| Patents for C07D 501 - Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (7,574) |
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| 10/30/2003 | US20030204082 To an aqueous solution of cefdinir an organic solvent is added in a percentage v/v up to 10%, the solution is cooled to a temperature 0-6 degree C. in acedic pH, to enhance precipitation of cefdinir new crystals |
| 10/29/2003 | CN1125825C Process for producing halogenated beta lactam compound |
| 10/28/2003 | US6639068 Method of preparing highly pure cefpodoxime proxetil |
| 10/23/2003 | WO2003087105A1 INHIBITORS OF SERINE AND METALLO-ß-LACTAMASES |
| 10/23/2003 | WO2002083634A3 Process for the preparation of cefpodoxime acid |
| 10/23/2003 | US20030199712 Hydrolysis and halogenation of ester of 2-substitued imino-3-methyloxo-butyric acid by photochemical irradiation in one pot using a halogenting agent to form 4-halogeno-2-substituted imino-3-oxo-butyric acid |
| 10/22/2003 | CN1451012A Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts |
| 10/22/2003 | CN1451011A 7-acylamino-3-heteroarylthio-3-cephem carboxylic and prodrugs thereof |
| 10/16/2003 | US20030195364 Coupling N-benzyl-3-pyrrolidinamine compound with acyl halide; cyclization in presence of a base; reacting with triphenylphosphine to obtain phosphonium salt; reacting with di-tert. -butyl-dicarbonate under hydrogenation conditions |
| 10/15/2003 | CN1124277C Preparation method of penicillin and cephalosporin |
| 10/09/2003 | US20030191105 7-acylamino-3-(imino)methyl cephalosporins; 7-[[(5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluormethoxyimino)acetyl]amino]-3-[[(piperazinoiminomethyl)hydrazono]methyl]-3-cephem-4-carboxylic acid; imination of 3-methyl derivative; acylation at the 7-amino; 1-[hydrazino(methylimino)methyl]piperazine intermediate |
| 10/08/2003 | CN1447812A Process for prepn. of highly pure crystalline (R.S)-cefuroxime axetil |
| 10/02/2003 | WO2003080543A1 Process for producing cyclic compound |
| 10/01/2003 | EP1347970A1 Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
| 09/30/2003 | CA2099692C Process for preparing cephalosporin intermediates |
| 09/25/2003 | WO2003078440A1 Broad-spectrum cephem compounds |
| 09/25/2003 | CA2479354A1 Broad-spectrum cephem compounds |
| 09/18/2003 | WO2003076640A2 A process for the preparation of cephalosporan acid derivatives from cephalosporin c |
| 09/18/2003 | US20030176670 Multivalent macrolide antibiotics |
| 09/17/2003 | EP1344830A1 A process for the preparation of cephalosporan acid derivatives from cephalosporin C |
| 09/17/2003 | EP1343790A2 Cephalosporin production |
| 09/16/2003 | US6620930 Dissolving 7-aminocephalosporanic acid in methanesulfonic acid, then reacting with azeotropic mixtures of trimethyl borate and methanol to form chemical intermediates for antibiotics such as cefpodoxime proxetil |
| 09/11/2003 | US20030171577 Intermediates in cephalosporin production |
| 09/04/2003 | WO2003072582A1 Novel cephalosporin compounds and process for preparing the same |
| 09/04/2003 | US20030166922 Antibiotics; therapy for antibiotic resistant infections |
| 09/03/2003 | EP1340762A1 Cephalosporin synthesis |
| 09/03/2003 | EP1339723A1 Process and ester derivatives useful for preparation of cephalosporins |
| 09/03/2003 | EP1339722A1 Coupling process and intermediates useful for preparing cephalosphorins |
| 08/28/2003 | WO2003031449A3 Cross-linked glycopeptide-cephalosporin antibiotics |
| 08/28/2003 | US20030162763 Antibacterial agent, particularly against strains such as methicillin-resistant Staphylococcus aureus |
| 08/28/2003 | US20030162762 Novel cephalosporin compounds and process for preparing the same |
