1 Topical application of enzymes using a peelable film |
| 02/02/2000 | EP0775210B1 Mutated penicillin g acylase genes |