Patents
Patents for C07D 459 - Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone (97)
04/2014
04/16/2014CN102627641B Method for extracting multiple alkaloids from rauvolfia vomitoria
03/2014
03/26/2014CN103664974A Aryl [a] indole [2,3-g] quinolizine compound as well as preparation method, pharmaceutical composition and application thereof
01/2014
01/16/2014WO2014009222A1 Combination therapy for the treatment of cancer and immunosuppression
07/2013
07/03/2013CN102010409B Method for extracting and separating yohimbine from Africa yohimbe bark
01/2013
01/09/2013CN102863439A Method for extracting yohimbine hydrochloride from yohimbe barks
01/02/2013CN102020641B Method for extracting ajmaline from Rauwolfia root bark
12/2012
12/19/2012CN101735214B Method for extracting ajmaline from devilpepper waste liquor
11/2012
11/29/2012WO2012042541A3 Method for predicting and modeling anti-psychotic activity using virtual screening model
11/06/2012CA2560778C A process for the semisynthesis of deserpidine
08/2012
08/08/2012CN102627641A Method for extracting multiple alkaloids from rauvolfia vomitoria
08/02/2012US20120197016 Screening methods of modulating adrenergic receptor gene expressions implicated in melanogenesis
05/2012
05/09/2012CN102002039B Method for extracting yohimbine from yohimbine bark
03/2012
03/20/2012CA2363067C Compounds and methods to inhibit or augment an inflammatory response
03/15/2012US20120065401 Methods to inhibit or augment an inflammatory response
11/2011
11/16/2011EP2386565A2 Compounds and methods to inhibit or augment an inflammatory response
07/2011
07/20/2011CN101623310B Method for extracting total alkali, reserpine and rutin from devilpepper
05/2011
05/18/2011CN101475570B Method for extracting hypotensor raw material alserin from davilpepper
05/04/2011CN102040605A Method for extracting high-content yohimbine
04/2011
04/27/2011CN102030747A Preparation method for yohimbine
04/20/2011CN102020641A Method for extracting ajmaline from Rauwolfia root bark
04/13/2011CN102010409A Method for extracting and separating yohimbine from Africa yohimbe bark
04/06/2011CN102002039A Method for extracting yohimbine from yohimbine bark
06/2010
06/16/2010CN101735214A Method for extracting ajmaline from devilpepper waste liquor
07/2009
07/08/2009CN101475570A Method for extracting hypotensor raw material alserin from davilpepper
06/2009
06/03/2009CN100494194C Method of extracting reserpine from davilpepper
05/2009
05/26/2009US7538223 Compounds, compositions and methods
04/2009
04/08/2009CN100475811C A process for the semisynthesis of deserpidine
12/2008
12/23/2008US7468438 Demethylation of reserpic acid lactone to give 11-O-demethyl reserpic acid lactone, converting to deserpidic acid lactone, hydrolysis to methyl deserpidate esterification of methyl deserpidate with trimethoxybenzoic acid to give deserpidine
10/2008
10/02/2008US20080242864 Process for the Semisynthesis of Deserpidine
06/2008
06/25/2008EP1737855B1 A process for the semisynthesis of deserpidine
12/2007
12/05/2007CN101081849A Technique for synthesizing ground shepping
11/2007
11/07/2007EP1852422A2 Nitrosated and nitorsylated alpha-andrenergic receptor antagonist compounds, compositions and their uses
08/2007
08/15/2007CN101016297A Method of extracting reserpine from davilpepper
08/01/2007EP1018879B1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
03/2007
03/21/2007CN1934110A A process for the semisynthesis of deserpidine
01/2007
01/03/2007EP1737855A1 A process for the semisynthesis of deserpidine
09/2006
09/14/2006WO2005095394A8 A process for the semisynthesis of deserpidine
10/2005
10/13/2005WO2005095394A1 A process for the semisynthesis of deserpidine
08/2005
08/25/2005US20050187222 Therapy for impotency, erectile dysfuction; benign prostatic hyperplasia; hypotensive agents; congestive heart failure; vision defects; neurodegenerative disorders; incotinence; cognition activators
03/2005
03/24/2005US20050065161 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
08/2004
08/11/2004CN1161097C Method and composition for causing skin lightening
07/2004
07/28/2004CN1515242A Method and composition for whiting skin
02/2003
02/04/2003US6514934 For treating sexual dysfunctions in males and females
10/2002
10/22/2002US6469065 Compound that donates, transfers or releases nitric oxide, elevates endogenous levels of nitric oxide
10/03/2002US20020143007 Donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase; for use in therapy
08/2002
08/13/2002US6433182 Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
07/2002
07/09/2002US6417162 Female impotence treated with heterocyclic compound containing nitro groups
05/2002
05/23/2002US20020061879 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
01/2002
01/02/2002EP1164848A1 Compositions and methods for preventing and treating sexual dysfunctions
11/2001
11/27/2001US6323211 Alpha.-adrenergic receptor antagonist and at least one compound that elevates endogenous nitric oxide or endothelium-derived relaxing factor in vivo
10/2001
10/10/2001EP1141011A2 Compounds and methods to inhibit or augment an inflammatory response
09/2001
09/25/2001US6294517 Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
06/2001
06/27/2001EP1109542A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
05/2001
05/31/2001WO2000042071A3 Compounds and methods to inhibit or augment an inflammatory response
12/2000
12/13/2000CN1276715A Method and composition for causing skin lightening
10/2000
10/12/2000WO2000059304A1 Compositions and methods for preventing and treating sexual dysfunctions
08/2000
08/01/2000US6096295 Composition for causing skin lightening
07/2000
07/20/2000WO2000042071A2 Compounds and methods to inhibit or augment an inflammatory response
07/20/2000CA2697598A1 Compounds and methods to inhibit or augment an inflammatory response
07/19/2000EP1018879A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
03/2000
03/09/2000WO2000012075A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
03/09/2000CA2339145A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
11/1999
11/30/1999US5994294 Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
08/1999
08/03/1999US5932538 Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
04/1999
04/01/1999WO1999015149A1 Method and composition for causing skin lightening
04/01/1999CA2304452A1 Method and composition for causing skin lightening
03/1999
03/09/1999US5879665 Extract of johimbe tree bark and topical vehicle or carrier
08/1997
08/07/1997WO1997027749A1 NITROSATED AND NITROSYLATED α-ADRENERGIC RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND THEIR USES
08/07/1997CA2244879A1 Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
08/1994
08/03/1994EP0608604A1 Ajmaline to reduce elevated intraocular pressure
08/02/1994US5334385 New alkaloid derivatives, their use and pharmaceutical formulations containing them
05/1994
05/03/1994US5308849 Ajmaline
12/1993
12/08/1993EP0573260A1 New alkaloid derivatives, their use and pharmaceutical formulations containing them
10/1992
10/13/1992CA1308720C Sulphonamides
02/1991
02/27/1991EP0413709A1 Fatty amino acids, and homo- and hetero-oligomers and conjugates thereof
11/1989
11/02/1989WO1989010348A1 Fatty amino acids, and homo- and hetero-oligomers and conjugates thereof
11/1988
11/29/1988US4788202 Sulphonamide derivatives as α2 -adrenoceptor antagonists
10/1987
10/13/1987CA1228026A1 Treatment for selective weight control
03/1987
03/11/1987EP0213793A2 Sulphonamides
10/1985
10/29/1985CA1195978A2 Hydroxyamino-eburnane derivatives and a process for the preparation thereof
06/1985
06/25/1985US4525359 Applying adrenergic stimulator to local area
04/1985
04/02/1985US4508715 Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs
10/1984
10/03/1984EP0120165A2 A preparation and a process for achieving regional weight control
04/1984
04/18/1984EP0105361A1 Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs
10/1983
10/27/1983WO1983003541A1 Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs
06/1983
06/14/1983CA1148157A1 Hydroxyamino-eburnane derivatives and a process for the preparation thereof
08/1982
08/17/1982US4345082 Process for the preparation of hydroxyamino-eburnane derivatives and octahydroindoloquinolizine intermediates
12/1980
12/09/1980US4238491 Method for treating hypertension with methylreserpate
02/1980
02/12/1980CA1071628A1 Indolo-quinolizines
12/1979
12/04/1979CA1067496A1 1-(2-cyano-ethyl)-1,2,3,4,6,7-hexahydro-12h-indolo(2,3-a) quinolizino compounds
04/1979
04/03/1979CA1051900A1 1-hydroxymethyl-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine compounds
10/1978
10/03/1978CA1039728A1 Reserpine derivatives
10/1977
10/04/1977US4052404 Indolo (2,3-α)quinolizines
07/1977
07/19/1977US4036841 Vasodilators
08/1976
08/31/1976US3978065 Hypotensive
08/10/1976US3974164 Reserpic acid derivatives
02/1976
02/24/1976US3940387 Yohimbine derivatives, process for their preparation and their applications