C07D 503 - Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Patents for C07D 503 - Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (648)
11/1999
11/16/1999	US5985625 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804
11/16/1999	US5985624 Monitoring, controlling during fermentation ammonium concentration
10/1999
10/13/1999	CN1045604C Process for the production of clavulanic acid salts
10/12/1999	US5965728 Process for the preparation of a salt clavulanic acid
09/1999
09/15/1999	EP0941229A1 Purification of fermented clavulanic acid
09/07/1999	CA2136042C 3-(7'-oxo-1'-aza-4'-oxabicyclo¬3.2.0\| hept-3'-yl) propionic acid derivative
09/01/1999	CN1227488A Improved method for preparing potassim clavulanate
08/1999
08/25/1999	EP0937725A2 Method for removing the protecting group for hydroxy group
08/25/1999	EP0937084A1 Process for the preparation of salts and esters of clavulanic acid
08/24/1999	CA2176974C Phenyl heterocycles as cyclooxygenase-2 inhibitors
06/1999
06/02/1999	EP0918520A1 Process for preparing potassium clavulanate
05/1999
05/20/1999	WO1999024441A1 Crystallization of beta-lactam compounds
05/18/1999	US5905076 Treatment of muscular dystrophy, arthritis, myocardial infarction, alzheimer's disease, bacterial infection, common cold, osteoporosis or cancer metastasis
04/1999
04/07/1999	EP0906312A1 Process for the preparation of carbapenem derivatives and intermediates thereof
04/07/1999	EP0799233B1 Diclavulanic acid salts with diamino ethers and process for their preparation
03/1999
03/31/1999	EP0904284A1 6-substituted amino-4-oxa-1-azabicyclo (3,2,0) heptan-7-one derivatives as cysteine protease inhibitors
03/24/1999	EP0673432B1 Process for preparing clavulanic acid
02/1999
02/09/1999	US5869299 Using an enzyme system from streptomyces, particularly s. clavuligerus.
02/03/1999	CN1041934C Process for preparing and/or purifying bar acid or medicinal salt or ester thereof
02/03/1999	CN1041933C Diamine salts of clavulanic acid and their preparation process and use
01/1999
01/12/1999	US5859238 Reacting crude clavulanic acid extract in organic solvent with alkylenediamine to form diammonium salt, isolating, reacting with potassium 2-ethylhexanaote in isopropanol to form potassium clavulanate
01/06/1999	CN1204337A Production of salt clavulanic acid
12/1998
12/30/1998	WO1998058931A1 PROCESS FOR PRODUCING β-LACTAM DERIVATIVES
11/1998
11/19/1998	WO1998033896A3 Microorganisms with increased production of clavulanic acid
11/04/1998	EP0874855A1 Production of a salt of clavulanic acid
10/1998
10/22/1998	WO1998046566A1 IMPROVED β-LACTAM ANTIBIOTICS
10/15/1998	WO1998045300A1 A process for the preparation of a metal salt of clavulanic acid
10/13/1998	US5821364 Diamine salts of clavulanic acid
10/01/1998	WO1998042858A1 Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
09/1998
09/30/1998	EP0867515A1 Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
09/23/1998	CN1193975A Isolation of clavulanic acid from fermentation broth by ultrafiltration
08/1998
08/27/1998	WO1998037084A1 3-substituted clavams for calpain inhibition
08/26/1998	EP0859780A1 Isolation of clavulanic acid from fermentation broth by ultrafiltration
08/06/1998	WO1998033896A2 Microorganisms with increased production of clavulanic acid
08/06/1998	CA2279207A1 Novel compounds
08/04/1998	US5789584 Substituted-pyridinyl cephalosporin antibiotics active against methicillin resistant bacteria
07/1998
07/28/1998	US5786351 Bactericides
07/14/1998	US5780274 Culturing, micro and ultrafiltration, concentration, solvent extraction to prodce clavulanic acid, drying, reacting with n,n'-diisopropylethylenediamine producing intermediate, reacting intermediate with potassium 2-ethylhexanoate
06/1998
06/17/1998	CN1185158A Prepn. of clavulanate salts
06/17/1998	CN1185155A Method for mfg. clavulanic acid salt
06/04/1998	WO1998023622A1 Purification of fermented clavulanic acid
06/04/1998	CA2273021A1 Purification of fermented clavulanic acid
06/02/1998	US5760218 Diamine salts of clavulanic acid
05/1998
05/27/1998	EP0843680A1 Process for the preparation of potassium clavulanate
05/27/1998	EP0843552A2 Pharmaceutical formulations
05/26/1998	US5756493 Active against methicillin resistant bacteria
05/22/1998	WO1998021212A1 Process for the preparation of salts and esters of clavulanic acid
