Patents
Patents for C07D 295 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms (34,005)
03/1999
03/23/1999US5886024 Thiophene-containing butonic acid derivatives as matrix metalloprotease inhibitors
03/23/1999US5885999 Treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia
03/23/1999US5885990 Fibrinolysis promoting action; thrombolysis action
03/23/1999US5885985 Antiinflammatory agents
03/23/1999US5885984 Blockade of ion channels and the treatment of arrhythmias.
03/23/1999CA2092794C Naphthylalkylamines, process for their preparation and pharmaceutical compositions that contain them
03/18/1999WO1999012889A1 Quaternary ammonium phosphate compound and method of preparing the same
03/18/1999WO1999012877A1 Enantioselective reduction of ketones with a silane agent/metal compound/chiral ligand system
03/18/1999CA2298533A1 Reduction enantioselective de cetones avec un systeme agent silanique/compose metallique/ligand chiral
03/17/1999EP0902014A1 Process for producing aryl carbamates
03/17/1999EP0901469A1 Arylalkylpiperazine compounds as antioxidants
03/16/1999US5883257 N-piperidinyl- and N-tetrahydropyridinyl-2-anthracenecarboxamides: dopamine receptor subtype specific ligands
03/16/1999US5883096 Di-n-substituted piperazine derivatives; alzheimer*s disease, cognition activators; synergistic mixtures with acetylcholinesterase inhibitors
03/16/1999US5883092 Pyrimidine derivatives as endothelin antagonists
03/16/1999CA2158108C Compositions containing sertraline and a 5-ht1d receptor agonist or antagonist
03/16/1999CA2146906C Reductive amination catalysts
03/11/1999WO1999011608A1 Malonic acid based matrix metalloproteinase inhibitors
03/11/1999WO1999011606A2 Inhibitors of protein tyrosine phosphatase
03/11/1999WO1999011258A1 Lymphocyte function antigen-1 antagonists
03/11/1999WO1998056771A3 Piperazine derivatives and their use as anti-inflammatory agents
03/11/1999CA2302037A1 Malonic acid based matrix metalloproteinase inhibitors
03/11/1999CA2298601A1 Inhibitors of protein tyrosine phosphatase
03/10/1999EP0900190A1 Novel acetals of hydroxy carboxylic acids, derivatives thereof and process for the preparation thereof
03/09/1999US5880151 Treating or preventing disease characterized by high levels of low density lipoprotein particles or cholesterol in blood
03/09/1999US5880147 Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use
03/09/1999US5880120 Treating depression by administering an antidepressant
03/09/1999US5879681 Compounds and compositions for delivering active agents
03/04/1999WO1999010316A1 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both
03/04/1999WO1999010313A1 N-aroylphenylalanine derivatives
03/04/1999WO1999010312A1 N-alkanoylphenylalanine derivatives
03/04/1999CA2301559A1 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both
03/04/1999CA2300121A1 N-alkanoylphenylalanine derivatives
03/03/1999EP0899268A2 Process for the preparation of omeprazole and intermediate compounds
03/03/1999EP0898567A1 Novel n-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
03/03/1999CN1209803A Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method therefor
03/03/1999CN1209754A Perfluoroalkyl-containing metal complexes, its preparing method and use in NMR diagnostics
03/02/1999US5877342 Skin disorders; respiratory system disorders; cardiovascular disorders
03/02/1999US5877317 Heterocyclic compounds for the treatment of CNS and cardiovascular disorders
03/02/1999US5877315 Dimeric N-Alkyl ammonium acetonitrile bleach activators
03/02/1999US5877219 Non-steroidal ligands for the estrogen receptor
03/02/1999US5877203 Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
03/02/1999US5876710 Drug delivery; using a brominated benzamide compound
03/02/1999CA2117250C Alkoxyphenylalkylamine derivatives
02/1999
02/25/1999WO1999009015A1 2-{3-[4-(2-t-butyl-6- trifluoromethylpyridin-4-yl) piperazin-1-yl] propylmercapto} pyrimidin-4-ol-fumarate
02/25/1999WO1999009002A1 Phenol derivatives
02/25/1999WO1999009000A2 Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
02/25/1999DE19837386A1 New CCR-3 antagonist piperazine derivatives and analogues
02/25/1999CA2301297A1 2-{3-[4-(2-t-butyl-6- trifluoromethylpyridin-4-yl) piperazin-1-yl] propylmercapto} pyrimidin-4-ol-fumarate
02/25/1999CA2301038A1 Novel inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
02/24/1999EP0897382A1 Alkoxy acetic acid derivatives
02/24/1999EP0800541B1 Siloxane-containing networks
02/24/1999CN1209124A Novel compounds with analgesic effect