| 08/27/2003 | CN1439014A Novel cephalosporin compounds and process for preparing the same |
| 08/27/2003 | CN1439013A Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil |
| 08/26/2003 | US6610845 Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds |
| 08/20/2003 | CN1437606A Novel cephalosporin compounds and process for preparing the same |
| 08/14/2003 | US20030153785 Dissolving a 4-(4,6-dialkyl-aryloxy-s-triazin-2-yl)-), 4-methylmorpholinium halide in water and freezing; or, decreasing the content of a 4,6-dialkyl-s-triazine impurity; condensation agents for amidation and esterification reactions |
| 08/14/2003 | US20030153748 Cephalosporin intermediates |
| 08/14/2003 | US20030153747 Depletion of 7-aminodesacetoxy-cephalosporonic acid in a mixture with 7-amino-3-vinyl-cephalosporonic acid |
| 08/13/2003 | EP1333836A2 Cephalosporin antibiotics and prodrugs thereof |
| 08/07/2003 | WO2003064430A1 Crystalline hydrochloride of 7-(((5-amino-1, 2, 4-thiadiazol-3-yl)(fluoromethoxyimino) acetyl) amino) -3- ((imino-1-piperazinylmethyl)methylhydrazono)-methyl-3-cephem-4-carboxylic acid |
| 08/07/2003 | US20030149014 Imidazo[4,5-b]-pyridinium-containing cephem compounds having broad antibacterial spectrum activity |
| 08/07/2003 | CA2471934A1 Crystalline hydrochloride of 7-(((5-amino-1,2,4-thiadiazol-3-yl)(fluoromethoxyimino)acetyl)amino)-3-((imino-1-piperazinylmethyl)methylhydrazono)-methyl-3-cephem-4-carboxylic acid |
| 08/06/2003 | CN1117095C Antibacterial substituted 7-2cylamino-3(methylhydrazono) methyl-cephalosponins and intermediates |
| 08/05/2003 | US6602999 Preparing a solution of cefpodoxime proxetil in a suitable solvent and recovering amorphous form of cefpodoxime proxetil from said solution by spray drying |
| 07/30/2003 | CN1116299C Crystalline substance of cefditoren pivoxyl and prodn. of same |
| 07/29/2003 | US6599893 Such as (7R)-7-(2-(2-amino-5-chlorothiazol-4-yl)-2-trityl-oxyiminoacetylamino)-3-(4 -methyl-(1,2, 3)thiadiazol-5-ylsulfanyl)-8-oxo-5-thia-1-aza-bicyclo(4.2.0)oct-2-ene-2 -carboxylic acid benzhydryl ester; methicillin-resistance |
| 07/29/2003 | US6599892 Beta-lactamase inhitiors |
| 07/24/2003 | WO2003059914A1 An improved synthesis of ceftiofur intermediate |
| 07/24/2003 | WO2003059908A1 Novel thioester derivatives and process for preparation of cephalosporin |
| 07/24/2003 | US20030139595 Novel process for the fermentative production of cephalosporin |
| 07/23/2003 | CN1431211A Amine salt of cefathiamiding, its preparing method and application |
| 07/23/2003 | CN1115147C Improved method for preparing potassium clavulanate |
| 07/22/2003 | CA2294178C Process for the selective preparation of z-isomers of 3-(2-substituted vinyl)cephalosporins |
| 07/17/2003 | US20030135041 Synthesis of ceftiofur intermediate |
| 07/16/2003 | CN1430621A New process for preparation of vinyl-pyrrolidinone cephalosporine derivatives |
| 07/15/2003 | CA2163080C Cephem compound, process for producing the compound, and antimicrobial composition containing the same |
| 07/15/2003 | CA2077562C Diastereomers of 1-(isopropoxycarbonyloxy) ethyl 3-cephem-4-carboxylate and processes for their preparation |
| 07/10/2003 | WO2003055893A1 An improved synthesis of ceftiofur intermediate |
| 07/10/2003 | WO2003055892A1 Process for the stabilization of an acidic aqueous phase comprising cephradine |
| 07/10/2003 | US20030130502 Synthesis of ceftiofur intermediate |
| 07/10/2003 | US20030130236 Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| 07/10/2003 | US20030130173 Bactericides for drug resistant bacteria |
| 07/09/2003 | EP1325923A1 Cephem compounds and esbl-detecting reagents containing the same |
| 07/09/2003 | CN1113885C Process for producing beta-lactam derivs. |
