Patents
Patents for C07D 305 - Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms (5,442)
06/1999
06/15/1999US5912263 13-amino derivatives of taxanes; potent antitumor and -carcinogenic agents
06/15/1999CA2213952C Preparative scale isolation and purification of taxanes
06/03/1999WO1999026939A1 Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
06/03/1999CA2479828A1 Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
06/02/1999EP0918764A1 Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position
06/02/1999CN1043530C Process for obtaining 10-deacetylbaccatin III
06/02/1999CN1043529C Carbonylation of epoxides
06/02/1999CN1043528C Method for preparation of taxol using an oxazinone
06/01/1999US5908835 Anti-tumor compositions containing taxane derivatives
06/01/1999US5908759 Culturing tree (taxus) fragments on agar until fungal growth occurs, culturing hyphae, grinding mycelium, adding solvent, performing chromatography, spraying with vanillin-sulfuric acid and comparing to standards
06/01/1999CA2142314C Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol
05/1999
05/27/1999WO1999025705A1 Recovery of taxanes from plant material
05/27/1999WO1999025704A1 Method for preparing derivatives of the taxoid class
05/27/1999WO1999025334A1 Halogenated paclitaxel derivatives
05/27/1999CA2310332A1 Recovery of taxanes from plant material
05/26/1999EP0580759B1 Methods and compositions for isolating taxanes
05/25/1999US5907042 Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
05/25/1999US5906990 Taxoids, preparation thereof, and pharmaceutical compositions containing same
05/19/1999EP0666857B1 Method for preparing taxane derivatives
05/18/1999CA2086452C Long-chain ketene dimers
05/11/1999US5902886 Protection of the hydroxy group of an hydroxy ester with an acid-labile acetal protecting group, reduction of the o-protected hydroxy ester to an o-protected hydroxy aldehyde, condensation of the aldehyde with a metal enolate
05/11/1999US5902822 Novel antitumor derivatives for use as antitumor agents
05/06/1999EP0912536A1 Taxane hydroxy monoacylation method
05/06/1999EP0912535A1 Conjugates of cis-docosahexaenoic acid and paclitaxel
05/06/1999EP0912504A1 Process to prepare taxol
05/05/1999CN1216039A Process to prepare taxol
05/04/1999CA2163706C Amino acid derivatives of paclitaxel
05/04/1999CA2142354C Process of converting taxanes into baccatin iii and 10-deacetylbaccatin iii
04/1999
04/22/1999WO1999018798A1 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
04/22/1999CA2307208A1 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
04/21/1999CN1214717A Coating composition comprising bicyclo- or spiro-orthoester-functional compound
04/15/1999DE19804815C1 10-Hydroxytaxane O-acetyltransferase enzyme
04/08/1999WO1999016761A1 Oxygenic heterocyclic derivatives
04/07/1999EP0906095A1 7-o-methoxymethyl paclitaxel
04/07/1999EP0659181B1 Sulfonamide inhibitors of hiv-aspartyl protease
04/06/1999US5892063 Cephalomannine epoxide, its analogues and a method for preparing the same
04/06/1999CA2077394C Substituted taxanes and pharmaceutical compositions containing them
03/1999
03/31/1999EP0905130A1 A process for the production of taxol
03/31/1999EP0788492B1 Novel taxoids, preparation thereof, and pharmaceutical compositions containing same
03/30/1999US5889043 Esterification
03/25/1999WO1999014209A1 New taxane derivatives
03/24/1999EP0902783A1 Hydrolysis-promoting taxane hydrophobic derivatives
03/24/1999EP0605637B1 Preparation of substituted isoserine esters using metal alkoxides and s-lactams
03/24/1999CN1211919A Radiosensitizing taxanes and their pharmaceutical preparations
03/23/1999US5886199 From 1,1-bis(chloromethyl)-1-hydroxymethylalkane or its carboxylate ester through a dehydrogen chloride reaction or a deacid chloride reaction, conducted in an aqueous solution or suspension of an alkaline compound
03/23/1999CA2116078C A process for the production of ketene dimers
03/18/1999WO1998052614A3 Composition and method for enhancing transport across biological membranes
03/16/1999CA2109861C 6,7-modified paclitaxels
03/10/1999CN1210535A Taxane derivatives having pyridil substituted C13 side chain, their preparation and their use as anti-tumor agents
03/10/1999CN1210525A Taxoids, preparation thereof and pharmaceutical compositions containing same
03/09/1999US5880131 Polyoxyalkylene derivatives