05/22/1998	CA2271847A1 Process for the preparation of salts and esters of clavulanic acid
05/12/1998	US5750685 Precipitation with potassium clavulanic acid
05/06/1998	EP0705254B1 Phenyl heterocycles as cyclooxygenase-2 inhibitors
04/1998
04/21/1998	US5741903 Diamine salts for purification of clavulanic acid
04/15/1998	CN1179161A Clavulanic acid extractim process
04/08/1998	CN1037967C Novel intermediate and its use of preparation of acid
03/1998
03/31/1998	US5734048 Process for manufacturing clavulanic acid salt
03/11/1998	EP0827504A2 Process for manufacturing clavulanic acid salt
03/11/1998	CN1175952A Clavulanic acid salts and method for preparing same
03/10/1998	US5726170 Clavulanic acid salts
02/1998
02/17/1998	US5719277 Diamine salts of clavulanic acid
02/04/1998	EP0822190A1 Phenyl heterocycles as cyclooxygenase-2 inhibitors
02/04/1998	EP0821687A1 Preparation of clavulanate salts
01/1998
01/21/1998	CN1171111A Diclavulanate salt of diamino ether and its preparing method
01/20/1998	US5710140 Phenyl heterocycles as COX-2 inhibitors
12/1997
12/31/1997	CN1169162A Process for fermentative prepn. of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
12/29/1997	EP0813536A1 Process for the preparation of pharmaceutically acceptable salts of clavulanic acid
12/18/1997	WO1997047621A1 Process for the preparation of carbapenem derivatives and intermediates thereof
12/18/1997	WO1997047301A1 Improved process for preparing potassium clavulanate
12/18/1997	CA2257968A1 Improved process for preparing potassium clavulanate
12/16/1997	US5698547 Cephalosporin antibiotics
12/03/1997	CN1036592C Novel method for preparation and/or purification of clavulanic acid or pharmaceutical salt or ester of same
11/1997
11/18/1997	US5688786 β-lactam antibiotics
11/12/1997	EP0806426A1 Process for the preparation of clavulanic acid
11/05/1997	EP0804441A1 Clavulanic acid extraction process
10/1997
10/22/1997	EP0748387B1 Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. p 6621 ferm p 2804
10/21/1997	US5679789 Pharmaceutical compositions comprising potassium clavulanate and methods of using them
10/16/1997	WO1997038008A1 6-substituted amino-4-oxa-1-azabicyclo[3,2,0] heptan-7-one deriv atives as cysteine protease inhibitors
10/16/1997	CA2252086A1 6-substituted amino-4-oxa-1-azabicyclo¬3,2,0\|heptan-7-one derivatives as cysteine protease inhibitors
10/15/1997	EP0801069A1 Process for the preparation of clavulanic acid
10/08/1997	EP0799233A2 Clavulanic acid salts
09/1997
09/30/1997	US5672600 Antimicrobial dithiocarbamoyl quinolones
09/24/1997	EP0796340A1 Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
09/09/1997	CA1339450C Stable oxapenem-3-carboxylic acids
08/1997
08/19/1997	US5658887 Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivatite
08/12/1997	US5656623 Bactericides; antibiotics
07/1997
07/29/1997	US5652234 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as antitumor agent
07/15/1997	US5648346 Antimicrobial carbacephem-quinolones
07/08/1997	US5646139 Antimicrobial carbapenem quinolones
06/1997
06/10/1997	US5637580 Antimicrobial penem-quinolones
05/1997
05/22/1997	WO1997018216A1 Production of a salt of clavulanic acid
05/21/1997	CN1150153A Use of 2-amino-2,4,4,-trimethylpentane salt of clavulanic acid
05/20/1997	US5631256 Antimicrobial quinolone thioureas
05/14/1997	CN1149874A Cephalosporin antibiotics
04/1997
04/10/1997	WO1997006798A3 Pharmaceutical formulations
03/1997
03/26/1997	CN1145906A Process for production of pharmaceutically acceptable salt of alavulanic acid
03/25/1997	US5614199 Inclusion complexes of clavulanic acid and of alkali salts thereof with hydrophilic and hydrophobic β-cyclodextrin derivatives, a process for the preparation thereof and the use thereof
03/20/1997	WO1997010247A1 Clavulanic acid derivatives for treating atherosclerosis
03/06/1997	WO1997008175A1 Isolation of clavulanic acid from fermentation broth by ultrafiltration
03/05/1997	CN1144528A Process for preparation of salt of clavulanic acid
03/04/1997	US5608052 Enzyme inhibitors of beta-lactamase
03/04/1997	US5607926 Active against methicillin resistant bacteria
02/1997
02/27/1997	WO1997006798A2 Pharmaceutical formulations

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