02/23/1999US5874616 Preparation of bis (fluoroalkylenesulfonyl) imides and (fluoroalkysulfony) (fluorosulfonyl) imides
02/23/1999US5874530 Cyclic depsipeptide sulfonylation, sulfenylation and phosphorylation process
02/23/1999US5874473 Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
02/23/1999US5874434 10,11-methanodibenzosuberane derivatives
02/18/1999WO1999007689A1 Aniline derivatives as calcium channel blockers
02/18/1999WO1999007672A1 Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
02/18/1999WO1999007668A1 Non-steroidal ligands for the estrogen receptor
02/18/1999WO1999007666A1 Amine derivatives and process for producing the same
02/18/1999WO1999007377A1 1-[4-(substituted alkoxy)benzyl]naphthalene compounds having estrogen inhibitory activity
02/18/1999DE19735410A1 New stable fumarate salt of pyrimidinol derivative dopamine D3 receptor ligand, having improved solubility and suitable for oral administration
02/18/1999CA2300273A1 Amine derivatives and method for producing the same
02/18/1999CA2298651A1 1-¬4-(substituted alkoxy)benzyl|naphthalene compounds having estrogen inhibitory activity
02/18/1999CA2245043A1 Ccr-3 receptor antagonists
02/17/1999EP0896590A1 Rapid purification by polymer supported quench
02/17/1999EP0896533A2 Pentafluorobenzenesulfonamides and analogs
02/17/1999CN1208409A Novel benzoyl guanidine derivatives process for their preparation and their use in the preparation of medicines
02/16/1999US5872256 Cyclobutenedione derivative, process for preparing the same, and nonlinear optical element
02/16/1999US5872138 Thrombin inhibitors
02/16/1999US5872125 Polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it
02/16/1999US5872119 2-Naphthamide derivatives and their therapeutic applications
02/16/1999US5872118 Relaxation of skeletal muscle in spastic, hypertonic and hyperkinetic conditions
02/16/1999US5872117 Treating cerebrovascular dementia, senile dementia, alzheimer's dementia, sequelae of ischemic encephalopathy and cerebral apoplexy
02/16/1999US5872115 Compounds for treatment of hypercholesterolemia, ischemic heart disease, cerebrovascular disease or atherosclerosis
02/11/1999WO1999006384A1 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
02/11/1999WO1999006383A1 Piperazine derivatives active on the lower urinary tract
02/11/1999WO1999006381A1 A crystalline dibenzothiazepine derivative and its use as an antipsychotic agent
02/11/1999WO1999006351A1 Process for converting propargylic amine-n-oxides to enaminones
02/11/1999WO1999006340A2 Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors
02/11/1999CA2298617A1 Acyclic metalloprotease inhibitors
02/11/1999CA2298595A1 Process for converting propargylic amine-n-oxides to enaminones
02/11/1999CA2297095A1 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
02/10/1999EP0895993A1 Process for the preparation of N-aryl-N'aklyl-piperazines
02/10/1999EP0895989A1 1-[4-(Substituted alkoxy)benzyl] naphthalene compounds having estrogen inhibitory activity
02/10/1999EP0895988A1 Arylsulfonylamino hydroxamic acid derivatives
02/10/1999CN1207734A Metalloproteinase inhibitors, pharmaceutical compositions contg. them and their pharmaceutical uses, and methods and intermediates useful for their preparation
02/10/1999CN1042029C 1,4-di(phenylalkyl) piperizine deriv. and pharmaceutical composition contg. same
02/09/1999US5869661 Condensing a 6-fluoroquinolonecarboxylic acid with a saturated heterocyclic amine with or without a solvent
02/09/1999US5869655 Diamine compounds, methods of making same, method of use of same and intermediates
02/09/1999US5869484 Treating diseases derived by acetylcholine deficiency; alzheimer*s disease
02/04/1999WO1999005134A1 Substituted 1,2,3,4-tetrahydronaphthalene derivatives
02/04/1999WO1999005133A1 Benzamide cycloalkyl stimulating high and low gastrointestinal motricity
02/04/1999WO1999005096A2 Urokinase inhibitors
02/04/1999WO1999005095A1 Aminocycloalkane compounds
02/04/1999WO1999005093A1 Isocyanoalkyl carbonic acid derivatives, their conversion into secondary amidoalkyl carbonic acid derivatives by isocyanide-multicomponent reactions, as well as these secondary amidoalkyl carbonic acid derivatives.
02/04/1999WO1999005091A1 Novel compound having effect of promoting neuron differentiation
02/04/1999WO1999004796A1 Fibrinogen receptor antagonists
02/04/1999WO1999004794A1 Cyclic amine modulators of chemokine receptor activity
02/04/1999WO1999004778A1 Pharmaceutical compounds