| Patents for C12P 35 - Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin (1,082) |
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| 01/14/2004 | EP1379531A2 Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
| 01/06/2004 | CA2080573C Novel bioprocesses for preparing 7-aca and 7-adac |
| 01/01/2004 | US20040002133 Novel compounds |
| 12/17/2003 | EP0458932B2 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase |
| 11/18/2003 | US6649369 Process for delaying the deactivation of glutaryl amidase during enzyme catalysis |
| 11/12/2003 | CN1127571C Permentative production of valuable compounds on industrial scale using chemically defined media |
| 11/05/2003 | EP1185683B1 Method for delaying the deactivation of glutaryl amidase during an enzyme catalysis |
| 11/04/2003 | US6642020 Process for preparing cephalosporin derivatives |
| 10/21/2003 | US6635458 Enzymatic process for the preparation of cephalosporanic 7$B(G)-(4-Carboxybutanamide) acid by means of the modified enzyme D-aminoacid oxidase of trigonopsis variabilis produced in escherichia coli |
| 10/15/2003 | EP1352968A1 Esterase free enzymes |
| 10/15/2003 | CN1449450A Process for the preparation of a beta-lactam nucleus and the application thereof |
| 10/15/2003 | CN1448506A Mutation penicillin ring enlargement enzyme and process preparing 7-ADCA using same |
| 10/09/2003 | US20030190695 Mutated penicillin expandase and process for preparing 7-ADCA using the same |
| 10/08/2003 | CN1446908A Method of using saltative ring enlargement enzyme to prepare 7-amino-desacetoxy cephalosporin acid |
| 10/02/2003 | US20030186354 Mutated penicillin expandase and process for preparing 7- ADCA using the same |
| 10/01/2003 | EP1348759A1 Mutated penicillin expandase and process for preparing 7-ADCA using the same |
| 09/25/2003 | US20030180893 Biotransformation of biologically active compounds made of various classes of chemical substance by means of laccase and manganese peroxidase enzymes |
| 09/25/2003 | US20030180834 Novel compounds |
| 09/18/2003 | WO2003076640A2 A process for the preparation of cephalosporan acid derivatives from cephalosporin c |
| 09/17/2003 | EP1344830A1 A process for the preparation of cephalosporan acid derivatives from cephalosporin C |
| 08/07/2003 | WO2003064613A2 Amidases, nucleic acids encoding them and methods for making and using them |
| 08/07/2003 | CA2474567A1 Amidases, nucleic acids encoding them and methods for making and using them |
| 07/31/2003 | WO2003062430A1 Fermentation of pentose sugars |
| 07/31/2003 | US20030143715 Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203 |
| 07/31/2003 | CA2474033A1 Fermentation of pentose sugars |
| 07/24/2003 | US20030139595 Novel process for the fermentative production of cephalosporin |
| 07/09/2003 | EP0975326B1 Topical application of enzymes using a peelable film |
| 07/02/2003 | EP1322751A2 Glutaryl cephalosporin amidase from pseudomonas diminuta bs-203 |
| 06/26/2003 | US20030119087 Enzymatic process for the preparation of cephalosporanic 7$b(g)-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of trigonopsis variabilis produced in escherichia coli |
| 06/26/2003 | US20030119085 Substrates for beta-lactamase and uses thereof |
| 06/18/2003 | EP1319087A2 PROCESS FOR THE PREPARATION OF A $g(b)-LACTAM NUCLEUS AND THE APPLICATION THEREOF |
| 06/05/2003 | US20030104515 "Process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives" |
| 05/30/2003 | WO2002072806A3 Variant glutaryl amidase (cephalosporin acylase) and uses thereof |
