Patents
Patents for C07H 23 - Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin b12 (1,716)
03/2002
03/07/2002WO2002018405A2 Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
02/2002
02/27/2002EP1150990A4 Erythromycin a compounds and process for preparing the same
02/26/2002US6350863 3, 4-di(acylamino)phenyl ribofuranosides, 2'-deoxyribofuranosides, and methods of making
02/20/2002CN1336933A Protecting groups for carbohydrate synthesis
01/2002
01/23/2002EP1173184A1 Rho-boronophenylalanine complexes with fructose and related carbohydrates and polyols
01/16/2002EP1172446A2 Nucleic acid mediated electron transfer
01/15/2002US6339066 Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
01/15/2002US6338943 Methods for labeling nucleotides, labeled nucleotides and useful intermediates
01/10/2002WO2002002588A1 Sugar chain-containing carbosilane dendrimer compounds, process for producing the same and verotoxin neutralizers and antiviral agents
01/02/2002EP1165569A1 Boronic acid containing reagents and oligonucleotides
01/02/2002EP1165563A1 Bicyclic heterocycles, method for producing them and their use as herbicides and pharmaceutical agents
12/2001
12/20/2001WO2001096356A1 Antisense molecules and method of controlling expression of gene function by using the same
12/06/2001WO2001092288A2 Cobalamin compounds useful as antibiotic agents and as imaging agents
12/06/2001WO2001092283A2 Cobalamin compounds useful as cardiovascular agents and as imaging agents
12/06/2001WO2001091807A2 Ethylenedicysteine (ec)-drug conjugates
12/05/2001CN1324801A One-pot three-step synthesis of 6-phenmethyl-3(or 2)-silyl monoglycoside and its application
11/2001
11/29/2001US20010046679 Site-selective nucleic acid modification with redox active transition metal complexes
11/27/2001US6323339 Glycosylating substrate in presence of lewis acid; purification; combinatorial chemistry
11/22/2001WO2001005769A3 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
11/21/2001EP1155025A1 Platinum (ii) compounds
11/20/2001CA2040927C Sucrose-6-ester production process
11/15/2001WO2001014339A3 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
11/13/2001US6315978 Bioconjugates and delivery of bioactive agents
11/07/2001EP1150990A1 Erythromycin a compounds and process for preparing the same
10/2001
10/30/2001US6310042 Derivatives of carbohydrates and compositions containing them
10/25/2001US20010034033 Nucleic acid mediated electron transfer
10/23/2001CA2038740C Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
10/17/2001EP1144430A1 Protecting groups for carbohydrate synthesis
10/17/2001EP1143974A1 Pharmaceutical compositions for alleviating discomfort
10/11/2001US20010029252 Prevent brain and nervous system damage; anemia
10/04/2001US20010026921 Solid matrix with a intercalator capable of binding DNA, RNA, or DNA-RNA hybrid, a intercalator fluorophore acting as energy acceptor or donator, and a oligo- or polynucleotide probe with a lanthanide metal chelate bound to it
10/04/2001EP0529002B1 Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
09/2001
09/27/2001WO2001070724A1 Radioisotope-labeled complexes of glucose derivatives and kits for the preparation thereof
09/26/2001EP0707591B1 Methylphosphonic acid ester, process for preparing the same and its use
09/26/2001EP0528991B1 Detectably labelled marker component comprising a fluorophore moiety , fluorescent probe comprising the marker component and uses thereof.
09/25/2001US6294664 Preparing oligonucleotide blocks having common subsequences, phospitylating, and performing solid phase synthesis (sps) to form target oligonucleotides wherein the synthons used in sps comprise phosphitylated oligonucleotide blocks
09/18/2001US6291669 Support system for synthesizing oligomers includes a hydroxyl-containing compound bound to support by a disiloxyl linkage; efficient oligonculeotide synthesis
09/18/2001US6291188 Metallic solid supports modified with nucleic acids
09/11/2001US6287780 Compounds for mass spectrometry comprising nucleic acid bases and aryl ether mass markers
08/2001
08/30/2001US20010018510 Synthesis of oligonucleotides
08/21/2001US6277576 Nucleic acid mediated electron transfer
08/07/2001CA2085345C Pyrimidine nucleoside derivatives
08/01/2001EP1119577A2 Synthesis of oligosaccharides, reagents and methods related thereto
07/2001
07/31/2001US6268150 Nucleic acid mediated electron transfer
07/31/2001US6268149 Nucleic acid mediated electron transfer
07/31/2001CA2237263C Radionuclide labeling of vitamin b12 and coenzymes thereof
07/24/2001US6265558 Compound of linked nucleosides having thiol group attatched at 5-pyrimidine or 2-, 6-, or 8-purine positions; attachment reporter molecules, reporter enzymes, steroids, lipophilic molecules, peptides, proteins and other groups
07/24/2001US6265391 Method for preventing peripheral nerve damage
07/24/2001US6265155 Metallic solid supports modified with nucleic acids
07/19/2001US20010008936 Oligonucleotides having chiral phosphorus linkages
07/17/2001US6262241 Antisense compounds which cleave phosphorodiester bonds and improve pharmacodynamic and pharmacokinetic properties of oligonucleotides, useful in diagnosing diseases
07/11/2001EP0731808B1 Nucleosides and oligonucleotides containing boron clusters
07/10/2001US6258941 Metal complex covalently linked to nucleoside, nucleotide, or oligonucleotide; complex is capable of hydrolyzing rna; synthetic ribozymes/antisense agents for gene expression inhibition
