| Patents for C07D 503 - Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (648) |
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| 08/27/2003 | CN1119423C Process for ferment ative preparation of clavam derivatives wherehy the levels of ammonia and urea in the fermentation medium are kept low |
| 08/20/2003 | CN1118469C Preparation of and/or purifing method for clavate acid or salt or ester acceptable in pharmacy |
| 08/14/2003 | US20030153549 Clavulinic acid derivatives; antibiotics |
| 07/23/2003 | EP1328528A1 Pharmaceutical compositions |
| 07/23/2003 | CN1115147C Improved method for preparing potassium clavulanate |
| 07/16/2003 | EP1326608A1 Stable compositions of oxapenem-3-carboxylic acids by co-lyophilisation with pharmaceutical carriers |
| 07/16/2003 | EP1326607A1 Pharmaceutical compositions containing oxapenem-3-carboxilic acids |
| 07/09/2003 | CN1429227A Process for purification of salt of clavulanic acid |
| 07/09/2003 | CN1113885C Process for producing beta-lactam derivs. |
| 07/03/2003 | US20030124690 Novel compounds |
| 06/26/2003 | WO2003052113A1 Cyclisation process for the preparation of c-2 beta-lactam compounds |
| 06/18/2003 | EP1319086A1 Process for the preparation of clavulanic acid |
| 05/20/2003 | US6566106 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof |
| 05/07/2003 | EP0821687B1 Preparation of clavulanate salts |
| 04/16/2003 | CN1105724C Chavulanic acid extracting process |
| 03/19/2003 | EP0711350B1 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid |
| 02/26/2003 | EP1284978A1 Process for the purification of a salt of clavulanic acid |
| 02/26/2003 | EP0796340B1 Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low |
| 02/12/2003 | CN1101396C Isolation of claulanic acid from fermentation broth by ultrafiltration |
| 01/30/2003 | US20030022882 Forming the 2-amino-2,4,4-trimethylpentane salt of clavulanic acid and converting that salt into a pharmaceutically acceptable salt of clavulanic acid, such as potassium clavulanate |
| 01/30/2003 | US20030022321 Novel compounds |
| 11/13/2002 | EP1255760A1 Clavams as protease inhibitors |
| 09/11/2002 | CN1090636C Production of salt clavulanic acid |
| 09/04/2002 | EP1236729A1 Clavulanic acid aldehyde, beta-lactamase inhibitor |
| 07/09/2002 | US6417352 Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
| 07/02/2002 | US6414142 Concurrently adding solution of potassium 2-ethyl hexanoate in isopropanol and solution of tertiary-butylamino clavulanate in aqueous isopropanol to mixture of isopropanol and acetone, precipitating potassium clavulanate as rosette-like starbursts |
| 06/13/2002 | US20020072513 Process for the production of clavulanic acid salts |
| 05/07/2002 | CA2215038C Process for the preparation of pharmaceutically acceptable salts of clavulanic acid |
| 04/30/2002 | CA2226683C Isolation of clavulanic acid from fermentation broth by ultrafiltration |
| 04/25/2002 | WO2002032906A1 Pharmaceutical compositions |
| 04/25/2002 | WO2002032424A1 Stable compositions of oxapenem-3-carboxylic acids by co-lyophilisation with pharmaceutical carriers |
| 04/25/2002 | WO2002032423A1 Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| 04/24/2002 | EP1199077A1 Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers |
| 04/17/2002 | CN1345231A Agglomerates by crystallisation |
| 04/09/2002 | US6369219 Preparation of clavulanate salts |
| 03/27/2002 | CN1081640C Diclavulanate salt of diamino ether and its preparing method |
| 03/21/2002 | WO2002022846A1 Process |
| 01/30/2002 | EP0904284B1 6-substituted amino-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives as cysteine protease inhibitors |
| 01/29/2002 | CA2092330C Novel alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof |
| 01/02/2002 | EP1165049A2 Agglomerates by crystallisation |
| 11/22/2001 | WO2001087891A1 Process for the purification of a salt of clavulanic acid |
| 11/01/2001 | US20010036940 Chemical intermediates |
| 10/31/2001 | CN1320166A Fermentation of clavulanic acid at a controlled level of ammonia |
| 10/11/2001 | US20010029038 Purification of fermented clavulanic acid |
| 10/09/2001 | US6300495 Process for the preparation of a metal salt of clavulanic acid |
| 09/27/2001 | US20010025104 Amination of clavulanic acid |
| 09/12/2001 | EP0843680B1 Process for the preparation of potassium clavulanate |
