| Patents for C07D 503 - Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (648) |
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| 02/19/1997 | CN1143388A Novel process for isolation of clavulanic acid and of pharmaceutically acceptable salts |
| 02/18/1997 | US5604218 Cephalosporin antibiotics |
| 02/13/1997 | WO1997005142A1 Process for the preparation of potassium clavulanate |
| 01/22/1997 | EP0754687A1 Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 01/22/1997 | EP0754184A1 Cephalosporin antibiotics |
| 01/14/1997 | US5593986 Cephalosporin antibiotics |
| 12/31/1996 | US5589592 Process for preparing β-lactam derivative and synthetic intermediate |
| 12/24/1996 | US5587474 Method for removing the protecting group for carboxyl group |
| 12/17/1996 | US5585373 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid derivative as antitumor agent |
| 12/11/1996 | EP0747383A2 Polyamine salts of clavulanic acid |
| 12/11/1996 | EP0644887B1 Intermediates in a process for the purification of clavulanic acid |
| 12/05/1996 | WO1996038450A1 Cephalosporin antibiotics |
| 12/05/1996 | WO1996038448A1 β-LACTAM ANTIBIOTICS |
| 11/13/1996 | EP0741732A1 Process for the preparation of a salt of clavulanic acid |
| 10/24/1996 | WO1996033197A1 Preparation of clavulanate salts |
| 10/24/1996 | CA2218648A1 Preparation of clavulanate salts |
| 10/23/1996 | EP0654995B1 4-oxa-1-azabicyclo (3,2,0) heptan-7-one derivatives as antitumor agents |
| 10/01/1996 | US5561126 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents |
| 09/19/1996 | WO1996028452A1 Process for the preparation of pharmaceutically acceptable salts of clavulanic acid |
| 09/12/1996 | WO1996020199A3 Diclavulanate salt with a diamino ether and process of preparation |
| 09/06/1996 | WO1996026944A1 Clavulanic acid salts |
| 09/06/1996 | CA2213563A1 Clavulanic acid salts |
| 09/04/1996 | EP0729961A1 Clavulanic acid salts |
| 08/27/1996 | US5550142 Phenyl heterocycles as cox-2 inhibitors |
| 07/25/1996 | WO1996022296A1 Clavulanic acid extraction process |
| 07/24/1996 | EP0647229B1 Diamine salts of clavulanic acid |
| 07/16/1996 | US5536752 Phenyl heterocycles as COX-2 inhibitors |
| 07/04/1996 | WO1996020199A2 Diclavulanate salt with a diamino ether and process of preparation |
| 07/03/1996 | EP0719778A1 Diamine salts of clavulanic acid |
| 07/03/1996 | CN1125944A Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 06/20/1996 | WO1996018743A1 Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low |
| 06/20/1996 | CA2207411A1 Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low |
| 05/15/1996 | EP0711350A1 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid |
| 03/12/1996 | US5498788 Inclusion complexes of clavulanic acid and of potassium salts thereof with hydrophobic β-cyclodextrin derivatives a process for the preparation thereof |
| 03/12/1996 | CA1338143C Enzymatic preparation of clavulanic acid and its precursor |
| 03/07/1996 | WO1995034194A3 Process for manufacturing clavulanic acid salt |
| 03/06/1996 | EP0699682A1 Process for the preparation and/or purification of clavulanic acid |
| 02/13/1996 | US5491139 Antimicrobial quinolonyl lactams |
| 01/10/1996 | EP0690714A1 3-(7-oxo-1-aza-4-oxabicyclo 3.2.0]hept-3-yl) alanine derivative as antitumor agent |
| 12/27/1995 | EP0688324A1 Novel 3-(substituted methyl)-4-oxa-1-azabicyclo 3.2.0]heptan-7-one derivatives useful as antitumor agents |
| 12/21/1995 | WO1995034194A2 Process for manufacturing clavulanic acid salt |
| 12/13/1995 | CN1113244A Novel process |
| 12/12/1995 | US5474995 Phenyl heterocycles as cox-2 inhibitors |
| 12/06/1995 | CN1112928A Novel method for preparation and/or purification of clavulanic acid or pharmaceutical salt or ester of same |
| 11/08/1995 | EP0680322A1 Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
| 10/12/1995 | WO1995026966A1 Cephalosporin antibiotics |
| 10/12/1995 | CA2186894A1 Cephalosporin antibiotics |
| 09/27/1995 | EP0673432A1 Process for preparing clavulanic acid |
| 09/20/1995 | EP0672670A1 Process for the preparation of clavulanic acid |
| 09/20/1995 | EP0672669A1 Process for the preparation of clavulanic acid |
| 09/08/1995 | WO1995023870A1 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804 |
| 09/08/1995 | CA2184619A1 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804 |
| 09/06/1995 | CN1108029A Diamine salts of clavulanic acid |
