| Patents for C07D 503 - Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (648) |
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| 10/21/2014 | US8865891 Optically-detectable enzyme substrates and their method of use |
| 06/04/2014 | CN103833774A Method of recovering effective components from potassium clavulanate mixed powder |
| 03/26/2014 | EP2710016A1 Regulation of nitric oxide release and biofilm development |
| 03/19/2014 | CN103649098A Regulation of nitric oxide release and biofilm development |
| 12/31/2013 | US8618285 Triazole derivatives |
| 09/18/2013 | CN103304583A Method for recovering clavulanic acid from clavaminic acid salt crystallization mother liquor |
| 04/11/2013 | US20130090470 Optically-detectable enzyme substrates and their method of use |
| 12/26/2012 | CN102838624A Method for purifying clavulanic acid from fermentation liquor |
| 11/27/2012 | US8318450 Optically-detectable enzyme substrates and their method of use |
| 11/22/2012 | WO2012155203A1 Regulation of nitric oxide release and biofilm development |
| 11/22/2012 | CA2835642A1 Regulation of nitric oxide release and biofilm development |
| 02/21/2012 | US8119795 Triazole derivatives II |
| 02/16/2012 | US20120040380 Optically-detectable enzyme substrates and their method of use |
| 01/10/2012 | CA2408853C Process |
| 08/31/2011 | EP1489061B1 Process for producing cyclic compound |
| 07/06/2011 | EP1165049B2 Agglomerates by crystallisation |
| 02/24/2011 | US20110045082 Agglomerates by crystallisation |
| 02/01/2011 | CA2364342C Agglomerates by crystallisation |
| 10/12/2010 | US7812014 such as (5R,6Z)-6-[(5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)methylene]-7oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, in combination with beta-lactam antibiotics, for the treatment of bacterial infections |
| 08/03/2010 | US7767823 washing, crystallizing |
| 05/26/2010 | CN1649883B Bicyclic 6-alkylidene-penems as lactamases inhibitors |
| 04/06/2010 | US7691842 Tricyclic 6-alkylidene-penems as β-lactamase inhibitors |
| 03/30/2010 | CA2424462C Clavulanic acid pharmaceutical compositions |
| 01/28/2010 | US20100022540 Triazole derivatives ii |
| 05/06/2009 | CN100484943C Novel method for preparing clavulanate |
| 04/28/2009 | CA2425314C Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| 02/19/2009 | US20090047692 Optically-detectable enzyme substrates and their method of use |
| 12/25/2008 | US20080318921 5R,6Z)-6-(Imidazo[2,1-b][1,3]benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; beta -Lactamases hydrolyze beta -lactam antibiotics and as such serve as the primary cause of bacterial resistance |
| 12/18/2008 | US20080312203 such as (5R,6Z)-6-[(5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)methylene]-7oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, in combination with beta-lactam antibiotics, for the treatment of bacterial infections |
| 12/02/2008 | US7459551 Method for preparing cyclic compounds |
| 11/05/2008 | EP1988093A1 Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors |
| 10/08/2008 | CN101279982A Novel method for preparing clavulanate |
| 09/10/2008 | EP1284978B2 Process for the purification of a salt of clavulanic acid |
| 07/23/2008 | EP1326607B1 Pharmaceutical compositions containing oxapenem-3-carboxilic acids |
| 05/06/2008 | CA2237763C Production of a salt of clavulanic acid |
| 04/08/2008 | CA2182504C Process for the preparation of a salt of clavulanic acid |
| 04/01/2008 | CA2210748C Clavulanic acid extraction process |
| 03/18/2008 | US7344869 Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and Streptomyces hosts capable of improved clavulanic acid production |
| 12/27/2007 | US20070298470 Improving manufacture of clavulanic acid; DNA encoding genes essential for clavam-2-carboxylate (C2C), 2-hydroxymethylclavam (2HMC), or 2-(3-alanyl)clavam (AC) biosynthesis in S. clavuligerus which are not essential for clavulanic acid biosynthesis |
| 11/21/2007 | EP0970087B1 A process for the preparation of a metal salt of clavulanic acid |
| 11/13/2007 | CA2286369C A process for the preparation of a metal salt of clavulanic acid |
| 07/24/2007 | US7247622 Antibiotic; beta-lactamase inhibitor; therapy for infection |
| 06/14/2007 | CA2783572A1 Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| 04/25/2007 | CN1312086C Process for producing cyclic compound |
| 10/18/2006 | EP1711504A2 Derivatives of cephalosporin and clavulanic acid for detecting beta-lactamase in a sample |
| 09/28/2006 | US20060217361 Bicyclic 6-alkylidene-penems as beta-lactamase inhibitors |
| 09/26/2006 | US7112582 penicillins and oxapenicillins with a fused bicyclic N-heteroarymethylene group; 6-[(5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)methylene]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; antibiotic resistance is reduced when administered alone or with other B-lactam antibiotics |
