Patents
Sitemap › C40 - Combinatorial technology › C40B - Combinatorial chemistry; Libraries, e.g. chemical libraries, in silico libraries › C40B 10 - Directed molecular evolution of macromolecules, e.g. rna, dna or proteins
Patents for C40B 10 - Directed molecular evolution of macromolecules, e.g. rna, dna or proteins (164)
09/2014
09/04/2014WO2014134166A1 Methods for the production of libraries for directed evolution
06/2014
06/24/2014US8759058 Photosynthetic hydrogen production from the green alga chlamydomonas reinhardii
06/03/2014US8741810 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
05/2014
05/07/2014EP2726651A1 Protein variant generation by region shuffling
03/2014
03/13/2014WO2014039662A1 Methods and products for mutating nucleotide sequences
11/2013
11/12/2013US8580714 Methods of affinity maturing antibodies
10/2013
10/08/2013US8551725 Method of identifying agents that inhibit quorum sensing activity of gamma-proteobacteria
10/01/2013US8546129 Sample analysis chip, sample analyzer using sample analysis chip, sample analysis method, and method of producing sample analysis chip
07/2013
07/24/2013EP2617827A1 Method for displaying engineered proteins on a cell surface
05/2013
05/30/2013US20130137582 Quantitative pcr-based method to predict the efficiency of target enrichment for next-generation sequencing using repetitive dna elements (lines/sines) as negative controls
04/2013
04/04/2013US20130085072 Recombinant renewable polyclonal antibodies
03/2013
03/07/2013US20130059732 Aav capsid proteins for nucleic acid transfer
02/2013
02/28/2013US20130053543 Peptide clearing agents
02/21/2013US20130045871 Engineering correctly folded antibodies using inner membrane display of twin-arginine translocation intermediates
02/14/2013US20130040823 Method for the synthesis of a bifunctional complex
02/07/2013US20130034879 DNA Polymerases
02/06/2013EP2553150A1 Generation of antibodies to an epitope of interest
01/2013
01/31/2013US20130029850 Competitive Differential Screening
01/03/2013WO2013003290A1 Protein variant generation by region shuffling
01/03/2013US20130005582 Preparation of restriction endonucleases in ivcs using fret and facs selection
01/03/2013US20130005581 Structural nucleic acid guided chemical synthesis
12/2012
12/27/2012US20120329067 Methods of Generating Zinc Finger Nucleases Having Altered Activity
12/13/2012US20120316071 Methods for affinity maturation-based antibody optimization
11/2012
11/22/2012US20120295793 Methods of generating modified polynucleotide libraries and methods of using the same for directed protein evolution
10/2012
10/11/2012US20120258865 Mirac proteins
10/04/2012US20120252681 Evolution of whole cells and organisms by recursive sequence recombination
09/2012
09/27/2012US20120245036 Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
08/2012
08/30/2012US20120220010 Photosynthetic hydrogen production from the green alga chlamydomonas reinhardii
08/16/2012US20120208704 Universal fibronectin type iii bottom-side binding domain libraries
08/16/2012CA2824387A1 Methods for non-invasive prenatal ploidy calling
07/2012
07/12/2012US20120178917 Rna aptamers and methods for identifying the same
07/05/2012US20120172236 Selection and Enrichment of Proteins Using In Vitro Compartmentalization
07/05/2012US20120172235 Peptide libraries
07/05/2012CA2823621A1 Optimization of multigene analysis of tumor samples
06/2012
06/28/2012US20120165201 Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
06/19/2012US8202823 Structural nucleic acid guided chemical synthesis
05/2012
05/24/2012US20120129702 Structure-Based Selection and Affinity Maturation of Antibody Library
05/10/2012WO2012061585A2 In silico prediction of high expression gene combinations and other combinations of biological components
05/10/2012US20120115734 In silico prediction of high expression gene combinations and other combinations of biological components
05/03/2012US20120108466 Immunoglobulin libraries
03/2012
03/29/2012US20120077710 Method for an in vitro molecular evolution of antibody function
02/2012
02/28/2012CA2402240C A method for in vitro molecular evolution of antibody function
02/23/2012US20120046175 Methods and systems for solution based sequence enrichment
02/15/2012CN101258244B 用于在体内进行蛋白质的选择性进化的方法 Selective in vivo method for the evolution of a protein
02/02/2012US20120030839 Expression and High-Throughput Screening of Complex Expressed DNA Libraries in Filamentous Fungi
02/02/2012US20120028812 Method for producing second-generation library
02/02/2012US20120028811 Device for rapid identification of nucleic acids for binding to specific chemical targets
01/2012
01/19/2012US20120015820 Methods and compositions for polypeptide engineering
01/19/2012US20120015819 Mixture of at least two fusion proteins, the production thereof and the use of the same
