| Patents for C12N 15 - Mutation or genetic engineering; Dna or rna concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor (402,210) |
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| 07/11/2000 | US6087555 By insertion of a selectable marker sequence and resulting in decreased bone density compared to wild-type animal; for animal models to screen therapeutics |
| 07/11/2000 | US6087554 Transgenic mouse whose germ cells and somatic cells contain a nucleic acid encoding a detectable marker operably linked to 5' regulatory region of bovine keratin gene; for expression in hair bulb and epidermis in response to retinoic acid |
| 07/11/2000 | US6087489 Antisense oligonucleotide modulation of human thymidylate synthase expression |
| 07/11/2000 | US6087488 Potassium ion channel genes and proteins |
| 07/11/2000 | US6087487 Cdna molecule encoding a protein having nap domains and factor xa inhibitory activity; for in vitro diagnostic agents; in vivo therapy |
| 07/11/2000 | US6087484 Contacting target rna with mixture; activation without reducing specificity |
| 07/11/2000 | US6087483 DNA coding an inositol 1,4,5,-triphosphate binding protein |
| 07/11/2000 | US6087477 Compositions and methods for the treatment and diagnosis of cardiovascular disease |
| 07/11/2000 | US6087476 Photoprotein like aequorin, obelin, berovin, or mnemiopsin linked to antigen-specific protein like light-chain or heavy-chain immunoglobulin, avidin, strepavidin, protein a, or an antigenic peptide or fragment; sensitive immunoassay |
| 07/11/2000 | US6087343 Antisense oligonucleotides targeted to β-1 adrenoceptor and methods of use |
| 07/11/2000 | US6087331 Therapeutic use of platelet-endothelial cell adhesion molecule-1 compositions |
| 07/11/2000 | US6087329 A genetic engineered cd40-l polypeptide that binds cd40, and comprises an extracellular region, transmembrane region and cytoplasmic region |
| 07/11/2000 | US6087326 A mixture of an isolated mammamlian netrin and an isolated mammalian netrin receptor selected from the group consisting of ?deleted in colorectal carcinoma? and neogenin |
| 07/11/2000 | US6087323 Use of neuregulins as modulators of cellular communication |
| 07/11/2000 | US6087315 Protease variants |
| 07/11/2000 | US6087178 Method for down regulating CD4 expression in a T cell |
| 07/11/2000 | US6087177 Selection methods |
| 07/11/2000 | US6087175 By modulating the level and/or catalytic activity of a cell cycle control protein like p34(cdc2) or a related molecule having a cyclin related kinase function; increased yield or weather/environment resistance |
| 07/11/2000 | US6087173 Antisense modulation of X-linked inhibitor of apoptosis expression |
| 07/11/2000 | US6087172 For treatment of rheumatoid arthritis by suppression of interleukin-15 production |
| 07/11/2000 | US6087171 Method for inducing DNA synthesis in neurons |
| 07/11/2000 | US6087169 HKABY60: polynucleotide encoding a helix-loop-helix ubiquitous kinase family polypeptide |
| 07/11/2000 | US6087168 Obtaining basal epidermal cells, transfecting with expression vectors coding for neurogenic transcription factors, adding antisense oligonucleotide to suppress negative regulators of neuronal differentiation, culturing with retinoid and factors |
| 07/11/2000 | US6087167 Promoting neuron survival or neurite outgrowth by contacting neurons with an amount of an eck receptor binding protein of specific amino acid sequence |
| 07/11/2000 | US6087166 Transcriptional activators with graded transactivation potential |
| 07/11/2000 | US6087164 Introducing polynucleotide comprising a regulatory sequence, derived from a genomically imprinted gene specifically expressed in tumor cell, linked to a heterologous sequence encoding cytotoxic product; antitumor agents; gene therapy |
| 07/11/2000 | US6087163 Mycobacterium tuberculosis specific proteins and genes, mixtures of anitgens and uses thereof |
| 07/11/2000 | US6087162 Transgenic plants resistant to geminivirus infection |
| 07/11/2000 | US6087161 Recombinant polynucleotide of promoter and sequence encoding protein with translation stop codon in open reading frame at 3' end resuling in deletion of c-terminal amino acids important for vacuolar targeting; for fungi resistant plants |
| 07/11/2000 | US6087160 Programmed cell death genes and proteins |
| 07/11/2000 | US6087154 Rhesus neuropeptide Y1 receptor |
| 07/11/2000 | US6087152 Dna sequence which codes geranylgeranyl pyrophosphate synthase of flavobacterium species r1534; improved biosynthesis from farnesyl pyrophosphate and isopentyl pyrophosphate to beta-carotene, lycopene, and others |
| 07/11/2000 | US6087150 Interleukin-1 β converting enzyme like apoptosis protease-3 and 4 |
| 07/11/2000 | US6087149 Nucleotide and amino acid sequences of isoamylase from rhodothermus species; for recombinant production of debranching enzyme for by-product inhibition of the undesired trisaccharide panose |
| 07/11/2000 | US6087147 Nucleic acid encoding maltopentaose-producing alpha-amylase having amino acid sequence derived from pseudomonas species but modified by amino acid replacement to reduce degrading activity; does not degrade product to maltotriose or maltose |
| 07/11/2000 | US6087146 Recombinant thermostable enzyme for converting maltose into trehalose |
| 07/11/2000 | US6087145 Esterase gene and its use |
| 07/11/2000 | US6087144 Mammalian enzymatic protein receptor; for the activation of cell differentiation and propagation; for screening modulators or receptor activity |
| 07/11/2000 | US6087142 Valyl tRNA synthetase from streptococcus pneumoniae |
| 07/11/2000 | US6087140 Preparing an alchol by fermentation; aerobically culturing a recombinant microorganism which expresses enzyme activity and metabolizes a carbon source into a alchol, isolating alchol |
| 07/11/2000 | US6087133 Accumulation of preferential nucleotide sequences; incubation of nucleotide sequences with polymerase, nucleotide triphosphates and primers, heat, allow hybridization, extend chains, accumulate target sequences |
| 07/11/2000 | US6087132 Preparing deoxyribonucleotide; incubation of enzymatic polypeptide with nucleic acids, enzymatic polypeptide catalyzes the reduction of the ribosyl group of the nucleic acids to form deoxyribonucleic acid, recovering |
| 07/11/2000 | US6087130 Antibody substances that bind to ICAM-related protein |
| 07/11/2000 | US6087129 Recombinant expression of proteins from secretory cell lines |
| 07/11/2000 | US6087128 DNA encoding an avian E. coli iss |
| 07/11/2000 | US6087127 Nucleotide sequence which codes a viral disease polypeptide; for the development of vaccines for prevention of viral infection |
| 07/11/2000 | US6087126 Bactericidal/permeability-increasing protein (BPI) deletion analogs |
| 07/11/2000 | US6087124 Genetic transformation of ciliate cells through microcarrier bombardment with DNA-loaded gold particles |
| 07/11/2000 | US6087122 Polynucleotide sequence which codes a mammalian polypeptide synthetases; for diagnosis, evaluation, prevention, and treatment of physiological defects |
| 07/11/2000 | US6087117 Murine immunoglobulin which binds to mamalian tumor protein; for genetic testing of cancer senesitivity, diagnosis, and treatment |
| 07/11/2000 | US6087116 Interleukin-18 (IL-18) receptor polypeptides and their uses |
| 07/11/2000 | US6087115 Methods of identifying negative antagonists for G protein coupled receptors |
| 07/11/2000 | US6087110 Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| 07/11/2000 | US6087108 Detecting a polynucleotide sequence coding a polypeptide; hybridizing polynucleotide to nucleic acid in sample, form and detect hybrid, presence of hybrid is indicative of polynucleotide coding polypeptide |
| 07/11/2000 | US6087107 Therapeutics and diagnostics for congenital heart disease based on a novel human transcription factor |
| 07/11/2000 | US6087106 Nucleic acids conferring and inducible resistance to glycopeptides particularly in gram-positive bacteria |
| 07/11/2000 | US6087105 Nucleotide sequences coding a protein associated with adherence and infection of bacterial parasite; for detection of modulators of bacterial adhesion |
| 07/11/2000 | US6087103 Tagged ligand arrays for identifying target-ligand interactions |
| 07/11/2000 | US6087102 Biopolymer targets immobilized on a surface of a rigid solid support; for gene expression analysis |
| 07/11/2000 | US6087100 Nucleic acid mediated electron transfer |
| 07/11/2000 | US6087099 Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
| 07/11/2000 | US6087096 Screening lymphocyte propagation in human; obtaining cells, generation of genetic map, comparing control genetic map to the genetic map of sample |
| 07/11/2000 | US6087095 DNA sequencing method |
| 07/11/2000 | US6086913 Introduction of nucleic acid fragments into geomes of cells |
| 07/11/2000 | US6086902 Recombinant bovine herpesvirus type 1 vaccines |
| 07/11/2000 | US6086897 Isolation peptide from a protein allergen of dermatophagoide |
| 07/11/2000 | US6086895 Treatment with proteins and polypeptides |
| 07/11/2000 | US6086894 Recombinant vaccine for diseases caused by encapsulated organisms |
| 07/11/2000 | US6086891 Plasmids |
| 07/11/2000 | US6086890 Bovine adenovirus expression vector system |
| 07/11/2000 | US6086871 Prothrombin derivatives |
| 07/11/2000 | US6086870 Co-precipitates of adenovirus with metal salts |
| 07/11/2000 | US6086867 By contacting the cell with a soluble polypeptide comprising the amino acid sequence of the extracellular domain of the transforming growth factor-beta (tgf-b) type iii receptor protein or mammalian dna encoding it |
| 07/11/2000 | US6086737 Identifying strands of dna by marking with a chromophore |
| 07/11/2000 | CA2082948C Immunogenic peptides, antibodies and uses thereof relating to cd4 receptor binding |
| 07/11/2000 | CA2079912C Hepatitis c virus epitopes |
| 07/11/2000 | CA2033069C Saf polypeptide, gene, promoter and use for expression in streptomyces |
| 07/11/2000 | CA2024279C Recombinant c-terminal -amidating enzyme of human thyroid origin |
| 07/11/2000 | CA2012740C A monoclonal antibody recognizing c-terminus of anp |
| 07/11/2000 | CA1341050C Neurite growth regulatory factors |
| 07/11/2000 | CA1341049C Optically transparent cell cultivation dish with planar electrode |
| 07/11/2000 | CA1341048C Method and compositions for making acsf and acsf antagonists |
| 07/06/2000 | WO2000039588A1 Detection of preactivated phagocytes |
| 07/06/2000 | WO2000039587A1 Composite arrays utilizing microspheres |
| 07/06/2000 | WO2000039347A1 A tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein |
| 07/06/2000 | WO2000039345A1 Mutation scanning array, and methods of use thereof |
| 07/06/2000 | WO2000039341A1 Method for determining therapeutic index from gene expression profiles |
| 07/06/2000 | WO2000039339A1 Statistical combining of cell expression profiles |
| 07/06/2000 | WO2000039337A1 Methods for robust discrimination of profiles |
| 07/06/2000 | WO2000039336A1 Methods of characterizing drug activities using consensus profiles |
| 07/06/2000 | WO2000039332A1 Genotyping cytochrome expression |
| 07/06/2000 | WO2000039331A1 Single nucleotide polymorphism in a pyruvate dehydrogenase kinase isoenzyme 2 (pdk2) in humans |
| 07/06/2000 | WO2000039327A1 Peptidoglycan recognition proteins |
| 07/06/2000 | WO2000039323A2 Production of proteins in gram-positive microorganisms |
| 07/06/2000 | WO2000039322A1 Methods for producing polypeptides in aspergillus mutant cells |
| 07/06/2000 | WO2000039320A1 Transfectacons comprising calcium phosphate and a nucleic acid |
| 07/06/2000 | WO2000039319A2 Target cell-specific adenoviral vectors containing e3 and methods of use thereof |
| 07/06/2000 | WO2000039318A1 Compositions and methods for packaging of alphavirus vectors |
| 07/06/2000 | WO2000039317A1 Gene transfer vector for the diagnosis and therapy of malign tumors |
| 07/06/2000 | WO2000039316A1 Transgenic rodents and rodent cell lines expressing hiv co-receptors |