| 07/03/2003 | WO2003053522A1 Methods of treating bacterial infections in dogs and cats |
| 07/03/2003 | CA2470995A1 Methods of treating bacterial infections in dogs and cats |
| 07/02/2003 | EP0973780B1 Antibacterial substituted 7-acylamino -3-(methylhydrazono) methyl-cephalosporins and intermediates |
| 07/02/2003 | EP0973779B1 Crystalline amine salt of cefdinir |
| 07/02/2003 | EP0892805B1 Production of 7-aminocephalosporanic acid derivative |
| 07/02/2003 | EP0757691B1 Cephalosporin synthesis |
| 06/26/2003 | US20030119085 Substrates for beta-lactamase and uses thereof |
| 06/25/2003 | EP1320533A1 Prodrugs of a 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotic |
| 06/25/2003 | CN1426416A Cephalosporin Intermediates |
| 06/24/2003 | US6583133 Especially against Gram-positive organisms, e.g. methicillin-sensitive (MSSA) and methicillin- resistant (MRSA) staphylococci, enterococci and pneumococci |
| 06/19/2003 | WO2003050125A1 A new method for the preparation of ceftiofur sodium |
| 06/19/2003 | WO2003050124A1 Crystalline cefdinir potassium dihydrate |
| 06/19/2003 | US20030114665 Such as 7-(((5-amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluoro-methoxyimino)acetyl)amino)-3-(imino-1-piperazinylmethyl) methylhydrazono)methyl-3-cephem-4-carboxylic acid |
| 06/18/2003 | EP1319009A1 Intermediates in cephalosporin production |
| 06/18/2003 | EP1158995B1 Biologically active compounds of ganoderma pfeifferi dms 13239 |
| 06/18/2003 | CN1424316A Preparation of cephalosporin compound |
| 06/18/2003 | CN1111537C Preparation of highly pure crystalline form of cefuroxime axetil |
| 06/18/2003 | CN1111410C Process for preparation of pharmaceutical composition |
| 06/12/2003 | WO2002046199A8 Process and ester derivatives useful for preparation of cephalosporins |
| 06/10/2003 | US6576761 Process for the preparation of cephem compounds |
| 06/05/2003 | US20030105066 For use in producing antiviral, antifungal and antibacterial medicaments |
| 06/05/2003 | US20030104515 "Process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives" |
| 06/04/2003 | EP1044204B1 Process for the preparation of alpha-oxolactams |
| 06/04/2003 | EP0759437B1 Processes for the production of 2-isocephem derivatives |
| 05/22/2003 | WO2003042219A1 Novel c-3 s/o- and s/n formaldehe acetal derivatives of cephalo sporins and their use as antibiotics |
| 05/22/2003 | WO2003020732A3 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors. |
| 05/22/2003 | US20030096858 The parent drug compound is modified by forming one or more of predetermined chemical arrangement within parent drug structure for programming specific course and rate of metabolism for drug that leads to inactive nontoxic metabolite |
| 05/22/2003 | US20030095992 Altering a drug's distribution, metabolism and elimination properties, especially by modifying with aralkyl ester moieties to increase rate of metabolism to inactive and nontoxic metabolites when exposure is halted; surgery, riots |
| 05/22/2003 | CA2461577A1 Novel c-3 s/o- and s/n formaldehe acetal derivatives of cephalosporins and their use as antibiotics |
| 05/21/2003 | EP1311518A1 Preparation of n-protected-3-pyrrolidine-lactam substituted phosphonium salts |
| 05/21/2003 | CN1419560A Anti-infective actatm |
| 05/21/2003 | CN1419450A Nitrite salts of antimicrobial agents |
| 05/20/2003 | US6566509 Compound for use as bactericide |
| 05/15/2003 | WO2003040148A1 A process for the preparation of cefixime via alkyl-or aryl-sulfonates |
| 05/15/2003 | WO2003040116A1 A process for the preparation of cephalosporins side chains |
| 05/15/2003 | US20030092696 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors |