| Patents for C07B 59 - Introduction of isotopes of elements into organic compounds (2,678) |
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| 04/13/2006 | WO2006037950A1 Method of deprotection |
| 04/12/2006 | CN1758925A Methods of radiofluorination of biologically active vectors |
| 04/05/2006 | EP0991660B8 DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
| 04/04/2006 | US7022310 Deuterated hydrogen in protein, radioactive carbon or nitrogen; bioassay of accurate analyzing the structure of the target high molecular weight protein; producing stable isotope-labeled fumaric acid, tartaric acid through esterification, oxidation, hydrolysis; chemical peptide synthesis |
| 03/30/2006 | US20060069038 Irreversible caspase-3 inhibitors as active site probes |
| 03/30/2006 | US20060067884 for radiolabeling proteins, peptides and ligands with therapeutic radioisotopes such that these radiolabeled agents may be administered directly to patients without the need for additional purification; for the treatment of cancer |
| 03/28/2006 | US7018610 Poly-L-R-Y, where poly represents a polymer( such as polystyrene homo or copolymer) R= aryl or heteroaryl, L= R3-Sn-R3 (R3= alkyl, alenyl or alkynyl), Y= hydrogen, alkyl, alkoxy, carbonyl, formyl, amido, amino, carobxyamido etc. |
| 03/23/2006 | WO2005090267A3 Methods to prepare carbon-isotope organohalides with high specific radioactivity from carbon-isotope monoxide |
| 03/22/2006 | CN1246041C Solid-phase nucleophilic fluorination |
| 03/15/2006 | EP1633703A2 Isotopically labeled chemically stable reagents and process for the synthesis thereof |
| 03/09/2006 | US20060052290 Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution |
| 03/08/2006 | EP1632236A1 Inhibitors of the anandamide transporter |
| 03/08/2006 | EP1198454B1 Mutilin derivatives and their use as antibacterials |
| 03/08/2006 | EP0538402B1 Method of preparing a radioactive rhenium complex solution |
| 03/08/2006 | CN1244521C Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor |
| 02/23/2006 | US20060039855 Treatment of a solid support-bound precursor of formula:SOLID SUPPORT-LINKER-SO2 O-TRACER with 18F- to produce the labelled tracer, removal of excess 18F-, for example by ion-exchange chromatography; and/or removal of any protecting groups; and/orremoval of organic solvent |
| 02/22/2006 | CN1738782A Deuterated catecholamine derivatives and medicaments comprising said compounds |
| 02/16/2006 | WO2005045850A3 Radioactive arsenic triiodide and use thereof for radioactive markings |
| 02/16/2006 | US20060036103 Process for preparing a deuterated or tritiated compound |
| 02/15/2006 | EP1624901A2 Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals |
| 02/08/2006 | CN1732135A Method of deuterization |
| 02/07/2006 | US6995247 Ac-HEHA and related compounds, methods of synthesis and methods of use |
| 02/07/2006 | US6994840 Kit for radiolabeling ligands with yttrium-90 |
| 02/02/2006 | US20060025596 Method for deuteration or tritiation of heterocyclic ring |
| 02/01/2006 | EP1620373A2 Device and method for the fluorination of nucleophiles |
| 01/31/2006 | US6992180 Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides |
| 01/26/2006 | CA2513080A1 Inhibitors of the anandamide transporter |
| 01/19/2006 | WO2005079864A3 Improvement in the ligand protection for mercaptoacetyl triglycine |
| 01/11/2006 | EP1613571A1 Deuterated catecholamine derivatives and medicaments comprising said compounds |
| 01/05/2006 | CA2572056A1 Method for deuterating haloacrylic acid or its salt |
| 01/04/2006 | CN1234680C Image forming agent, its precursor and preparing process thereof |
| 12/28/2005 | EP1332138B1 Radiopharmaceuticals for diagnosing alzheimer's disease |
| 12/28/2005 | EP0991660B1 DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
| 12/28/2005 | CN1714060A Method for deuteration or tritiation of heterocyclic ring |
| 12/22/2005 | WO2005121315A1 Cholesterol-producing yeast strains and uses thereof |
| 12/22/2005 | WO2005120584A2 Radiolabeled arylsulfonyl compounds and uses thereof |
| 12/22/2005 | CA2562773A1 Cholesterol-producing yeast strains and uses thereof |
| 12/15/2005 | WO2005092820A3 Synthesis of carbon-labeled perfluoroalkyl compounds |
| 12/08/2005 | WO2005115971A1 Radioactive tyrosine derivative, method for producing same, labeling agent for positron imaging and medical agent for assessing grade of malignancy of tumor respectively composed of radioactive tyrosine derivative, and method for detecting tumor |
| 12/08/2005 | US20050271586 Design and synthesis of renal dipeptidase inhibitors |
| 12/07/2005 | EP1601384A1 Methods of radiofluorination of biologically active vectors |
| 12/01/2005 | WO2005113471A1 Method of labeling with isotope of oxygen |
| 12/01/2005 | DE102004022461A1 Metallkomplexe auf der Basis von Tetrathiol-Liganden und deren Anwendung in der nuklearmedizinischen Diagnostik und Endoradionuklidtherapie sowie Verfahren zur Herstellung der Metallkomplexe Metal complexes based on Tetrathiol ligands and their use in nuclear medical diagnosis and endoradionuclide therapy and methods for preparing the metal complexes |
| 11/17/2005 | WO2005108330A1 Metal complexes based on tetrathiol ligands and their use in nuclear medical diagnostics and endoradionuclide therapy and method for producing said metal complexes |
| 11/17/2005 | WO2005107819A2 Methods for the purification of radiolabeled products using a solid- support scavanger |
| 11/16/2005 | EP1594819A1 Irreversible caspase-3 inhibitors as active site probes |
| 11/15/2005 | CA2302360C Fluorination of proteins and peptides for f-18 positron emission tomography |
| 11/10/2005 | WO2005105708A1 Novel 15o-labeled monosaccharide and producing method thereof |
| 10/20/2005 | WO2005097713A1 Fluoridation method |
| 10/20/2005 | US20050232861 Microfluidic apparatus and method for synthesis of molecular imaging probes including FDG |
| 10/13/2005 | US20050226776 Use of microfabricated devices |
| 10/11/2005 | US6953567 Radiolabeling peptides by reacting thiol-containing peptides with an F-18-bound labelling reagent which also has a group that is reactive with thiols; targeted to a tissue using bispecific antibodies |
| 10/06/2005 | WO2005092820A2 Synthesis of carbon-labeled perfluoroalkyl compounds |
| 09/29/2005 | WO2005090268A1 Radiolabeled 3-[3-(benzoyl-amido)benzyloxy]aspartic acid derivative and method of producing the same |
| 09/29/2005 | WO2005090267A2 Methods to prepare carbon-isotope organohalides with high specific radioactivity from carbon-isotope monoxide |
| 09/29/2005 | WO2005090266A1 Radiosynthesis of acid chlorides |
| 09/28/2005 | CN1675145A Method of deuterating aromatic ring |
| 09/21/2005 | EP1577280A1 Method of deuterization |
| 09/14/2005 | EP1572601A1 Solid-phase preparation of 18 f-labelled amino acids |
| 09/09/2005 | WO2004108636A3 Isotopically labeled chemically stable reagents and process for the synthesis thereof |
| 09/09/2005 | CA2825161A1 Catalytic radiofluorination |
| 09/08/2005 | US20050197510 Synthesis of carbon-labeled perfluoroalkyl compounds |
| 09/01/2005 | WO2005079864A2 Improvement in the ligand protection for mercaptoacetyl triglycine |
| 09/01/2005 | CA2555953A1 Improvement in the ligand protection for mercaptoacetyl triglycine |
| 08/25/2005 | WO2005077967A1 Radiolabeled compounds and compositions, their precursors and methods for their production |
| 08/25/2005 | CA2555597A1 Radiolabeled compounds and compositions, their precursors and methods for their production |
