Patents
Patents for C07D 453 - Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids (5,704)
02/2003
02/05/2003CN1100535C Pharmaceutical agents for treatment of emesis
02/04/2003US6514977 For treating p38 kinase mediated disorders
01/2003
01/30/2003WO2003007949A1 Bridged piperidine derivatives as melanocortin receptor agonists
01/29/2003EP1278758A1 Combretastatin a-1 phosphate and combretastatin b-1 phosphate prodrugs
01/29/2003EP1278735A1 2,4-di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents
01/23/2003WO2003006371A1 N,n-dinitramide salts as solubilizing agents for biologically active agents
01/23/2003WO2003006019A1 Medicinal composition for treatment of interstitial cystitis
01/23/2003CA2453179A1 N,n-dinitramide salts as solubilizing agents for biologically active agents
01/22/2003CN1099419C Azebicyclic compound
01/16/2003WO2003004493A1 Novel compounds, their preparation and use
01/16/2003US20030013876 Process for the synthesis of gonadotropin releasing hormone antagonists
01/16/2003CA2448913A1 Sulfone containing bicyclic aromatic ring compounds, their preparation and use as nicotinic acetyl-chloine receptors
01/15/2003EP0820451B1 Novel heterocyclic compounds
01/09/2003US20030008867 Compounds
01/08/2003EP1272182A2 Use of sabcomeline in the treatment of anxiety
01/08/2003CN1390216A Polymorphsof crystalline (2-benzhycrryl-1-azabicyclo [2,2,2] oct-3-YC)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as NK-1 receptor antagonists
01/03/2003WO2003000682A1 (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds
01/03/2003WO2002040058A3 Hydroxyapatite-targeting poly(ethylene glycol) and related polymers
01/03/2003CA2450555A1 (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds
01/02/2003US20030004208 Squalene synthetase inhibitors; antilipemic agents, anticholesterol agents
01/02/2003EP1268470A1 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof
01/02/2003EP1268051A2 Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form
12/2002
12/31/2002US6500840 Central nervous system disorders
12/27/2002WO2002102766A2 Combretastatin a-3 prodrug
12/27/2002CA2418102A1 Combretastatin a-3 prodrug
12/24/2002CA2131019C Nitrosation process
12/19/2002WO2002100858A2 Quinuclidine-substituted heteroaromatic compounds as ligands at nicotinic acetylcholine receptors
12/19/2002US20020193405 For prophylaxis and therapy of diseases, such as cell proliferation or apoptosis mediated diseases
12/19/2002CA2445471A1 Quinuclidine-substituted heteroaromatic compounds as ligands at nicotic acetylcholine receptors
12/11/2002CN1384100A Benzo-1,3-dioxole and benzofuran substituted pentazane derivative
12/10/2002US6492516 Pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
12/10/2002US6492386 Treating a disease or condition in a mammal, wherein the alpha 7 nicotinic-acetylcholine receptor is implicated
12/10/2002US6492385 Quinuclidine-substituted heteroaryl moieties for treatment of disease
12/10/2002US6492355 Adamantane derivatives
12/05/2002WO2002096855A2 Anticholinergic compounds and methods of use
12/05/2002WO2002064124A3 Medicament formulation containing a muscarinic agonist
12/05/2002CA2443346A1 Anticholinergic compounds and methods of use
12/03/2002US6489477 Nmda nr2b antagonists. accordingly, another aspect of the invention is the treatment of pain, migraine, depression, anxiety, schizophrenia, parkinson's disease, or stroke--maladies that are amenable to amelioration through
11/2002
11/28/2002WO2002094790A1 Fused heterocyclic compound and medicinal use thereof
11/27/2002EP1259512A1 Pteridine compounds for the treatment of psoriasis
11/27/2002EP1259508A1 Novel biarylcarboxamides
11/26/2002US6486172 Quinuclidine-substituted aryl compounds for treatment of disease
11/21/2002WO2002022598A8 Quinolinone derivatives as tyrosine kinase inhibitors
11/21/2002US20020173507 Antiproliferative agents; apoptosis; anticancer agents
11/21/2002US20020173494 Ammonium salts of inositol hexaphosphate, and uses thereof
11/20/2002EP0892780B1 M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS
11/20/2002EP0699199B1 Heteroatom substituted alkyl benzylaminoquinuclidines as substance p antagonists
11/19/2002US6482834 Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
11/14/2002US20020169208 Oxybutynin analogs; antichloinergic agents; side effect reduction; short half-life; water-soluble metabolites; incontinence; mydriatic and bronchodilator agents; respiratory system disorders; antiperspirants
11/13/2002EP1256573A1 Process for producing stereoisomer of pyrrolidine derivative
11/13/2002EP1256568A1 Intermediates for the preparation of enantiomerically pure cyclopentane and cyclopentene beta amino acids
