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Recurrent seizures were generated by pilocarpine injections and weeks later once the reactive reaction has taken place, slices were recorded from the sclerotic hippocampus. Many somatostatin positive GABAergic neurons were lost. Surviving interneurons were patch clamp recorded and morphologically reconstructed for identification. Interneurons in TLE had a higher frequency of ongoing synaptic currents suggesting an enhanced activity in synaptic inputs. This in turn will compensate for the loss and preserve some somatic inhibition. Reproduced with permission from Epsztejn et al ¹⁸⁶.