| 08/18/2005 | WO2005075486A1 Method of synthesizing compounds having a phosphorus-fluorine-18 bond |
| 08/18/2005 | US20050182027 radiolabeled phosphonium or ammonium salts that accumulate in mitochondria of cancer cells; cancer diagnosis; tomography; distinguishes between tissue inflammation and tumors; e.g. F18-3-fluoropropyltriphenyl phosphonium bromide |
| 08/18/2005 | CA2555305A1 Method of synthesizing compounds having a phosphorus-fluorine-18 bond |
| 08/17/2005 | EP1562640A2 Methods for purifying radiolabelled compounds |
| 08/17/2005 | EP1202945B1 Methods for preparing perfluorinated [18 f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection |
| 08/11/2005 | US20050177015 Process for deuteration of inert methylene |
| 08/11/2005 | US20050176628 Deuterated cyclosporin analogs and their use as immunomodulating agents |
| 08/11/2005 | US20050175534 Method of synthesizing compounds having a phosphorus-fluorine-18 bond |
| 08/10/2005 | EP1561741A1 Method for deuteration or tritiation of heterocyclic ring |
| 08/09/2005 | US6927212 Design and synthesis of renal dipeptidase inhibitors |
| 08/04/2005 | WO2005070853A1 Method of deuteration using mixed catalyst |
| 08/04/2005 | DE10361547A1 Lead dioxide and hydroxybenzotriazole mediated oxidation of organic substances soluble in organic phase with molecular oxygen isotopes |
| 08/04/2005 | CA2553376A1 Method of deuteration using mixed catalyst |
| 07/21/2005 | WO2005066100A1 Methods for carbon isotope labeling synthesis of ketones and amines by suzuki coupling reactions using carbon-isotope monoxide |
| 07/21/2005 | US20050158240 Method for labeling with tritium |
| 07/20/2005 | EP1554231A2 Process for the preparation of fluorohaloalkanes |
| 07/13/2005 | EP1551291A2 Method for obtaining dynamic and structural data pertaining to proteins and protein/ligand complexes |
| 07/13/2005 | CN1636976A Mutilin derivatives and their use as antibacterials |
| 07/12/2005 | CA2237218C Amino acid analogs for tumor imaging |
| 07/07/2005 | WO2005061445A1 Methods for carbon isotope labeling synthesis by rhodium-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide |
| 07/07/2005 | WO2005061415A1 Radical trap in fluoridation of iodonium salt |
| 07/07/2005 | US20050147535 Fluidly connectable to a solvent delivery module, a high performance liquid chromatography (HPLC) pump and an HPLC column; a labeling module includes a loop and valves having different orientations to provide different fluid pathways of solvent, radiolabeling agent and inert gas through the system |
| 06/30/2005 | US20050142061 Radiofluorination methods |
| 06/29/2005 | EP1268497B1 Ternary ligand complexes useful as radiopharmaceuticals |
| 06/22/2005 | EP1383752B1 Deuterated 3-piperidinopropiophenone and medicaments containing said compounds |
| 06/16/2005 | WO2005054132A1 Tagged polymeric materials and methods for their preparation |
| 06/16/2005 | WO2005054128A2 Method and apparatus for synthesis of [11c] phosgen using concentrated [11c] carbon monoxide with uv light |
| 06/16/2005 | DE10350397A1 Radioaktives Arsentriiodid und dessen Verwendung zur radioaktiven Markierung Radioactive Arsentriiodid and the use thereof for radiolabeling |
| 06/15/2005 | CN1627962A Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts |
| 06/02/2005 | WO2005050226A1 Fluorous labeling for selective processing of biologically-derived samples |
| 06/02/2005 | CA2545685A1 Fluorous labeling for selective processing of biologically-derived samples |
| 06/01/2005 | EP1535889A1 Method of deuterating aromatic ring |
| 06/01/2005 | EP1169282B1 Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor |
| 05/26/2005 | WO2004100490A3 Device and method for the fluorination of nucleophiles |