| Patents for C07D 499 - Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula: , e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring (3,448) |
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| 09/12/1986 | WO1986005182A1 Beta-lactam compound |
| 09/10/1986 | CN86101695A Process for the preparation of beta-lactam antibiotics and their use as medicaments |
| 09/09/1986 | US4610823 Process for preparing substituted 2-thioxopenams and 2-substituted thiopenems |
| 09/09/1986 | US4610822 Improved yields using an ethyl acetate/water mixture for the reaction and adding a base to control the ph |
| 09/02/1986 | US4609652 Methods of using β-lactam antibacterial agents |
| 08/26/1986 | CA1210388A1 Process for debromination of dibromopenicillanic acid and derivatives |
| 08/26/1986 | CA1210387A1 .beta.-LACTAM ANTIBIOTICS |
| 08/19/1986 | US4607029 Novel sodium amoxicillin preparations |
| 08/19/1986 | US4606865 Catalytic reaction of acetaldehyde with carbonyl bromide |
| 08/19/1986 | CA1209983A1 Process for 6-(aminomethyl)penicillanic acid 1,1- dioxide and derivatives thereof |
| 08/12/1986 | US4605744 Antibiotics |
| 08/12/1986 | CA1209477A1 Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| 07/30/1986 | EP0189287A2 Novel B-lactam antibiotics |
| 07/30/1986 | EP0188464A1 New 2-oxoazetidines, process for the preparation and utilization thereof |
| 07/29/1986 | CA1208626A1 Process for the preparation of hydrochlorides |
| 07/23/1986 | EP0188247A1 Process for preparing azetidinone intermediates |
| 07/22/1986 | CA1208205A1 Oxidation process |
| 07/16/1986 | EP0187626A1 Stabilized bacampicillin hydrochloride, process for the stabilization and pharmaceutical compositions |
| 07/15/1986 | US4600773 Crystalline cephalexin hydrochloride monohydrate |
| 07/15/1986 | CA1207754A2 2-(fluoroalkylthio)substituted penems, processes for preparing them, and pharmaceutical compositions containing them |
| 07/15/1986 | CA1207753A1 2-(fluoroalkylthio)substituted penems, processes for preparing them, and pharmaceutical compositions containing them |
| 07/15/1986 | CA1207752A2 PROCESS FOR PREPARING DERIVATIVES OF .beta.-LACTAM AND DERIVATIVES SO PRODUCED |
| 07/08/1986 | US4599151 Process for preparing 2,2-bishalomethylpenam derivatives |
| 07/02/1986 | CA1206957A 6-(aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor |
| 07/01/1986 | US4598074 Peniclillin |
| 06/25/1986 | EP0185651A1 Intermediates for the production of antibacterial penem derivates |
| 06/25/1986 | EP0185221A2 Process for the preparation of aminothiazolylacetic-acid derivatives |
| 06/24/1986 | US4596677 Anhydropenicillin intermediates |
| 06/17/1986 | US4595539 Preparation of penem derivatives and azetidinone intermediates |
| 06/17/1986 | CA1206148A1 7-oxo-4-thia-1-azabicyclo¬3,2,0|heptane derivatives |
| 06/17/1986 | CA1206147A1 6.alpha.-METHOXY-PENICILLINS, THE SALTS THEREOF, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| 06/10/1986 | US4594246 Pharmaceutically-acceptable amine salts of 6-β-halopenicillanic acids |
| 06/10/1986 | CN85108996A Process for the manufacture of aminothiazole acetic acid derivatives |
| 05/27/1986 | US4591459 Beta-lactamase inhibitors, penicillins, cephalosporins, bactericides |
| 05/21/1986 | EP0181831A2 Process for the preparation of optically active acyloxyazetidinones |
| 05/21/1986 | EP0181702A1 6-Substituted penicillanic acid 1,1-dioxide compounds |
| 05/21/1986 | EP0181571A1 Crystalline aminomethyl compound |
| 05/20/1986 | US4590073 Beta-lactamase inhibitors |
| 05/20/1986 | CA1204736A1 Process and intermediates for preparation of 1,1- dioxopenicillan-oyloxymethyl 6-beta- aminopenicillanate |
| 05/13/1986 | US4588527 Process for preparing penicillanic acid 1,1-dioxide derivatives |
| 05/13/1986 | CA1204435A1 Preparation of penicillin and cephalosporin compounds and novel intermediates useful therein |
| 05/07/1986 | EP0180252A1 Process of preparing azetidinone compounds |
| 05/06/1986 | US4587241 Heterocyclic substituted penems |
| 04/29/1986 | US4585874 Process for preparing penem derivatives |
| 04/29/1986 | US4585767 Antibiotics, beta-lactamase inhibitors |
| 04/29/1986 | CA1203797A1 Antibacterial 6'-(2-amino-2-¬4-acyloxyphenyl|- acetamido) penicillanoyloxymethyl penicillanate 1,1- dioxide compounds |
| 04/22/1986 | US4584133 Silver reagent eliminated from azetidinones, by protection of hydroxy group and cylization |
| 04/22/1986 | CA1203530A1 .alpha.-SUBSTITUTED UREIDOBENZYLPENICILLANIC ACID AND PROCESS FOR PRODUCING THE SAME |
| 04/16/1986 | EP0178089A1 2(N-heterocyclyl)penems |
| 04/16/1986 | EP0177596A1 Beta-lactam derivatives, preparation, compositions containing them |
| 04/15/1986 | US4582829 Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds |
| 04/10/1986 | CN85108260A Process for stabilization of bacampicillin hydrochloride |
| 04/09/1986 | EP0176716A1 Crystalline sodium salt of D-6-(alpha-[(2-oxo-3-furfurylidene-amino-imidazolidin-1-yl)carbonylamine]-thienyl-2-acetamido)-penicillanic acid, process for its preparation and its use in pharmaceutical compounds |
| 04/08/1986 | US4581166 Extraction at low temperature and pressure between the critical pr |
| 04/08/1986 | CA1202959A1 Process for the preparation of penam derivatives |
| 04/02/1986 | EP0176064A1 Intermediates for the production of 7-oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia-1-aza[3,2,0]hept-2-ene derivatives |
| 04/01/1986 | US4579684 Process for the manufacture of enol derivatives |
| 04/01/1986 | CA1202617A1 Bacampicillin napsylate |
| 03/19/1986 | EP0174561A1 7-Oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives |
| 03/18/1986 | US4577016 Process for the preparation of penem derivatives |
| 03/18/1986 | US4576939 Penem derivatives |
| 03/18/1986 | US4576754 Preparation of 6,6-dibromo-penicillanic acid-1,1-dioxide |
| 03/18/1986 | CA1202020A1 Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1, 3-dioxolen-4- yl) methyl ester group |
| 03/12/1986 | EP0174129A1 Isopenicillin N derivatives, their preparation and use and intermediates therefor |
| 03/11/1986 | CA1201709A1 BIS-ESTERS OF 1,1-ALKANEDIOLS WITH 6-.beta.- HYDROXYMETHYLPENICILLANIC ACID 1,1-DIOXIDE AND .beta. LACTAM ANTIBIOTICS |
| 03/04/1986 | CA1201433A1 Penicillin derivatives and process for preparation of the same |
| 03/04/1986 | CA1201431A1 .beta.-LACTAM COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND INTERMEDIATE PRODUCTS FOR THE PREPARATION THEREOF |
| 02/26/1986 | EP0172463A1 A process for producing thiazole glutaconic acid derivatives |
| 02/12/1986 | EP0171362A1 Aminoalkyl penem compounds |
| 02/11/1986 | CA1200545A1 Bis-esters of methanediol with penicillins and penicillanic acid 1, 1-dioxide |
| 02/11/1986 | CA1200543A1 7-epi-3-exomethylenecepham derivatives |
| 02/05/1986 | EP0170192A1 Penicillin derivatives as anti-inflammatory and antidegenerative agents |
| 02/05/1986 | EP0170028A1 Antibacterial 7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives |
| 02/05/1986 | EP0169995A2 A high yield process for preparing beta-lactam antibiotics having a high purity degree |
| 02/04/1986 | CA1200239A1 Process for preparing 6-¬d-(-)-alpha-(4-c1-c4 alkyl- 2,3-dioxo-1-piperazinocarbonyl-amino)- phenylacetamido|penicillanic acid |
| 01/30/1986 | WO1986000615A1 New 2-oxoazetidines, process for the preparation and utilization thereof |
| 01/28/1986 | CA1199909A1 Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides |
| 01/22/1986 | EP0168440A1 Preparation of penicillin sulfoxide |
| 01/14/1986 | US4564473 6-Unsubstituted-7-oxo-4-oxa-diazabicyclo(3.2.0)hept-2-ene derivatives |
| 01/08/1986 | EP0167100A1 Penem derivatives |
| 01/08/1986 | EP0167011A2 Beta-lactam compounds, intermediates thereof, their use in preparing beta-lactams having a diketopiperazine group |
| 01/08/1986 | EP0166972A1 Penem derivatives, methods of producing them, their use and pharmaceutical compositions |
| 01/02/1986 | EP0166377A1 Process for the preparation of beta-lactam compounds and intermediates therefor |
| 12/31/1985 | US4562253 Penicillins and cephalosportins to corresponding amine |
| 12/31/1985 | US4562073 Penicillin derivatives |
| 12/31/1985 | CA1198729A2 6-aminoalkylpenicillanic acid 1,1-dioxides and derivatives as beta-lactamase inhibitors |
| 12/27/1985 | EP0165272A1 Heterocyclic substituted penems |
| 12/24/1985 | US4560550 Synergistic compositions containing 6-alkylidene penems and their use |
| 12/17/1985 | US4559333 Hydrazone substituted penems |
| 12/10/1985 | US4558124 Preparation of cephalosporin intermediate compounds |
| 12/10/1985 | US4558042 β-Lactam-containing antibacterial agents and β-lactamase inhibitors |
| 12/10/1985 | US4557932 Antibacterial synergistic pharmaceutical compositions |
| 12/10/1985 | CA1197841A2 7-oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia- 1-aza[3,2,0]-hept-2-ene derivatives |
| 12/10/1985 | CA1197840A1 Penicillin derivatives and process for preparation of the same |
| 12/10/1985 | CA1197839A1 7-oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia- 1-aza[3,2,0]hept-2-ene derivatives |
| 12/03/1985 | US4556516 Process for the preparation of acylureido penicillin derivatives |
| 12/03/1985 | CA1197504A1 Process and intermediates for 6'-amino penicillanoyloxymethyl penicillanate 1,1 dioxide |
| 11/27/1985 | EP0162193A1 Novel 2-penem-type compounds and pharmaceutical compositions contaning them |
| 11/26/1985 | US4555363 Treating an imine with a nucleophilic derivative of formamide |
| 11/19/1985 | US4554160 Penicillin esters, salts thereof and methods for their preparation |