| Patents for A61K 31 - Medicinal preparations containing organic active ingredients (785,912) |
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| 05/15/2008 | US20080114051 Pyrrolidine derivatives as prostaglandin modulators |
| 05/15/2008 | US20080114050 Use of 5-(2-Cyano-5-pyrolyl)-2-indolinones for contraception; e.g. 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile; also use in hormone replacement therapy, dysmenorrhea, premenstrual syndrome, hormone-dependent cancers, uterine bleeding |
| 05/15/2008 | US20080114049 (1S,6R)-6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane; use in therapy as serotonin (5-HT), dopamine (DA) and norepinephrine (NE), re-uptake inhibitors |
| 05/15/2008 | US20080114048 Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators |
| 05/15/2008 | US20080114047 Mycobacterium tuberculosis infection; protozoan pathogens; fungal pathogens; 2-((4-Amidinobenzofuran-2-yl)methyl)benzofuran-4-carboxamidine; 4,5-Dihydro-2-(2-(2-(5-(4,5-dihydro-1H-imidazol-2-yl)benzofuran-2-yl)ethyl)benzofuran-5-yl)-1H-imidazole |
| 05/15/2008 | US20080114046 Pharmaceutical Combination of Angiotensin II Antagonists and Angiotensin I Converting Enzyme Inhibitors |
| 05/15/2008 | US20080114045 Process for the Production of Candesartan |
| 05/15/2008 | US20080114044 Isoxazole compounds as Peroxisome Proliferator-Activated Receptor (PPAR) delta modulators; (5-{4-[2-(2,4-Dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid; diabetes, cardiovascular disorders, dyslipidemias, irritable bowel disease, cancer, skin disorders, eye disorders |
| 05/15/2008 | US20080114043 Medicinal Composition for Inhalation |
| 05/15/2008 | US20080114042 Compound |
| 05/15/2008 | US20080114041 Benzothiazolesulfonamides |
| 05/15/2008 | US20080114040 Epothilone Derivatives |
| 05/15/2008 | US20080114039 3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; Cystic Fibrosis, Duchenne Muscular Dystrophy |
| 05/15/2008 | US20080114038 Drugs Derived from Diclofenac Containing No-Donor Heterocycles, Composition and Method of Inflammation Treatment |
| 05/15/2008 | US20080114037 Histone deacetylase inhibitors |
| 05/15/2008 | US20080114036 Novel Compounds, Their Preparations And Use |
| 05/15/2008 | US20080114035 Novel intermediate compounds useful in the preparation of oxazoles and pharmaceutical actives for the regulation of lipid and glucose metabolism |
| 05/15/2008 | US20080114034 ethyl 1-benzyl-5-(3-carboxypropoxy)-2-methyl-6-pyrid-3-yl-1H-indole-3-carboxylate; peroxisome proliferator activated receptors agonist; dyslipidaemia, atherosclerosis, diabetes, obesity; high level lipoprotein controllong |
| 05/15/2008 | US20080114033 N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; Met kinase inhibitor; hypatocyte growth factor antagonist; anticarcinogenic agent |
| 05/15/2008 | US20080114032 Method of treating or preventing central nervous system disorders with compounds having selectivity for the alpha 3 subunit of the benzodiazepine receptor |
| 05/15/2008 | US20080114031 1,2;5,6-Di-O-isopropylidene-3-deoxy-3-[{(4-chloro-phenyl)amino}-carbonyl]-amino- alpha -D-allofuranoside; |
| 05/15/2008 | US20080114030 Diarymethyl and related compounds |
| 05/15/2008 | US20080114029 Crystalline form of 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline; urinary antispasmodic |
| 05/15/2008 | US20080114028 Combining solifenacin, succinic acid, and a solvent; urinary antispasmodic; selective antagonist to the M(3)-receptor |
| 05/15/2008 | US20080114027 Postoperative delirium, sepsis associated delirium, and drug or alcohol withdrawal associated delirium; using ibudilast; kits |
| 05/15/2008 | US20080114026 1-[4-(4-chloro-2-methyl-3H-imidazo[4,5-c]pyridin-3-ylmethyl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea; antitumor, antiinflammatory agent, autoimmune diseases; kinase signal transduction (tyrosine, Raf) mediated diseases: solid tumors, leukemia, psoriasis, arthritis, endometriosis, |
| 05/15/2008 | US20080114025 Inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general vascular therapeutic and diagnostic procedures; use of ADP receptor antagonist and a thromboxane A2 receptor antagonist |
| 05/15/2008 | US20080114024 such as 5-(3-Aminopropylamino)-2-benzyloxy-7-(4-methoxyphenyl)-[1,6]naphthyridine; spleen tyrosine kinase inhibitor; controlling activation of mast cells; antiallergens, antiinflamamtory agents; asthma, chronic obstructive pulmonary disease (COPD), Crohn's disease, bronchitis, conjunctivitis, psoriasis |
| 05/15/2008 | US20080114023 Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
| 05/15/2008 | US20080114022 (1-Benzyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid; chemoattractant receptor-homologous molecule expressed on helper T-cells antagonist; antiinflammatory agent, antiallergen; obstructive airways disease |
| 05/15/2008 | US20080114021 Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent |
| 05/15/2008 | US20080114020 Difluoro-Substituted Imidazopyridines |
| 05/15/2008 | US20080114019 Immunomodulators for inducing cytokine biosynthesis, for treatment of diseases including viral and neoplastic diseases; 1-[3-(Aminooxy)propyl]-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine; N-[3-(4-Amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propoxy]cyclopropanecarboxamide |
| 05/15/2008 | US20080114018 Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands |
| 05/15/2008 | US20080114017 2-Methyl-1-thioxo-10-(3-trifluoromethoxy-phenyl)-1,2,3a,4,9,10-hexahydro-2,9,10a-triaza-cyclopenta[b]fluoren-3-one; anticarcinogenic agent; solid tumor and leukemia; cell-cycle specific mode of action: DNA replication or interfering directly with basic cellular molecules like DNA |
| 05/15/2008 | US20080114016 5-(3-aminopropyl)-3-methyl-2,5,7,8,9,10-hexahydro-4H-benzo[g]pyrazolo[4,3-c]quinolin-4-one; anticarcinogenic agent; enhance DNA damaging agents by initiating mitosis before DNA repair is complete and thereby causing tumor cell death; in preparation of a anticancer medicaments |
| 05/15/2008 | US20080114015 NF-kB inhibitors and uses thereof |
| 05/15/2008 | US20080114014 Treating urinary and fecal incontinence in a patient being treated for a cognitive disorder consisting of one of a group of acute dementia and cognitive impairment by administration of a therapeutic amount of a quaternary ammonium anti-cholinergic muscarinic receptor antagonist |
| 05/15/2008 | US20080114013 Spiroindolinone derivatives |
| 05/15/2008 | US20080114012 1-(1,3-benzodioxol-5-yl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro[ beta -carboline-4,1'-cyclopropane]-2(3H)-carboxamide; mitochondrial benzodiazepine receptor modulator; digestive system disease caused by stress: irritable bowel syndrome, ulcerative colitis, or Crohn's disease |
| 05/15/2008 | US20080114011 Enhancement of Effectiveness of 5-Fluorouracil in Treatment of Tumor Metastases and Cancer |
| 05/15/2008 | US20080114010 Novel Substituted Imidazole Compounds |
| 05/15/2008 | US20080114009 Farnesyl Transferase Inhibiting 1,2-Annelated Quinoline Enantiomer |
| 05/15/2008 | US20080114008 Quinazoline Derivatives as Antiviral Agents |
| 05/15/2008 | US20080114007 8-indan-5-yl-5-oxo-2-(3-piperazin-1-yl-phenylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid isopropylamide; antiinflammatory, anticarcinogenic agent, cardiovascular disease; glomerulonephritis, immune nephritis, rheumatoid arthritis, asthma, pancreatitis, HIV infection, psoriasis |
| 05/15/2008 | US20080114006 For example, 1-(5-(2-amino-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-2-fluorophenyl)-3-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies |
| 05/15/2008 | US20080114005 2-Methyl-2-{4-[2-(2-methyl-4-oxo-4H-quinazolin-3-yl)-ethylamino]-phenylsulfanyl}-propionic acid ethyl ester; peroxisome proliferaor activated receptors alfa and gamma agonist; diabetic dyslipidemia, metabolic syndrome, diabetes, non-insulin dependent diabetes, cardiovascular disease, and obesity |
| 05/15/2008 | US20080114004 Hydrazone derivatives as kinase inhibitors |
| 05/15/2008 | US20080114003 Pyrimidinylisoxazole Derivatives |
| 05/15/2008 | US20080114002 3-[2-(3-Cyanophenoxy)-4-(trifluoromethyl)phenyl]propanoic acid;prostaglandin D2 inhibitor, orphan receptor CRTH2 antagonist; antiinflammatory, analgesic, antipyretic; respiratory system disorders: asthma and rhinitis; coupling amino/thio-phenyl derivatives with ester followed by hydrolysis to acid |
| 05/15/2008 | US20080114001 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-trifluoromethyl)phenyl]-benzamide; antitumor and antiproliferative agent, angiogenesis inhibitor; leukemia, myelodysplastic syndromes or pulmonary hypertension |
| 05/15/2008 | US20080114000 Suppressor of excess accumulation of intracellular sodium ions |
| 05/15/2008 | US20080113999 Use of Amidomethyl-Substituted 2-(4-Sulfonylamino)-3-Hydroxy-3,4-Dihydro-2H-Chromen-6-yl-Compounds in the Treatment of Cardiac Arrhythmia and Other Disease States |
| 05/15/2008 | US20080113997 Compounds, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| 05/15/2008 | US20080113996 Treatment of renal diseases or conditions associated with abnormal ion flux in a mammal such as a human which comprises the administration of a hPPAR gamma modulator or salt or solvate thereof, such as farglitazar or rosiglitazone |
| 05/15/2008 | US20080113995 1-Cyclopentyl-4-{2-[5-(4-methanesulfonylphenyl)[1,2,4]oxadiazol-3-yl]ethyl}piperidine; histamine-H3 receptor antagonist or inverse agonist; nervous system, cardiovascular , respiratory system, gastrointestinal system and endocrinological system disorders |
| 05/15/2008 | US20080113993 Barbituric acid analogs as therapeutic agents |
| 05/15/2008 | US20080113992 Cyclin-dependent and serine/threonine kinases inhibitor; cell cycle arrest in the G2/M phase; antiproliferative, antitumor agent; leukemia, sarcoma, lung, breast, prostate, pancreas cancer; autoimmune diseases, arthritis, Alzheimer's disease |
| 05/15/2008 | US20080113991 Pyridopyrazines and the use thereof as kinase inhibitors |
| 05/15/2008 | US20080113990 Biphenyl derivatives as modulators of voltage gated ion channels |
| 05/15/2008 | US20080113989 For example, N-(1-Carbamoyl-1-oxo-3-phenylpropan-2-yl)-2-(E-2-(4-(1-pyrrolidinylmethyl)phenyl)ethen-1-yl)benzamide; calcium channel blockers; cardiovascular disorders; antiarthritic agents; inhibitors of enzymes, especially cysteine proteases such as calpain and cathepsins |
| 05/15/2008 | US20080113988 Isoxazoline-Indole Derivatives With an Improved Antipsychotic and Anxiolytic Activity |
| 05/15/2008 | US20080113987 2-(2-methylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine; phosphatidylinositol 3-kinase (PI3K) inhibitor; transplantation of organs or tissues, inflammatory bowel diseases, psoriasis or atopic dermatitis, chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, scleroderma |
| 05/15/2008 | US20080113986 such as serine/threonine, fusion, and tyrosine kinase receptors as nerve and fibroblast growth factor; abnormal activation of immune and nervous systems; antiproliferative; N-[4-methyl-3-(8-methyl-2-methylamino-7-oxo-7,8-dihydropteridin-6-yl)-phenyl]-3-morpholin-4-yl-5-trifluoromethyl-benzamide |
| 05/15/2008 | US20080113985 Modulators of ATP-binding cassette transporters |
| 05/15/2008 | US20080113984 3-Aryl-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| 05/15/2008 | US20080113983 (N (R)-1-Azabicyclo[2.2.2]oct-3-yl)-3-fluoro-5-phenylthiophene-2-carboxylic acid amide; antidepressant, anxiolytic, analgesic agent, cognition activator, attention disorders |
| 05/15/2008 | US20080113982 Azacyclosteroid histamine-3 receptor ligands |
| 05/15/2008 | US20080113981 Treating pulmonary diseases, asthma, chronic obstructive pulmonary disease, chronic bronchitis, pre-term labor, neurological and cardiac disorders; improved duration of action, potency, selectivity; 8-hydroxy-5-((R)-1-hydroxy-2-{2-[4-(6-methoxybiphenyl-3-yloxy)phenyl]-ethylamino}ethyl)-1H-quinolin-2-one |
| 05/15/2008 | US20080113980 Substituted-2-imidazoles |
| 05/15/2008 | US20080113978 Substituted imidazo[1,2-b]pyridazine compounds such as N-{4-chloro-5-[8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-thiazol-2-yl}-morpholine; use as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases |
| 05/15/2008 | US20080113977 For example, 7-Bromo-4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline; for treating physiological disorders, particularly congestive heart disease |
| 05/15/2008 | US20080113976 asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis; Azetidine-1-carboxylic acid {2-[({2-hydroxy-1-[(isopropyl-methyl-amino)-methyl]-pentylcarbamoyl}-methyl)-carbamoyl]-4-trifluoromethyl-phenyl}-amide |
| 05/15/2008 | US20080113975 Thiourea compounds |
| 05/15/2008 | US20080113974 Heterocyclic Oxime Compounds, A Process For Their Preparation And Pharmaceutical Compositions Containing Them. |
| 05/15/2008 | US20080113973 Pharmaceutical composition in unit dose form which contains a COX-2 inhibitor and a thromboxane A2 receptor antagonist; for treatment of pain or inflammation; less risk of inducing adverse cardiovascular effects than when COX-2 inhibitors are administered alone |