01/12/2012DE102008063592B4 Multifunktionaler Laborprozessbeutel für die Reinherstellung von Biomolekülen Multifunctional Laboratory Process bag for clean production of biomolecules
12/2011
12/21/2011EP2397549A2 Non-stochastic generation of genetic vaccines and enzymes
12/15/2011US20110306503 Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks
10/2011
10/27/2011US20110263434 Selective enrichment of cpg islands
10/06/2011WO2011123857A1 Generation of antibodies to an epitope of interest
10/06/2011US20110245479 Method for Generating Aptamers with Improved Off-Rates
10/06/2011CA2794851A1 Generation of antibodies to an epitope of interest
09/2011
09/29/2011DE19641876B4 Streptavidinmuteine Streptavidin muteins
09/01/2011US20110212842 Method for screening ligand
08/2011
08/25/2011US20110207199 Novel method to generate meganucleases with altered characteristics
08/18/2011US20110201506 Methods of Primer Extension Using Porous Particle Supports
08/04/2011US20110190141 Evolving New Molecular Function
08/04/2011US20110190140 Evolution of whole cells and organisms by recursive sequence recombination
07/2011
07/28/2011US20110183855 Somatic hypermutation systems
07/07/2011US20110166213 Method for obtaining oligonucleotide aptamers and uses thereof
06/2011
06/14/2011US7960103 Method for obtaining new life forms
05/2011
05/19/2011US20110118124 Method for improving the properties of a drug lead compound
04/2011
04/28/2011US20110098184 Competitve differntial screeing
04/21/2011WO2011047146A2 Methods of affinity maturing antibodies
04/21/2011US20110092372 Methods of Affinity Maturing Antibodies
03/2011
03/17/2011US20110065587 Epitope testing using soluble hla
03/03/2011US20110053781 Methods and compositions for polypeptide engineering
02/2011
02/24/2011US20110045989 Selective enrichment of n-terminally modified peptides from complex samples
12/2010
12/30/2010US20100331192 Surface display of recombinant proteins in lower eukaryotes
12/02/2010US20100304462 Synthetic Binding Proteins
11/2010
11/18/2010US20100292083 Providing improved immunoglobulin sequences by mutating cdr and/or fr positions
09/2010
09/15/2010EP1799823B9 Method for modulating the evolution of a polypeptide encoded by a nucleic acid sequence
08/2010
08/12/2010US20100204450 Preparation Method for a Protein With New Function Through Simultaneous Incorporation of Functional Elements
04/2010
04/01/2010US20100081575 Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules
02/2010
02/25/2010US20100048407 Method for detection of human immunodeficiency virus
02/25/2010DE102008062965A1 System, useful e.g. to produce a medicament to treat malignant diseases and metastatic tumors and for the isolation of a specific element of a molecular library, comprises a reaction chamber partitioned into a number of compartments
01/2010
01/21/2010WO2010008690A1 Methods for systematic control of protein stability
01/21/2010CA2729899A1 Methods for systematic control of protein stability
12/2009
12/24/2009US20090318297 Antibody Ultrahumanization by Predicted Mature CDR Blasting and Cohort Library Generation and Screening
11/2009
11/25/2009EP1799823B1 Method for modulating the evolution of a polypeptide encoded by a nucleic acid sequence
10/2009
10/22/2009US20090264298 Methods for enriching subpopulations
09/2009
09/17/2009US20090233801 Microstructures and use thereof for the directed evolution of biomolecules
09/11/2009WO2009111586A2 Autonomous in vitro evolution
09/10/2009US20090227463 Autonomous in vitro evolution
08/2009
08/19/2009EP1913139B1 Methods for carrying out the selective evolution of proteins in vivo
08/13/2009US20090203572 Method for in Vitro Molecular Evolution of Protein Function
08/13/2009US20090203530 Polymer evolution via templated synthesis
07/2009
07/30/2009DE102005052275B4 Ethylamin-spezifische Aptamere, deren Verwendung und ein Kit umfassend diese Aptamere Ethylamine-specific aptamers, their use and a kit comprising these aptamers
07/16/2009WO2008093010A8 Method for the random diversification of a genetic sequence while preserving the identity of some inner segments of said genetic sequence
07/02/2009US20090170712 Using Oligonucleotide Microarrays to Analyze Genomic Differences for the Prediction of Heterosis
07/02/2009US20090170711 Selection Method for Cell Internalizing Nucleic Acids
06/2009
06/11/2009US20090149331 Methods and compositions for polypeptide engineering
06/04/2009US20090143232 Method for synthesising templated molecules
06/04/2009US20090142820 Directed evolution methods for improving polypeptide folding, solubility and stability
04/2009
04/23/2009WO2007046818A3 Compositions and methods related to synchronous selection of homing peptides for multiple tissues by in vivo phage display
04/23/2009US20090105081 Methods and systems for solution based sequence enrichment
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