| 05/08/2003 | US20030088058 Isopenicillin n synthetase and deacetoxycephalosporin c synthetase enzymes and methods |
| 05/06/2003 | US6558921 Promoters of the genes glutamate deshydrogenase, β-N-acetylhexosaminidase and γ-actin and their use in filamentous fungi expression, secretion and antisense systems |
| 04/30/2003 | CN1107070C Process for preparation of antibiotic |
| 04/23/2003 | EP1303631A2 Biotransformation of biologically active compounds made of various classes of chemical substances by means of laccase and manganese peroxidase enzymes |
| 04/22/2003 | US6552185 Acidifying and/or contacting with carbon dioxide followed by adsorption chromatography |
| 04/17/2003 | US20030073156 Enzymatically converting a 3-thiolated cephalosporin C compound to form a 3-thiolated -glutaryl-7-amino cephalosporanic acid compound; enzymatically converting to form 3-thiolated-7-amino cephalosporanic acid compound |
| 03/26/2003 | CN1103814C Process for the efficient production of 7-ADCA via 2-(carboxyethylthio) acetyl-7-ADCA and 3-(carboxymethylthio) propionyl-7-ADCA |
| 03/19/2003 | EP1178991B1 A process for the preparation of beta-lactam derivatives |
| 03/19/2003 | EP1023454B1 Process for the preparation of a (beta)-lactam antibiotic |
| 03/19/2003 | EP0865443B1 Process for the preparation of an antibiotic |
| 03/19/2003 | EP0711348B1 Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca |
| 03/06/2003 | US20030044884 Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase |
| 03/05/2003 | EP0920527A4 SYNTHESIS OF beta-LACTAM ANTIBACTERIALS USING SOLUBLE SIDE CHAIN ESTERS AND ENZYME ACYLASE |
| 03/04/2003 | US6528300 Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203 |
| 02/12/2003 | CN1101395C Process for recovery of cephalexin |
| 02/11/2003 | US6518039 Such as 7-ADCA (3-methyl-4-carboxy-7-amino-3-cephem), via production of the 7-acylated counterparts |
| 02/06/2003 | WO2002085914A3 ENZYMATIC PROCESS FOR PREPARING CEPHALOSPORANIC ACID DERIVATIVES USING α-KETOACID DERIVATIVES |
| 02/06/2003 | WO2002024879A3 Glutaryl cephalosporin amidase from pseudomonas diminuta bs-203 |
| 01/29/2003 | EP0915988B1 Process for the fermentative production of deacylated cephalosporins |
| 01/09/2003 | WO2002086143A3 Enzymatic process for preparing cephalosporin derivatives |
| 01/07/2003 | US6503727 Process for the preparation of an antibiotic |
| 01/02/2003 | US20030004336 Solvent extraction; antibiotic |
| 12/19/2002 | US20020192766 Esterase free enzymes |
| 12/11/2002 | EP1263969A2 Direct production of deacetylcephalosporin c |
| 12/11/2002 | CN1095875C Process for preparation of beta-lactams at constantly high concentration of reactants |
| 10/31/2002 | WO2002086143A2 Enzymatic process for preparing cephalosporin derivatives |
| 10/31/2002 | WO2002085914A2 ENZYMATIC PROCESS FOR PREPARING CEPHALOSPORANIC ACID DERIVATIVES USING α-KETOACID DERIVATIVES |
| 10/31/2002 | WO2002085913A1 Penicillin and cephalosporin compound |
| 10/31/2002 | US20020160500 Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203 |
| 10/30/2002 | EP1066294B1 Novel process for the fermentative production of cephalosporin |
| 10/29/2002 | US6472205 Expression control sequences adapted for function in eukaryotic cell, operably linked to sequence coding cytosolic beta-lactamase; screening by contacting host cell with membrane permeable, fluorescent substrate of beta-lactamase |
| 10/24/2002 | WO2002020819A3 AN ENZYMATIC PROCESS FOR PREPARING β-LACTAM COMPOUNDS |
| 10/24/2002 | US20020155566 Process for delaying the deactivation of glutaryl amidase during enzyme catalysis |
| 10/15/2002 | US6465233 Genetic engineering using bacillus; deacetylation of cephalosporins |
| 10/15/2002 | US6465227 Spherical particles containing microorganism cells having enzyme activity |
| 10/02/2002 | CN1371999A Double gene coexpression plasmid, construction method and application thereof |
| 10/01/2002 | US6458558 Process for the preparation of β-lactam derivatives |
| 09/19/2002 | WO2002072806A2 Variant glutaryl amidase (cephalosporin acylase) and uses thereof |
| 09/19/2002 | DE10112608A1 New non-naturally occurring variant of glutaryl amidase comprising histidine or glutamate in its substrate binding pocket, binds cephalosporin C (CPC) as substrate and catalyzes conversion of CPC to 7-aminocephalosporanic acid |
| 09/12/2002 | US20020128250 Modulating the expression of a gene |
| 09/11/2002 | EP1237914A1 Methods for improving secondary metabolite production in fungi |
| 07/31/2002 | EP1226266A2 Method for enhancing secretion of beta-lactam compounds |
| 07/17/2002 | CN1087780C Process for the efficient production of 7-ADCA VIA 3-(carboxyethylthio) propionyl-7-ADCA |
| 07/10/2002 | CN1087350C Process for enzymatic synthesis of beta-lactam antibiotics in pressence of enzyme inhibitor |
| 07/09/2002 | CA2040707C Cephalosporin acetylhydrolase gene and protein encoded by said gene |
| 07/03/2002 | CN1357051A Method for producing T-aminodesacetoxycephalosporanic acid (7-ADCA) |
| 06/26/2002 | EP0578761B1 Enzymatic process for the production of cefonicid |
| 06/25/2002 | US6410259 Fermenting microbial strains |
| 06/20/2002 | WO2001098518A3 Biotransformation of biologically active compounds made of various classes of chemical substances by means of laccase and manganese peroxidase enzymes |
| 06/11/2002 | US6403356 Mutant penicillin G acylases |
| 05/30/2002 | WO2002018618A3 PROCESS FOR THE PREPARATION OF A β-LACTAM NUCLEUS AND THE APPLICATION THEREOF |
| 05/29/2002 | CN1351605A Process for the preparation of beta-lactam derivatives |
| 05/28/2002 | US6395507 Process for delaying the deactivation of glutaryl amidase during catalysis with a thiol |
| 05/21/2002 | CA2215310C Substrates for beta-lactamase and uses thereof |
| 05/15/2002 | CN1084791C Process for production of 7-ADCA via expandase activity on penicillin G |
| 05/15/2002 | CN1084750C Process for producing cefazolin |
| 05/07/2002 | US6383773 To cephalosporins; using expandase enzyme |
| 05/07/2002 | US6383772 Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent |
| 04/25/2002 | US20020048781 Direct production of desacetylcephalosporin C |
| 04/09/2002 | US6368820 Process for the preparation of cephalosporins using acremonium chrysogenum |
| 04/09/2002 | US6368595 Forming a formulation comprising protease enzyme and polyvinyl alcohol film forming agent, topically applying the formulation, incubating to form a film incorporating enzyme, removing the film incorporating the enzyme from the site |
| 04/04/2002 | US20020039758 Fermentative production of valuable compounds on an industrial scale using chemically defined media |
| 03/28/2002 | WO2002024879A2 Glutaryl cephalosporin amidase from pseudomonas diminuta bs-203 |
| 03/28/2002 | WO2002024865A2 Modulation of secondary metabolite production by zinc binuclear cluster proteins |
| 03/28/2002 | US20020037547 Process for the fermentative production of deacylated cephalosporins |
| 03/28/2002 | CA2423161A1 Glutaryl cephalosporin amidase from pseudomonas diminuta bs-203 |
| 03/28/2002 | CA2422730A1 Modulation of secondary metabolite production by zinc binuclear cluster proteins |