Patents
Patents for C07D 475 - Heterocyclic compounds containing pteridine ring systems (2,718)
07/1994
07/07/1994CA2152485A1 Methotrexate derivative
07/01/1994CA2100136A1 Oncopterin, a pteridine compound useful as a diagnostic agent for cancerogenic diseases
06/1994
06/28/1994US5324836 Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid
06/21/1994CA1330378C Amine derivatives of folic acid analogs
06/08/1994EP0600460A1 Process for the preparation of 6(S)-5,6,7,8-tetrahydrofolic acid
06/08/1994EP0599983A1 Anti-hiv (aids) agents
05/1994
05/26/1994WO1994011001A1 Hydroxyl-containing compounds
05/26/1994CA2151617A1 Hydroxyl-containing compounds
05/18/1994CN1024553C Process for separating folinic acid
05/17/1994US5312922 Europium and terbium chelators for time-resolved fluorometric assays
05/10/1994CA1329361C Preparation of riboflavin, produced by a microbial method, in the form of spray-dried granules or microgranules
04/1994
04/19/1994US5304310 Forming solution in water and organic solvent, adjusting pH, adding sodium chloride, separating aqueous phase
04/06/1994EP0590428A1 Azaquinoxalines, process for their preparation, and their use
04/06/1994EP0590106A1 A process for the separation of folinic acids
04/05/1994US5300509 2-furyl-oxazolo[5,4-d]-pyrimidines
04/05/1994US5300505 Stable salts of 5,10-methylenetetrahydrofolic acid
04/05/1994US5300303 Subjecting aqueous binder-free suspension of finely divided riboflavin to fluidized bed spray drying
03/1994
03/31/1994WO1994006431A1 Novel epoxide-containing compounds
03/31/1994CA2145192A1 Novel epoxide-containing compounds
03/30/1994EP0589375A1 Micronutrient compositions
03/23/1994EP0587814A1 Substituted pyrimidinones bearing acidic functional groups as angiotensin ii antagonists
03/08/1994US5292735 Cyclic amide derivatives
02/1994
02/15/1994US5286726 Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
02/03/1994WO1994002148A1 Novel bioactive compositions, preparation and use thereof
02/03/1994DE4225353A1 4-Amino-2,7-bis cyclic amino-6-phenyl-pteridine derivs. - for sensitising tumours with primary or secondary resistance to chemotherapeutics and thus bringing resistant tumours into remission
02/03/1994CA2140630A1 Novel bioactive compositions, preparation and use thereof
01/1994
01/19/1994EP0578733A1 Use of riboflavin in the treatment of hiv, herpes virus, retinitis pigmentosa and malaria related deseases
01/19/1994EP0578633A1 10-deazaaminopterin: a new arthritis remittive drug
01/11/1994US5278043 Ruthenium-lumazine energy transfer systems
12/1993
12/22/1993EP0574906A2 Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same
12/18/1993CA2098562A1 Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same
12/14/1993US5270465 4(3H)-pteridinone compounds
11/1993
11/11/1993WO1993022316A1 Process for preparing 10-deazaaminopterins and 5,10- and 8,10-dideazaaminopterins from pteroic dicarboxylic acid diesters
11/11/1993WO1993022315A1 Heteroaroyl-10-deazaaminopterins for treatment of inflammation
11/09/1993US5260296 Thiophene substituted antitumor antifolates
11/03/1993CN1077956A Methotrexate derivative
10/1993
10/27/1993EP0191824B1 Encapsulation of antineoplastic agents in liposomes
10/27/1993EP0190315B1 Dehydrated liposomes
10/14/1993WO1993020054A1 Europium and terbium chelators for time-resolved fluorometric assays
09/1993
09/30/1993WO1993019069A1 Intermediates and a process for synthesis of tetrahydropteridine c6-stereoisomers, including (6s)-tetrahydrofolate and n5-formyl-(6s)-tetrhydrofolate
09/29/1993EP0562641A1 Dehydrated liposomes
09/22/1993EP0561424A1 Dehydrated liposomes
09/16/1993WO1993017682A1 Angiotensin ii receptor antagonists
09/02/1993WO1993017022A1 Process for separating stereoisomers of folinic acid
08/1993
08/24/1993US5239074 Diastereoisomeric compounds derived from tetrahydrofolic acid, process for their preparation and use in the synthesis of diastereoisomers 6s and 6r of reduced folates
08/05/1993WO1993015077A1 Methotrexate derivative
07/1993
07/23/1993WO1993015076A1 A process for the separation of folinic acids
07/23/1993CA2100667A1 Process for the separation of folinic acids
07/21/1993EP0551642A1 Process of diastereoselective hydration of folic acid in tetrahydrofolic acid
07/17/1993CA2086911A1 Diastereoselective hydrogenation of folic acid to tetrahydrofolic acid
07/08/1993WO1993013102A1 Deazaaminopterins
06/1993
06/30/1993EP0548895A2 Process for the preparation of pure diasteroisomers of tetrahydrofolates
06/29/1993US5223501 Substituted pyrimidinones bearing acidic functional groups as angiotensin ii antagonists