11/12/2002US6479510 N-((2s,3r)-2-methyl-1-azabicyclo(2.2.2)oct-3-yl)-4-(4-hydroxyp henoxy)- benzamide for example; treating diseases of the alpha-7-nicotinic acetylcholine receptor i.e. schizophrenia, or psychosis
11/12/2002US6479480 1h-indole derivatives bearing an optionally substituted phenyl moiety at the 2-position of the indole ring system and a methylene-linked heterocyclic moiety at the 3-position of the indole ring system; schizophrenia treatment
11/07/2002WO2002088114A2 Heteroaryl ofefinic azacyclic and heteroaryl acetylenic azacyclic compounds for the treatment of cns disorders
11/07/2002US20020165393 Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids
11/07/2002US20020165251 Such as 1-phenylsulfonyl-4-piperazinylindole hydrochloride for treatment or prophylaxis of disease mediated by serotonin related receptor, obesity, and/or central nervous system disorder
11/06/2002EP1254123A1 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
11/06/2002EP1254115A2 Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
11/06/2002EP0788473B1 Novel high enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene-beta-amino acids
10/2002
10/31/2002WO2002085901A1 Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists)
10/31/2002WO2002085848A2 Synthesis of pancratistatin prodrugs
10/31/2002WO2002053564A3 Quinuclidine derivatives and their use as m3 antagonists
10/31/2002US20020161252 Zinc complex with a chiral ligand, such as diethylzinc((S,S)-N-N'-ethylene-bis-(1-phenylethylamine))
10/31/2002CA2444471A1 Synthesis of pancratistatin prodrugs
10/31/2002CA2439960A1 Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor antagonists)
10/30/2002EP0799221B1 Quinazolines as inhibitors of endothelin converting enzyme
10/30/2002CN1377349A Quiunclidine compounds and drugs containing the same as the active ingredient
10/24/2002WO2002083670A1 Novel phase transfer catalyst and method for producing alpha-amino acid using the same
10/24/2002US20020156095 Treatment of depression, anxiety, psychosis, obesity, pain, Parkinson's disease, Alzheimer's disease, neurodegenerative diseases, movement disorders, respiratory diseases, inflammatory diseases, neuropathy, immune disorders, etc.
10/22/2002US6468998 Pyrrolidine compounds and medicinal utilization thereof
10/17/2002WO2002081420A1 Cyclooctanone derivative and cyclodecanone derivative, and use thereof
10/17/2002US20020151744 Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids
10/16/2002EP1248617A1 2-aza-bicyclo 2.2.2]octane nmda/nr2b antagonists
10/16/2002EP0934316B1 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
10/15/2002US6465513 Multicyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
10/15/2002US6465449 Heteroaromatic bicyclic derivatives useful as anticancer agents
10/15/2002US6465437 Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
10/09/2002CN1373760A Quinuclidine derivs. as muscarinic M3 receptors ligand and their use
10/03/2002WO2002076981A1 Isoquinuclidine derivative, process for producing the same, and medicinal composition containing the same
10/03/2002WO2002076975A1 Chemical derivatives and their use as anti-telomerase agent
10/03/2002WO2002076973A1 N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient
10/03/2002WO2001023385A9 Novel tropane analogs
10/03/2002WO2000034265A3 Quinoline-indole antimicrobial agents
10/03/2002US20020143185 Nitrosation process
10/03/2002CA2442012A1 Chemical derivatives and their use as anti-telomerase agent
10/03/2002CA2441838A1 Isoquinuclidine derivatives, method of manufacturing the same and therapeutic agents containing these compounds
10/02/2002CN1091768C Novel benzo-1,3-dioxolyl-and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
10/01/2002US6458985 Use of compressed CO2 in chemical reactions
10/01/2002US6458948 Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt
10/01/2002CA2245857C 1,4-dihydropyridine compounds as bradykinin antagonists
10/01/2002CA2241845C 4,5-dihydronaphth¬1,2-c|isoxazoles and derivatives thereof having cns activity
10/01/2002CA2228370C Piperazino derivatives as neurokinin antagonists
10/01/2002CA2089769C Heterocyclic compounds and their preparation and use
09/2002
09/26/2002WO2002024692A8 1-azabicyclo[2.2.2]octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors
09/26/2002WO2002018334B1 Sodium channel modulators
09/26/2002US20020137741 Use as topical antibiotics
09/25/2002EP1243589A1 Heteroaryl-substituted pyrrole derivates, their preparation and their therapeutic uses
09/25/2002EP1242396A1 New p2x 7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases
09/25/2002EP0986390B1 Pharmaceutical compositions containing cinchonine dichlorhydrate
09/25/2002EP0918521B1 Formulation for the treatment and/or prophylaxis of dementia
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