| 09/12/2001 | CN1312814A Improved process for preparing salts and esters of clavulanic acid |
| 08/15/2001 | CN1308682A Fermentation process to produce clavulanic acid at a low concentration of free amino acids |
| 08/14/2001 | US6274575 Isolation of clavulanic acid from fermentation broth by ultrafiltration |
| 08/02/2001 | WO2001055153A1 Clavams as protease inhibitors |
| 07/25/2001 | EP1117820A1 Fermentation of clavulanic acid at a controlled level of ammonia |
| 07/12/2001 | US20010007761 Novel process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof |
| 06/20/2001 | EP0741732B1 Process for the preparation of a salt of clavulanic acid |
| 05/29/2001 | US6239173 Antiinflammatory, antipyretic, analgesic, and antiarthritic agents |
| 05/22/2001 | US6235506 Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low |
| 05/16/2001 | CN1295065A Phenyl heterocyclic compound used as epoxy enzyme -2 inhibitor |
| 05/09/2001 | EP1097238A1 Fermentation process to produce clavulanic acid at a low concentration of free amino acids |
| 05/02/2001 | EP1095046A1 Improved process for the preparation of salts and esters of clavulanic acid |
| 05/02/2001 | CN1065246C Process for preparation of salt of clavulanic acid |
| 04/17/2001 | US6218380 Pharmaceutical compositions |
| 04/11/2001 | CN1064364C Method for mfg clavulanic acid salts |
| 04/04/2001 | EP1088826A1 Process for the preparation of potassium clavulanate |
| 03/27/2001 | US6207428 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 |
| 02/13/2001 | CA2001203C Novel antimicrobial dithiocarbamoyl quinolones |
| 01/30/2001 | US6180782 Preparation of clavulanate salts |
| 01/09/2001 | US6172221 Clavulanic acid extraction process |
| 12/19/2000 | CA2001225C Antimicrobial lactam-quinolones |
| 11/02/2000 | WO2000041478A3 Agglomerates by crystallisation |
| 11/01/2000 | CN1058008C Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 10/17/2000 | US6133441 Production of a salt of clavulanic acid |
| 10/17/2000 | CA2001205C Antimicrobial quinolonyl lactams |
| 10/03/2000 | US6127358 Purification by membrane microfiltration, then ultrafiltration |
| 09/13/2000 | EP1034784A2 Pharmaceutical formulations containing clavulanic acid and an antibacterial agent |
| 08/23/2000 | CN1055694C Novel process for isolation of clavulanic acid and of pharmaceutically acceptable salts |
| 08/22/2000 | CA2176973C Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 07/20/2000 | WO2000041478A2 Agglomerates by crystallisation |
| 07/05/2000 | EP0680322B1 Use of clavulanate and an antibacterial compound for the treatment of infections |
| 06/28/2000 | CN1258298A Process for preparation of metal salt of clavulanic acid |
| 06/28/2000 | CN1258297A Process for producing beta-lactam derivs. |
| 05/17/2000 | EP1000945A1 PROCESS FOR PRODUCING $g(b)-LACTAM DERIVATIVES |
| 05/03/2000 | EP0997466A1 Novel antimicrobial lactam-quinolones |
| 04/26/2000 | EP0827504B1 Process for manufacturing clavulanic acid salt |
| 04/26/2000 | CN1251612A Novel compound |
| 04/18/2000 | US6051703 Broad spectrum antibiotic |
| 04/11/2000 | US6048977 Clavulanic acid and salts thereof |
| 04/06/2000 | WO2000018947A1 Fermentation of clavulanic acid at a controlled level of ammonia |
| 04/06/2000 | CA2342181A1 Fermentation of clavulanic acid at a controlled level of ammonia |
| 02/29/2000 | US6031093 Solid salts of clavulanic acid |
| 02/23/2000 | EP0980866A2 Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 01/27/2000 | WO2000004028A1 Improved process for the preparation of salts and esters of clavulanic acid |
| 01/27/2000 | CA2337072A1 Improved process for the preparation of salts and esters of clavulanic acid |
| 01/13/2000 | WO2000001840A1 Fermentation process to produce clavulanic acid at a low concentration of free amino acids |
| 01/13/2000 | CA2336363A1 Fermentation process to produce clavulanic acid at a low concentration of free amino acids |
| 01/12/2000 | EP0970198A2 Novel compounds |
| 01/12/2000 | EP0970087A1 A process for the preparation of a metal salt of clavulanic acid |
| 12/15/1999 | CN1238776A Process for the preparation of salts and esters of clavulanic acid |
| 12/07/1999 | US5998612 Antibiotic synthesis |
| 11/30/1999 | US5994534 Process for the preparation of pharmaceutically acceptable salts of clavulanic acid |
| 11/30/1999 | US5994342 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents |