Patents for C40B 40 - Libraries per se, e.g. arrays, mixtures (17,361)
10/1995
10/11/1995EP0675963A1 Method and apparatus for enzymatic synthesis of oligonucleotides
10/11/1995EP0675953A1 Soluble peptides having constrained, secondary conformation in solution and method of making same
10/11/1995EP0675760A1 Method and apparatus for creating biopolymer arrays on a solid support surface
10/03/1995US5455008 Apparatus for robotically performing sanger dideoxynucleotide DNA sequencing reactions using controlled pipet
09/1995
09/27/1995EP0593460B1 Method and apparatus for biopolymer synthesis
09/26/1995US5453487 Solid phase peptide synthesizer
09/26/1995US5453247 Instrument and method for the sequencing of genome
09/21/1995WO1995025116A1 Method and apparatus for performing multiple sequential reactions on a matrix
09/21/1995CA2184589A1 Method and apparatus for performing multiple sequential reactions on a matrix
09/20/1995EP0672751A1 Gene macromolecule reaction method and apparatus therefor
09/20/1995EP0672142A1 Multivalent and multispecific binding proteins, their manufacture and use
09/20/1995EP0672049A1 Support for the synthesis of modular polymers
09/19/1995US5451683 Spatially-addressable immobilization of anti-ligands on surfaces
09/14/1995WO1995024476A1 Method of cloning
09/13/1995EP0670905A1 Recombinant viruses displaying a nonviral polypeptide on their external surface
09/12/1995US5449754 Generation of combinatorial libraries
09/05/1995US5447692 Automatic chemical reactors and reservoirs for controlling delivery and bubbling
08/1995
08/31/1995WO1995018814A3 Polymer-supported solution synthesis of oligosaccharides
08/30/1995EP0668932A1 Positional sequencing by hybridization
08/29/1995US5445934 Selective photoremovable groups on surface
08/24/1995WO1995022625A1 Dna mutagenesis by random fragmentation and reassembly
08/17/1995WO1995022056A1 Highly specific surfaces for biological reactions, method of preparation and utilization
08/17/1995WO1995021939A1 Method for ordering macromolecules by means of a moving meniscus, and uses thereof
08/17/1995WO1995021914A1 Method for preparing a multicombinatorial library of antibody gene expression vectors
08/17/1995WO1995021850A1 Generation and screening of synthetic drug libraries
08/10/1995WO1995021265A1 Methods for discovering ligands
08/10/1995WO1995021263A1 Heterologous dimeric proteins produced in heterokaryons
08/10/1995WO1995021126A1 Preparation of hydrogen cyanide
08/08/1995US5439650 Reaction vessel
08/03/1995WO1995020601A1 Reagents binding vinculin, dynein, and glutathione s-transferase from peptide libraries
08/03/1995WO1995020401A1 Polyclonal antibody libraries
08/02/1995EP0665293A2 Method of determining base sequence of nucleic acid
08/01/1995US5437979 Immobilizing on support located inside the tip of a pipette; automated; programmable; time reduction; uniformity
07/1995
07/26/1995EP0663953A1 Phagemids coexpressing a surface receptor and a surface heterologous protein
07/26/1995EP0663856A1 Apparatus and method for multiple simultaneous synthesis
07/25/1995US5436143 Genetic engineering; one vessel; enzyme deactivation
07/13/1995WO1995018814A2 Polymer-supported solution synthesis of oligosaccharides
07/13/1995CA2180979A1 Polymer-supported solution synthesis of oligosaccharides
07/11/1995US5432018 Peptide library and screening systems
07/04/1995US5429807 Method and apparatus for creating biopolymer arrays on a solid support surface
06/1995
06/29/1995WO1995017509A1 Bacteria used to produce stable fusion proteins and method for their identification
06/27/1995US5427946 For in vitro fertilization of an egg; nesting chamber, channels of sperm migration
06/27/1995US5427908 Transforming cell with filamentous bacteriophage expression vector, culturing for expression and assembly of particle with antibody Fab fragment on coat, selecting encoding particle by binding to specific ligand, removing nonbinding particles
06/22/1995WO1995016918A1 Combinatorial libraries and methods for their use
06/21/1995EP0658566A1 Process of polynucleotide preparation on a solid support and apparatus allowing it to be carried out
06/15/1995WO1995016027A1 Method of selecting specific bacteriophages
06/15/1995CA2178205A1 Method of selecting specific bacteriophages
06/14/1995EP0656941A1 Methods for producing members of specific binding pairs
06/13/1995US5424186 Very large scale immobilized polymer synthesis
06/08/1995WO1995015393A1 Novel expression screening vector
06/08/1995WO1995015388A1 Recombinant binding proteins and peptides
06/08/1995WO1995011912A3 Biopolymer synthesis utilizing surface activated, organic polymers
06/08/1995CA2177988A1 Expression vector for preparing an anti-body-variable-region library
06/08/1995CA2177367A1 Recombinant binding proteins and peptides
05/1995
05/31/1995EP0655135A1 Random generation and bio-specific selection of chemical compounds
05/30/1995US5419874 Synthesis reaction column
05/24/1995EP0653965A1 Fluid delivery system uitlizing multiple port valve.
