| Patents for C07D 461 - Heterocyclic compounds containing indolo [3, 2, 1-d, e] pyrido [3, 2, 1-i, j] [1, 5]-naphthyridine ring systems, e.g. vincamine (286) |
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| 11/30/1993 | CA1324789C 20,21-dinoreburnamenin derivatives substituted in c-15 by an amino group and their salts, process for their preparation and intermediates thus obtained, their application as medicine and pharmaceutical compounds containing them |
| 07/07/1993 | CN1073945A Novel 14-(N-substituted aminomethyl) eburnane derivatives, process for their preparation and compositions containing them |
| 06/08/1993 | US5218119 Process for preparing the octahydro-indolo[2,3-a] quinolizine diester derivatives |
| 03/09/1993 | CA1314286C Process for the preparation of eburnamenine derivatives |
| 07/15/1992 | CN1017429B Method making eburnamenine derivative |
| 06/25/1992 | WO1992010495A1 Novel 14-(n-substituted aminomethyl)eburnane derivatives, process for their preparation and compositions containing them |
| 06/16/1992 | US5122607 Racemic and optically active octahydro-indolo(2,3-a) tetrahydropyranyl (2,3-c) quinolizine diester derivatives and process for preparing the same |
| 03/24/1992 | CA1297878C Process for the obtention of the ethyl ester of the apovincaminic acid |
| 03/03/1992 | US5093337 Substituted derivatives of 20,21-dinoreburnamenine, their use as medicaments and the pharmaceutical compositions containing them |
| 02/26/1992 | CN1058966A Preparation of vincamine amino acid ester |
| 01/14/1992 | US5081120 Analgesics |
| 11/20/1991 | CN1014788B Process for obtantion of ester apovincaminic acid |
| 10/30/1991 | CN1014520B Process for preparing apovincaminol derivative |
| 08/28/1991 | EP0443918A1 Derivatives of 20,21-dinoreburnamenine, process for their preparation and intermediates, their use as medicines and compositions containing them |
| 07/23/1991 | US5034396 Method of treating depression with optically active isomers of 20,21-dinoreburnamenines |
| 05/01/1991 | CN1051042A Process for preparing derivatives substituted in position 15 of 20,21 dinoreburnamenine |
| 04/24/1991 | EP0424248A2 20,21-Dinoreburnamine derivatives, substituted in position 15, process for their preparation and novel intermediates so obtained, their use as medicines and compositions containing them |
| 04/18/1991 | CA2027724A1 15-substituted 20,21-dinoreburnamenine derivatives, process for preparing the same and new intermediates thus produced, use thereof as drugs and compositions containing them |
| 12/25/1990 | US4980474 Apovincaminic acid derivatives |
| 05/29/1990 | US4929440 Process for the preparation of (-) eburnamenin-14-(15H)-one resinates |
| 04/04/1990 | EP0361888A2 Apovincaminic acid derivatives |
| 03/13/1990 | CA1266659A1 Nitroapovincaminic acid derivatives, pharmaceutical compositions containing them and process for preparing same |
| 03/13/1990 | CA1266658A1 9- or 11-substituted apovincaminic acid derivatives and process for their preparation |
| 02/06/1990 | CA1265520A1 Apovincaminol derivatives, process for their preparation and pharmaceutical compositions containing them |
| 01/11/1990 | WO1990000171A1 New derivatives of 20,21-dinoreburnamenine substituted at 15 by an amine group and their salts, the process for preparing them and the intermediates thus obtained, their use as medicaments and the pharmaceutical compounds containing them |
| 01/03/1990 | EP0349424A1 20,21-Dinoreburnamenine derivatives substituted in position 15 by an amino group and their salts, process for their preparation and the intermediates so obtained, their use as medicines and pharmaceutical compositions containing them |
| 11/28/1989 | US4883876 Cerebral vascular disorders, arteriosclerosis, stroke, dementia |
