| Patents for C07D 501 - Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (7,574) |
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| 10/24/2002 | WO2002083634A2 Process for the preparation of cefpodoxime acid |
| 10/24/2002 | US20020156272 Producing ceftriaxone or cefotaxime by amidation, cyclization, desilylation and optionally salt formation |
| 10/24/2002 | US20020155094 Method of treating sepsis and ARDS using chemokine beta-9 |
| 10/22/2002 | US6468995 Cephem compounds |
| 10/22/2002 | CA2227264C Amine acid salt compounds and process for the production thereof |
| 10/16/2002 | EP0827961B1 Process for the preparation of beta-lactam compounds |
| 10/16/2002 | CN1092663C Novel cephalosporin derivatives and processes for producing the same |
| 10/16/2002 | CN1092662C Cephalosporin synthesis |
| 10/10/2002 | US20020146390 Therapy of sepsis and adult respiratory distress syndrome using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent |
| 10/03/2002 | US20020141972 Administering protein and antiinflection agent |
| 10/02/2002 | CN1372554A Method for storing quaternary ammonium salt |
| 10/01/2002 | US6458950 Compounds and pharmaceutical compositions containing the same |
| 10/01/2002 | US6458949 New route to ceftiofur using novel intermediates |
| 10/01/2002 | US6458948 Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt |
| 10/01/2002 | US6458558 Process for the preparation of β-lactam derivatives |
| 09/25/2002 | CN1371381A Improved amorphous form of cefpodoxime proxetil |
| 09/25/2002 | CN1371380A Process for preparation of cephem compounds |
| 09/19/2002 | DE10112608A1 New non-naturally occurring variant of glutaryl amidase comprising histidine or glutamate in its substrate binding pocket, binds cephalosporin C (CPC) as substrate and catalyzes conversion of CPC to 7-aminocephalosporanic acid |
| 09/12/2002 | WO2002070017A1 Siderophore antibiotic conjugates with tetra- or hexadentate iron chelators on the basis of amino acids or peptides, method for producing them and the use thereof |
| 09/12/2002 | WO2002070016A2 Catecholate beta-lactam conjugates, method for producing the same and the use thereof |
| 09/12/2002 | US20020128469 Beta-lactam production |
| 09/12/2002 | CA2439574A1 Catecholate beta-lactam conjugates, method for producing the same and the use thereof |
| 09/11/2002 | CN1090635C Cephalosporin crystals and process for producing same |
| 09/10/2002 | US6448393 Deprotecting carboxylic acid group, dehalogenating and sulfiding with heteroaryl-thio substituted compound producing 3-thiomethylcephem compounds; chemical intermediates to antibiotics, such as cefazolin and ceftriaxone |
| 09/10/2002 | CA2087967C Cephalosporins and homologues, preparations and pharmaceutical compositions |
| 09/06/2002 | WO2002068678A2 Beta-lactamase substrates having phenolic ethers |
| 09/06/2002 | WO2002068429A1 Process for the preparation of cefpodoxime proxetil |
| 09/06/2002 | WO2002068428A1 Method of preparing cephalosporins using 4-hydroxyphenylglycine derivatives |
| 09/06/2002 | WO2002067943A1 Oral pharmaceutical composition of cefpodoxime proxetil |
| 09/06/2002 | CA2434679A1 Beta-lactamase substrates having phenolic ethers |
| 09/05/2002 | DE10111163A1 Neue Siderophor-Antibiotikakonjugate mit 4- oder 6-zähnigen Eisenchelatoren auf der Basis von Aminosäuren oder Peptiden, Verfahren zu ihrer Herstellung und Ihre Anwendung New siderophore Antibiotikakonjugate with 4- or 6-dentate iron chelators on the basis of amino acids or peptides, process for their preparation and their use |
| 09/05/2002 | DE10111160A1 Neue Catecholat-ß-Laktamkonjugate, Verfahren zu ihrer Herstellung und ihre Anwendung New cathecolate ß-Laktamkonjugate, processes for their preparation and their use |
| 09/04/2002 | CN1367683A Non-crystalline cefuroxime axetil solid dispersant, process for preparing same and composition for oral administration thereof |
| 08/29/2002 | US20020120136 Method of preparing cephalosporins using 4-hydroxyphenylglycine derivatives |
| 08/28/2002 | CN1366527A Process for preparation of 3-vinylcephem compound |
| 08/27/2002 | US6441162 Crystalline substance of cefditoren pivoxyl and the production of the same |
| 08/27/2002 | US6440957 Cephalosporines having cyclic aminoguanidine substituents as antibiotics |
| 08/22/2002 | US20020115852 7-(((5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluormethoxyimino) -acetyl)amino)-3(E)-((imino-1-piperazinylmethyl)-methylhydrazono)methyl-3 -cephem-4-carboxylic acid hydrochloride, for example |
| 08/22/2002 | US20020115650 Cephalosporin antibiotics and prodrugs thereof |
| 08/22/2002 | US20020115642 3-(2-(2,4-dichlorophenoxy)-5-chlorophenoxy)methyl-7-(2 -thienylacetamido)-3-cephem-4-carboxylic acid; for antibiotic (vancomycin) sensitive/resistant microorganisms |
| 08/21/2002 | CN1365362A Process for the preparation of basic anti-biotic-inorganic acid and intermediate oxalates |
| 08/20/2002 | US6437119 Forming acid chloride of nalidixic acid, perfloxacin, or ofloxacin with thionyl chloride, condensing with betalactam, intermediate reacts with triaryl phosphine and carbon tetrachloride, then tetracycline, metronidazole, chloramphen |
| 08/15/2002 | WO2002042266A3 Process for the production of ceftifur sodium salt |
| 08/14/2002 | CN1364169A Process for the synthesis of beta-lactam derivatives |
| 08/08/2002 | WO2002060866A2 Preparation of pure 3-alkoxymethyl cephalosporins. |
| 08/07/2002 | EP1228074A1 Method of preparing highly pure cefpodoxime proxetil |
| 08/07/2002 | EP1077981B1 Novel cephalosporin compounds, processes for preparation thereof and antimicrobial compositions containing the same |
| 08/07/2002 | EP1016665B1 Process for the selective preparation of z-isomers of 3-(2-substituted vinyl)cephalosporins |
| 08/07/2002 | CN1088711C Cephem compounds and drugs containing the compounds |
| 08/01/2002 | WO2002059272A2 Covalent chemical inducers of protein dimerization and their uses in high throughput binding screens |
| 07/31/2002 | EP1227100A1 3-cephem derivative crystal and method for preparing the same |
| 07/25/2002 | US20020099206 Stable for a long period under economical storage conditions |
| 07/25/2002 | US20020099205 Cyclization of (2-Oxo-4-(2-oxo-2-(tetrahydrofuran-2-yl)-ethylsulfanyl)-3-phenylacetylamino -azetidin-1-yl)-(trimethyl- alpha -phosphanylidene)-acetic acid 4-nitro-benzyl ester; reacting with acid |
| 07/17/2002 | EP1222194A1 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof |
| 07/16/2002 | US6420554 Process for preparation of 3-cephem compound |
| 07/16/2002 | CA2234410C Novel phloroglucide derivatives and their pharmaceutical use |
| 07/11/2002 | WO2002053563A1 Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
| 07/11/2002 | US20020091252 7-(((5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluormethoxyimino) -acetyl)amino)-3(E)-((imino-1-piperazinylmethyl)-methylhydrazono)methyl-3 -cephem-4-carboxylic acid trihydrochloride for example |
| 07/11/2002 | CA2433783A1 Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
| 07/10/2002 | EP1221446A1 Antibacterial cephalosporins |
| 07/10/2002 | EP1220859A1 Process for preparing 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid |
| 07/09/2002 | US6417351 Process for producing 3-alkenylcephem compounds |
| 07/09/2002 | US6417175 Phosphonocephem derivatives, process for the preparation of the same, and use thereof |
| 07/04/2002 | US20020086992 Precipitation process of 7-aminocephalosporanic acid (7-ACA) |