| 08/10/1995 | WO1995021173A1 Process for the preparation of a salt of clavulanic acid |
| 07/13/1995 | WO1995018807A1 Novel 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents |
| 07/13/1995 | WO1995018611A1 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl) alanine derivative as antitumor agent |
| 07/13/1995 | CA2157603A1 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl) alanine derivative as antitumor agent |
| 07/13/1995 | CA2157602A1 Novel 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents |
| 05/09/1995 | US5414081 Treating a 1-aza-3-thiabicycloalkane with base and phosphine or phosphite desulfurizing agent, and reacting the product with an active esterifying agent |
| 04/13/1995 | WO1995000501A3 Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 03/07/1995 | US5395931 6-amido-1-methyl-2-(substituted-thio)carbapenems |
| 02/07/1995 | US5387748 Antimicrobial dithiocarbamoyl quinolones |
| 02/02/1995 | WO1995003416A1 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid |
| 01/05/1995 | WO1995000501A2 Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 01/05/1995 | CA2364039A1 Use of phenyl heterocycles in the relief or treatment of rheumatoid arthritis, osteoarthritis, fever, pain, headache or dysmenorrhea |
| 01/05/1995 | CA2163888A1 Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 11/16/1994 | CN1095069A Novel process |
| 11/02/1994 | EP0621783A1 Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivative |
| 10/13/1994 | WO1994022873A1 Diamine salts of clavulanic acid |
| 10/13/1994 | CA2135671A1 Diamine salts of clavulanic acid |
| 09/29/1994 | WO1994021647A1 Diclavulanate salt with a diamine and process of preparation |
| 08/04/1994 | WO1994016696A1 Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
| 07/12/1994 | US5328908 Antimicrobial quinolone thioureas |
| 06/09/1994 | WO1994012654A1 Process for preparing clavulanic acid |
| 05/10/1994 | US5310898 Enzyme inhibitors |
| 04/27/1994 | EP0594099A1 Process for the purification of crude clavulanic acid |
| 04/27/1994 | EP0593457A1 Antimicrobial quinolone thioureas |
| 04/22/1994 | CA2107928A1 Process for the purification of crude clavulanic acid |
| 02/22/1994 | US5288861 Dissolving, crystallization, precipitation; visible under magnification |
| 01/25/1994 | CA1326486C Potassium clavulanate |
| 01/20/1994 | WO1994001109A1 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents |
| 01/20/1994 | CA2139633A1 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents |
| 01/12/1994 | EP0578231A1 Inclusion complexes of clavulanic acid and of alkali salts thereof with beta-cyclodextrines |
| 01/09/1994 | CA2100045A1 Inclusion complexes of clavulanic acid and of alkali salts thereof with hydrophilic and hydrophobic .beta. - cyclodextrin derivatives, a proce ss for the preparation thereof and the use thereof |
| 12/23/1993 | WO1993025557A1 Process for the preparation of clavulanic acid |
| 12/23/1993 | CA2117538A1 Process for the preparation of clavulanic acid |
| 12/22/1993 | EP0574940A1 Method for removing the protecting group for carboxyl group |
| 12/22/1993 | CN1079743A Process for the production of clavulanic acid salts |
| 12/12/1993 | CA2160768A1 Process for the preparation of clavulanic acid |
| 11/09/1993 | US5260438 With fluorine compound |
| 11/03/1993 | EP0567949A1 Method for removing the protecting group for hydroxy group |
| 09/30/1993 | DE4307422A1 Verfahren zur Herstellung von Clavulansäuresalzen Process for the preparation of salts of clavulanic acid |
| 09/29/1993 | EP0562583A1 Alkylene diammonium diclavulanate derivatives, process for their preparation and for their use |
| 09/08/1993 | EP0559533A1 Process for preparing beta-lactam derivative and synthetic intermediate thereof |
| 09/07/1993 | CA2085540A1 Process for preparing beta-lactam derivative and synthetic intermediate the reof |
| 08/05/1993 | WO1993014770A1 Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivative |
| 06/30/1993 | EP0548790A1 (1'S)-Hydroxyalkyloxapenem-3-carboxylic acids and their use as beta-lactamase inhibitors |
| 06/21/1993 | CA2085834A1 (1s) -hydroxyalkyl-oxapenem-3-carboxylic acids and their use as betalactamase inhibitors |
| 09/08/1992 | CA1307223C Preparation of clavulanic acid and its salts and esters |
| 07/14/1992 | US5130241 Clavam derivatives and its enzymatic preparation |