| Patents for C12P 37 - Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin (637) |
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| 10/29/1998 | CA2258562A1 Process for the inactivation of genes which code for enzymes for the catabolism of phenyl acetate, plasmids involved in such process and strains transformed therewith |
| 10/14/1998 | EP0869960A1 Process for the recovery of ampicillin |
| 09/23/1998 | EP0865443A1 Process for the preparation of an antibiotic |
| 09/23/1998 | CN1194002A Phenylacetyl-CoA ligase from penicillium chrysogenum |
| 09/11/1998 | WO1998039459A1 PROMOTERS OF THE GENES GLUTAMATE DESHYDROGENASE, β-N-ACETYLHEXOSAMINIDASE AND $b(g)-ACTINE, AND THEIR USE IN SYSTEMS OF EXPRESSION, SECRETION AND ANTI-SENS IN FILAMENTARY FUNGI |
| 09/11/1998 | CA2253250A1 Promoters of the genes glutamate deshydrogenase, .beta.-n-acetylhexosaminidase and $b(g)-actine, and their use in systems of expression, secretion and anti-sens in filamentary fungi |
| 08/27/1998 | WO1998037179A2 Fermentative production of valuable compounds on an industrial scale using chemically defined media |
| 08/19/1998 | CN1190990A An improved immobilized penicillin G acylase |
| 08/05/1998 | EP0856516A1 Novel bioprocess for preparing 7-aca and 7-adac |
| 07/08/1998 | EP0458932B1 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase |
| 06/25/1998 | WO1998027221A1 Process for the production of penicillin g or v, cephalosporin g or v, and derivatives thereof |
| 06/17/1998 | CN1185157A Recovery of ampicillin |
| 05/20/1998 | EP0843013A2 Novel bioprocess for preparing 7-ADCA |
| 05/19/1998 | US5753458 Acylation method for penicillins and cephalosporins |
| 05/19/1998 | US5753435 Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production |
| 05/06/1998 | EP0839192A1 An improved immobilized penicillin g acylase |
| 05/05/1998 | US5747285 DNA comprising regulatory regions from gene y of penicillium chrysogenum |
| 04/22/1998 | CN1179795A Process for preparation of 'beta'-lactam antibiotic |
| 04/15/1998 | EP0835316A1 PHENYLACETYL-CoA LIGASE FROM PENICILLIUM CHRYSOGENUM |
| 03/25/1998 | EP0831150A1 PROCESS FOR INCREASING THE PRODUCTION OF PENICILLIN G (BENZYLPENICILLIN) IN PENICILLIUM CHRYSOGENUM THROUGH THE EXPRESSION OF THE GENE pcl |
| 03/04/1998 | EP0826776A1 Alternative process for producing 6-amino-penicillanic acid (6-apa) |
| 02/05/1998 | WO1998004732A1 SYNTHESIS OF β-LACTAM ANTIBACTERIALS USING SOLUBLE SIDE CHAIN ESTERS AND ENZYME ACYLASE |
| 02/05/1998 | CA2253521A1 Synthesis of .beta.-lactam antibacterials using soluble side chain esters and enzyme acylase |
| 11/26/1997 | EP0712443B1 Process for the enzymatic preparation of a beta-lactam derivative and separation of d-phenylglycine amide |
| 10/15/1997 | CN1162337A Process of producing beta-lactam antibiotics applying microorganisms with increased ligase activity |
| 09/25/1997 | WO1997035029A1 Alternative process for producing 6-amino-penicillanic acid (6-apa) |
| 09/25/1997 | WO1997035013A1 PROCESS FOR INCREASING THE PRODUCTION OF PENICILLIN G (BENZYLPENICILLIN) IN PENICILLIUM CHRYSOGENUM THROUGH THE EXPRESSION OF THE GENE pcl |
| 09/03/1997 | CN1158638A Mutated penicilling acylase Genes |
| 07/29/1997 | US5652132 Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production |
| 07/16/1997 | EP0783582A1 PROCESS OF PRODUCING $g(b)-LACTAM ANTIBIOTICS APPLYING MICROORGANISMS WITH INCREASED LIGASE ACTIVITY |
| 07/16/1997 | EP0783581A1 Process for the production of secondary metabolites |
| 06/26/1997 | WO1997022610A1 Process for the preparation of an antibiotic |
| 06/25/1997 | CN1152945A Process for preparation of beta-lactams at constantly high concentration of reactants |
| 05/28/1997 | EP0775210A1 Mutated penicillin g acylase genes |
| 05/13/1997 | US5629171 Recombinant bioprocess for the preparation of 7-amino cephalosporanic acid (7-ACA) |
| 05/07/1997 | EP0771357A1 PROCESS FOR PREPARATION OF $g(b)-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS |
| 04/15/1997 | US5621096 Process for preparing penems |
| 03/05/1997 | CN1144274A Improved enzymatic process for producing penicillins and cephalosporins |
| 02/06/1997 | WO1997004086A1 An improved immobilized penicillin g acylase |
| 01/23/1997 | WO1997002349A1 PHENYLACETYL-CoA LIGASE FROM PENICILLIUM CHRYSOGENUM |
| 12/11/1996 | CN1137568A Process for enzymatic synthesis of beta-lactam antibiotics in presence of enzyme inhibitor |
| 10/03/1996 | WO1996030376A1 Process for the recovery of ampicillin |
| 10/02/1996 | EP0734452A1 Improved acylation method for penicillins and cephalosporins |
| 09/24/1996 | US5559005 Bioprocess for preparing 7-ACA and 7-ADAC |
| 09/04/1996 | EP0730036A1 Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor |
| 09/04/1996 | EP0730035A1 Improved enzymatic process for producing penicillins and cephalosporins |
| 08/29/1996 | CA2167118A1 Enzymatic process for producing penicillins and cephalosporins |