| 11/21/1989 | US4882336 Administering ethyl apovincaminate |
| 09/26/1989 | US4870178 Process for the obtention of the ethyl ester of the apovincaminic acid |
| 09/26/1989 | CA1261840A1 Process for the preparation of vincaminic acid esters |
| 08/17/1989 | DE3902980A1 Verfahren zur herstellung von vincamin und epivincamin durch zuechtung von vinca-minor-zellkulturen Process for the preparation of Vincamine and epivincamine by growing vinca-minor-cell cultures |
| 08/01/1989 | CA1258071A1 Process for the preparation of apovincaminic acid esters |
| 06/13/1989 | US4839362 Vasodilators |
| 06/01/1989 | WO1989004830A1 New substituted derivatives of 20,21-dinoreburnamenine, process for preparing them and the new intermediate products so obtained, their application as drugs and the pharmaceutical compositions containing them |
| 05/24/1989 | EP0317427A1 Substituted derivatives of 20,21-dinoreburnamenine, process for their preparation and intermediates obtained in this way, their use as medicines, and pharmaceutical compositions containing them |
| 05/24/1989 | EP0317426A1 Optically active products of derivatives of 20,21-dinoreburnamenine, process for their preparation, their use as medicines and pharmaceutical compositions containing them |
| 05/02/1989 | CA1253505A1 Eburnane derivatives, a process for their preparation and pharmaceutical compositions containing them |
| 04/11/1989 | CA1252467A1 Process for the preparation of eburnamonine derivatives |
| 03/15/1989 | EP0307167A2 Vincaminic acid derivatives |
| 03/07/1989 | US4810709 Antihypoxic, anticonvulsant |
| 03/01/1989 | EP0305181A2 Ethyl-(+)-apovincaminate for treating demyelinization clinical patterns of autoimmune origin |
| 07/19/1988 | US4758666 Process for the preparation of an apovincaminol derivative |
| 06/07/1988 | US4749707 Citric acid salt of (+) vinpocetine |
| 05/25/1988 | EP0268245A2 Process for the preparation of eburnamenine oxime derivatives |
| 04/05/1988 | US4735946 Treatment of nervous system disorders-anticonvulsants |
| 04/05/1988 | US4735943 Vasodilators |
| 11/18/1987 | CN86103220A Process for preparing apovincaminol derivative |
| 10/21/1987 | CN86107896A Process for obtantion of ethyl ester apovincaminic acid |
| 07/14/1987 | US4680397 Psoriasis |
| 03/25/1987 | CN85106058A Amino eburnalkane carboxylic acid derivatives and the preparation of their pharmaceutical compositions |
| 02/04/1987 | CN86102655A Method making eburnamenine derivative |
| 01/14/1987 | CN85105334A Process for the preparation of 9- or 11- substituted apovincaminoacid |
| 12/09/1986 | CA1215061A2 17-18-dehydro-apovincaminol and process therefor |
| 09/30/1986 | US4614824 Novel apovincaminic acid derivatives |
| 03/19/1986 | EP0174459A1 9- respectively 11-(nitro)-apovincaminic acid derivatives, process for their preparation, and medicaments containing these compounds |
| 03/18/1986 | CA1202029A1 17,18-dehydro-apovincaminol-3',4',5'- trimethoxybenzoate, intermediate, and process therefore |
| 03/18/1986 | CA1202028A1 Apovincaminol-3',4',5'-trimethoxy-benzoate compounds |
| 03/12/1986 | EP0173824A1 Racemic or optically active 9- respectively 11-substituted apovincamine acid derivatives and process for their preparation |
| 02/12/1986 | EP0170926A1 Eburnanecarboxylic acid derivatives having an amino group in position 9 or 11, the amino group eventually being substituted, process for their preparation, and medicaments containing these compounds |
| 01/28/1986 | CA1199920A1 Apovincaminic acid derivatives and process for preparing same |
| 01/28/1986 | CA1199919A1 Eburnane oxime derivatives and process for preparing same |
| 01/21/1986 | CA1199638A1 Eburnane-oxime ethers, process for their preparation and pharmaceutical compositions containing them |