07/10/2001US6258545 Performing polymerase chain reaction, hybridizing amplified target sequence to single-stranded nucleic acid covalently attached to electrode, detecting electron transfer between moiety on hybridization complex and electrode as indicator
07/04/2001EP1113020A2 Nucleosides and oligonucleotides containing boron clusters
06/2001
06/14/2001WO2001042271A1 Process for production of methylcobalamin
06/13/2001EP1105383A2 Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
06/05/2001US6242592 Process for the preparation of 2′-O-alkyl-guanosine, cytidine, and uridine phosphoramidites
05/2001
05/29/2001US6239271 Solid matrix with immoblized intercalator capable of binding nucleic acid, another intercalator which may be labeled with fluorophore, and nucleic acid probe labeled with lanthanide or fluorophore; time resolved fluorescence hybridization
05/29/2001US6239265 Oligonucleotides having chiral phosphorus linkages
05/29/2001US6238870 Single stranded nucleic acid labeled with electron transfer moiety and attached to electrode by a three-dimensional polymer matrix; bioconductors and diagnostic probes
05/25/2001WO2001035966A1 Boron compounds and complexes as anti-inflammatory agents
05/02/2001EP1095052A1 Silicon-containing linkers for nucleic acid mass markers
05/02/2001EP1095051A1 Metal ion-binding mass markers for nucleic acids
04/2001
04/26/2001WO2001028592A1 Cobalamin conjugates useful as imaging agents and as antitumor agents
04/26/2001CA2387757A1 Cobalamin conjugates useful as imaging agents and as antitumor agents
04/04/2001EP1088872A2 Near infrared absorbing compound
04/03/2001US6211355 Reacting cobalamin compound with chelating compound to compound useful for in vivo imaging of organs and tumors
04/03/2001US6211350 Synthesis of oligonucleotides
03/2001
03/28/2001EP1086118A1 Vitamin b 12? derivatives and methods for their preparation
03/28/2001CA2317152A1 Near infrared absorbing compound
03/13/2001US6200761 Mixture of two nucleic acids
03/01/2001WO2001014339A2 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
03/01/2001CA2376275A1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
02/2001
02/14/2001EP1075544A1 Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
01/2001
01/30/2001US6180766 Nucleosides and oligonucleotides containing boron clusters
01/30/2001US6180352 Nucleic acid mediated electron transfer
01/25/2001WO2001005769A2 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
01/23/2001US6177250 Nucleic acid mediated electron transfer
01/16/2001US6175005 Single stage reaction for blocking hydroxyl groups on cyclic ether by reacting with defined difunctional silicon compound, with defined monofunctional silicon group, then with hydrofluoric acid in the presence of a nitrogen base
01/02/2001US6169076 P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols
12/2000
12/27/2000EP0716604A4 Thiol-derivatized nucleosides and oligonucleosides
12/26/2000US6166199 Contacting purine with amino, hydrazine, hydroxylamine, thiol, semicarbazide, thiosemicarbazide, hydrazone, hydrazide, imidazole, tetrazole, triazole, pyrrolidine, piperidine, piperazine, morpholine, aldehyde, ketone, alcohol; antisense
11/2000
11/21/2000US6150341 Reacting the 5'oh group of vb12 or an analogue thereof with a bifunctional carbonyl electrophile to form an active intermediate, and subsequently reacting the intermediate with a nucleophilic spacer molecule to yield vb12 derivative
10/2000
10/26/2000WO2000020428A9 Synthesis of oligosaccharides, reagents and methods related thereto
10/17/2000US6133438 Alkylating unblocked cytidine to form 2'-o-alkylated cytidine, blocking the 5'-hydroxyl moiety, and phosphitylating the 3'-position
10/17/2000US6133038 Diagnostic kit includes container with platinum-based linker compound and container with detectable marker moiety; for preparation of labeled probes
10/11/2000EP1042345A1 Compounds for mass spectrometry comprising nucleic acid bases and aryl ether mass markers
10/11/2000EP1042344A1 Conductive metal-containing nucleic acids
10/05/2000WO2000057887A1 p-BORONOPHENYLALANINE COMPLEXES WITH FRUCTOSE AND RELATED CARBOHYDRATES AND POLYOLS
10/03/2000US6127119 Detecting nucleotide sequences with receptivity to blood vessels; incubating mixture of nucleotide sequences with blood vessels, partitioning sequences with amplified affinity, amplifying nucleotide sequences
09/2000
09/28/2000WO2000056740A1 Boronic acid containing reagents and oligonucleotides
09/28/2000WO2000056734A1 Bicyclic heterocycles, method for producing them and their use as herbicides and pharmaceutical agents
09/28/2000CA2368101A1 Boronic acid containing reagents and oligonucleotides
09/26/2000US6124450 Processes and intermediates for phosphorous-containing covalent linkages
09/21/2000WO2000004865A3 Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
09/21/2000DE19912636A1 Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel Bicyclic heterocycles, process for their preparation and their use as herbicides and pharmaceutical compositions
09/14/2000WO2000020428A3 Synthesis of oligosaccharides, reagents and methods related thereto
09/06/2000EP1032708A1 Nucleic acid ligands of tissue target
09/05/2000US6114513 Medical diagnosis; transfer across cell membranes
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