Patents
Sitemap › C40 - Combinatorial technology › C40B - Combinatorial chemistry; Libraries, e.g. chemical libraries, in silico libraries › C40B 50 - Methods of creating libraries, e.g. combinatorial synthesis
Patents for C40B 50 - Methods of creating libraries, e.g. combinatorial synthesis (5,219)
12/1999
12/15/1999EP0963246A1 Automated chemical synthesis device
12/14/1999US6001966 Reacting n-terminal protected amino acid with peptide starting material forming a peptide product, partitioning from unreacted material and reagents based on presence of n-terminal blocking/anchoring group
12/14/1999US6001311 Apparatus for diverse chemical synthesis using two-dimensional array
12/14/1999US6001309 Jet droplet device
12/02/1999WO1999061653A2 Light-mediated regional analysis of biologic material
12/01/1999EP0960335A2 Modulators of insulin receptor activity
12/01/1999EP0959985A2 Methods for radiation grafting to polymeric surfaces
12/01/1999EP0959984A1 System and methods for parallel synthesis of organic compounds
11/1999
11/25/1999WO1999060007A2 Libraries of oligomers labelled with different tags
11/25/1999WO1999059722A1 Three-dimensional array of supports for solid-phase parallel synthesis and method of use
11/25/1999WO1999059716A2 Combinational method for microgram-scale production and characterization of crystalline and amorphous libraries of materials
11/25/1999CA2333178A1 Combinational method for microgram-scale production and characterization of crystalline and amorphous libraries of materials
11/25/1999CA2332862A1 Libraries of oligomers labelled with different tags
11/18/1999WO1999058947A2 Modulation of molecular interaction sites on rna and other biomolecules
11/18/1999WO1999058476A2 Method and device for nonsynthetic deconvolution
11/18/1999WO1999058474A1 Generation of combinatorial libraries of compounds corresponding to virtual libraries of compounds
11/18/1999WO1999051546A9 Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
11/18/1999DE19822077A1 Preparation of library of spatially separted solids by wet-chemical methods on a removable reaction plate, used e.g. to screen for new catalysts or materials
11/16/1999US5985551 Method and apparatus for conducting an array of chemical reactions on a support surface
11/11/1999WO1999048897A3 Synthesis of compounds and libraries of compounds
11/11/1999WO1999041007A3 Method and apparatus for chemical and biochemical reactions using photo-generated reagents
11/04/1999WO1999056129A1 Methods of selecting internalizing antibodies
10/1999
10/28/1999WO1999039817A9 Method of quality control in manufacturing processes
10/28/1999WO1999025724A3 Oligonucleotide synthesis using high boiling point solvents
10/21/1999WO1999053101A1 Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
10/21/1999CA2325013A1 Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
10/14/1999WO1999051546A1 Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
10/14/1999CA2326387A1 Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
10/07/1999WO1999050664A1 Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
10/07/1999CA2326573A1 Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
10/06/1999EP0947820A2 Method for sample preparation
10/06/1999EP0946286A1 Chemical amplification for the synthesis of patterned arrays
10/05/1999US5962338 Solid phase organic synthesis by adding two or more organic compounds to reaction vessel containing solvent and bead, sonicating, removing solvent while retaining bead with magnetism, recovering product
09/1999
09/30/1999WO1999048897A2 Synthesis of compounds and libraries of compounds
09/30/1999CA2324016A1 Synthesis of compounds and libraries of compounds
09/28/1999US5959297 Mass spectrometers and methods for rapid screening of libraries of different materials
09/28/1999US5958792 Combinatorial libraries of substrate-bound cyclic organic compounds
09/28/1999US5958342 Pulsation; miniaturization
09/16/1999WO1999031506A9 Parallel solution phase synthesis of lactams
09/16/1999WO1998041531A3 Solvent for biopolymer synthesis, solvent microdroplets and methods of use
09/10/1999WO1999044741A1 Reaction block docking station
09/10/1999CA2291767A1 Reaction block docking station
09/02/1999CA2627799A1 Tumor tissue microarrays for rapid molecular profiling
08/1999
08/26/1999WO1999042450A1 Solid phase synthesis of 1-aminohydantoins
08/26/1999CA2321085A1 Solid phase synthesis of 1-aminohydantoins
08/25/1999EP0781436A4 System and method of automatically generating chemical compounds with desired properties
08/19/1999WO1999041007A2 Method and apparatus for chemical and biochemical reactions using photo-generated reagents
08/19/1999WO1999041005A1 Method for the combinatorial production and testing of heterogeneous catalysts
08/12/1999WO1999039817A1 Method of quality control in manufacturing processes
08/12/1999WO1998039099A9 Apparatus and methods for the preparation of chemical compounds