| 08/08/2006 | US7087748 Process |
| 08/02/2006 | CN1267437C Pharmaceutical compositions |
| 06/07/2006 | CN1258535C Process for preparation of metal salt of clavulanic acid |
| 06/06/2006 | USH2158 Process for the production of clavulanic acid salts |
| 04/13/2006 | US20060079676 washing, crystallizing |
| 04/13/2006 | US20060079496 Agglomerates by crystallisation |
| 03/14/2006 | CA2278241C Phenyl heterocycles as cyclooxygenase-2 inhibitors |
| 12/27/2005 | US6979735 Agglomerates by crystallization |
| 12/15/2005 | WO2005071096A3 Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample |
| 12/14/2005 | EP0970198B1 Micro-organisms with increased production of clavulanic acid |
| 12/07/2005 | EP1326608B1 Stable compositions of oxapenem-3-carboxylic acids by co-lyophilisation with pharmaceutical carriers |
| 11/16/2005 | CN1696301A Process for clavulanic acid production by microbial thallus |
| 10/13/2005 | US20050227309 Optically-detectable enzyme substrates and their method of use |
| 10/12/2005 | CN1222528C Process for purification of salt of clavulanic acid |
| 09/22/2005 | US20050209450 High yield for industrial production; beta -lactam antibacterial agents; allyl (5R,6S)-6((R)-1-t-butyldimethyl-silyloxyethyl)-7-oxo-3-((R)-2-tetrahydrofuryl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (3-2) |
| 09/21/2005 | CN1219512C Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| 08/30/2005 | US6936458 Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and streptomyces hosts capable of improved clavulanic acid production |
| 08/17/2005 | CN1656046A Process for producing cyclic compound |
| 08/04/2005 | WO2005071096A2 Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample |
| 08/03/2005 | CN1649883A Bicyclic 6-alkylidene-penems as lactamases inhibitors |
| 07/06/2005 | CN1209099C Agglomerates by crystallisation |
| 04/27/2005 | CN1198940C Fermentation of clavulanic acid at a controlled level of ammonia |
| 03/31/2005 | US20050070519 Cyclisation process for the preparation of c-2 beta-lactam compounds |
| 03/09/2005 | CN1192107C 5S clavate alkyl gene separated from rhabdion streptomycete and its application in clavulanic acid production |
| 01/26/2005 | EP1499621A1 Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors |
| 12/29/2004 | EP1328528B1 Pharmaceutical compositions comprising clavulanic acid |
| 12/22/2004 | EP1489061A1 Process for producing cyclic compound |
| 11/25/2004 | DE4307422B4 Verfahren zur Herstellung von Clavulansäuresalzen Process for the preparation of salts of clavulanic acid |
| 11/03/2004 | EP1319086B1 Process for the preparation of clavulanic acid |
| 09/15/2004 | EP1456393A1 Cyclisation process for the preparation of c-2 beta-lactam compounds |
| 09/08/2004 | EP0813536B1 Process for the preparation of pharmaceutically acceptable salts of clavulanic acid |
| 08/18/2004 | EP1284978B1 Process for the purification of a salt of clavulanic acid |
| 04/22/2004 | US20040077622 penicillins and oxapenicillins with a fused bicyclic N-heteroarymethylene group; 6-[(5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)methylene]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; antibiotic resistance is reduced when administered alone or with other B-lactam antibiotics |
| 04/08/2004 | US20040067929 Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| 04/07/2004 | EP1405913A2 Process for improving the production of 5R clavams |
| 04/01/2004 | US20040063930 Selective adsorption |
| 03/17/2004 | EP0804441B1 Clavulanic acid extraction process |
| 03/04/2004 | US20040043981 Pharmaceutical composistions |
| 03/04/2004 | US20040043980 Bactericides; storage stability |
| 02/25/2004 | EP1165049B1 Agglomerates by crystallisation |
| 02/18/2004 | EP0874855B1 Production of a salt of clavulanic acid |
| 02/17/2004 | US6692950 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid |
| 01/21/2004 | CN1469880A Pharmaceutical compositions |
| 01/21/2004 | CN1469744A Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| 12/03/2003 | CN1129576C Phenyl heterocyclic compound used as epoxy enzyme-2 inhibitor |
| 11/27/2003 | US20030219867 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid |
| 11/13/2003 | WO2003093279A1 BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS |
| 11/13/2003 | CA2483538A1 Bicyclic 6-alkylidene-penems as .szlig.-lactamases inhibitors |
| 10/30/2003 | US20030203886 Process for the production of clavulanic acid salts |
| 10/07/2003 | CA2208520C Diclavulanate salt with a diamino ether and process of preparation |
| 10/02/2003 | WO2003080543A1 Process for producing cyclic compound |
| 09/04/2003 | US20030166175 Process for clavulanic acid production |
| 09/03/2003 | EP0941229B1 Purification of fermented clavulanic acid |