05/11/1995WO1995012808A1 Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics
05/11/1995WO1995012608A1 Synthesizing and screening molecular diversity
05/11/1995CA2175587A1 Synthesizing and screening molecular diversity
05/10/1995EP0651762A1 Method and apparatus for the rapid synthesis of substrate-bound or free peptides or oligonucleotides, flat material synthesized in this way and the use of such material
05/09/1995US5413762 Device for the purification of synthetic oligonucleotides
05/04/1995WO1995011995A1 Arrays of nucleic acid probes on biological chips
05/04/1995WO1995011912A2 Biopolymer synthesis utilizing surface activated, organic polymers
05/04/1995WO1995011755A1 Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
05/04/1995WO1995011748A1 Method and apparatus for creating biopolymer arrays on a solid support surface
05/03/1995EP0650393A1 Synthesis reaction column.
05/02/1995US5412087 Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
04/1995
04/27/1995WO1995011262A1 Apparatus and method for polymer synthesis using arrays
04/26/1995EP0649341A1 On-line process flow and reaction monitor.
04/19/1995EP0648221A1 Trityl monitor for automated polynucleotide synthesis
04/11/1995US5405783 Removing photoremovable protective group from region of substrate, contacting with protected amino acid, repeating to form peptide
04/11/1995US5405585 Designed for handling different type of fluids in flow system and reduces chemical reagent cross contamination; used for nuclic acid and other biosynthesis; automatic
04/05/1995EP0646176A1 Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria
04/04/1995US5403484 Viruses expressing chimeric binding proteins
03/1995
03/29/1995EP0644792A1 System for solid phase reactions
03/16/1995WO1994026886A3 Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable
03/09/1995DE4328637A1 Process for the synthesis and selection of sequences of covalently linked building blocks
03/07/1995US5395750 Constructing a plurality of synthetic genes, expressing proteins encoded by genes in a microorganism and contacting proteins with antigen to obtain antibody binding to the antigen
03/07/1995US5395594 Simultaneous multiple chemical synthesizer
02/1995
02/23/1995WO1995005454A1 Engineered bacteriophages and vaccines containing them
02/23/1995DE4328332A1 Method of synthesising and selecting sequences of covalently bonded building blocks
02/22/1995EP0639223A1 Microfabricated sperm handling devices.
02/22/1995EP0463036B1 Immobilized oligonucleotide probes and uses therefor
02/16/1995WO1995004834A1 Method of manufacturing a matrix for the detection of mismatches
02/16/1995WO1995004833A1 Method of immobilizing water-soluble bio-organic compounds on a capillary-porous carrier
02/16/1995WO1995001559A3 Sample holder and its use
02/15/1995EP0638173A1 Optical and electrical methods and apparatus for molecule detection
02/15/1995EP0637999A1 Polynucleotide amplification analysis using a microfabricated device
02/15/1995EP0637998A1 Fluid handling in microfabricated analytical devices.
02/15/1995EP0637997A1 Analysis based on flow restriction
02/15/1995EP0637996A1 Microfabricated detection structures.
02/08/1995EP0637344A1 Electrochemical treatment of surfaces
02/01/1995EP0636413A2 Nucleic acid amplification reaction apparatus and method
01/1995
01/31/1995US5386022 Primes and probes for the amplification and detection of aids associated nucleic acids
01/26/1995WO1995002566A1 Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
01/26/1995CA2167391A1 Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
01/24/1995US5384261 Channel blocking on rotating stage, treatment with light
01/19/1995WO1995002049A1 Purification method and apparatus
01/19/1995CA2166772A1 Purification method and apparatus