| 07/24/1996 | CN1127531A Process for the enzymatic preparation of a beta-lactam derivative |
| 06/11/1996 | US5525483 By enzymatic reaction with parent amino beta-lactam |
| 05/28/1996 | US5521068 Process for 7-aminodesacetoxycephalosporanic acid |
| 05/22/1996 | EP0712443A1 Process for the enzymatic preparation of a beta-lactam derivative and separation of d-phenylglycine amide |
| 04/04/1996 | WO1996010085A1 PROCESS OF PRODUCING β-LACTAM ANTIBIOTICS APPLYING MICROORGANISMS WITH INCREASED LIGASE ACTIVITY |
| 04/04/1996 | WO1996010084A1 Process for the production of secondary metabolites |
| 04/04/1996 | CA2201485A1 Process of producing .beta.-lactam antibiotics applying microorganisms with increased ligase activity |
| 03/19/1996 | US5500352 Producing 6-aminopenicillanic acid from a 6-acylaminopenicillanic acid |
| 02/22/1996 | WO1996005318A1 Mutated penicillin g acylase genes |
| 02/01/1996 | WO1996002663A1 PROCESS FOR PREPARATION OF β-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS |
| 12/21/1995 | WO1995034675A1 Improved acylation method for penicillins and cephalosporins |
| 12/12/1995 | US5474912 Method for increasing production of microbial metabolites by genetic engineering |
| 11/28/1995 | US5470717 Method for the preparation of certain β-lactam antibiotics |
| 11/08/1995 | EP0599891B1 Method for the fermentative production of cephalosporin c using acremonium chrysogenum |
| 10/31/1995 | US5462862 Antibiotics from microorganisms |
| 08/10/1995 | DE19503977A1 Verfahren zur Herstellung von Penemen A process for the production of penems |
| 03/01/1995 | EP0640014A1 Separation method |
| 02/15/1995 | EP0638649A2 New use of alcaligenes faecalis penicillin G acylase |
| 02/02/1995 | WO1995003420A1 Process for the enzymatic preparation of a beta-lactam derivative |
| 12/06/1994 | CA1333369C 3-propadienyl penicillin derivatives and intermediates |
| 10/12/1994 | EP0618979A1 AN IMPROVED METHOD FOR THE PREPARATION OF CERTAIN $g(b)-LACTAM ANTIBIOTICS |
| 07/12/1994 | US5328839 Oxido reductase enzyme system obtained from P. chrysogenum |
| 06/07/1994 | US5318896 In situ expression of expandase gene; ring expansion of adipoyl-6-amino penicillanic acid; cleavage of adipoyl side chain |
| 02/16/1994 | CN1081929A Separation method |
| 12/07/1993 | US5268271 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase |
| 11/25/1993 | WO1993023164A1 Separation method |
| 11/18/1993 | EP0569462A1 Process for separation of two solid components |
| 08/18/1993 | CN1075336A Novel bioprocess for preparing 7-ADCA |
| 07/21/1993 | CN1074484A Novel bioprocesses for preparing 7-ACA and 7-ADAC |
| 07/21/1993 | CN1021655C Composition and method for extracting penicillin |
| 06/24/1993 | WO1993012250A1 AN IMPROVED METHOD FOR THE PREPARATION OF CERTAIN β-LACTAM ANTIBIOTICS |
| 06/01/1993 | US5215891 Enzymatic hydrolysis of ester group of the 2-substituent by lipase enzyme |
| 05/12/1993 | CN1071953A Process for fermentative production of cephalosporin c using acremonium chrysogenum |
| 05/05/1993 | EP0540210A1 Novel bioprocesses for preparing 7-aca and 7-adac |
| 04/29/1993 | WO1993008287A1 Novel bioprocesses for preparing 7-aca and 7-adac |
| 04/21/1993 | EP0537255A1 PROCESS FOR PREPARATION OF $g(b)-LACTAMS |
| 04/07/1993 | EP0311640B1 Higher alkyl pyrrolidone extractants for water soluble phenolic or carboxylic antibiotics |
| 03/18/1993 | WO1993005158A1 Novel bioprocess for preparing 7-adca |
| 03/17/1993 | EP0532341A1 Novel bioprocess for preparing 7-ADCA |
| 03/04/1993 | WO1993004188A1 Method for the fermentative production of cephalosporin c using acremonium chrysogenum |
| 03/04/1993 | CA2116019A1 Process for the fermentative production of cephalosporin c using acremonium chrysogenum |
| 11/03/1992 | CA1309675C Recombinant dna expression vectors and dna compounds that encode isopenicillin n synthetase from penicillium chrysogenum |
| 11/03/1992 | CA1309673C Recombinant dna expression vectors and dna compounds which encode isopenicillin n synthetase |
| 07/26/1992 | WO1992012782A1 Process for separation of two solid components |
| 07/26/1992 | CA2101256A1 Process for separation of two solid components |
| 05/27/1992 | EP0487118A1 Transformation selection marker system adapted for Penicillium |
| 05/12/1992 | CA1300539C Process for preparing penems |
| 04/30/1992 | WO1992007079A1 Transformation selection marker system adapted for penicillium |
| 04/28/1992 | US5108918 Screening dna of host capable of producing metabolite using probes obtained from the rna or dna of bacteria or fungi lacking the ability to product the metabolite, transforming the host and cloning |
| 03/04/1992 | EP0473008A2 Improved process for preparing penicillins and cephalosporins |
| 01/23/1992 | WO1992001061A1 PROCESS FOR PREPARATION OF β-LACTAMS |
| 01/07/1992 | US5079146 Penicillinacylase is used to remove ester protecting group |
| 12/27/1991 | EP0462674A1 An oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production |