06/29/1993US5223500 Liver disorders, antitumor, anticarcinogenic agents
06/02/1993EP0544445A2 Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists
06/02/1993EP0543997A1 Novel methotrexate derivative
05/1993
05/27/1993WO1993010118A1 Method of separating the enantiomers of 5-methyl-tetrahydrofolic acid
05/26/1993CA2082333A1 Heterocyclic compounds
05/13/1993DE4136921A1 Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure Process for the separation of 5-methyl-tetrahydrofolsaeure
05/11/1993US5210023 Method of purifying ferment-produced riboflavin
05/05/1993EP0539987A2 Process for the purification of crude alkalinic earth metal salts of N(5)-methyl-5,6,7,8-tetrahydrofolic acid
04/1993
04/21/1993EP0537937A2 Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists
04/21/1993EP0537842A2 A process for the preparation of substituted tetrahydrofolic derivatives in the 6(R,S)(-) forms and of their active 6(S)(-) N5 diastereoisomers in form of alkali and earth alkali metal salts
04/21/1993EP0537492A2 Stable salts of 5,10-methylenetetrahydrofolic acid
04/20/1993CA1316533C Ornithine derivatives
04/11/1993CA2080178A1 Process for the preparation of substituted tetrahydrofolic derivatives in the [6[r,s) (-) forms and of their active [6(s) (-)]n5 diastereoisomers in form of alkali and earth alkalimetal salts
04/08/1993CA2079982A1 Substituted pyrazino (2,3-d)-pyrimidinones as angiotensin ii antagonists
04/07/1993EP0535710A1 Process for the preparation of alkaline earth metal salts of (6R)-N(10)-formyl-5,6,7,8-tetrahydrofolic acid
04/01/1993WO1993005784A1 Immunopotentiating and infection protective agent and production thereof
03/1993
03/30/1993US5198547 Process for N5-formylating tetrahydropteridines
03/24/1993EP0533342A1 Anti-HIV (AIDS) agents
03/23/1993US5196533 Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
03/17/1993EP0345308B1 Ornithine derivatives and their use as inhibitors of methotrexate resistant cells
03/16/1993US5194611 Separation technique for a mixture of (6RS)-diastereoisomers of an ammonium salt of N5 -methyl-5,6,7,8-tetrahydrofolic acid into single (6R) and (6S)-diastereoisomers
03/10/1993EP0489029A4 Method for recovery of riboflavin
03/04/1993WO1993004043A1 Anti-hiv (aids) agents
03/04/1993CA2115581A1 Anti-hiv (aids) agents
01/1993
01/07/1993WO1992017173A3 Use of riboflavin for treating hiv-related diseases, herpes, retinitis pigmentosa and malaria
12/1992
12/08/1992US5169759 Removal of riboflavin from fermentation suspensions
12/01/1992US5167949 Antiallergic
11/1992
11/26/1992WO1992020687A1 Substituted pyrimidinones bearing acidic functional groups as angiotensin ii antagonists
11/26/1992CA2102801A1 Substituted pyrimidinones bearing acidic functional groups as angiotensin ii antagonists
11/04/1992EP0511221A1 Process for enriching or cleaning hirudin.
10/1992
10/21/1992EP0373213B1 Utilization of a folinic substance as platelet antiaggregating agent
10/06/1992US5153309 Esterification, deprotecting
10/03/1992WO1992017173A2 Use of riboflavin for treating hiv-related diseases, herpes, retinitis pigmentosa and malaria
10/03/1992CA2107078A1 Use of riboflavin in the treatment of hiv-linked diseases, herpes, retinitis pigmentosa and malaria
09/1992
09/22/1992US5149811 Flavin modifying agent for conductive substrate
08/1992
08/05/1992CN1063285A Process for preparation of (6s)-and (6r)- tetrahydrofolic acid
07/1992
07/28/1992US5134235 Process for separating folinic acid
07/22/1992EP0495204A1 Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid
07/14/1992US5129941 Pre-and postemergence
07/14/1992CA1305054C2 Encapsulation of antineoplastic agents in liposomes
06/1992
06/24/1992EP0491282A2 Pteridin derivatives, process for their preparation and their use in the preparation of immunogens
06/23/1992US5124452 Reduction of folic acid; methylation separation; purification; reducing agent stabilizer
06/23/1992US5124326 Antiarrhythmic, hypotensive agents; diuretics
06/11/1992DE4038932A1 Diuretic and anti-kaliuretic pteridine derivatives - administered with rapidly acting loop diuretics e.g. furosemide and more water-soluble than triamterene
06/10/1992EP0489029A1 Method for recovery of riboflavin
04/1992
04/29/1992EP0482493A2 Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at last one compound selected from the group consisting of S-adenosyl-L-methionine salt, 5-methyl-tetrahydrofolic acid, 5-formyltetrahydrofolic acid
04/14/1992US5104443 Heterocyclic 2-alkoxyphenoxysulfonylureas and the use thereof as herbicides or plant growth regulators
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