| 05/15/2008 | US20080113972 Enzyme inhibitors of cGMP-metabolizing phosphodiesterases, for TREATMENT OF CARDIOVASCULAR DIORDERS, CEREBROVASCULAR DISORDERS, UROGENITAL DISORDERS AND ERECTILE DYSFUNCTION; chemical synthesis |
| 05/15/2008 | US20080113971 improved potency; reduced undesirable side effects; pain, inflammation, arthritis etc; ethyl 1-(2-aminoethyl)-3-pyridin-4-yl-1H-pyrazole-5-carboxylate dihydrochloride |
| 05/15/2008 | US20080113970 Transnasal anticonvulsive pharmaceutical composition |
| 05/15/2008 | US20080113969 Administering allosteric adenosine A1 receptor enhancer in conjunction with opioid analgesics or 2-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)/kainate antagonists for alleviating postoperative pain |
| 05/15/2008 | US20080113968 Substituted piperazines and diazepanes |
| 05/15/2008 | US20080113967 Enzyme modulators and treatments |
| 05/15/2008 | US20080113966 CGRP (Calcitonin Gene-Related Peptide); migraine and cluster headache; compounds based on 6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine or 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine |
| 05/15/2008 | US20080113965 Skeletal muscle protecting agent |
| 05/15/2008 | US20080113964 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives and Their Use As Progesterone Receptor Modulators |
| 05/15/2008 | US20080113963 Prepared by submitting benzimidazole compound to a cyclization reaction; gastric secretion inhibiting and gastric and intestinal protective action properties; for gastrointestinal disorders; for example, 2,3-Dimethyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-a]imidazole-5-carboxylic acid dimethylamide |
| 05/15/2008 | US20080113962 Condensed Tricyclic Benzimidazoles For the Treatment of Gastrointestinal Disorders |
| 05/15/2008 | US20080113961 Immunosuppressants with low toxicity; 1-({4-Methyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylic acid for example; autoimmune diseases and transplant rejection; N-substituted azetidine, pyrrolidine or piperidine compounds |
| 05/15/2008 | US20080113960 Combinations comprising a low molecular weight thrombin inhibitor and a prodrug of a low molecular weight thrombin inhibitor |
| 05/15/2008 | US20080113959 {Beta}-Lactamyl vasopression V1a antagonists and methods of use |
| 05/15/2008 | US20080113958 Treating neurodegenerative diseases, psychological disorders, pain, glaucoma, dru eye, dry mouth, Sjogren's syndrome, asthma, bradycardia, wound healing, gastrointestinal disorders; compounds based on amide- or urea-functional 1,2,3,4-tetrahydrospiro[benzo[b]azepine-5,4'-piperidine] rings |
| 05/15/2008 | US20080113957 azetidine-2-imines or fused ring derivatives thereof; inhibiting aspartyl proteases including beta-secretase; cardiovascular diseases, cognitive and neurodegenerative diseases such as Alzheimer's, inhibiting Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes |
| 05/15/2008 | US20080113956 Substituted Porphyrins |
| 05/15/2008 | US20080113955 Treatment of various patient populations at lower doses of stannsoporfin (tin (IV) mesoporphyrin IX dichloride) than previously believed effective, providing advantages in therapeutic administration; liver disorders |
| 05/15/2008 | US20080113954 Supramolecular Metallic Complexes Exhibiting Both DNA Binding and Photocleavage |
| 05/15/2008 | US20080113953 Administering ethinyl estradiol or prodrug thereof to patient with improved bioavailability by orally administering solid dosage form that releases effective amount of ethinyl estradiol or prodrug thereof in oral cavity for absorption through oral mucosa; for hormone replacement therapy or contraception |
| 05/15/2008 | US20080113952 Combination Therapy For Treating Heart Disease |
| 05/15/2008 | US20080113951 Administering in combination, a cyclooxygenase-2 inhibitor consisting of celecoxib or rofecoxib, low dose aspirin, and antioxidant flavonoids/isoflavones; synergistic; preventing thrombotic complications due to the long-term use of COX2 inhibitors |
| 05/15/2008 | US20080113950 analgesic drug for treating neuropathic pain is selected from gabapentine, norvaline, pregabaline, (S)3-isobutylGABA, arginine, thiocitrulline, agmantine, vigabatrin etc. and a NO donar drugs belonging to the classes of aspirin, ibuprofen, paracetamol, naproxen, diclofenac or flurbiprofen |
| 05/15/2008 | US20080113949 Use of dipyridamole in combination with acetylsalicylic acid and an angiotensin II antagonist for stroke prevention |