03/03/1999EP0898557A1 Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates
03/03/1999EP0882231A4 Recovery of taxanes from conifers
02/1999
02/25/1999WO1999009021A1 Process for selective derivatization of taxanes
02/25/1999WO1999008986A1 Method for the synthesis of taxanes
02/25/1999CA2597799A1 Process for selective derivatization of taxanes
02/25/1999CA2302699A1 Method for the synthesis of taxanes
02/25/1999CA2268662A1 Process for selective derivatization of taxanes
02/24/1999CN1209168A Prodn. and screening process for phytochemical prodn. by plant cell cultures
02/23/1999US5874595 Single step, selective acetylation of 10-deacetylbaccatin iii into baccatin iii using lewis acid catalysts in the reaction with acetic anhydride; preparation of taxol from baccatin iii
02/17/1999EP0896577A1 Taxane derivatives having a pyridil substituted c13 side chain, their preparation and their use as anti-tumor agents
02/17/1999CN1208399A Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates
02/16/1999US5871979 Method for mass production of taxol by semi-continuous culture with Taxus chinensis cell culture
02/16/1999CA2123256C Process for the manufacture of alkyl ketene dimer
02/10/1999CN1207389A Method for separation and purification of taxol and taxane
02/09/1999US5869680 Reacting a oxazolidine derivative with protected hydroxy-taxol; decyclization and amination
02/03/1999EP0773938B1 Semi-synthetic taxanes with anti-tumoural activity
02/03/1999EP0702517A4 Quaternary ammonium and waterproofing/preservative compositions
02/03/1999EP0669918B1 Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
02/02/1999US5866045 Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability
01/1999
01/27/1999CN1206412A Method for selective protection of baccation derivatives and its application to taxane synthesis
01/26/1999CA2149151C Extraction of taxanes by ion exchange media
01/20/1999CN1205697A Novel taxoids, prepn. thereof and pharmaceutical compsns. containing same
01/19/1999US5861515 Esterification of protected baccatin iii or 10-deacetylbaccatin iii using a carboxylic acid substituted oxazolidine, then deprotecting and acylation
01/19/1999US5861302 Genus taxus for production of taxol or taxane from culture
01/19/1999CA2092962C Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
01/14/1999WO1999001428A1 Hydrazine derivatives
01/14/1999CA2295062A1 Hydrazine derivatives
01/13/1999EP0889885A1 Method for selective protection of baccatin derivatives and its application to taxane synthesis
01/13/1999EP0809639A4 Isolation and purification of paclitaxel and cephalomannine
01/07/1999DE19829229A1 Hydrazinderivate Hydrazine
01/06/1999CN1204329A Tax-11-ene-13 'alpha'-Yl (2R,3S)-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate dihydrate and method for preparing same
01/05/1999US5856532 Isolating the xyloside analogue of taxols from stem bark of taxus wallichiana, extracting, heating, precipitating, dissolving in a solvent, cleaving diol of xyloside to dialdehyde, reducing, acetylating, protecting, deprotecting
01/05/1999US5856353 Sulfonamide inhibitors of aspartyl protease
12/1998
12/29/1998US5854278 Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
12/23/1998EP0885887A2 Sulfonamide inhibitors of HIV-Aspartyl protease
12/23/1998EP0885208A1 Taxoids, their preparation and pharmaceutical compositions containing them
12/23/1998CN1041310C Process for obtaining 10-deacetylbaccatin III
12/23/1998CN1041281C Polymer-bound taxol derivatives
12/17/1998WO1998056500A1 Use of chromium (iii) carboxylates as a catalyst
12/16/1998EP0884314A2 Metal alkoxides
12/16/1998CN1202166A Hydrolysis-promoting taxane hydrophobic derivatives
12/15/1998CA2163667C Imidazole lipoxygenase inhibitors
12/09/1998EP0882231A1 Recovery of taxanes from conifers
12/09/1998EP0882106A1 Coating composition comprising a bicyclo- or spiro-orthoester-functional compound
12/08/1998US5847170 Taxoids, their preparation and pharmaceutical compositions containing them
12/08/1998US5847161 1, 2 chemiluminescent dioxetanes of improved performance
12/02/1998CN1200731A Intermediary compounds for the hemisynthesis of taxanes and prepn. processes therefor
11/1998
11/26/1998WO1998052614A2 Composition and method for enhancing transport across biological membranes
11/24/1998US5840931 Antitumor agents
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