Patents
Sitemap › A61 - Medical or veterinary science; Hygiene › A61K - Preparations for medical, dental, or toilet purposes › A61K 48 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Patents for A61K 48 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy (86,964)
11/1999
11/16/1999US5985655 Retroviral vector particle containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell; a portion of the envelope gene deleted and replaced with another receptor binding region or ligand
11/16/1999US5985640 Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same
11/16/1999US5985621 Capable of cleaving a rna
11/16/1999US5985613 Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "to inhibit the replication of viruses, in particular of retroviruses
11/16/1999US5985600 Nucleic acid encoding delta opioid receptor
11/16/1999US5985585 Competitive binding; detection
11/16/1999US5985583 Hybridization; measurement signal transduction
11/16/1999US5985573 Cationic polyacrylates and poly(alkyl) acrylates or the corresponding acrylamides for use in synthetic transfection or blocking systems
11/16/1999US5985552 Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
11/16/1999US5985320 Drug delivery; medical diagnosis; genetic engineering; administering agent that interacts with cell surface receptors
11/16/1999US5985290 Purified pancreatic tumor cell lines and related compositions and method
11/16/1999US5985287 Compounds and methods for treatment and diagnosis of mycobacterial infections
11/16/1999US5985283 Adenovirus E1A-Associated protein BS69, inhibitor of E1A-transactivation
11/16/1999US5985281 Antibody directed enzyme prodrug therapy (adept) using a non-naturally occuring mutant form of a host enzyme, especially a mutant form of ribonuclease.
11/16/1999US5985266 Sensitize tumors, retrovirus comprises operatively linked to a promoter a gene encoding a viral thymidine kinase; such that said tumor cells become transduced by said retrovirus and express said viral thymidine kinase gene;
11/16/1999CA2217668C Genetic markers for breast and ovarian cancer
11/14/1999CA2271582A1 Method for administration of therapeutic agents, including antisense, with repeat dosing
11/13/1999CA2271267A1 Overexpressing human methenyltetrahydrofolate synthetase to sensitize cancer cells to 5-fluorouracil cytotoxicity
11/13/1999CA2248987A1 Novel compounds
11/13/1999CA2235094A1 Overexpressing human methenyltetrahydrofolate synthetase to sensitize cancer cells to 5-fluorouracil cytotoxicity
11/11/1999WO1999057320A1 Antisense modulation of cd40 expression
11/11/1999WO1999057296A1 Partially deleted adenoviral vectors
11/11/1999WO1999057295A1 Recombinant virus expressing foreign dna encoding feline cd80, feline ctla-4 or feline cd86 and uses thereof
11/11/1999WO1999057293A1 Human bmp-7 promoter and method for exploring bone-related substance by using the same
11/11/1999WO1999057292A1 Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery
11/11/1999WO1999057291A1 Genomic sequences upstream of the coding region of the g-csf gene for protein production and delivery
11/11/1999WO1999057290A1 Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
11/11/1999WO1999057275A1 Introduction of naked dna or rna encoding non-human vertebrate peptide hormones or cytokines into a non-human vertebrate
11/11/1999WO1999057273A2 Cytoplasmic antiproteinase-3 coding sequence in gene therapy
11/11/1999WO1999057266A2 Immunosuppression by blocking t cell co-stimulation signal 2 (b7/cd28 interaction)
11/11/1999WO1999057263A1 Modifying the expression of the fsh beta gene by homologous recombination
11/11/1999WO1999057140A2 Growth-associated protease inhibitor heavy chain precursor
11/11/1999WO1999057132A1 Secreted proteins and polynucleotides encoding them
11/11/1999WO1999057131A1 Method of treating bladder and lower urinary tract syndromes
11/11/1999WO1999057094A2 Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds
11/11/1999WO1999056785A2 Cell mediated gene delivery using muscle derived cells for treating muscle-and bone-related injury or dysfunction
11/11/1999WO1999056784A2 Inprovements in gene therapy using compositions comprising a polynucleotide and a nuclease inhibitor or interleukin-10
11/11/1999WO1999056778A1 The cytokine family member, 2-19
11/11/1999WO1999056775A1 Use of interleukin-18 as vaccine adjuvant
11/11/1999WO1999056700A2 Avian polyomavirus vaccines in psittacine birds
11/11/1999WO1999049316A3 Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer
11/11/1999WO1999047563A3 Ribonucleotide polypeptides containing metal
11/11/1999WO1999042574B1 Sequences of an ih ionic channel and the use thereof
11/11/1999WO1999041402A3 Targeting of genetic vaccine vectors
11/11/1999WO1999040214A3 Nucleic acid delivery vehicles
11/11/1999WO1999030736A3 Methods to treat undesirable immune responses
11/11/1999WO1999022773B1 Sequences for targeting metastatic cells
11/11/1999CA2328506A1 Modifying the expression of the fsh beta gene by homologous recombination
11/11/1999CA2328476A1 Genomic sequences upstream of the coding region of the g-csf gene for protein production and delivery