| 01/21/1986 | CA1199637A1 10- and 11- substituted apovincaminol compounds and esters thereof with 3,4,5-trimetroxy benzoic and process for producing them |
| 01/15/1986 | EP0168197A2 Eburnamonine oxime derivatives and their preparation and pharmaceutical compositions containing them |
| 12/18/1985 | EP0164478A2 Citric-acid salt of (-)vinburnine and process for its preparation |
| 12/10/1985 | US4558052 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them |
| 11/19/1985 | US4554274 Nb Quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof |
| 11/12/1985 | US4552877 Antiarrhythmia agents |
| 11/05/1985 | US4551462 Eburnane derivatives, process for their preparation and pharmaceutical compositions containing them |
| 10/23/1985 | EP0159160A1 Eburnane derivatives |
| 10/22/1985 | US4549020 Sedatives, muscle relaxants |
| 09/24/1985 | CA1194022A1 Process for preparing alkoxy-vincaminic acid esters and alkoxy-apovincaminic acid esters |
| 09/18/1985 | EP0154756A1 Citrate of vinpocetine, and process for its preparation |
| 04/30/1985 | CA1186311A1 Preparation process of new derivatives of e-substituted 20-21-inoreburnamenine |
| 02/26/1985 | US4501740 Blood oxygenating and cerebral vasoregulating 20,21-dinoreburnamenines |
| 12/04/1984 | US4486437 Phthalidyl apovincaminate with cerebral eubolic activity |
| 10/02/1984 | US4474960 Vasodilation |
| 08/07/1984 | US4464535 Process for the preparation of eburnamonine derivatives |
| 08/07/1984 | US4464534 Process for the preparation of vincaminic acid esters |
| 07/24/1984 | CA1171411A1 Method of preparing vincristine |
| 06/26/1984 | US4456607 9-Bromo-hexahydro- and octahydro-indolo[2,3 a]quinolizines and use for increasing blood circulation |
| 05/08/1984 | CA1166965A1 Dermatological compositions and process for their preparation |
| 05/01/1984 | US4446139 Hexahydroindoloquinolizinium and octahydroindoloquinolizine esters, and method of increasing blood flow in an animal with hydroxyamino-eburnane derivatives |
| 02/21/1984 | US4432982 Halogen- apovincaminol and trimethoxybenzoate salts |
| 02/21/1984 | CA1162543A1 Process for the preparation of apovincaminic acid esters |
| 01/31/1984 | US4429129 1α-Ethyl-1β-(2'-alkoxy carbonyl-2'-hydroxyiminoethyl)-10-methoxy 1,2,3,4,6,7,12,12β-octahydroindolo(2,3A)quinolizines |
| 01/31/1984 | US4428877 Cis-10-bromo-E-homoeburnanes |
| 01/03/1984 | US4424224 Apovincaminol derivative and compositions and methods utilizing it for treating psoriasis |
| 01/03/1984 | US4424223 Polycyclic compounds containing a double bond in the D-ring pharmaceutical compositions containing them, and methods of treating psoriasis with them |
| 12/06/1983 | US4419359 Nitro-substituted polycyclic derivatives useful in the treatment of psoriasis |
| 08/23/1983 | US4400514 Hydrogenation of halogen substituted derivative |
| 08/23/1983 | US4400249 From vincadiformine or tabersomine |
| 08/16/1983 | US4399069 Process for an enantioselective synthesis of optically active 14-oxo-E-homo-eburnane derivatives |
| 08/16/1983 | CA1152076A1 Halovincamone derivatives and a process for the preparation thereof |
| 06/14/1983 | CA1148157A1 Hydroxyamino-eburnane derivatives and a process for the preparation thereof |
| 05/31/1983 | CA1147331A1 10-bromosandwicine, 10-bromoisosandwicine, methods for preparing and using same and pharmaceutical compositions thereof |
| 05/31/1983 | CA1147330A1 N.sub.b-quaternary derivatives of sandwicine and isosandwicine methods and intermediate products in the manufacture of their derivatives and methods of using same and pharmaceutical compositions thereof |
| 05/31/1983 | CA1147329A1 N.sub.b-quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof |
| 05/10/1983 | US4382936 Cerebral vasodilator eburnane derivatives |
| 04/12/1983 | US4379935 Process for the synthesis of vincamine and related indole alkaloids |