08/12/1999CA2320810A1 Method of quality control in manufacturing processes
08/11/1999EP0934515A1 Infrared spectroscopy and imaging of libraries
08/10/1999US5935527 Using phosphoramidite or hydrogen phosphonate chemistry on a nonswellable porous polystyrene support
07/1999
07/28/1999EP0931259A2 Matrices with memories in automated drug discovery and units therefor
07/15/1999WO1999034931A1 Method and apparatus for high-speed dot array dispensing
07/13/1999US5922534 Fused silica substrate with dried aliquots of known oligonucleotides covalently bound to substrate; for diagnostic hybridizations; increased storage and transport stability and archival potential after assay
07/08/1999WO1998039099A8 Apparatus and methods for the preparation of chemical compounds
06/1999
06/24/1999WO1999031506A1 Parallel solution phase synthesis of lactams
06/24/1999WO1999030817A1 Method and apparatus for chemical synthesis
06/24/1999CA2314073A1 Method and apparatus for chemical synthesis
06/23/1999EP0923590A1 Combinatorial synthesis and analysis of organometallic compounds and catalysts
06/03/1999WO1999026902A1 A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring
06/03/1999CA2311490A1 A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring
06/02/1999EP0821619A4 Methods and apparatus for the generation of chemical libraries
05/1999
05/27/1999WO1999025724A2 Oligonucleotide synthesis using high boiling point solvents
05/27/1999CA2309927A1 Oligonucleotide synthesis using high boiling point solvents
05/26/1999EP0917493A1 Solid phase organic synthesis device with pressure-regulated manifold
05/20/1999WO1999024645A1 Array of functionalized micro-electrodes
05/19/1999EP0916396A2 Combinatorial strategies for polymer synthesis
05/06/1999EP0912469A1 Polymers as a support for combinatorial synthesis
05/04/1999US5901069 System, method, and computer program product for at least partially automatically generating chemical compounds with desired properties from a list of potential chemical compounds to synthesize
04/1999
04/27/1999US5897838 Apparatus for rapid evaporation of aqueous solutions
04/22/1999WO1999019344A1 Coding combinatorial libraries with fluorine tags
04/22/1999WO1998058745A9 Electrospraying solutions of substances for mass fabrication of chips and libraries
04/22/1999CA2305771A1 Coding combinatorial libraries with fluorine tags
04/14/1999EP0907625A1 Fluorous reaction and separation systems
03/1999
03/31/1999EP0904540A1 Methods for spatially-dispersed positionally-encoded combinatorial library synthesis
03/30/1999US5888830 Plurality of reaction vessels mounted in inlets in a manifold valve block
03/11/1999WO1999011654A1 Randomly generated glycopeptide combinatorial libraries
03/11/1999CA2302472A1 Randomly generated glycopeptide combinatorial libraries
03/10/1999EP0900285A1 Technique for representing combinatorial chemistry libraries resulting from selective combination of synthons
03/09/1999US5880972 Method and apparatus for generating and representing combinatorial chemistry libraries
03/03/1999EP0898575A2 A combinatorial protecting group strategy for multifunctional molecules
03/03/1999EP0898495A1 Jet droplet device and method
02/1999
02/25/1999WO1998032017A3 Modulators of insulin receptor activity
02/23/1999US5874532 Method for solution phase synthesis of oligonucleotides and peptides
02/02/1999US5866342 Systems and methods for the synthesis of organic compounds
02/02/1999US5866330 Isolating and analyzing short defined sequence tags corresponding to expressed genes
01/1999
01/27/1999EP0892963A1 Method of creating and searching a molecular virtual library using validated molecular structure descriptors
01/21/1999CA2584453A1 A method for increasing the concentration of nucleic acids
01/19/1999US5861492 Solution and solid-phase formation of glycosidic linkages
12/1998
12/30/1998WO1998058745A1 Electrospraying solutions of substances for mass fabrication of chips and libraries
12/30/1998CA2294449A1 Electrospraying solutions of substances for mass fabrication of chips and libraries
12/17/1998WO1998056770A1 Method for producing quinazoline-diones in solid phase and use of the same
12/17/1998DE19724983A1 Verfahren zur Herstellung von Chinazolindionen an fester Phase und ihre Verwendung Process for the preparation of quinazolinediones on a solid phase, and their use
12/17/1998CA2294175A1 Method for producing quinazoline-diones in solid phase and use of the same
12/10/1998WO1998055449A1 Hydroxamic acid compounds having anticancer and anti-parasitic properties
12/08/1998US5847105 Methods for performing multiple sequential reactions on a matrix
12/03/1998WO1998041534A3 Multifunctional ceramic particles as supports for solid phase and combinatorial synthesis
12/03/1998WO1998031732A3 Methods for radiation grafting to polymeric surfaces
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