11/11/1999CA2328459A1 Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery
11/11/1999CA2328132A1 Growth-associated protease inhibitor heavy chain precursor
11/11/1999CA2328059A1 Use of interleukin-18 as vaccine adjuvant
11/11/1999CA2327543A1 Method of treating bladder and lower urinary tract syndromes
11/11/1999CA2327457A1 Secreted proteins and polynucleotides encoding them
11/11/1999CA2326957A1 Human bmp-7 promoter and method for exploring bone-related substance by using the same
11/11/1999CA2326671A1 Immunosuppression by blocking t cell co-stimulation signal 2 (b7/cd28 interaction)
11/11/1999CA2324650A1 Introduction of naked dna or rna encoding non-human vertebrate peptide hormones or cytokines into a non-human vertebrate
11/11/1999CA2295510A1 Use of a nuclease inhibitor or interleukin-10 (il-10) for the preparation of a therapeutic composition for improving transfection of a polynucleotide into a cell and compositions useful in gene therapy
11/11/1999CA2248963A1 Novel compounds
11/11/1999CA2230991A1 Dna demethylase, therapeutic and diagnosic uses thereof
11/10/1999EP0955373A2 Packaging systems for human recombinant adenovirus to be used in gene therapy
11/10/1999EP0955359A1 Method for introducing genetic material into a cell
11/10/1999EP0954602A1 Hereditary hemochromatosis gene
11/10/1999EP0954598A1 Screening assay for compounds stimulating somatostatin and insulin production
11/10/1999EP0954594A2 Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, and in vitro generation of dendritic cells and macrophages
11/10/1999EP0954593A1 Recombinant pox virus for immunization against tumor-associated antigens
11/10/1999EP0954592A1 System for the production of aav vectors
11/10/1999EP0954591A2 Mini-adenoviral vector
11/10/1999EP0954585A2 Human telomerase catalytic subunit
11/10/1999EP0954580A1 Human sdf-5 protein and compositions
11/10/1999EP0954579A1 Gene therapy for obesity
11/10/1999EP0954577A2 Secreted proteins and polynucleotides encoding them
11/10/1999EP0954573A1 Preparation of ionically cross-linked polyphosphazene microspheres by coacervation
11/10/1999EP0954537A2 Chitosan-conjugates with acidic chelate-complex forming agents
11/10/1999EP0954525A1 Novel compounds
11/10/1999EP0954339A2 Cationic amphiphile compositions for intracellular delivery of therapeutic molecules
11/10/1999EP0954338A2 Cationic amphiphile/dna complexes
11/10/1999EP0954334A1 Use of macrophage migration inhibitory factor antagonists for anti-cancer therapy
11/10/1999EP0954331A1 Novel compounds
11/10/1999EP0954222A1 Gene therapy for proliferative vitreoretinopathy
11/10/1999EP0724588B1 Drug binding protein
11/10/1999CN1234836A Retroviral vectors
11/10/1999CN1234835A Gene therapy for congestive heart failure
11/10/1999CN1234834A Methods for preventing graft rejection in transplantation and for producing universal gene therapy host cell
11/10/1999CN1234406A Single-chain multiple antigen-binding molecule, its preparation and use
11/09/1999US5981731 Anticarcinogenic/antitumor/antiproliferative agents and diagnostic agents targeted against gene which codes for a protein kinase involved in signal transduction
11/09/1999US5981717 Mammalian tolloid-like gene and protein
11/09/1999US5981714 Monoclonal antibodies which bind to specific epitopes; for detecting transport protein in biological samples; for purifying transport protein from an impure solution; for determining orientation in membrane of lipid vesicle
11/09/1999US5981712 Antibody which binds to carboxyamido-triazole resistance protein; for detecting resistance to drug which prevents calcium influx in biological samples/cells
11/09/1999US5981707 Nucleotide and amino acid sequences of protein which binds to telomerase rna; for investigating aging and proliferation; antiproliferative agents
11/09/1999US5981702 Polypeptide which is can bind to cyclin-dependent kinase; for diagnosis and therapy of cell proliferative defects in animals; antiproliferative agents
11/09/1999US5981502 Methods and compositions for inducing apoptosis in tumor cells
11/09/1999US5981487 Method of inhibiting smooth muscle cell proliferation
11/09/1999US5981486 Peptide suppressing IκBα phosphorylation
11/09/1999US5981484 Administering to a human in need of antiangiogenesis therapy an effective amount of mammalian kringle 5 peptide fragment
11/09/1999US5981275 Plasmid comprising heterologous genes linked to cytomegalo virus promoters and stably produces heterologous gene product; for delivery to cells
11/09/1999US5981274 Genetically engineered viral genome with heterologous gene sequences which express functional gene product; for the encapsultion/packaging of virus genome; for antitumor agents, viricides and gene therapy for liver disorders
11/09/1999US5981273 Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells
11/09/1999US5981265 Controlling mitogen kinase polypeptide activity in a cell using transformation and transfection; for treating animals having cancer, inflammation, neurological disorders, autoimmune diseases, allergiies; anticarcinogenic agents
11/09/1999US5981259 CD4+ T-lymphocyte protease genes and inhibitors thereof
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