| 07/03/2002 | EP0759436B1 Process for the preparation of beta-lactam derivative |
| 07/02/2002 | US6414142 Concurrently adding solution of potassium 2-ethyl hexanoate in isopropanol and solution of tertiary-butylamino clavulanate in aqueous isopropanol to mixture of isopropanol and acetone, precipitating potassium clavulanate as rosette-like starbursts |
| 07/02/2002 | US6414140 Process for the production of 3-vinyl cephalosporins |
| 06/27/2002 | WO2002000616A3 Novel cephalosporin compounds and process for preparing the same |
| 06/27/2002 | US20020082248 Hydrochloric or hydrobromic salt reacted with sodium hydroxide in aqueous solution; formed sodium chloride and/or bromide are continuously removed via permselective membrane; solution is concentrated and sodium salt isolated by drying |
| 06/18/2002 | US6407091 β-lactamase inhibiting compounds |
| 06/18/2002 | US6406688 Method of treating sepsis and ARDS with chemokine β-4 |
| 06/13/2002 | WO2002046199A1 Process and ester derivatives useful for preparation of cephalosporins |
| 06/13/2002 | WO2002046198A1 Coupling process and intermediates useful for preparing cephalosphorins |
| 06/13/2002 | WO2002017854A3 Cephalosporin antibiotics and prodrugs thereof |
| 06/05/2002 | EP0874853B1 Process for preparation of cefdinir |
| 06/04/2002 | US6399770 Reducing 3-ketocepham compound |
| 05/30/2002 | WO2002042266A2 Process for the production of ceftifur sodium salt |
| 05/30/2002 | US20020065412 Cephalosporin compound and a process for its preparation |
| 05/30/2002 | US20020065262 7-(2-(2-formylaminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido)-3-methoxymethyl-3-cephem-4-carboxylic acid-1-(isopropoxycarbonyloxy)ethyl ester chemical intermediate for cefpodoxime proxetil |
| 05/29/2002 | EP1209160A1 Process for the preparation of cephem compounds |
| 05/29/2002 | CN1351605A Process for the preparation of beta-lactam derivatives |
| 05/21/2002 | CA2215310C Substrates for beta-lactamase and uses thereof |
| 05/16/2002 | US20020058806 Cyclization cepham derivative |
| 05/15/2002 | EP1204667A1 An improved amorphous form of cefpodoxime proxetil |
| 05/15/2002 | EP0667868B1 Cephem compounds |
| 05/15/2002 | CN1349539A Crystalline beta-lactam intermediate |
| 05/15/2002 | CN1084750C Process for producing cefazolin |
| 05/14/2002 | US6388070 Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
| 05/08/2002 | CN1347884A Vinyl-pyrrolidone cynnematin with alkali subtituent |
| 05/08/2002 | CN1347883A Vinyl-pyrrolidone cynnematin with alkali subtituent |
| 05/08/2002 | CN1347882A Vinyl-pyrrolidone cynnematin with alkali subtituent |
| 05/07/2002 | US6384215 Reacting 4-halo-2-methoxyimino-3-oxo-butyric acid with 2-mercapto-1,3,4-oxadiazole to produce 2-mercapto-1,3,4-oxadiazolyl-4-halo-2-methoxyimino butyric acid; reacting with 7-amino-cephem carboxylic acid and thiourea |
| 05/07/2002 | US6384214 Process for producing cephalosporin derivatives |
| 05/07/2002 | US6384213 Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil |
| 05/07/2002 | US6384212 Directly acylating 7-amino cephalosporanic acid derivative with crystalline 2-aminothiazole compound; ceftazidime; cefixime; (2-carboxyprop-2-oxyimino)acetamido)-3-(1 -pyridiniummethyl)-ceph-3-em-4-carboxylate dihydrochloride |
| 05/02/2002 | EP1201670A2 Process for preparing 2-oxaisocephem derivatives |
| 05/02/2002 | EP1201669A2 Process for preparing halogenated cephem derivatives |
| 05/02/2002 | EP1201665A1 Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates |
| 05/02/2002 | EP1201654A2 Process for preparing allenyl beta-lactam derivatives |
| 04/30/2002 | US6380181 Synthetic catechol derivatives, method for production and use thereof |